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Conserved domains on  [gi|767909580|ref|XP_011507950|]
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ADAMTS-like protein 4 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 509-622 6.30e-29

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 111.90  E-value: 6.30e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580   509 LVSGNLTdRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVDP-PGSYRAGGTVFRYNRPPREe 587
Cdd:pfam05986    1 TVSGSFT-EGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPA- 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 767909580   588 gkGESLSAEGPTTQPVDVYMIFQEE---NPGVFYQYVI 622
Cdd:pfam05986   79 --LEELHAPGPTQEDLEIQVLRQYGkgtNPGITYEYFI 114
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 750-806 7.33e-16

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 72.49  E-value: 7.33e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909580   750 WEAGEWTSCSRSCGPGTQHRQLQCRQEfgGGGSSVPPERCGHLPRPNITQSCQLRLC 806
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 937-993 2.56e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.55  E-value: 2.56e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909580   937 WYTGPWGECSSECGSGTQRRDIICVSKLGteFNVTSPSNCSHLPRPPALQPCQGQAC 993
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGG--GSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 997-1048 4.63e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.00  E-value: 4.63e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767909580   997 WFSTPWSPCSRSCQGGTQTREVQCLSTN---QTLSTRCPPQLRPSRKRPCNSQPC 1048
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsIVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 1056-1085 8.36e-11

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


:

Pssm-ID: 462560  Cd Length: 31  Bit Score: 57.55  E-value: 8.36e-11
                           10        20        30
                   ....*....|....*....|....*....|
gi 767909580  1056 CKDSSPHCPLVVQARLCVYPYYTATCCRSC 1085
Cdd:pfam08686    1 CKDKFANCSLVVQARLCSHKYYRQFCCRSC 30
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 436-507 7.89e-10

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 57.41  E-value: 7.89e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767909580   436 QGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGAP------DICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDSTC 507
Cdd:pfam19236   38 QGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPredgtlSLCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 809-864 3.26e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 53.61  E-value: 3.26e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909580   809 WEVGsPWSQCSVRCGRGQRSRQVRCVG-NNGDEVSEQECaSGPPQPPSREACDMGPC 864
Cdd:pfam19030    1 WVAG-PWGECSVTCGGGVQTRLVQCVQkGGGSIVPDSEC-SAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 868-931 8.43e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 49.76  E-value: 8.43e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767909580   868 WFHSDWSSkCSAECGTGIQRRSVVCLGSGaalgpGQGEAGagtGQSCPTGSRPPDMRACSLGPC 931
Cdd:pfam19030    1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKG-----GGSIVP---DSECSAQKKPPETQSCNLKPC 55
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 143-392 5.29e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 5.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  143 ARRSRLRDPIKPGMFGYGRVPfalplhrnrRHPRSPPRSELSLISSRGEEAIPSP---TPRAEPFSANGSPQTELPPTEL 219
Cdd:PHA03247 2581 AVTSRARRPDAPPQSARPRAP---------VDDRGDPRGPAPPSPLPPDTHAPDPpppSPSPAANEPDPHPPPTVPPPER 2651

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  220 SVHTPSPQAEPLSPETAQTEVAPRTRPAPLRHHPRA---------QASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWA 290
Cdd:PHA03247 2652 PRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAarptvgsltSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQA 2731

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  291 SPQV-AGRRPDPFPSVPRGRGqqGQGPWGTGGTPHGPRLEPDPQHPGA----WLPLLSNGPHASSLWSLFAPSSPIPRCS 365
Cdd:PHA03247 2732 SPALpAAPAPPAVPAGPATPG--GPARPARPPTTAGPPAPAPPAAPAAgpprRLTRPAVASLSESRESLPSPWDPADPPA 2809

