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    ADAMTSL4 ADAMTS like 4 [ Homo sapiens (human) ]

    Gene ID: 54507, updated on 3-Dec-2024

    Summary

    Official Symbol
    ADAMTSL4provided by HGNC
    Official Full Name
    ADAMTS like 4provided by HGNC
    Primary source
    HGNC:HGNC:19706
    See related
    Ensembl:ENSG00000143382 MIM:610113; AllianceGenome:HGNC:19706
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TSRC1; ECTOL2; ADAMTSL-4
    Summary
    This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Sep 2014]
    Expression
    Biased expression in placenta (RPKM 57.7), lung (RPKM 14.8) and 11 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ADAMTSL4 in Genome Data Viewer
    Location:
    1q21.2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (150549408..150560937)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (149673436..149684971)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (150521884..150533413)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150482970-150483840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1300 Neighboring gene extracellular matrix protein 1 Neighboring gene focally amplified long non-coding RNA in epithelial cancer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:150505206-150506196 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:150507812-150509011 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:150515782-150516282 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:150516283-150516783 Neighboring gene CRISPRi-validated cis-regulatory element chr1.8461 Neighboring gene ADAMTSL4 antisense RNA 2 Neighboring gene Sharpr-MPRA regulatory region 6123 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1302 Neighboring gene uncharacterized LOC124904417 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150523090-150523779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150524269-150525138 Neighboring gene microRNA 4257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1692 Neighboring gene ADAMTSL4 antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:150534269-150535120 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:150535121-150535974 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:150539574-150540284 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:150540285-150540996 Neighboring gene RNA, 7SL, cytoplasmic 473, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 600, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    ADAMTS-like protein 4
    Names
    thrombospondin repeat-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012172.1 RefSeqGene

      Range
      4987..16512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001288607.2NP_001275536.1  ADAMTS-like protein 4 isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AL122085, AL356356, AY358122, BC144581, CB960863, HY002139
      Consensus CDS
      CCDS91048.1
      UniProtKB/TrEMBL
      A0A669KBE7, B7ZMJ3
      Related
      ENSP00000501255.1, ENST00000674058.1
      Conserved Domains (3) summary
      smart00209
      Location:938987
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:508618
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:9941023
      PLAC; PLAC (protease and lacunin) domain
    2. NM_001288608.2NP_001275537.1  ADAMTS-like protein 4 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001275537.1

      Status: REVIEWED

      Source sequence(s)
      AL356356
      Consensus CDS
      CCDS72908.1
      UniProtKB/TrEMBL
      B7ZMJ3
      Related
      ENSP00000358035.5, ENST00000369039.9
      Conserved Domains (3) summary
      smart00209
      Location:10001049
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:508622
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:10561085
      PLAC; PLAC (protease and lacunin) domain
    3. NM_001378596.1NP_001365525.1  ADAMTS-like protein 4 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL356356
      Consensus CDS
      CCDS955.1
      UniProtKB/Swiss-Prot
      B2RTT0, F8WAD0, Q5T5F7, Q6IPM6, Q6UY14, Q8N643, Q9HBS6
      UniProtKB/TrEMBL
      B7ZMJ3
      Conserved Domains (5) summary
      smart00209
      Location:4777
      TSP1; Thrombospondin type 1 repeats
      PHA03247
      Location:143392
      PHA03247; large tegument protein UL36; Provisional
      pfam05986
      Location:485599
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:10331062
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:727783
      TSP1_ADAMTS; Thrombospondin type 1 domain
    4. NM_019032.6NP_061905.2  ADAMTS-like protein 4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_061905.2

      Status: REVIEWED

      Source sequence(s)
      AL356356
      Consensus CDS
      CCDS955.1
      UniProtKB/Swiss-Prot
      B2RTT0, F8WAD0, Q5T5F7, Q6IPM6, Q6UY14, Q8N643, Q9HBS6
      UniProtKB/TrEMBL
      B7ZMJ3
      Related
      ENSP00000271643.4, ENST00000271643.9
      Conserved Domains (5) summary
      smart00209
      Location:4777
      TSP1; Thrombospondin type 1 repeats
      PHA03247
      Location:143392
      PHA03247; large tegument protein UL36; Provisional
      pfam05986
      Location:485599
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:10331062
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:727783
      TSP1_ADAMTS; Thrombospondin type 1 domain
    5. NM_025008.5NP_079284.2  ADAMTS-like protein 4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_079284.2

      Status: REVIEWED

      Source sequence(s)
      AL356356, AY358122, CB960863, CX164541, HY002139
      Consensus CDS
      CCDS30852.1
      UniProtKB/Swiss-Prot
      Q6UY14
      Related
      ENSP00000358037.5, ENST00000369041.9
      Conserved Domains (2) summary
      smart00209
      Location:786841
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:485599
      ADAM_spacer1; ADAM-TS Spacer 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      150549408..150560937
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422820.1XP_047278776.1  ADAMTS-like protein 4 isoform X3

      UniProtKB/TrEMBL
      B7ZMJ3
    2. XM_047422830.1XP_047278786.1  ADAMTS-like protein 4 isoform X4

      UniProtKB/Swiss-Prot
      B2RTT0, F8WAD0, Q5T5F7, Q6IPM6, Q6UY14, Q8N643, Q9HBS6
      UniProtKB/TrEMBL
      B7ZMJ3
    3. XM_017001506.3XP_016856995.1  ADAMTS-like protein 4 isoform X3

