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Conserved domains on  [gi|1063709376|ref|NP_001327806|]
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SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 152-419 1.90e-94

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


:

Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 284.65  E-value: 1.90e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 152 PKFTYIPHNIVYQSAYLHvslARISDEDCCaNCKGNCLsaDFPCTCARETSGEYAYTKEGLLKEkfldtclkmkkepdsf 231
Cdd:cd10538     1 PSFTYIKDNIVGKNVQPF---SNIIDSVGC-KCKDDCL--DSKCACAAESDGIFAYTKNGLLRL---------------- 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 232 pkvyckdcplerdhdkgtygkcdgHLIRKFIKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQeGKGWGLRTLQDLPKGT 311
Cdd:cd10538    59 ------------------------NNSPPPIFECNSKCSCDDDCKNRVVQRGLQARLQVFRTS-KKGWGVRSLEFIPKGS 113

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 312 FICEYIGEILTNTELYDRNVRSSSERHTYPVTLDADWGSEkdlKDEEALCLDATICGNVARFINHRCeDANMIDIPIEIE 391
Cdd:cd10538   114 FVCEYVGEVITTSEADRRGKIYDKSGGSYLFDLDEFSDSD---GDGEELCVDATFCGNVSRFINHSC-DPNLFPFNVVID 189

                         250       260
                  ....*....|....*....|....*...
gi 1063709376 392 TPDRHYYHIAFFTLRDVKAMDELTWDYM 419
Cdd:cd10538   190 HDDLRYPRIALFATRDILPGEELTFDYG 217
WIYLD pfam10440
Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha ...
 9-66 8.84e-21

Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha helices. The domain was named the WIYLD domain based on the pattern of most conserved residues. It binds ubiquitin. In the Arabidopsis thaliana histone-lysine N-methyltransferase SUVR4, binding of ubiquitin to this domain stimulates enzymatic activity and converts its activity from a strict dimethylase to a di/trimethylase.


:

Pssm-ID: 431288  Cd Length: 58  Bit Score: 85.38  E-value: 8.84e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063709376   9 KDEKVLKALERTRQLDIPDEKTMPVLMKLLEEAGGNWSYIKLDNYTALVDAIYSVEDE 66
Cdd:pfam10440   1 GDRRIDAAIDAMRPLGIPKEKIRPVLKNLLKVYGGNWPLIEEDNYRVLADAIFEKQDE 58
 
Name Accession Description Interval E-value
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 152-419 1.90e-94

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 284.65  E-value: 1.90e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 152 PKFTYIPHNIVYQSAYLHvslARISDEDCCaNCKGNCLsaDFPCTCARETSGEYAYTKEGLLKEkfldtclkmkkepdsf 231
Cdd:cd10538     1 PSFTYIKDNIVGKNVQPF---SNIIDSVGC-KCKDDCL--DSKCACAAESDGIFAYTKNGLLRL---------------- 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 232 pkvyckdcplerdhdkgtygkcdgHLIRKFIKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQeGKGWGLRTLQDLPKGT 311
Cdd:cd10538    59 ------------------------NNSPPPIFECNSKCSCDDDCKNRVVQRGLQARLQVFRTS-KKGWGVRSLEFIPKGS 113

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 312 FICEYIGEILTNTELYDRNVRSSSERHTYPVTLDADWGSEkdlKDEEALCLDATICGNVARFINHRCeDANMIDIPIEIE 391
Cdd:cd10538   114 FVCEYVGEVITTSEADRRGKIYDKSGGSYLFDLDEFSDSD---GDGEELCVDATFCGNVSRFINHSC-DPNLFPFNVVID 189

                         250       260
                  ....*....|....*....|....*...
gi 1063709376 392 TPDRHYYHIAFFTLRDVKAMDELTWDYM 419
Cdd:cd10538   190 HDDLRYPRIALFATRDILPGEELTFDYG 217
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 288-425 2.79e-28

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 108.58  E-value: 2.79e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376  288 LQVYFTqEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHTYPVTLDADWGsekdlkdeeaLCLDATIC 367
Cdd:smart00317   3 LEVFKS-PGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAKAFYLFDIDSD----------LCIDARRK 71

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063709376  368 GNVARFINHRCEdANMIDIPIEIETPDrhyyHIAFFTLRDVKAMDELTWDYMIDFNDK 425
Cdd:smart00317  72 GNLARFINHSCE-PNCELLFVEVNGDD----RIVIFALRDIKPGEELTIDYGSDYANE 124
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 298-418 4.84e-23

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 93.74  E-value: 4.84e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 298 GWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHtypvtLDADWGSE-KDLKDEEALCLDATI--CGNVARFI 374
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLLITKEEADKRELLYYDKL-----ELRLWGPYlFTLDEDSEYCIDARAlyYGNWARFI 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1063709376 375 NHRCeDANMIDIPIEIETpdrhYYHIAFFTLRDVKAMDELTWDY 418
Cdd:pfam00856  76 NHSC-DPNCEVRVVYVNG----GPRIVIFALRDIKPGEELTIDY 114
WIYLD pfam10440
Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha ...
 9-66 8.84e-21

Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha helices. The domain was named the WIYLD domain based on the pattern of most conserved residues. It binds ubiquitin. In the Arabidopsis thaliana histone-lysine N-methyltransferase SUVR4, binding of ubiquitin to this domain stimulates enzymatic activity and converts its activity from a strict dimethylase to a di/trimethylase.