                         250       260
                  ....*....|....*....|....*....
gi 767909580  366 GESEQLRA--CSQAPCPPEQPDPRALQCA 392
Cdd:PHA03247 2810 AVLAPAAAlpPAASPAGPLPPPTSAQPTA 2838
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 47-77 8.99e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.03  E-value: 8.99e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 767909580     47 WGPWVQWASCSQPCGVGVQRRSRTCQLPTVQ 77
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQ 31
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 697-746 3.39e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 36.66  E-value: 3.39e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 767909580   697 SACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASpEPCHGTPC 746
Cdd:pfam19030    7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPET-QSCNLKPC 55
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 509-622 6.30e-29

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 111.90  E-value: 6.30e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580   509 LVSGNLTdRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVDP-PGSYRAGGTVFRYNRPPREe 587
Cdd:pfam05986    1 TVSGSFT-EGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPA- 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 767909580   588 gkGESLSAEGPTTQPVDVYMIFQEE---NPGVFYQYVI 622
Cdd:pfam05986   79 --LEELHAPGPTQEDLEIQVLRQYGkgtNPGITYEYFI 114
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 750-806 7.33e-16

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 72.49  E-value: 7.33e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909580   750 WEAGEWTSCSRSCGPGTQHRQLQCRQEfgGGGSSVPPERCGHLPRPNITQSCQLRLC 806
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 937-993 2.56e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.55  E-value: 2.56e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909580   937 WYTGPWGECSSECGSGTQRRDIICVSKLGteFNVTSPSNCSHLPRPPALQPCQGQAC 993
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGG--GSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 997-1048 4.63e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.00  E-value: 4.63e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767909580   997 WFSTPWSPCSRSCQGGTQTREVQCLSTN---QTLSTRCPPQLRPSRKRPCNSQPC 1048
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsIVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 1056-1085 8.36e-11

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 57.55  E-value: 8.36e-11
                           10        20        30
                   ....*....|....*....|....*....|
gi 767909580  1056 CKDSSPHCPLVVQARLCVYPYYTATCCRSC 1085
Cdd:pfam08686    1 CKDKFANCSLVVQARLCSHKYYRQFCCRSC 30
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 436-507 7.89e-10

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 57.41  E-value: 7.89e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767909580   436 QGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGAP------DICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDSTC 507
Cdd:pfam19236   38 QGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPredgtlSLCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 809-864 3.26e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 53.61  E-value: 3.26e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909580   809 WEVGsPWSQCSVRCGRGQRSRQVRCVG-NNGDEVSEQECaSGPPQPPSREACDMGPC 864
Cdd:pfam19030    1 WVAG-PWGECSVTCGGGVQTRLVQCVQkGGGSIVPDSEC-SAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 868-931 8.43e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 49.76  E-value: 8.43e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767909580   868 WFHSDWSSkCSAECGTGIQRRSVVCLGSGaalgpGQGEAGagtGQSCPTGSRPPDMRACSLGPC 931
Cdd:pfam19030    1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKG-----GGSIVP---DSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1000-1049 4.19e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 44.89  E-value: 4.19e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 767909580   1000 TPWSPCSRSCQGGTQTREVQCLSTNQTLS-TRCPPQLRpsRKRPCNSQPCS 1049
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGgGPCTGEDV--ETRACNEQPCP 53
PHA03247 PHA03247
large tegument protein UL36; Provisional
 143-392 5.29e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 5.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  143 ARRSRLRDPIKPGMFGYGRVPfalplhrnrRHPRSPPRSELSLISSRGEEAIPSP---TPRAEPFSANGSPQTELPPTEL 219
Cdd:PHA03247 2581 AVTSRARRPDAPPQSARPRAP---------VDDRGDPRGPAPPSPLPPDTHAPDPpppSPSPAANEPDPHPPPTVPPPER 2651

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  220 SVHTPSPQAEPLSPETAQTEVAPRTRPAPLRHHPRA---------QASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWA 290
Cdd:PHA03247 2652 PRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAarptvgsltSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQA 2731

