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ru roughoid [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44856, updated on 4-Jan-2025

Summary

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Official Symbol
ruprovided by FlyBase
Official Full Name
roughoidprovided by FlyBase
Primary source
FLYBASE:FBgn0003295
Locus tag
Dmel_CG1214
See related
AllianceGenome:FB:FBgn0003295
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1214; Dmel\CG1214; rho-3; Rho-3; Rho-related [62A1]; rho3; Rho3; Ru
Summary
Enables serine-type endopeptidase activity. Involved in several processes, including compound eye morphogenesis; epidermal growth factor receptor ligand maturation; and epithelial cell migration, open tracheal system. Located in apical part of cell; bounding membrane of organelle; and endoplasmic reticulum. Is expressed in several structures, including adult heart; embryonic head sensory system; organism subdivision; and sensory nervous system primordium. Orthologous to several human genes including RHBDL1 (rhomboid like 1) and RHBDL3 (rhomboid like 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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Location:
61F8-61F8; 3-0 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1370628..1387437)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1370628..1387437)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene indra Neighboring gene Protein tyrosine phosphatase 61F Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Glutamic acid-CTC 3-1 Neighboring gene transfer RNA:Glutamic acid-CTC 3-2 Neighboring gene transfer RNA:Glutamic acid-CTC 3-3 Neighboring gene transfer RNA:Glutamic acid-CTC 3-4 Neighboring gene transfer RNA:Glutamic acid-CTC 3-5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Induced crossing-over in the presterile broods of Drosophila melanogaster males. Hannah-Alava A. Genetica, 1968. PMID 5722790
  2. Surface structure of the compound eye of various Drosophila species and eye mutants of Drosophila melanogaster. Stumm-Tegethoff BF, et al. Theor Appl Genet, 1974 Jan. PMID 24424475
  3. Developmental roles of Rhomboid proteases. Shilo BZ. Semin Cell Dev Biol, 2016 Dec. PMID 27423914
  4. Purine-resistant Drosophila melanogaster result from mutations in the adenine phosphoribosyltransferase structural gene. Johnson DH, et al. Proc Natl Acad Sci U S A, 1983 May. PMID 6407004, Free PMC Article
  5. Ultrastructural analysis of wild type and mutant Drosophila melanogaster using helium ion microscopy. Boseman A, et al. Micron, 2013 Aug. PMID 23850418

See all (121) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. demonstrate that rhomboid 3 mediated activation of the EGF receptor pathway is necessary for proper adult cardiac function
    Title: Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila.
  2. Rho-3, which is expressed in the developing eye, cleaves the Spitz precursor and Star already in the endoplasmic reticulum, in addition to its activity in the late compartment.
    Title: Drosophila EGFR signalling is modulated by differential compartmentalization of Rhomboid intramembrane proteases.
  3. evidence presented that Rhomboid 3/EGF signalling, which originates from the midline of the Drosophila ventral nerve cord, repels tracheal ganglionic branches and prevents them from crossing it
    Title: Rhomboid 3 orchestrates Slit-independent repulsion of tracheal branches at the CNS midline.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in compound eye cone cell fate commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye photoreceptor fate commitment IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in epidermal growth factor receptor ligand maturation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epidermal growth factor receptor ligand maturation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in epidermal growth factor receptor ligand maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial cell migration, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heart process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in leg disc proximal/distal pattern formation TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of protein secretion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
roughoid
Names
CG1214-PA
Rhomboid-3
rhomboid
rhomboid 3
rhomboid3
roughoid/rhomboid-3
ru-PA
NP_524790.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1370628..1387437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080051.3 → NP_524790.1  roughoid [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524790.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BML3, Q9W0F8
    Related
    FBpp0072574
    Conserved Domains (1) summary
    pfam01694
    Location:129 → 282
    Rhomboid; Rhomboid family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W0F8 Q9W0F8

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