Pssm-ID: 431288  Cd Length: 58  Bit Score: 85.38  E-value: 8.84e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063709376   9 KDEKVLKALERTRQLDIPDEKTMPVLMKLLEEAGGNWSYIKLDNYTALVDAIYSVEDE 66
Cdd:pfam10440   1 GDRRIDAAIDAMRPLGIPKEKIRPVLKNLLKVYGGNWPLIEEDNYRVLADAIFEKQDE 58
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
295-442 1.13e-20

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 87.71  E-value: 1.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 295 EGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSErHTYPVTLDADWGsekdlkdeealcLDATICGNVARFI 374
Cdd:COG2940    14 PIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPHKEPL-HTYLFELDDDGV------------IDGALGGNPARFI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063709376 375 NHRCeDANMidipiEIETPDRHYYhiaFFTLRDVKAMDELTWDYMIDFNDkshpvKAFRCCCGseSCR 442
Cdd:COG2940    81 NHSC-DPNC-----EADEEDGRIF---IVALRDIAAGEELTYDYGLDYDE-----EEYPCRCP--NCR 132
 
Name Accession Description Interval E-value
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 152-419 1.90e-94

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 284.65  E-value: 1.90e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 152 PKFTYIPHNIVYQSAYLHvslARISDEDCCaNCKGNCLsaDFPCTCARETSGEYAYTKEGLLKEkfldtclkmkkepdsf 231
Cdd:cd10538     1 PSFTYIKDNIVGKNVQPF---SNIIDSVGC-KCKDDCL--DSKCACAAESDGIFAYTKNGLLRL---------------- 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 232 pkvyckdcplerdhdkgtygkcdgHLIRKFIKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQeGKGWGLRTLQDLPKGT 311
Cdd:cd10538    59 ------------------------NNSPPPIFECNSKCSCDDDCKNRVVQRGLQARLQVFRTS-KKGWGVRSLEFIPKGS 113

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 312 FICEYIGEILTNTELYDRNVRSSSERHTYPVTLDADWGSEkdlKDEEALCLDATICGNVARFINHRCeDANMIDIPIEIE 391
Cdd:cd10538   114 FVCEYVGEVITTSEADRRGKIYDKSGGSYLFDLDEFSDSD---GDGEELCVDATFCGNVSRFINHSC-DPNLFPFNVVID 189

                         250       260
                  ....*....|....*....|....*...
gi 1063709376 392 TPDRHYYHIAFFTLRDVKAMDELTWDYM 419
Cdd:cd10538   190 HDDLRYPRIALFATRDILPGEELTFDYG 217
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 152-442 3.09e-55

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 184.08  E-value: 3.09e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 152 PKFTYIPHNIvyQSAYLHVSLARISDEDCcaNCKGNCLSADfpCTCAReTSGEYAYTKEGLLKEKFldtclkMKKEPdsf 231
Cdd:cd10543     1 PDFLYVTENC--ETSPLNIDRNITSLQTC--SCRDDCSSDN--CVCGR-LSVRCWYDKEGRLLPDF------NKLDP--- 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 232 pkvyckdcPLerdhdkgtygkcdghlirkfIKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTqEGKGWGLRTLQDLPKGT 311
Cdd:cd10543    65 --------PL--------------------IFECNRACSCWRNCRNRVVQNGIRYRLQLFRT-RGMGWGVRALQDIPKGT 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 312 FICEYIGEILTNTELYDRnvrsssERHTYPVTLDAdwgsekdlKDEEALCLDATICGNVARFINHRCEdANMIDIPIEIE 391
Cdd:cd10543   116 FVCEYIGELISDSEADSR------EDDSYLFDLDN--------KDGETYCIDARRYGNISRFINHLCE-PNLIPVRVFVE 180

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063709376 392 TPDRHYYHIAFFTLRDVKAMDELTWDYMIDFNDKSHpvKAFRCCCGSESCR 442
Cdd:cd10543   181 HQDLRFPRIAFFASRDIKAGEELGFDYGEKFWRIKG--KYFTCRCGSPKCK 229
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 152-442 3.81e-53

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 179.03  E-value: 3.81e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 152 PKFTYIPHNIVYQSAYLhvslarisDED----CcaNCKGNCLSADFPCtCARETSGEYAYTKEGLLKekfldtclkmkke 227
Cdd:cd10542     1 PNFQYINDYIPGDGVKI--------PEDflvgC--ECTEDCHNNNPTC-CPAESGVKFAYDKQGRLR------------- 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 228 pdsfpkvyckdcplerdhdkgtygKCDGHLIRkfikECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQEGKGWGLRTLQDL 307
Cdd:cd10542    57 ------------------------LPPGTPIY----ECNSRCKCGPDCPNRVVQRGRKVPLCIFRTSNGRGWGVKTLEDI 108

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 308 PKGTFICEYIGEILTNTELYDRNVRSSSERHTYPVTLDADwgsekdlKDEEALCLDATICGNVARFINHRCeDANMIDIP 387
Cdd:cd10542   109 KKGTFVMEYVGEIITSEEAERRGKIYDANGRTYLFDLDYN-------DDDCEYTVDAAYYGNISHFINHSC-DPNLAVYA 180

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063709376 388 IEIETPDRHYYHIAFFTLRDVKAMDELTWDYMIDFNDKSH-----PVKAFR--CCCGSESCR 442
Cdd:cd10542   181 VWINHLDPRLPRIAFFAKRDIKAGEELTFDYLMTGTGGSSestipKPKDVRvpCLCGSKNCR 242
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 123-444 9.75e-52

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 176.71  E-value: 9.75e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 123 KYKSRIADITKGSESVKIPLVDDVGSEAVPKFTYIPHNIVYQSAYLHVSlariSDEDCCANCKGNCLSADfPCTCARETS 202
Cdd:cd10517     1 KPYYYICDISYGKEGVPIPCVNEIDNSSPPYVEYSKERIPGKGVNINLD----PDFLVGCDCTDGCRDKS-KCACQQLTI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 203 GEYAYTKEGLLkekfldtclkmkkepdsfpkvyckdcplerDHDKGTYGKCDGHLIRKFIKECWRKCGCDMQCGNRVVQR 282
Cdd:cd10517    76 EATAATPGGQI------------------------------NPSAGYQYRRLMEKLPTGVYECNSRCKCDKRCYNRVVQN 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 283 GIRCQLQVYFTQEgKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSErhtYPVTLD-------ADWGSEKDlK 355
Cdd:cd10517   126 GLQVRLQVFKTEK-KGWGIRCLDDIPKGSFVCIYAGQILTEDEANEEGLQYGDE---YFAELDyievvekLKEGYESD-V 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 356 DEEALCLDATICGNVARFINHRCeDANMIDIPIEIETPDRHYYHIAFFTLRDVKAMDELTWDYmiDFNDKSHPVKAFRCC 435
Cdd:cd10517   201 EEHCYIIDAKSEGNLGRYLNHSC-SPNLFVQNVFVDTHDLRFPWVAFFASRYIRAGTELTWDY--NYEVGSVPGKVLYCY 277


