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    caz cabeza [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32587, updated on 4-Jan-2025

    Summary

    Official Symbol
    cazprovided by FlyBase
    Official Full Name
    cabezaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0285954
    Locus tag
    Dmel_CG3606
    See related
    AllianceGenome:FB:FBgn0285954
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-Pen19; BcDNA:GM09207; Cabeza; cas; Caz; CG3606; dFUS; Dmel\CG3606; EWSR1; l(1)5g11; p19; P19; pen19; Pen19; Sarfh; SARFH; TFIID
    Summary
    Enables chromatin binding activity. Involved in several processes, including adult locomotory behavior; positive regulation of synaptic assembly at neuromuscular junction; and synaptic assembly at neuromuscular junction. Located in nucleoplasm. Part of catalytic step 2 spliceosome. Colocalizes with euchromatin. Is expressed in several structures, including adult head; brain; central nervous system; larval muscle system; and larval neurons. Used to study amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 6; and frontotemporal dementia. Human ortholog(s) of this gene implicated in connective tissue cancer (multiple); essential tremor 4; and neurodegenerative disease (multiple). Orthologous to several human genes including EWSR1 (EWS RNA binding protein 1) and TAF15 (TATA-box binding protein associated factor 15). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See caz in Genome Data Viewer
    Location:
    14B8-14B9; 1-53 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16288810..16293520)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16182843..16187553)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene easily shocked Neighboring gene uncharacterized protein Neighboring gene Ubiquinol-cytochrome c reductase 14 kDa subunit Neighboring gene Endoplasmic reticulum protein 44 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45485 Neighboring gene beta Hydroxy acid dehydrogenase 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding  
    enables RNA binding  
    enables chromatin binding PubMed 
    enables mRNA binding PubMed 
    enables transcription coregulator activity  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome PubMed 
    colocalizes_with euchromatin PubMed 
    located_in nucleoplasm PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    part_of transcription factor TFIID complex PubMed 

    General protein information

    Preferred Names
    cabeza
    Names
    CG3606-PB
    CG3606-PC
    CG3606-PD
    CG3606-PE
    Sarcoma-associated RNA-binding fly homolog
    caz-PB
    caz-PC
    caz-PD
    caz-PE
    lethal (1) 5g11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16288810..16293520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078641.4 → NP_523365.2  cabeza, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523365.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24445, Q27294, Q8T3M2, Q9VXI4
      Related
      FBpp0073996
      Conserved Domains (4) summary
      COG0724
      Location:118 → 205
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12534
      Location:122 → 204
      RRM_SARFH; RNA recognition motif in Drosophila melanogaster RNA-binding protein cabeza and similar proteins
      sd00025
      Location:279 → 298
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:275 → 304
      zf-RanBP; Zn-finger in Ran binding protein and others
    2. NM_001272673.1 → NP_001259602.1  cabeza, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259602.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHV6
    3. NM_167493.2 → NP_727946.2  cabeza, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727946.2

      Status: REVIEWED

      Conserved Domains (4) summary
      COG0724
      Location:103 → 190
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12534
      Location:107 → 189
      RRM_SARFH; RNA recognition motif in Drosophila melanogaster RNA-binding protein cabeza and similar proteins
      sd00025
      Location:264 → 283
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:260 → 289
      zf-RanBP; Zn-finger in Ran binding protein and others
    4. NM_001272672.1 → NP_001259601.1  cabeza, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259601.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PH94
      Conserved Domains (4) summary
      COG0724
      Location:74 → 161
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12534
      Location:78 → 160
      RRM_SARFH; RNA recognition motif in Drosophila melanogaster RNA-binding protein cabeza and similar proteins
      sd00025
      Location:235 → 254
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:231 → 260
      zf-RanBP; Zn-finger in Ran binding protein and others
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