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  291 SPQV-AGRRPDPFPSVPRGRGqqGQGPWGTGGTPHGPRLEPDPQHPGA----WLPLLSNGPHASSLWSLFAPSSPIPRCS 365
Cdd:PHA03247 2732 SPALpAAPAPPAVPAGPATPG--GPARPARPPTTAGPPAPAPPAAPAAgpprRLTRPAVASLSESRESLPSPWDPADPPA 2809

                         250       260
                  ....*....|....*....|....*....
gi 767909580  366 GESEQLRA--CSQAPCPPEQPDPRALQCA 392
Cdd:PHA03247 2810 AVLAPAAAlpPAASPAGPLPPPTSAQPTA 2838
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 809-864 3.11e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.57  E-value: 3.11e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 767909580    809 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDeVSEQECasgPPQPPSREACDMGPC 864
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQ-NGGGPC---TGEDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 47-77 8.99e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.03  E-value: 8.99e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 767909580     47 WGPWVQWASCSQPCGVGVQRRSRTCQLPTVQ 77
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQ 31
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 99-316 5.88e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 43.87  E-value: 5.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580    99 GQGPRPQTSPETLPLYRTQSRGRGGPLRGPAShlgreeTQEIRAARRSRLRDPIKPGMFGYGRVPFALPLHRNRRHPRSP 178
Cdd:pfam09770  164 GVAPKKAAAPAPAPQPAAQPASLPAPSRKMMS------LEEVEAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFP 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580   179 PRSElslissrgeeaiPSPTPRAEPFSANGSPQTELPPTELSvHTPSPQAEPLSPetaqtevAPRTRPAPLRHHPRAQas 258
Cdd:pfam09770  238 PQIQ------------QQQQPQQQPQQPQQHPGQGHPVTILQ-RPQSPQPDPAQP-------SIQPQAQQFHQQPPPV-- 295

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767909580   259 gtePPSPTHSLgeggffrasPQPRRPSSQGWASPQVAGRRPDPFPSVPRGRGQQGQGP 316
Cdd:pfam09770  296 ---PVQPTQIL---------QNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGR 341
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 806-853 2.41e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.87  E-value: 2.41e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767909580  806 CGHWEvgsPWSQCSVRCGRGQRSRQ-----VRCVGNNGDEVSEQECasgPPQP 853
Cdd:PTZ00441  240 CGPWD---EWTPCSVTCGKGTHSRSrpilhEGCTTHMVEECEEEEC---PVEP 286
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 697-746 3.39e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 36.66  E-value: 3.39e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 767909580   697 SACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASpEPCHGTPC 746
Cdd:pfam19030    7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPET-QSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 750-806 6.46e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.03  E-value: 6.46e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909580    750 WEAGEWTSCSRSCGPGTQHRQLQCRqefgGGGSSVPPERCGHLPRpnITQSCQLRLC 806
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCC----SPPPQNGGGPCTGEDV--ETRACNEQPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 48-70 8.60e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 35.33  E-value: 8.60e-03
                           10        20
                   ....*....|....*....|...
gi 767909580    48 GPWVQWASCSQPCGVGVQRRSRT 70
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRT 26
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 196-387 8.86e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 40.14  E-value: 8.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  196 SPTPRAEPfsangSPQTELPPTELSVHTPSPQAEPlSPETAQTEVaprtRPAPLRHHPRAQASGTEPPSPTHSLGEGGFF 275
Cdd:NF033839  294 APKPGMQP-----SPQPEKKEVKPEPETPKPEVKP-QLEKPKPEV----KPQPEKPKPEVKPQLETPKPEVKPQPEKPKP 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  276 RASPQPRRPSSQGWASPQVAGRRPDPFPSVPRGRGQQgqgpwgtggTPHGPRLEPDPQhPGAWLPLLSNGPHASSLWSLF 355
Cdd:NF033839  364 EVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKP---------QPEKPKPEVKPQ-PEKPKPEVKPQPEKPKPEVKP 433