                  ....*....
gi 1063709376 436 CGSESCRDR 444
Cdd:cd10517   278 CGSSNCRGR 286
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 254-442 1.30e-41

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 148.16  E-value: 1.30e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 254 DGHLIRKF-------IKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQEgKGWGLRTLQDLPKGTFICEYIGEILTNTEl 326
Cdd:cd10535    52 DGRLLPEFnmaepplIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRD-MGWGVRSLQDIPPGTFVCEYVGELISDSE- 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 327 ydRNVRsssERHTYPVTLDAdwgsekdlKDEEALCLDATICGNVARFINHRCEdANMIDIPIEIETPDRHYYHIAFFTLR 406
Cdd:cd10535   130 --ADVR---EEDSYLFDLDN--------KDGEVYCIDARFYGNVSRFINHHCE-PNLVPVRVFMAHQDLRFPRIAFFSTR 195

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1063709376 407 DVKAMDELTWDYMIDFND-KShpvKAFRCCCGSESCR 442
Cdd:cd10535   196 LIEAGEQLGFDYGERFWDiKG---KLFSCRCGSPKCR 229
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 254-442 5.76e-39

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 141.31  E-value: 5.76e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 254 DGHLIRKFIK-------ECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQEgKGWGLRTLQDLPKGTFICEYIGEILTNTEl 326
Cdd:cd10533    52 DGRLLQEFNKiepplifECNQACSCWRNCKNRVVQSGIKVRLQLYRTAK-MGWGVRALQTIPQGTFICEYVGELISDAE- 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 327 ydRNVRsssERHTYPVTLDAdwgsekdlKDEEALCLDATICGNVARFINHRCeDANMIDIPIEIETPDRHYYHIAFFTLR 406
Cdd:cd10533   130 --ADVR---EDDSYLFDLDN--------KDGEVYCIDARYYGNISRFINHLC-DPNIIPVRVFMLHQDLRFPRIAFFSSR 195

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1063709376 407 DVKAMDELTWDYMIDFND-KShpvKAFRCCCGSESCR 442
Cdd:cd10533   196 DIRTGEELGFDYGDRFWDiKS---KYFTCQCGSEKCK 229
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 180-418 1.23e-38

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 140.23  E-value: 1.23e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 180 CCanCKGNCLSADFPCTCARETSGEYAYTKEGLLKEKfldtclkmkkepdsfpkvycKDCplerdhdkgtygkcdghlir 259
Cdd:cd10545    24 CD--CKNRCTDGASDCACVKKNGGEIPYNFNGRLIRA--------------------KPA-------------------- 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 260 kfIKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQEgKGWGLRTLQDLPKGTFICEYIGEILTNTELydrNVRSSSErhT 339
Cdd:cd10545    62 --IYECGPLCKCPPSCYNRVTQKGLRYRLEVFKTAE-RGWGVRSWDSIPAGSFICEYVGELLDTSEA---DTRSGND--D 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 340 YPVTLD-------ADWGSEKDLKDEEA------------LCLDATICGNVARFINHRCEdANMIDIPIEIETPDRHYYHI 400
Cdd:cd10545   134 YLFDIDnrqtnrgWDGGQRLDVGMSDGerssaedeesseFTIDAGSFGNVARFINHSCS-PNLFVQCVLYDHNDLRLPRV 212

                         250
                  ....*....|....*...
gi 1063709376 401 AFFTLRDVKAMDELTWDY 418
Cdd:cd10545   213 MLFAADNIPPLQELTYDY 230
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 262-442 6.79e-38

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 138.97  E-value: 6.79e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 262 IKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQEgKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHTYP 341
Cdd:cd10544    66 VFECNSMCKCSESCQNRVVQNGLQFKLQVFKTPK-KGWGLRTLEFIPKGRFVCEYAGEVIGFEEARRRTKSQTKGDMNYI 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 342 VTLDADWGSEKDLKDeealCLDATICGNVARFINHRCEdANMIDIPIEIETPdrhYYHIAFFTLRDVKAMDELTWDYMID 421
Cdd:cd10544   145 IVLREHLSSGKVLET----FVDPTYIGNIGRFLNHSCE-PNLFMVPVRVDSM---VPKLALFAARDIVAGEELSFDYSGE 216

                         170       180       190
                  ....*....|....*....|....*....|
gi 1063709376 422 FNDKSHPVKAFR---------CCCGSESCR 442
Cdd:cd10544   217 FSNSVESVTLARqdesksrkpCLCGAENCR 246
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 262-444 8.23e-38

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 139.20  E-value: 8.23e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 262 IKECWRKCGCD-MQCGNRVVQRGIRCQLQVyFTQEGKGWGLRTLQDLPKGTFICEYIGEILTNT---ELYDRNVRSSSER 337
Cdd:cd10523    83 LYECNVSCKCNrMLCQNRVVQHGLQVRLQV-FKTEKKGWGVRCLDDIDKGTFVCIYAGRVLSRArspTEPLPPKLELPSE 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 338 HTYPVTLDADWGSEKDLKDEEALCLDATICGNVARFINHRCEdANMIDIPIEIETPDRHYYHIAFFTLRDVKAMDELTWD 417
Cdd:cd10523   162 NEVEVVTSWLILSKKRKLRENVCFLDASKEGNVGRFLNHSCC-PNLFVQNVFVDTHDKNFPWVAFFTNRVVKAGTELTWD 240

                         170       180
                  ....*....|....*....|....*..
gi 1063709376 418 YMIDFNdkSHPVKAFRCCCGSESCRDR 444
Cdd:cd10523   241 YSYDAG--TSPEQEIPCLCGVNKCQKK 265
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 259-443 3.27e-34

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 129.36  E-value: 3.27e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 259 RKFIKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERH 338
Cdd:cd19473    78 RLPIYECHEGCACSDDCPNRVVERGRKVPLQIFRTSDGRGWGVRSTVDIKRGQFVDCYVGEIITPEEAQRRRDAATIAQR 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 339 --TYPVTLD--ADWGSEKDLKDEEALCLDATICGNVARFINHRCeDANMIDIPIEIETPDRHYYHIAFFTLRDVKAMDEL 414
Cdd:cd19473   158 kdVYLFALDkfSDPDSLDPRLRGDPYEIDGEFMSGPTRFINHSC-DPNLRIFARVGDHADKHIHDLAFFAIKDIPRGTEL 236

