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Conserved domains on  [gi|42572245|ref|NP_974217|]
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SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 141-408 1.65e-94

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


:

Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 284.65  E-value: 1.65e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 141 PKFTYIPHNIVYQSAYLHvslARISDEDCCaNCKGNCLsaDFPCTCARETSGEYAYTKEGLLKEkfldtclkmkkepdsf 220
Cdd:cd10538   1 PSFTYIKDNIVGKNVQPF---SNIIDSVGC-KCKDDCL--DSKCACAAESDGIFAYTKNGLLRL---------------- 58

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 221 pkvyckdcplerdhdkgtygkcdgHLIRKFIKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQeGKGWGLRTLQDLPKGT 300
Cdd:cd10538  59 ------------------------NNSPPPIFECNSKCSCDDDCKNRVVQRGLQARLQVFRTS-KKGWGVRSLEFIPKGS 113

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 301 FICEYIGEILTNTELYDRNVRSSSERHTYPVTLDADWGSEkdlKDEEALCLDATICGNVARFINHRCeDANMIDIPIEIE 380
Cdd:cd10538 114 FVCEYVGEVITTSEADRRGKIYDKSGGSYLFDLDEFSDSD---GDGEELCVDATFCGNVSRFINHSC-DPNLFPFNVVID 189

                       250       260
                ....*....|....*....|....*...
gi 42572245 381 TPDRHYYHIAFFTLRDVKAMDELTWDYM 408
Cdd:cd10538 190 HDDLRYPRIALFATRDILPGEELTFDYG 217
WIYLD pfam10440
Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha ...
 25-82 8.95e-21

Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha helices. The domain was named the WIYLD domain based on the pattern of most conserved residues. It binds ubiquitin. In the Arabidopsis thaliana histone-lysine N-methyltransferase SUVR4, binding of ubiquitin to this domain stimulates enzymatic activity and converts its activity from a strict dimethylase to a di/trimethylase.


:

Pssm-ID: 431288  Cd Length: 58  Bit Score: 85.38  E-value: 8.95e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 42572245    25 KDEKVLKALERTRQLDIPDEKTMPVLMKLLEEAGGNWSYIKLDNYTALVDAIYSVEDE 82
Cdd:pfam10440   1 GDRRIDAAIDAMRPLGIPKEKIRPVLKNLLKVYGGNWPLIEEDNYRVLADAIFEKQDE 58
 
Name Accession Description Interval E-value
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 141-408 1.65e-94

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 284.65  E-value: 1.65e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 141 PKFTYIPHNIVYQSAYLHvslARISDEDCCaNCKGNCLsaDFPCTCARETSGEYAYTKEGLLKEkfldtclkmkkepdsf 220
Cdd:cd10538   1 PSFTYIKDNIVGKNVQPF---SNIIDSVGC-KCKDDCL--DSKCACAAESDGIFAYTKNGLLRL---------------- 58

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 221 pkvyckdcplerdhdkgtygkcdgHLIRKFIKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQeGKGWGLRTLQDLPKGT 300
Cdd:cd10538  59 ------------------------NNSPPPIFECNSKCSCDDDCKNRVVQRGLQARLQVFRTS-KKGWGVRSLEFIPKGS 113

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 301 FICEYIGEILTNTELYDRNVRSSSERHTYPVTLDADWGSEkdlKDEEALCLDATICGNVARFINHRCeDANMIDIPIEIE 380
Cdd:cd10538 114 FVCEYVGEVITTSEADRRGKIYDKSGGSYLFDLDEFSDSD---GDGEELCVDATFCGNVSRFINHSC-DPNLFPFNVVID 189

                       250       260
                ....*....|....*....|....*...
gi 42572245 381 TPDRHYYHIAFFTLRDVKAMDELTWDYM 408
Cdd:cd10538 190 HDDLRYPRIALFATRDILPGEELTFDYG 217
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 277-414 2.32e-28

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 108.58  E-value: 2.32e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245    277 LQVYFTqEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHTYPVTLDADWGsekdlkdeeaLCLDATIC 356
Cdd:smart00317   3 LEVFKS-PGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAKAFYLFDIDSD----------LCIDARRK 71

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 42572245    357 GNVARFINHRCEdANMIDIPIEIETPDrhyyHIAFFTLRDVKAMDELTWDYMIDFNDK 414
Cdd:smart00317  72 GNLARFINHSCE-PNCELLFVEVNGDD----RIVIFALRDIKPGEELTIDYGSDYANE 124
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 287-407 5.00e-23

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 93.74  E-value: 5.00e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245   287 GWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHtypvtLDADWGSE-KDLKDEEALCLDATI--CGNVARFI 363
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLLITKEEADKRELLYYDKL-----ELRLWGPYlFTLDEDSEYCIDARAlyYGNWARFI 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 42572245   364 NHRCeDANMIDIPIEIETpdrhYYHIAFFTLRDVKAMDELTWDY 407
Cdd:pfam00856  76 NHSC-DPNCEVRVVYVNG----GPRIVIFALRDIKPGEELTIDY 114
WIYLD pfam10440
Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha ...
 25-82 8.95e-21

Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha helices. The domain was named the WIYLD domain based on the pattern of most conserved residues. It binds ubiquitin. In the Arabidopsis thaliana histone-lysine N-methyltransferase SUVR4, binding of ubiquitin to this domain stimulates enzymatic activity and converts its activity from a strict dimethylase to a di/trimethylase.


