SUVR4 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SUVR4
Official Full Name: SET-domain containing protein lysine methyltransferase family protein
Primary source: TAIR:AT3G04380
Locus tag: AT3G04380
See related: Araport:AT3G04380
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: SDG31; SET DOMAIN PROTEIN 31; T27C4.2; T27C4_2
Summary: Encodes SUVR4, a nucleolar histone methyltransferase with preference for monomethylated H3K9. One of the four closely related Arabidopsis SUVR proteins that belong to the SU(VAR)3-9 subgroup of SET-domain proteins. Proteins containing the evolutionarily conserved SET domain are involved in regulation of eukaryotic gene expression and chromatin structure through their histone lysine methyltransferase (HMTase) activity. SUVR1, SUVR2 and SUVR4 proteins contain a novel domain at their N-terminus, and a SUVR specific region preceding the SET domain.
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Genomic context

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See SUVR4 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 8

Sequence:: Chromosome: 3; NC_003074.8 (1161366..1164977)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The N-terminal and C-terminal parts of S4WIYLD constitute a surface that interacts with charged residues close to the hydrophobic patch of ubiquitin.
Title: The arabidopsis histone methyltransferase SUVR4 binds ubiquitin via a domain with a four-helix bundle structure.
SUVR4 is involved in the epigenetic defense mechanism by trimethylating H3K9 to suppress potentially harmful transposon activity
Title: The SUVR4 histone lysine methyltransferase binds ubiquitin and converts H3K9me1 to H3K9me3 on transposon chromatin in Arabidopsis.
A novel histone lysine methyltransferase specificity was demonstrated for SUVR4, in that monomethylated histone H3K9 is its preferred substrate in vitro.
Title: The Arabidopsis SUVR4 protein is a nucleolar histone methyltransferase with preference for monomethylated H3K9.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001337515.1

Supported by ESTs:

NM_001337516.1

Supported by ESTs:

NM_001337517.1

Supported by ESTs:

NM_111309.3

Supported by ESTs:

NM_202488.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables histone H3K9 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: SET-domain containing protein lysine methyltransferase family protein

NP_187088.2

SUVR4; FUNCTIONS IN: histone-lysine N-methyltransferase activity; INVOLVED IN: chromatin modification; LOCATED IN: nucleolus; CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), WIYLD domain (InterPro:IPR018848), Pre-SET zinc-binding sub-group (InterPro:IPR003606), Pre-SET domain (InterPro:IPR007728); BEST Arabidopsis thaliana protein match is: homolog of SU(var)3-9 1 (TAIR:AT1G04050.1); Has 4363 Blast hits to 4175 proteins in 400 species: Archae - 0; Bacteria - 292; Metazoa - 1951; Fungi - 458; Plants - 898; Viruses - 0; Other Eukaryotes - 764 (source: NCBI BLink).

NP_974217.1

SUVR4; FUNCTIONS IN: histone-lysine N-methyltransferase activity; INVOLVED IN: chromatin modification; LOCATED IN: nucleolus; CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), WIYLD domain (InterPro:IPR018848), Pre-SET zinc-binding sub-group (InterPro:IPR003606), Pre-SET domain (InterPro:IPR007728); BEST Arabidopsis thaliana protein match is: homolog of SU(var)3-9 1 (TAIR:AT1G04050.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

1161366..1164977

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001337514.1 → NP_001327806.1 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I9LTG1, A0A5S9X9D2

Conserved Domains (2) summary

cd10538
Location:152 → 419

SET_SETDB-like; SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins

pfam10440
Location:9 → 66

WIYLD; Ubiquitin-binding WIYLD domain
NM_111309.3 → NP_187088.2 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_187088.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q3EBC4, Q8W595, Q9M848

UniProtKB/TrEMBL

A0A5S9X9D2

Conserved Domains (3) summary

smart00317
Location:304 → 441

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam05033
Location:147 → 294

Pre-SET; Pre-SET motif

pfam10440
Location:26 → 82

WIYLD; Ubiquitin-binding WIYLD domain
NM_202488.2 → NP_974217.1 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974217.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9X9D2, F4J3N8

Conserved Domains (3) summary

smart00317
Location:277 → 414

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam05033
Location:120 → 267

Pre-SET; Pre-SET motif

pfam10440
Location:26 → 82

WIYLD; Ubiquitin-binding WIYLD domain
NM_001337516.1 → NP_001327807.1 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I9LTG2, A0A654F995
NM_001337515.1 → NP_001327808.1 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I9LTG3, A0A654F995
NM_001337517.1 → NP_001327809.1 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I9LTG4, A0A654F995