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1063709376 415 TWDYM-------IDFNDKSHPVKAFRCCCGSESCRD 443
Cdd:cd19473   237 TFDYVdgvtgldDDAGDEEKEKEMTKCLCGSPKCRG 272
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 262-442 2.21e-33

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 126.92  E-value: 2.21e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 262 IKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQEgKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHTYP 341
Cdd:cd20073    69 IYECNENCDCGINCPNRVVQRGRKLPLEIFKTKH-KGWGLRCPRFIKAGTFIGVYLGEVITQSEAEIRGKKYDNVGVTYL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 342 VTLDAdwgseKDLKDEEALCLDATICGNVARFINHRCeDANMIDIPIEIETPDRHYYHIAFFTLRDVKAMDELTWDYMID 421
Cdd:cd20073   148 FDLDL-----FEDQVDEYYTVDAQYCGDVTRFINHSC-DPNLAIYSVLRDKSDSKIYDLAFFAIKDIPALEELTFDYSGR 221

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1063709376 422 FNDksHPV--------------KAFRCC-CGSESCR 442
Cdd:cd20073   222 NNF--DQLgfignrsnskyinlKNKRPCyCGSANCR 255
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 262-444 5.03e-33

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 125.35  E-value: 5.03e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 262 IKECWRKCGCDMQ-CGNRVVQRGIRCQLQVYFTQEgKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSErhty 340
Cdd:cd10541    67 VYECNKLCKCDPNmCQNRLVQHGLQVRLQLFKTQN-KGWGIRCLDDIAKGTFVCIYAGKILTDDFADKEGLEMGDE---- 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 341 pvtldadWGSEKDLKDEEALCLDATICGNVARFINHRCEdANMIDIPIEIETPDRHYYHIAFFTLRDVKAMDELTWDYmi 420
Cdd:cd10541   142 -------YFANLDHIEESCYIIDAKLEGNLGRYLNHSCS-PNLFVQNVFVDTHDLRFPWVAFFASKRIKAGTELTWDY-- 211

                         170       180
                  ....*....|....*....|....
gi 1063709376 421 DFNDKSHPVKAFRCCCGSESCRDR 444
Cdd:cd10541   212 NYEVGSVEGKELLCCCGSNECRGR 235
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 262-442 1.95e-30

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 118.45  E-value: 1.95e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 262 IKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHTYP 341
Cdd:cd10532    60 IYECNSRCKCGPDCPNRVVQKGTQYSLCIFRTSNGRGWGVKTLQKIKKNSFVMEYVGEVITSEEAERRGQFYDSKGITYL 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 342 VTLDAdwgsekdlkDEEALCLDATICGNVARFINHRCeDANMIDIPIEIETPDRHYYHIAFFTLRDVKAMDELTWDYM-- 419
Cdd:cd10532   140 FDLDY---------ESDEFTVDAARYGNVSHFVNHSC-DPNLQVFNVFIDNLDTRLPRIALFSTRTIKAGEELTFDYQmk 209

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1063709376 420 ------IDFNDKSHPVKAFR--CCCGSESCR 442
Cdd:cd10532   210 gsgdlsSDSIDNSPAKKRVRtvCKCGAVTCR 240
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 262-442 1.36e-29

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 116.15  E-value: 1.36e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 262 IKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHTYP 341
Cdd:cd10525    62 IYECNSRCRCGPDCPNRVVQKGIQYDLCIFRTDNGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYL 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 342 VTLDAdwgsekdlkDEEALCLDATICGNVARFINHRCeDANMIDIPIEIETPDRHYYHIAFFTLRDVKAMDELTWDY--M 419
Cdd:cd10525   142 FDLDY---------VEDVYTVDAAYYGNISHFVNHSC-DPNLQVYNVFIDNLDERLPRIALFATRTIRAGEELTFDYnmQ 211

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1063709376 420 IDFND---------------KSHPVKAFR--CCCGSESCR 442
Cdd:cd10525   212 VDPVDaestkmdsnfglaglPGSPKKRVRieCKCGVRSCR 251
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 292-442 3.27e-29

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 111.62  E-value: 3.27e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 292 FTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRS-SSERHTYPVTLDadwgsekdlkdeEALCLDATICGNV 370
Cdd:cd19174     5 FRTEDKGWGVRTKEPIKAGQFIIEYVGEVVSEQEFRRRMIEQyHNHSHHYCLNLD------------SGMVIDGYRMGNE 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 371 ARFINHRCEdanmidipieietPDRH--------YYHIAFFTLRDVKAMDELTWDYMID-FNDKSHPVkafrCCCGSESC 441
Cdd:cd19174    73 ARFVNHSCD-------------PNCEmqkwsvngVYRIGLFALKDIPAGEELTYDYNFHsFNVEKQQP----CKCGSPNC 135


                  .
gi 1063709376 442 R 442
Cdd:cd19174   136 R 136
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 288-425 2.79e-28

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 108.58  E-value: 2.79e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376  288 LQVYFTqEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHTYPVTLDADWGsekdlkdeeaLCLDATIC 367
Cdd:smart00317   3 LEVFKS-PGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAKAFYLFDIDSD----------LCIDARRK 71

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063709376  368 GNVARFINHRCEdANMIDIPIEIETPDrhyyHIAFFTLRDVKAMDELTWDYMIDFNDK 425
Cdd:smart00317  72 GNLARFINHSCE-PNCELLFVEVNGDD----RIVIFALRDIKPGEELTIDYGSDYANE 124
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 292-442 3.47e-27

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 106.13  E-value: 3.47e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 292 FTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSE--RHTYPVTLDadwgsekdlKDEealCLDATICGN 369
Cdd:cd19172     7 FRTEKKGWGLRAAEDLPKGTFVIEYVGEVLDEKEFKRRMKEYAREgnRHYYFMALK---------SDE---IIDATKKGN 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063709376 370 VARFINHRCEdanmidiPiEIETPD---RHYYHIAFFTLRDVKAMDELTWDYMIDfndkSHPVKAFRCCCGSESCR 442
Cdd:cd19172    75 LSRFINHSCE-------P-NCETQKwtvNGELRVGFFAKRDIPAGEELTFDYQFE----RYGKEAQKCYCGSPNCR 138
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 291-442 1.66e-25