                         170       180       190
                  ....*....|....*....|....*....|..
gi 767909580  356 APSSPIPRCSGESEQLRacSQAPCPPEQPDPR 387
Cdd:NF033839  434 QPEKPKPEVKPQPEKPK--PEVKPQPETPKPE 463
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 509-622 6.30e-29

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 111.90  E-value: 6.30e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580   509 LVSGNLTdRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVDP-PGSYRAGGTVFRYNRPPREe 587
Cdd:pfam05986    1 TVSGSFT-EGRAKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPA- 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 767909580   588 gkGESLSAEGPTTQPVDVYMIFQEE---NPGVFYQYVI 622
Cdd:pfam05986   79 --LEELHAPGPTQEDLEIQVLRQYGkgtNPGITYEYFI 114
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 750-806 7.33e-16

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 72.49  E-value: 7.33e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909580   750 WEAGEWTSCSRSCGPGTQHRQLQCRQEfgGGGSSVPPERCGHLPRPNITQSCQLRLC 806
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 937-993 2.56e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.55  E-value: 2.56e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909580   937 WYTGPWGECSSECGSGTQRRDIICVSKLGteFNVTSPSNCSHLPRPPALQPCQGQAC 993
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGG--GSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 997-1048 4.63e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.00  E-value: 4.63e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767909580   997 WFSTPWSPCSRSCQGGTQTREVQCLSTN---QTLSTRCPPQLRPSRKRPCNSQPC 1048
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGggsIVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 1056-1085 8.36e-11

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 57.55  E-value: 8.36e-11
                           10        20        30
                   ....*....|....*....|....*....|
gi 767909580  1056 CKDSSPHCPLVVQARLCVYPYYTATCCRSC 1085
Cdd:pfam08686    1 CKDKFANCSLVVQARLCSHKYYRQFCCRSC 30
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 436-507 7.89e-10

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 57.41  E-value: 7.89e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767909580   436 QGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGAP------DICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDSTC 507
Cdd:pfam19236   38 QGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPredgtlSLCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 809-864 3.26e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 53.61  E-value: 3.26e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909580   809 WEVGsPWSQCSVRCGRGQRSRQVRCVG-NNGDEVSEQECaSGPPQPPSREACDMGPC 864
Cdd:pfam19030    1 WVAG-PWGECSVTCGGGVQTRLVQCVQkGGGSIVPDSEC-SAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 868-931 8.43e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 49.76  E-value: 8.43e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767909580   868 WFHSDWSSkCSAECGTGIQRRSVVCLGSGaalgpGQGEAGagtGQSCPTGSRPPDMRACSLGPC 931
Cdd:pfam19030    1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKG-----GGSIVP---DSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1000-1049 4.19e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 44.89  E-value: 4.19e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 767909580   1000 TPWSPCSRSCQGGTQTREVQCLSTNQTLS-TRCPPQLRpsRKRPCNSQPCS 1049
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGgGPCTGEDV--ETRACNEQPCP 53
PHA03247 PHA03247
large tegument protein UL36; Provisional
 143-392 5.29e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 5.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  143 ARRSRLRDPIKPGMFGYGRVPfalplhrnrRHPRSPPRSELSLISSRGEEAIPSP---TPRAEPFSANGSPQTELPPTEL 219
Cdd:PHA03247 2581 AVTSRARRPDAPPQSARPRAP---------VDDRGDPRGPAPPSPLPPDTHAPDPpppSPSPAANEPDPHPPPTVPPPER 2651

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  220 SVHTPSPQAEPLSPETAQTEVAPRTRPAPLRHHPRA---------QASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWA 290
Cdd:PHA03247 2652 PRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAarptvgsltSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQA 2731