Pssm-ID: 431288  Cd Length: 58  Bit Score: 85.38  E-value: 8.95e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 42572245    25 KDEKVLKALERTRQLDIPDEKTMPVLMKLLEEAGGNWSYIKLDNYTALVDAIYSVEDE 82
Cdd:pfam10440   1 GDRRIDAAIDAMRPLGIPKEKIRPVLKNLLKVYGGNWPLIEEDNYRVLADAIFEKQDE 58
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
284-431 1.01e-20

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 87.71  E-value: 1.01e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 284 EGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSErHTYPVTLDADWGsekdlkdeealcLDATICGNVARFI 363
Cdd:COG2940  14 PIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPHKEPL-HTYLFELDDDGV------------IDGALGGNPARFI 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42572245 364 NHRCeDANMidipiEIETPDRHYYhiaFFTLRDVKAMDELTWDYMIDFNDkshpvKAFRCCCGseSCR 431
Cdd:COG2940  81 NHSC-DPNC-----EADEEDGRIF---IVALRDIAAGEELTYDYGLDYDE-----EEYPCRCP--NCR 132
 
Name Accession Description Interval E-value
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 141-408 1.65e-94

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 284.65  E-value: 1.65e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 141 PKFTYIPHNIVYQSAYLHvslARISDEDCCaNCKGNCLsaDFPCTCARETSGEYAYTKEGLLKEkfldtclkmkkepdsf 220
Cdd:cd10538   1 PSFTYIKDNIVGKNVQPF---SNIIDSVGC-KCKDDCL--DSKCACAAESDGIFAYTKNGLLRL---------------- 58

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 221 pkvyckdcplerdhdkgtygkcdgHLIRKFIKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQeGKGWGLRTLQDLPKGT 300
Cdd:cd10538  59 ------------------------NNSPPPIFECNSKCSCDDDCKNRVVQRGLQARLQVFRTS-KKGWGVRSLEFIPKGS 113

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 301 FICEYIGEILTNTELYDRNVRSSSERHTYPVTLDADWGSEkdlKDEEALCLDATICGNVARFINHRCeDANMIDIPIEIE 380
Cdd:cd10538 114 FVCEYVGEVITTSEADRRGKIYDKSGGSYLFDLDEFSDSD---GDGEELCVDATFCGNVSRFINHSC-DPNLFPFNVVID 189

                       250       260
                ....*....|....*....|....*...
gi 42572245 381 TPDRHYYHIAFFTLRDVKAMDELTWDYM 408
Cdd:cd10538 190 HDDLRYPRIALFATRDILPGEELTFDYG 217
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 141-431 3.83e-55

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 183.31  E-value: 3.83e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 141 PKFTYIPHNIvyQSAYLHVSLARISDEDCcaNCKGNCLSADfpCTCAReTSGEYAYTKEGLLKEKFldtclkMKKEPdsf 220
Cdd:cd10543   1 PDFLYVTENC--ETSPLNIDRNITSLQTC--SCRDDCSSDN--CVCGR-LSVRCWYDKEGRLLPDF------NKLDP--- 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 221 pkvyckdcPLerdhdkgtygkcdghlirkfIKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTqEGKGWGLRTLQDLPKGT 300
Cdd:cd10543  65 --------PL--------------------IFECNRACSCWRNCRNRVVQNGIRYRLQLFRT-RGMGWGVRALQDIPKGT 115

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 301 FICEYIGEILTNTELYDRnvrsssERHTYPVTLDAdwgsekdlKDEEALCLDATICGNVARFINHRCEdANMIDIPIEIE 380
Cdd:cd10543 116 FVCEYIGELISDSEADSR------EDDSYLFDLDN--------KDGETYCIDARRYGNISRFINHLCE-PNLIPVRVFVE 180

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 42572245 381 TPDRHYYHIAFFTLRDVKAMDELTWDYMIDFNDKSHpvKAFRCCCGSESCR 431
Cdd:cd10543 181 HQDLRFPRIAFFASRDIKAGEELGFDYGEKFWRIKG--KYFTCRCGSPKCK 229
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 141-431 2.62e-53