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 101.18  E-value: 1.66e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 291 YFTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDR--NVRSSSERHTYPVTLDADwgsekdlkdeeaLCLDATICG 368
Cdd:cd10531     4 LFRTEKKGWGVKAKEDIQKGEFIIEYVGEVIDKKEFKERldEYEELGKSNFYILSLSDD------------VVIDATRKG 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063709376 369 NVARFINHRCEdANMIdipIEIETPDRHyYHIAFFTLRDVKAMDELTWDYmidfNDKSHPVKAFRCCCGSESCR 442
Cdd:cd10531    72 NLSRFINHSCE-PNCE---TQKWIVNGE-YRIGIFALRDIPAGEELTFDY----NFVNYNEAKQVCLCGAQNCR 136
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 298-418 4.84e-23

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 93.74  E-value: 4.84e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 298 GWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHtypvtLDADWGSE-KDLKDEEALCLDATI--CGNVARFI 374
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLLITKEEADKRELLYYDKL-----ELRLWGPYlFTLDEDSEYCIDARAlyYGNWARFI 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1063709376 375 NHRCeDANMIDIPIEIETpdrhYYHIAFFTLRDVKAMDELTWDY 418
Cdd:pfam00856  76 NHSC-DPNCEVRVVYVNG----GPRIVIFALRDIKPGEELTIDY 114
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 298-442 2.84e-22

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 92.66  E-value: 2.84e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 298 GWGLRTLQDLPKGTFICEYIGEILTN--TELYDRNVRSSSERHTYPVTLDADWgsekdlkdeealCLDATICGNVARFIN 375
Cdd:cd10518    25 GWGLFAKRPIAAGEMVIEYVGEVIRPivADKREKRYDEEGGGGTYMFRIDEDL------------VIDATKKGNIARFIN 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063709376 376 HRCeDANMIDIPIEIETPDrhyyHIAFFTLRDVKAMDELTWDYMIDFNDKshpvKAFRCCCGSESCR 442
Cdd:cd10518    93 HSC-DPNCYAKIITVDGEK----HIVIFAKRDIAPGEELTYDYKFPIEDE----EKIPCLCGAPNCR 150
WIYLD pfam10440
Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha ...
 9-66 8.84e-21

Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha helices. The domain was named the WIYLD domain based on the pattern of most conserved residues. It binds ubiquitin. In the Arabidopsis thaliana histone-lysine N-methyltransferase SUVR4, binding of ubiquitin to this domain stimulates enzymatic activity and converts its activity from a strict dimethylase to a di/trimethylase.


Pssm-ID: 431288  Cd Length: 58  Bit Score: 85.38  E-value: 8.84e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063709376   9 KDEKVLKALERTRQLDIPDEKTMPVLMKLLEEAGGNWSYIKLDNYTALVDAIYSVEDE 66
Cdd:pfam10440   1 GDRRIDAAIDAMRPLGIPKEKIRPVLKNLLKVYGGNWPLIEEDNYRVLADAIFEKQDE 58
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
295-442 1.13e-20

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 87.71  E-value: 1.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 295 EGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSErHTYPVTLDADWGsekdlkdeealcLDATICGNVARFI 374
Cdd:COG2940    14 PIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPHKEPL-HTYLFELDDDGV------------IDGALGGNPARFI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063709376 375 NHRCeDANMidipiEIETPDRHYYhiaFFTLRDVKAMDELTWDYMIDFNDkshpvKAFRCCCGseSCR 442
Cdd:COG2940    81 NHSC-DPNC-----EADEEDGRIF---IVALRDIAAGEELTYDYGLDYDE-----EEYPCRCP--NCR 132
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 297-442 2.29e-19

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 84.79  E-value: 2.29e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 297 KGWGLRTLQDLPKGTFICEYIGEILTNtELYDRNVR--SSSERHTYPVTLDADWgsekdlkdeealCLDATICGNVARFI 374
Cdd:cd19171    24 QGLGLYAARDIEKHTMVIEYIGEIIRN-EVANRREKiyESQNRGIYMFRIDNDW------------VIDATMTGGPARYI 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063709376 375 NHRCeDANMIdipIEIETPDRHyYHIAFFTLRDVKAMDELTWDYMIDFNDKSHPVKafrCCCGSESCR 442
Cdd:cd19171    91 NHSC-NPNCV---AEVVTFDKE-KKIIIISNRRIAKGEELTYDYKFDFEDDQHKIP---CLCGAPNCR 150
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 291-441 2.57e-17

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 78.51  E-value: 2.57e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 291 YFTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHT--YPVTLDADwgsekdlkdeeaLCLDATICG 368
Cdd:cd19173     6 PFKTGDRGWGLRTKRDIKKGDFVIEYVGELIDEEECRRRLKKAHENNITnfYMLTLDKD------------RIIDAGPKG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 369 NVARFINHRCeDANMidipieiET------PDrhyYHIAFFTLRDVKAMDELTWDYMIDF--NDKShpvkafRCCCGSES 440
Cdd:cd19173    74 NLSRFMNHSC-QPNC-------ETqkwtvnGD---TRVGLFAVRDIPAGEELTFNYNLDClgNEKK------VCRCGAPN 136


                  .
gi 1063709376 441 C 441
Cdd:cd19173   137 C 137
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 291-442 1.00e-16

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 76.69  E-value: 1.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 291 YFTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDR--NVRSSSERHTYPVTLDADwgsekdlkdeeaLCLDATICG 368
Cdd:cd19175     4 LVKTEKCGWGLVADEDINAGEFIIEYVGEVIDDKTCEERlwDMKHKGEKNFYMCEIDKD------------MVIDATFKG 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063709376 369 NVARFINHRCE-DANMIDIPIEIETpdrhyyHIAFFTLRDVKAMDELTWDY-MIDFNDKSHpvkafrCCCGSESCR 442
Cdd:cd19175    72 NLSRFINHSCDpNCELQKWQVDGET------RIGVFAIRDIKKGEELTYDYqFVQFGADQD------CHCGSKNCR 135
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 296-418 4.14e-16