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  291 SPQV-AGRRPDPFPSVPRGRGqqGQGPWGTGGTPHGPRLEPDPQHPGA----WLPLLSNGPHASSLWSLFAPSSPIPRCS 365
Cdd:PHA03247 2732 SPALpAAPAPPAVPAGPATPG--GPARPARPPTTAGPPAPAPPAAPAAgpprRLTRPAVASLSESRESLPSPWDPADPPA 2809

                         250       260
                  ....*....|....*....|....*....
gi 767909580  366 GESEQLRA--CSQAPCPPEQPDPRALQCA 392
Cdd:PHA03247 2810 AVLAPAAAlpPAASPAGPLPPPTSAQPTA 2838
PHA03247 PHA03247
large tegument protein UL36; Provisional
 94-416 2.09e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 2.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580   94 ALLPRGQGPRPqtsPETLPLYRTQSRGRGGPLRGPASHLGREETQEIRAARRSRLRDPIKPgmfgygrVPFALPLHRNRR 173
Cdd:PHA03247 2616 PLPPDTHAPDP---PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRA-------AQASSPPQRPRR 2685

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  174 HPRSPPRSELSLISSRgeeaiPSPTPRAEPFSANGSPQTELPPTELSVHTPSPQ-----AEPLSPETAQTEVAPRTRPAP 248
Cdd:PHA03247 2686 RAARPTVGSLTSLADP-----PPPPPTPEPAPHALVSATPLPPGPAAARQASPAlpaapAPPAVPAGPATPGGPARPARP 2760

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  249 LRHH-------PRAQASGTEPPSPTHSLGEGGFFRAS-PQPRRPSSQGWASPQVAGRRPD-------------PFPSVPR 307
Cdd:PHA03247 2761 PTTAgppapapPAAPAAGPPRRLTRPAVASLSESRESlPSPWDPADPPAAVLAPAAALPPaaspagplppptsAQPTAPP 2840

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  308 GRGQQGQGPWGTGGT--PHGPRLEPDPQHPGAWLPLLSNGPHASSLWSLFAPSSPIPRCSGESEQLRACSQAPCPPEQPD 385
Cdd:PHA03247 2841 PPPGPPPPSLPLGGSvaPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQ 2920

                         330       340       350
                  ....*....|....*....|....*....|.
gi 767909580  386 PRALQCAAFNSQEfmgqlyQWEPFTEAPLLP 416
Cdd:PHA03247 2921 PQPPPPPQPQPPP------PPPPRPQPPLAP 2945
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 809-864 3.11e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.57  E-value: 3.11e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 767909580    809 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDeVSEQECasgPPQPPSREACDMGPC 864
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQ-NGGGPC---TGEDVETRACNEQPC 52
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 175-337 6.93e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.90  E-value: 6.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  175 PRSPPRSELSLISSRGEEAIPSPTPRAEPFSANGSPQTELPPTELSVHTPSPQAEPLSPETAQTEVAPRTRPAPLRHHPR 254
Cdd:PRK07764  597 GEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGA 676

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  255 AQASGTEPPSPTHSLGEGGFFRASPQPRRPssQGWASPQVAGRRPDPfPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQH 334
Cdd:PRK07764  677 APAAPPPAPAPAAPAAPAGAAPAQPAPAPA--ATPPAGQADDPAAQP-PQAAQGASAPSPAADDPVPLPPEPDDPPDPAG 753


                  ...
gi 767909580  335 PGA 337
Cdd:PRK07764  754 APA 756
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 47-77 8.99e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.03  E-value: 8.99e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 767909580     47 WGPWVQWASCSQPCGVGVQRRSRTCQLPTVQ 77
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQ 31
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1000-1048 9.94e-05

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 41.11  E-value: 9.94e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 767909580  1000 TPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLrpsRKRPCNSQPC 1048
Cdd:pfam19028    7 SEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPELL---ERRPCNLPPC 52
PHA03247 PHA03247
large tegument protein UL36; Provisional
 100-392 4.53e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 4.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  100 QGPRPQTSPETL-PLYRTQSRGRGGPLRGPASHLGREETQEIRAARRSRLRDPIKPGMFGYGRVPFALPLHRNRRHPRSP 178
Cdd:PHA03247 2681 QRPRRRAARPTVgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP 2760

