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    Mrps10 mitochondrial ribosomal protein S10 [ Mus musculus (house mouse) ]

    Gene ID: 64657, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mrps10provided by MGI
    Official Full Name
    mitochondrial ribosomal protein S10provided by MGI
    Primary source
    MGI:MGI:1928139
    See related
    Ensembl:ENSMUSG00000034729 AllianceGenome:MGI:1928139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rpms10; 1110038B19Rik
    Summary
    Predicted to be a structural constituent of ribosome. Located in mitochondrion. Is expressed in several structures, including brain; early conceptus; gonad; heart; and liver. Orthologous to human MRPS10 (mitochondrial ribosomal protein S10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.0), placenta adult (RPKM 2.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrps10 in Genome Data Viewer
    Location:
    17 C; 17 23.0 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47679803..47692343)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47368887..47381418)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47276999-47277108 Neighboring gene predicted gene, 41589 Neighboring gene transcriptional regulating factor 1 Neighboring gene predicted gene, 36715 Neighboring gene STARR-seq mESC enhancer starr_42696 Neighboring gene STARR-seq mESC enhancer starr_42698 Neighboring gene STARR-seq mESC enhancer starr_42699 Neighboring gene STARR-seq mESC enhancer starr_42700 Neighboring gene guanylate cyclase activator 1B Neighboring gene guanylate cyclase activator 1a (retina) Neighboring gene Morf4 family associated protein 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. Koc EC, et al. J Biol Chem, 2000 Oct 20. PMID 10938081
    2. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article
    3. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
    4. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
    5. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial small ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of mitochondrial small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein uS10m
    Names
    28S ribosomal protein S10, mitochondrial
    MRP-S10
    S10mt
    NP_001139683.1
    NP_001139684.1
    NP_898909.2
    XP_011244868.1
    XP_011244869.1
    XP_030105834.1
    XP_030105835.1
    XP_030105836.1
    XP_036016633.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146211.1 → NP_001139683.1  small ribosomal subunit protein uS10m isoform 2

      See identical proteins and their annotated locations for NP_001139683.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, that results in a protein (isoform 2) that is one amino acid shorter than isoform 1.
      Source sequence(s)
      BB862036, BC096043, DV046794
      Consensus CDS
      CCDS50130.1
      UniProtKB/TrEMBL
      G5E8U8, Q501J4
      Related
      ENSMUSP00000113460.2, ENSMUST00000120737.8
      Conserved Domains (1) summary
      pfam00338
      Location:77 → 171
      Ribosomal_S10; Ribosomal protein S10p/S20e

    2. NM_001146212.1 → NP_001139684.1  small ribosomal subunit protein uS10m isoform 1

      See identical proteins and their annotated locations for NP_001139684.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK004151, BB862036, BC096043
      Consensus CDS
      CCDS50129.1
      UniProtKB/TrEMBL
      G5E8U5, Q501J4
      Related
      ENSMUSP00000113343.2, ENSMUST00000119945.8
      Conserved Domains (1) summary
      pfam00338
      Location:78 → 172
      Ribosomal_S10; Ribosomal protein S10p/S20e

    3. NM_183086.2 → NP_898909.2  small ribosomal subunit protein uS10m isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus when compared to isoform 1 and likely lacks a mitochondrial localization sequence.
      Source sequence(s)
      AC112683, BC096043
      Consensus CDS
      CCDS28846.1
      UniProtKB/Swiss-Prot
      Q4V9W5, Q80ZK0
      UniProtKB/TrEMBL
      E9QJS0
      Related
      ENSMUSP00000055301.7, ENSMUST00000060752.13
      Conserved Domains (1) summary
      pfam00338
      Location:37 → 131
      Ribosomal_S10; Ribosomal protein S10p/S20e

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      47679803..47692343
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249975.2 → XP_030105835.1  small ribosomal subunit protein uS10m isoform X2

      UniProtKB/TrEMBL
      Q501J4
      Conserved Domains (1) summary
      pfam00338
      Location:75 → 170
      Ribosomal_S10; Ribosomal protein S10p/S20e

    2. XM_011246566.3 → XP_011244868.1  small ribosomal subunit protein uS10m isoform X3

      UniProtKB/TrEMBL
      Q501J4
      Conserved Domains (1) summary
      pfam00338
      Location:74 → 169
      Ribosomal_S10; Ribosomal protein S10p/S20e

    3. XM_011246567.4 → XP_011244869.1  small ribosomal subunit protein uS10m isoform X2

      UniProtKB/TrEMBL
      Q501J4
      Conserved Domains (1) summary
      pfam00338
      Location:75 → 170
      Ribosomal_S10; Ribosomal protein S10p/S20e

    4. XM_036160740.1 → XP_036016633.1  small ribosomal subunit protein uS10m isoform X2

      UniProtKB/TrEMBL
      Q501J4
      Conserved Domains (1) summary
      pfam00338
      Location:75 → 170
      Ribosomal_S10; Ribosomal protein S10p/S20e

    5. XM_030249976.2 → XP_030105836.1  small ribosomal subunit protein uS10m isoform X3

      UniProtKB/TrEMBL
      Q501J4
      Conserved Domains (1) summary
      pfam00338
      Location:74 → 169
      Ribosomal_S10; Ribosomal protein S10p/S20e

    6. XM_030249974.2 → XP_030105834.1  small ribosomal subunit protein uS10m isoform X1

      Conserved Domains (1) summary
      pfam00338
      Location:155 → 250
      Ribosomal_S10; Ribosomal protein S10p/S20e
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80ZK0.1 GenPept UniProtKB/Swiss-Prot:Q80ZK0

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