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 74.30  E-value: 4.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 296 GKGWGLRTLQDLPKGTFICEYIGEILTNTElYDRNvrssSERH---TYPVTLDADwgsekdlkdeeALCLDATICGNVAR 372
Cdd:cd10522    12 HNGLGLFAAETIAKGEFVGEYTGEVLDRWE-EDRD----SVYHydpLYPFDLNGD-----------ILVIDAGKKGNLTR 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1063709376 373 FINHrCEDANmidipIE-IETPDRHYYHIAFFTLRDVKAMDELTWDY 418
Cdd:cd10522    76 FINH-SDQPN-----LElIVRTLKGEQHIGFVAIRDIKPGEELFISY 116
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 295-441 7.12e-16

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 74.26  E-value: 7.12e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 295 EGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRnVRSSSER---HTYPVTLDADwgsekdlkdeeaLCLDATICGNVA 371
Cdd:cd19211    10 EGKGWGLIAKRDIKKGEFVNEYVGELIDEEECMAR-IKHAHENditHFYMLTIDKD------------RIIDAGPKGNYS 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063709376 372 RFINHRCE-DANMIDIPIEIETpdrhyyHIAFFTLRDVKAMDELTWDYMIDF--NDKShpvkafRCCCGSESC 441
Cdd:cd19211    77 RFMNHSCQpNCETQKWTVNGDT------RVGLFAVCDIPAGTELTFNYNLDClgNEKT------VCRCGAPNC 137
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 131-278 7.64e-15

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 70.14  E-value: 7.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 131 ITKGSESVKIPLVDDVGSEAVP-KFTYIPHNIVYQSAYLHvslarisDEDCCaNCkGNCLSAdfPCTCARETSGE--YAY 207
Cdd:pfam05033   1 ISKGKENVPIPVVNEVDDEPPPpDFTYITSYIYPKEFLLI-------IPQGC-DC-GDCSSE--KCSCAQLNGGEfrFPY 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063709376 208 TKEGLLKEKfldtclkmkkepdsfpkvyckdcplerdhdkgtygkcdghlIRKFIKECWRKCGCDMQCGNR 278
Cdd:pfam05033  70 DKDGLLVPE-----------------------------------------SKPPIYECNPLCGCPPSCPNR 99
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 298-442 1.84e-14

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 70.44  E-value: 1.84e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 298 GWGLRTLQDLPKGTFICEYIGEILTNT--ELYDRNVRSSSERHTYPVTLDADwgsekdlkdeeaLCLDATICGNVARFIN 375
Cdd:cd19169    24 DWGLFALEPIAADEMVIEYVGQVIRQSvaDEREKRYEAIGIGSSYLFRVDDD------------TIIDATKCGNLARFIN 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063709376 376 HRCeDANMIDIPIEIETPDRhyyhIAFFTLRDVKAMDELTWDYMIDFNDKSHPvkafrCCCGSESCR 442
Cdd:cd19169    92 HSC-NPNCYAKIITVESQKK----IVIYSKRPIAVNEEITYDYKFPIEDEKIP-----CLCGAPQCR 148
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 298-418 6.07e-14

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 68.04  E-value: 6.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 298 GWGLRTLQDLPKGTFICEYIGEILTNTE------LYDRNVRSsserhtYPVTLDADWgsekdlkdeealCLDATICGNVA 371
Cdd:cd10519    12 GWGLFLKEPIKKDEFIGEYTGELISQDEadrrgkIYDKYNSS------YLFNLNDQF------------VVDATRKGNKI 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063709376 372 RFINHRCeDAN-----MIdipieietpDRHYYHIAFFTLRDVKAMDELTWDY 418
Cdd:cd10519    74 RFANHSS-NPNcyakvMM---------VNGDHRIGIFAKRDIEAGEELFFDY 115
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 292-441 8.26e-14

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 68.42  E-value: 8.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 292 FTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRnVRSSSER---HTYPVTLDADwgsekdlkdeeaLCLDATICG 368
Cdd:cd19210     7 FRTLGRGWGLRCKTDIKKGEFVNEYVGELIDEEECRAR-IRYAQEHditNFYMLTLDKD------------RIIDAGPKG 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063709376 369 NVARFINHRCEdANMIDIPIEIETPDRhyyhIAFFTLRDVKAMDELTWDYMIDFNDKSHPVkafrCCCGSESC 441
Cdd:cd19210    74 NYARFMNHCCQ-PNCETQKWTVNGDTR----VGLFALCDIKAGTELTFNYNLECLGNGKTV----CKCGAPNC 137
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 292-418 1.32e-13

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 67.21  E-value: 1.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 292 FTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHTYPVTLDADWGsekdlkdeealcLDATICGNVA 371
Cdd:cd19168     7 KSQLECGLGLFAAEDIKEGEFVIEYTGELISHDEGVRREHRRGDVSYLYLFEEQEGIW------------VDAAIYGNLS 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1063709376 372 RFINHRCEDANMIDIPIEIeTPDRHYYHIAFFTLRDVKAMDELTWDY 418
Cdd:cd19168    75 RYINHATDKVKTGNCMPKI-MYVNHEWRIKFTAIKDIKIGEELFFNY 120
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 278-418 1.38e-13

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 67.60  E-value: 1.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 278 RVVQRGIRCQLQVYFTqEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNvrssserhtypvtldadwgsEKDLKDE 357
Cdd:cd10528     9 ELILSGKEEGLKVIEI-DGKGRGVIATRPFEKGDFVVEYHGDLITITEAKKRE--------------------ALYAKDP 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063709376 358 EA-------------LCLDAT-ICGNVARFINHRCEDANMIDIPIEIETPDrhyyHIAFFTLRDVKAMDELTWDY 418
Cdd:cd10528    68 STgcymyyfqykgktYCVDATkESGRLGRLINHSKKKPNLKTKLLVIDGVP----HLILVAKRDIKPGEELLYDY 138
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 289-441 2.37e-13

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 67.26  E-value: 2.37e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 289 QVYFTqEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRnVRSSSERHT---YPVTLDADwgsekdlkdeeaLCLDAT 365
Cdd:cd19212     5 EIIKT-ERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLR-IKRAHENSVtnfYMLTVTKD------------RIIDAG 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063709376 366 ICGNVARFINHRCeDANMIDIPIEIETPDRhyyhIAFFTLRDVKAMDELTWDYMIDF--NDKShpvkafRCCCGSESC 441
Cdd:cd19212    71 PKGNYSRFMNHSC-NPNCETQKWTVNGDVR----VGLFALCDIPAGMELTFNYNLDClgNGRT------ECHCGADNC 137
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 299-442 3.79e-13