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  179 PRSElSLISSRGEEAIPSPTPRAEPFSAnGSPQTELPPTELSVHTPSPQAEPLSPETAQTEVAPR---TRPAPLRHHPRA 255
Cdd:PHA03247 2761 PTTA-GPPAPAPPAAPAAGPPRRLTRPA-VASLSESRESLPSPWDPADPPAAVLAPAAALPPAASpagPLPPPTSAQPTA 2838

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  256 QASGTEPPSPTHSLG----EGGFFRASPQPRRPSSQGWASPQVAGRRPdPFPSVPRGRGQQGQGPWG-----TGGTPHGP 326
Cdd:PHA03247 2839 PPPPPGPPPPSLPLGgsvaPGGDVRRRPPSRSPAAKPAAPARPPVRRL-ARPAVSRSTESFALPPDQperppQPQAPPPP 2917

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767909580  327 RLEPDPQHPGAWLPLLSNGPHASSLWSLFAPSSPIPRCSGESEQLRACSQAPCPPEQPDPRALQCA 392
Cdd:PHA03247 2918 QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA 2983
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 99-316 5.88e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 43.87  E-value: 5.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580    99 GQGPRPQTSPETLPLYRTQSRGRGGPLRGPAShlgreeTQEIRAARRSRLRDPIKPGMFGYGRVPFALPLHRNRRHPRSP 178
Cdd:pfam09770  164 GVAPKKAAAPAPAPQPAAQPASLPAPSRKMMS------LEEVEAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFP 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580   179 PRSElslissrgeeaiPSPTPRAEPFSANGSPQTELPPTELSvHTPSPQAEPLSPetaqtevAPRTRPAPLRHHPRAQas 258
Cdd:pfam09770  238 PQIQ------------QQQQPQQQPQQPQQHPGQGHPVTILQ-RPQSPQPDPAQP-------SIQPQAQQFHQQPPPV-- 295

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767909580   259 gtePPSPTHSLgeggffrasPQPRRPSSQGWASPQVAGRRPDPFPSVPRGRGQQGQGP 316
Cdd:pfam09770  296 ---PVQPTQIL---------QNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGR 341
dnaA PRK14086
chromosomal replication initiator protein DnaA;
173-387 5.96e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 44.05  E-value: 5.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  173 RHPRSPPRSELSLISSRGEEAIPSPTPRAEPfsangSPQTELPPTELSVHTPSPQAEPLSPETAQTEVAPRTRPAPLRHH 252
Cdd:PRK14086   76 RELGRPIRIAITVDPSAGEPAPPPPHARRTS-----EPELPRPGRRPYEGYGGPRADDRPPGLPRQDQLPTARPAYPAYQ 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  253 PRAQaSGTEPPSPthslgeggfFRASPQPRR---PSSQGWASPQVAGRRPDPF-PSVPRGRGQQGQgPWGTGGTPhgprl 328
Cdd:PRK14086  151 QRPE-PGAWPRAA---------DDYGWQQQRlgfPPRAPYASPASYAPEQERDrEPYDAGRPEYDQ-RRRDYDHP----- 214

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767909580  329 EPDPQHPGAW---LPLLSNG---PHASSLWSLFAPSSPIPRCSGESEQLRACSQAPCP-PEQPDPR 387
Cdd:PRK14086  215 RPDWDRPRRDrtdRPEPPPGaghVHRGGPGPPERDDAPVVPIRPSAPGPLAAQPAPAPgPGEPTAR 280
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 177-387 1.15e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.24  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  177 SPPRSELSLISSRGEEAIPSPTPRAEPFSANGSPQTE---LPPTELSVHTPSPQAEPLSPETAQtevAPRTRPAPLRHHP 253
Cdd:PHA03307  136 EMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAalpLSSPEETARAPSSPPAEPPPSTPP---AAASPRPPRRSSP 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  254 RAQASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWASPQVAGRRPDPFPSVPRGRGQQGQGPWGTG---------GTPH 324
Cdd:PHA03307  213 ISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSsrpgpasssSSPR 292