      UniProtKB/TrEMBL
      B7ZMJ3
      Conserved Domains (3) summary
      smart00209
      Location:10001049
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:508622
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:10561085
      PLAC; PLAC (protease and lacunin) domain
    4. XM_047422824.1XP_047278780.1  ADAMTS-like protein 4 isoform X3

      UniProtKB/TrEMBL
      B7ZMJ3
    5. XM_047422823.1XP_047278779.1  ADAMTS-like protein 4 isoform X3

      UniProtKB/TrEMBL
      B7ZMJ3
    6. XM_047422819.1XP_047278775.1  ADAMTS-like protein 4 isoform X2

      UniProtKB/TrEMBL
      B7ZMJ3
    7. XM_011509648.4XP_011507950.1  ADAMTS-like protein 4 isoform X3

      See identical proteins and their annotated locations for XP_011507950.1

      UniProtKB/TrEMBL
      B7ZMJ3
      Conserved Domains (3) summary
      smart00209
      Location:10001049
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:508622
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:10561085
      PLAC; PLAC (protease and lacunin) domain
    8. XM_047422832.1XP_047278788.1  ADAMTS-like protein 4 isoform X4

      UniProtKB/Swiss-Prot
      B2RTT0, F8WAD0, Q5T5F7, Q6IPM6, Q6UY14, Q8N643, Q9HBS6
      UniProtKB/TrEMBL
      B7ZMJ3
      Related
      ENSP00000358034.2, ENST00000369038.6
    9. XM_011509649.4XP_011507951.1  ADAMTS-like protein 4 isoform X5

      Conserved Domains (3) summary
      smart00209
      Location:80110
      TSP1; Thrombospondin type 1 repeats
      PHA03247
      Location:176425
      PHA03247; large tegument protein UL36; Provisional
      pfam05986
      Location:541655
      ADAM_spacer1; ADAM-TS Spacer 1
    10. XM_011509650.4XP_011507952.1  ADAMTS-like protein 4 isoform X6

      Conserved Domains (2) summary
      smart00209
      Location:80110
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:541655
      ADAM_spacer1; ADAM-TS Spacer 1
    11. XM_047422841.1XP_047278797.1  ADAMTS-like protein 4 isoform X7

    12. XM_047422842.1XP_047278798.1  ADAMTS-like protein 4 isoform X8

    13. XM_011509644.4XP_011507946.1  ADAMTS-like protein 4 isoform X1

      UniProtKB/TrEMBL
      B7ZMJ3
      Conserved Domains (3) summary
      smart00209
      Location:10331082
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:541655
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:10891118
      PLAC; PLAC (protease and lacunin) domain
    14. XM_011509651.3XP_011507953.1  ADAMTS-like protein 4 isoform X9

      See identical proteins and their annotated locations for XP_011507953.1

      Conserved Domains (3) summary
      smart00209
      Location:536585
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:44158
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:592621
      PLAC; PLAC (protease and lacunin) domain
    15. XM_011509652.3XP_011507954.1  ADAMTS-like protein 4 isoform X9

      See identical proteins and their annotated locations for XP_011507954.1

      Conserved Domains (3) summary
      smart00209
      Location:536585
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:44158
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:592621
      PLAC; PLAC (protease and lacunin) domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      149673436..149684971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337118.1XP_054193093.1  ADAMTS-like protein 4 isoform X3

      UniProtKB/TrEMBL
      B7ZMJ3
    2. XM_054337123.1XP_054193098.1  ADAMTS-like protein 4 isoform X4

      UniProtKB/TrEMBL
      B7ZMJ3
    3. XM_054337122.1XP_054193097.1  ADAMTS-like protein 4 isoform X3

      UniProtKB/TrEMBL
      B7ZMJ3
    4. XM_054337121.1XP_054193096.1  ADAMTS-like protein 4 isoform X3

      UniProtKB/TrEMBL
      B7ZMJ3
    5. XM_054337120.1XP_054193095.1  ADAMTS-like protein 4 isoform X3

      UniProtKB/TrEMBL
      B7ZMJ3
    6. XM_054337117.1XP_054193092.1  ADAMTS-like protein 4 isoform X2

      UniProtKB/TrEMBL
      B7ZMJ3
    7. XM_054337119.1XP_054193094.1  ADAMTS-like protein 4 isoform X3

      UniProtKB/TrEMBL
      B7ZMJ3
    8. XM_054337124.1XP_054193099.1  ADAMTS-like protein 4 isoform X4

      UniProtKB/TrEMBL
      B7ZMJ3
    9. XM_054337125.1XP_054193100.1  ADAMTS-like protein 4 isoform X5

    10. XM_054337126.1XP_054193101.1  ADAMTS-like protein 4 isoform X6

    11. XM_054337127.1XP_054193102.1  ADAMTS-like protein 4 isoform X7

    12. XM_054337128.1XP_054193103.1  ADAMTS-like protein 4 isoform X8

    13. XM_054337116.1XP_054193091.1  ADAMTS-like protein 4 isoform X1

      UniProtKB/TrEMBL
      B7ZMJ3
    14. XM_054337129.1XP_054193104.1  ADAMTS-like protein 4 isoform X9

    15. XM_054337130.1XP_054193105.1  ADAMTS-like protein 4 isoform X9