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 66.68  E-value: 3.79e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 299 WGLRTLQDLPKGTFICEYIGEILTNT--ELYDRNVRSSSERHTYPVTLDADwgsekdlkdeeaLCLDATICGNVARFINH 376
Cdd:cd20072    25 WGLYAMENISAKDMVIEYVGEVIRQQvaDEREKRYLRQGIGSSYLFRIDDD------------TVVDATKKGNIARFINH 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063709376 377 RCeDANMIDIPIEIETPDRhyyhIAFFTLRDVKAMDELTWDYMIDFNDKSHPvkafrCCCGSESCR 442
Cdd:cd20072    93 CC-DPNCTAKIIKVEGEKR----IVIYAKRDIAAGEELTYDYKFPREEDKIP-----CLCGAPNCR 148
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 298-442 5.41e-12

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 63.56  E-value: 5.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 298 GWGLRTLQDLPKGTFICEYIGEILTNTeLYDRNVRSSSERHT--YPVTLDADwgsekdlkdeeaLCLDATICGNVARFIN 375
Cdd:cd19170    25 GRGLFCKRNIDAGEMVIEYAGEVIRSV-LTDKREKYYESKGIgcYMFRIDDD------------EVVDATMHGNAARFIN 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063709376 376 HRCEdANMIDIPIEIETPDrhyyHIAFFTLRDVKAMDELTWDYMIDFNDKSHPvkafrCCCGSESCR 442
Cdd:cd19170    92 HSCE-PNCYSRVVNIDGKK----HIVIFALRRILRGEELTYDYKFPIEDVKIP-----CTCGSKKCR 148
SET_KMT2C cd19208
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...
 290-442 9.19e-12

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.


Pssm-ID: 380985 [Multi-domain]  Cd Length: 154  Bit Score: 63.11  E-value: 9.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 290 VYFTQEG-KGWGLRTLQDLPKGTFICEYIGEILTNtELYDRNVR--SSSERHTYPVTLDADWgsekdlkdeealCLDATI 366
Cdd:cd19208    17 VYLARSRiQGLGLYAARDIEKHTMVIEYIGTIIRN-EVANRKEKlyESQNRGVYMFRIDNDH------------VIDATL 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063709376 367 CGNVARFINHRCEdANMIDIPIEIETPDRhyyhIAFFTLRDVKAMDELTWDYMIDFNDKSHPVKafrCCCGSESCR 442
Cdd:cd19208    84 TGGPARYINHSCA-PNCVAEVVTFEKGHK----IIISSSRRIQKGEELCYDYKFDFEDDQHKIP---CHCGAVNCR 151
SET_KMT2D cd19209
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...
 297-442 8.58e-11

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380986 [Multi-domain]  Cd Length: 155  Bit Score: 60.09  E-value: 8.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 297 KGWGLRTLQDLPKGTFICEYIGEILTNtELYDR--NVRSSSERHTYPVTLDADWgsekdlkdeealCLDATICGNVARFI 374
Cdd:cd19209    26 QGLGLYAAKDLEKHTMVIEYIGTIIRN-EVANRreKIYEEQNRGIYMFRINNEH------------VIDATLTGGPARYI 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063709376 375 NHRCEdANMIDIPIEIETPDRhyyhIAFFTLRDVKAMDELTWDYMIDFNDKSHPVKafrCCCGSESCR 442
Cdd:cd19209    93 NHSCA-PNCVAEVVTFDKEDK----IIIISSRRIPKGEELTYDYQFDFEDDQHKIP---CHCGAWNCR 152
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 299-442 1.60e-10

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 59.27  E-value: 1.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 299 WGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSErhtypvtldaDWGSEKDLKDEEALCLDATICGNVARFINHRC 378
Cdd:cd19204    26 WGLFAMEPIAADEMVIEYVGQNIRQVVADMREKRYVQE----------GIGSSYLFRVDHDTIIDATKCGNLARFINHCC 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063709376 379 EdANMIDIPIEIETPDRhyyhIAFFTLRDVKAMDELTWDYMIDFNDKSHPvkafrCCCGSESCR 442
Cdd:cd19204    96 T-PNCYAKVITIESQKK----IVIYSKQPIGVNEEITYDYKFPIEDNKIP-----CLCGTENCR 149
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 300-418 1.82e-10

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 58.44  E-value: 1.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 300 GLRTLQDLPKGTFICEYIGEILTNTELYDRNvrsSSERHTYPVTLdadwgsEKDLKDEEALCLDATICGNVARFINHRCe 379
Cdd:cd10529    18 GLVATEDISPGEPILEYKGEVSLRSEFKEDN---GFFKRPSPFVF------FYDGFEGLPLCVDARKYGNEARFIRRSC- 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1063709376 380 danmidipieieTPD---RHYY------HIAFFTLRDVKAMDELT--WDY 418
Cdd:cd10529    88 ------------RPNaelRHVVvsngelRLFIFALKDIRKGTEITipFDY 125
SET_SETD1B cd19205
SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...
 299-442 3.61e-10

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.


Pssm-ID: 380982 [Multi-domain]  Cd Length: 153  Bit Score: 58.53  E-value: 3.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 299 WGLRTLQDLPKGTFICEYIGEILtntelydRNVRSSSERHTYPvtlDADWGSEKDLKDEEALCLDATICGNVARFINHRC 378
Cdd:cd19205    26 WGLFAMEPIAADEMVIEYVGQNI-------RQVIADMREKRYE---DEGIGSSYMFRVDHDTIIDATKCGNFARFINHSC 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063709376 379 eDANMIDIPIEIETPDRhyyhIAFFTLRDVKAMDELTWDYMIDFNDKSHPvkafrCCCGSESCR 442
Cdd:cd19205    96 -NPNCYAKVITVESQKK----IVIYSKQHINVNEEITYDYKFPIEDVKIP-----CLCGSENCR 149
PreSET smart00468
N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal ...
 128-216 2.79e-09

N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal to some SET domains. Function is unknown. Unpublished.