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767909580  325 GPRLEPDPQHPGAwlPLLSNGPHASSLWSLFAPSS-PIPRCSGESEqlRACSQAPCPPEQPDPR 387
Cdd:PHA03307  293 ERSPSPSPSSPGS--GPAPSSPRASSSSSSSRESSsSSTSSSSESS--RGAAVSPGPSPSRSPS 352
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 189-303 1.55e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  189 RGEEAIPSPTPRAEPFSANGSpqTELPPTElsvhTPSPQAEPLSPETAQTEVAPRTRPAPLRHH-PRAQASGTEPPSPTH 267
Cdd:PRK14951  383 RPEAAAPAAAPVAQAAAAPAP--AAAPAAA----ASAPAAPPAAAPPAPVAAPAAAAPAAAPAAaPAAVALAPAPPAQAA 456

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767909580  268 SLGEGGFFRASPQPRRPSSQGWASPQVAGRRPDPFP 303
Cdd:PRK14951  457 PETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTE 492
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 806-853 2.41e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.87  E-value: 2.41e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767909580  806 CGHWEvgsPWSQCSVRCGRGQRSRQ-----VRCVGNNGDEVSEQECasgPPQP 853
Cdd:PTZ00441  240 CGPWD---EWTPCSVTCGKGTHSRSrpilhEGCTTHMVEECEEEEC---PVEP 286
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 697-746 3.39e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 36.66  E-value: 3.39e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 767909580   697 SACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASpEPCHGTPC 746
Cdd:pfam19030    7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPET-QSCNLKPC 55
PHA03378 PHA03378
EBNA-3B; Provisional
 103-340 4.14e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.21  E-value: 4.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  103 RPQTSPETLPLYRT--QSRGRGGPLRGPASHLGREETQ----EIRAARRSRLrdPIKPGMFGYGRVPFALPLHRNRRHPR 176
Cdd:PHA03378  575 QPLTSPTTSQLASSapSYAQTPWPVPHPSQTPEPPTTQshipETSAPRQWPM--PLRPIPMRPLRMQPITFNVLVFPTPH 652

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  177 SPPRSELSLISSRGEE-----AIPSPTPRAEPFSANGSPQTELPPTELSVHTPSPQAEP--LSPETAQTEVAPRTRPAPL 249
Cdd:PHA03378  653 QPPQVEITPYKPTWTQighipYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPgrAQRPAAATGRARPPAAAPG 732

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  250 RHHPRAQASGTEPPsPTHSLGEGGFFRASPQPRRPSSQGWASPQvagrrPDPFPSVPRGRGQQgqgpwgtggtphgPRLE 329
Cdd:PHA03378  733 RARPPAAAPGRARP-PAAAPGRARPPAAAPGRARPPAAAPGAPT-----PQPPPQAPPAPQQR-------------PRGA 793

                         250
                  ....*....|.
gi 767909580  330 PDPQHPGAWLP 340
Cdd:PHA03378  794 PTPQPPPQAGP 804
TSP_1 pfam00090
Thrombospondin type 1 domain;
1000-1048 4.26e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 36.24  E-value: 4.26e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 767909580  1000 TPWSPCSRSCQGGTQTREVQCLStNQTLSTRCPPQLRpsRKRPCNSQPC 1048
Cdd:pfam00090    4 SPWSPCSVTCGKGIQVRQRTCKS-PFPGGEPCTGDDI--ETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 750-806 6.46e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.03  E-value: 6.46e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 767909580    750 WEAGEWTSCSRSCGPGTQHRQLQCRqefgGGGSSVPPERCGHLPRpnITQSCQLRLC 806
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCC----SPPPQNGGGPCTGEDV--ETRACNEQPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
813-836 6.97e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 35.86  E-value: 6.97e-03
                           10        20
                   ....*....|....*....|....
gi 767909580   813 SPWSQCSVRCGRGQRSRQVRCVGN 836
Cdd:pfam00090    4 SPWSPCSVTCGKGIQVRQRTCKSP 27
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
188-388 7.40e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 7.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  188 SRGEEAIPSPT--PRAEPFSANGSPQTELPPTELSVHTPSPQAEPLSPETAQTEVAPRTRPAPLRHHPRAQASGTEPPSp 265
Cdd:PRK12323  368 SGGGAGPATAAaaPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGG- 446

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  266 thslgeggffRASPQPRRPSS-QGWASPQVAGRRPDPFPSVPRGRGQQGQGPwgtggtphgPRLEPDPQHPGAWLP--LL 342
Cdd:PRK12323  447 ----------APAPAPAPAAApAAAARPAAAGPRPVAAAAAAAPARAAPAAA---------PAPADDDPPPWEELPpeFA 507

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 767909580  343 SNGPHASSLWSLFAPSSPIPRCSGESEQLRACSQAPCPPEQPDPRA 388
Cdd:PRK12323  508 SPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRA 553
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 192-387 7.60e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 7.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  192 EAIPSPTPRAEPFSANGSPQTELPPTELSVHTPSPQAE--------PLSPETAQTEVAPRTRPAPLRHHPRAQASGTEPP 263
Cdd:PRK07764  585 EAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAapaapapaGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASD 664

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  264 SPTHSLGEGGffRASPQPRRPSSQGWASPQ---VAGRRPDPFPSvPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAwLP 340
Cdd:PRK07764  665 GGDGWPAKAG--GAAPAAPPPAPAPAAPAApagAAPAQPAPAPA-ATPPAGQADDPAAQPPQAAQGASAPSPAADDP-VP 740

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 767909580  341 LLSNGPHASSLWSLFAPSSPIPRCSGESEQLRACSQAPCPPEQPDPR 387
Cdd:PRK07764  741 LPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAE 787
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 48-70 8.60e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 35.33  E-value: 8.60e-03
                           10        20
                   ....*....|....*....|...
gi 767909580    48 GPWVQWASCSQPCGVGVQRRSRT 70
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRT 26
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 196-387 8.86e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 40.14  E-value: 8.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  196 SPTPRAEPfsangSPQTELPPTELSVHTPSPQAEPlSPETAQTEVaprtRPAPLRHHPRAQASGTEPPSPTHSLGEGGFF 275
Cdd:NF033839  294 APKPGMQP-----SPQPEKKEVKPEPETPKPEVKP-QLEKPKPEV----KPQPEKPKPEVKPQLETPKPEVKPQPEKPKP 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767909580  276 RASPQPRRPSSQGWASPQVAGRRPDPFPSVPRGRGQQgqgpwgtggTPHGPRLEPDPQhPGAWLPLLSNGPHASSLWSLF 355
Cdd:NF033839  364 EVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKP---------QPEKPKPEVKPQ-PEKPKPEVKPQPEKPKPEVKP 433

                         170       180       190
                  ....*....|....*....|....*....|..
gi 767909580  356 APSSPIPRCSGESEQLRacSQAPCPPEQPDPR 387
Cdd:NF033839  434 QPEKPKPEVKPQPEKPK--PEVKPQPETPKPE 463
TSP_1 pfam00090
Thrombospondin type 1 domain;
48-74 8.92e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 35.47  E-value: 8.92e-03
                           10        20
                   ....*....|....*....|....*..
gi 767909580    48 GPWVQWASCSQPCGVGVQRRSRTCQLP 74
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSP 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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