Pssm-ID: 128744 [Multi-domain]  Cd Length: 98  Bit Score: 54.34  E-value: 2.79e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376  128 IADITKGSESVKIPLVDDV-GSEAVPKFTYIPHNIVYQSAylhVSLARISDEDCCaNCKGNClSADFPCTCARETSGEYA 206
Cdd:smart00468   1 CLDISNGKENVPVPLVNEVdEDPPPPDFEYISEYIYGQGV---PIDRSPSPLVGC-SCSGDC-SSSNKCECARKNGGEFA 75

                           90
                   ....*....|
gi 1063709376  207 YTKEGLLKEK 216
Cdd:smart00468  76 YELNGGLRLK 85
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 300-432 7.15e-09

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 55.10  E-value: 7.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 300 GLRTLQDLPKGTFICEYIGEILTNTE-LYDRNVRSSSERHTYP-VTLDADWgsekdlkdeeALCLDATICGNVARFINHR 377
Cdd:cd19183    15 GLFADRPIPAGDPIQELLGEIGLQSEyIADPENQYQILGAPKPhVFFHPQS----------PLYIDTRRSGSVARFIRRS 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063709376 378 CEdANMIDIPIEIETPDRhyYHIAFFTLRDVKAMDELT--WDYmidfnDKSHPVKAF 432
Cdd:cd19183    85 CR-PNAELVTVASDSGSV--LKFVLYASRDISPGEEITigWDW-----DNPHPFRRF 133
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 296-418 7.27e-09

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 52.25  E-value: 7.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 296 GKGWGLRTLQDLPKGTFICeyigeiltntelydrnvrssserhtypvtldadwgsekdlkdeealcldaticgnVARFIN 375
Cdd:cd08161     9 GAGFGLFATRDIPKGEVIG-------------------------------------------------------LARFIN 33

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1063709376 376 HRCeDANMIDIPIEIETPdrhyYHIAFFTLRDVKAMDELTWDY 418
Cdd:cd08161    34 HSC-EPNCEFEEVYVGGK----PRVFIVALRDIKAGEELTVDY 71
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 298-442 1.03e-08

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 54.26  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 298 GWGLRTLQDLPKGTFICEYIGEILtntelydRNVRSSSERHTYpvtlDADWGSEKDLKDEEALCLDATICGNVARFINHR 377
Cdd:cd19206    25 GRGLFCKRNIDAGEMVIEYSGNVI-------RSILTDKREKYY----DSKGIGCYMFRIDDSEVVDATMHGNAARFINHS 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063709376 378 CEdANMIDIPIEIETPDrhyyHIAFFTLRDVKAMDELTWDYMIDFNDKSHPVKafrCCCGSESCR 442
Cdd:cd19206    94 CE-PNCYSRVINIDGQK----HIVIFAMRKIYRGEELTYDYKFPIEDASNKLP---CNCGAKKCR 150
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 362-442 3.89e-08

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 52.72  E-value: 3.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 362 LDATICGNVARFINHRCEdANMIDIPIEIETPDrhyyHIAFFTLRDVKAMDELTWDYMIDFNDKSHPVKafrCCCGSESC 441
Cdd:cd19207    78 VDATMHGNAARFINHSCE-PNCYSRVIHVEGQK----HIVIFALRKIYRGEELTYDYKFPIEDASNKLP---CNCGAKRC 149


                  .
gi 1063709376 442 R 442
Cdd:cd19207   150 R 150
SET_EZH1 cd19217
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...
 281-418 5.70e-04

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380994  Cd Length: 136  Bit Score: 40.05  E-value: 5.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 281 QRGIRCQLqVYFTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHTYPVTLDADWgsekdlkdeeal 360
Cdd:cd19217     1 QRGLKKHL-LLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDF------------ 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063709376 361 CLDATICGNVARFINHRCeDANMIDIPIEIETPDRhyyhIAFFTLRDVKAMDELTWDY 418
Cdd:cd19217    68 VVDATRKGNKIRFANHSV-NPNCYAKVVMVNGDHR----IGIFAKRAIQQGEELFFDY 120
SET_EZH2 cd19218
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...
 298-418 1.71e-03

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380995  Cd Length: 120  Bit Score: 38.36  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 298 GWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHTYPVTLDADWgsekdlkdeealCLDATICGNVARFINH- 376
Cdd:cd19218    15 GWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDF------------VVDATRKGNKIRFANHs 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1063709376 377 ---RCEDANMidipieIETPDrhyYHIAFFTLRDVKAMDELTWDY 418
Cdd:cd19218    83 vnpNCYAKVM------MVNGD---HRIGIFAKRAIQTGEELFFDY 118
SET_SETD5 cd19181
SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and ...
 301-441 3.59e-03

SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. SETD5 loss-of-function mutations are a likely cause of a familial syndromic intellectual disability with variable phenotypic expression.


Pssm-ID: 380958  Cd Length: 150  Bit Score: 38.07  E-value: 3.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 301 LRTLQDLPKGTFICEYIGEILTNTELydrNVRSSSERHTYPVTLDADWGSEKDLkdeealCLDATICGNVARFINHRCed 380
Cdd:cd19181    21 LRAARDLALDTLIIEYRGKVMLRQQF---EVNGHFFKRPYPFVLFYSKFNGVEM------CVDARTFGNDARFIRRSC-- 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063709376 381 anmidipieieTPD---RH-----YYHIAFFTLRDVKAMDELTWDYMIDFNDKSHPVKafrCCC--GSESC 441
Cdd:cd19181    90 -----------TPNaevRHmiadgMIHLCIYAVAAIAKDAEVTIAFDYEYSNCNYKVD---CAChkGNRNC 146
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 289-436 7.46e-03

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 36.59  E-value: 7.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709376 289 QVYFTQEGKGWGLRTLQDLPKGTFICeyigeiltntelydrnvrssSERHTYPVTLDAdwGSEKDLKDEEALCLDATICg 368
Cdd:cd20071     1 EVRESEGSKGRGLVATRDIEPGELIL--------------------VEKPLVSVPSNS--FSLTDGLNEIGVGLFPLAS- 57

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063709376 369 nvarFINHRCeDANmidipIEIETPDRHyyHIAFFTLRDVKAMDELTWDYMIDFNDKSHPVKA------FRCCC 436
Cdd:cd20071    58 ----LLNHSC-DPN-----AVVVFDGNG--TLRVRALRDIKAGEELTISYIDPLLPRTERRREllekygFTCSC 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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