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 179.03  E-value: 2.62e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 141 PKFTYIPHNIVYQSAYLhvslarisDED----CcaNCKGNCLSADFPCtCARETSGEYAYTKEGLLKekfldtclkmkke 216
Cdd:cd10542   1 PNFQYINDYIPGDGVKI--------PEDflvgC--ECTEDCHNNNPTC-CPAESGVKFAYDKQGRLR------------- 56

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 217 pdsfpkvyckdcplerdhdkgtygKCDGHLIRkfikECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQEGKGWGLRTLQDL 296
Cdd:cd10542  57 ------------------------LPPGTPIY----ECNSRCKCGPDCPNRVVQRGRKVPLCIFRTSNGRGWGVKTLEDI 108

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 297 PKGTFICEYIGEILTNTELYDRNVRSSSERHTYPVTLDADwgsekdlKDEEALCLDATICGNVARFINHRCeDANMIDIP 376
Cdd:cd10542 109 KKGTFVMEYVGEIITSEEAERRGKIYDANGRTYLFDLDYN-------DDDCEYTVDAAYYGNISHFINHSC-DPNLAVYA 180

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42572245 377 IEIETPDRHYYHIAFFTLRDVKAMDELTWDYMIDFNDKSH-----PVKAFR--CCCGSESCR 431
Cdd:cd10542 181 VWINHLDPRLPRIAFFAKRDIKAGEELTFDYLMTGTGGSSestipKPKDVRvpCLCGSKNCR 242
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 112-433 8.51e-52

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 176.71  E-value: 8.51e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 112 KYKSRIADITKGSESVKIPLVDDVGSEAVPKFTYIPHNIVYQSAYLHVSlariSDEDCCANCKGNCLSADfPCTCARETS 191
Cdd:cd10517   1 KPYYYICDISYGKEGVPIPCVNEIDNSSPPYVEYSKERIPGKGVNINLD----PDFLVGCDCTDGCRDKS-KCACQQLTI 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 192 GEYAYTKEGLLkekfldtclkmkkepdsfpkvyckdcplerDHDKGTYGKCDGHLIRKFIKECWRKCGCDMQCGNRVVQR 271
Cdd:cd10517  76 EATAATPGGQI------------------------------NPSAGYQYRRLMEKLPTGVYECNSRCKCDKRCYNRVVQN 125

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 272 GIRCQLQVYFTQEgKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSErhtYPVTLD-------ADWGSEKDlK 344
Cdd:cd10517 126 GLQVRLQVFKTEK-KGWGIRCLDDIPKGSFVCIYAGQILTEDEANEEGLQYGDE---YFAELDyievvekLKEGYESD-V 200

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 345 DEEALCLDATICGNVARFINHRCeDANMIDIPIEIETPDRHYYHIAFFTLRDVKAMDELTWDYmiDFNDKSHPVKAFRCC 424
Cdd:cd10517 201 EEHCYIIDAKSEGNLGRYLNHSC-SPNLFVQNVFVDTHDLRFPWVAFFASRYIRAGTELTWDY--NYEVGSVPGKVLYCY 277


                ....*....
gi 42572245 425 CGSESCRDR 433
Cdd:cd10517 278 CGSSNCRGR 286
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 243-431 1.32e-41

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 147.77  E-value: 1.32e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 243 DGHLIRKF-------IKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQEgKGWGLRTLQDLPKGTFICEYIGEILTNTEl 315
Cdd:cd10535  52 DGRLLPEFnmaepplIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRD-MGWGVRSLQDIPPGTFVCEYVGELISDSE- 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 316 ydRNVRsssERHTYPVTLDAdwgsekdlKDEEALCLDATICGNVARFINHRCEdANMIDIPIEIETPDRHYYHIAFFTLR 395
Cdd:cd10535 130 --ADVR---EEDSYLFDLDN--------KDGEVYCIDARFYGNVSRFINHHCE-PNLVPVRVFMAHQDLRFPRIAFFSTR 195

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 42572245 396 DVKAMDELTWDYMIDFND-KShpvKAFRCCCGSESCR 431
Cdd:cd10535 196 LIEAGEQLGFDYGERFWDiKG---KLFSCRCGSPKCR 229
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 243-431 7.89e-39

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 140.92  E-value: 7.89e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 243 DGHLIRKFIK-------ECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQEgKGWGLRTLQDLPKGTFICEYIGEILTNTEl 315
Cdd:cd10533  52 DGRLLQEFNKiepplifECNQACSCWRNCKNRVVQSGIKVRLQLYRTAK-MGWGVRALQTIPQGTFICEYVGELISDAE- 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 316 ydRNVRsssERHTYPVTLDAdwgsekdlKDEEALCLDATICGNVARFINHRCeDANMIDIPIEIETPDRHYYHIAFFTLR 395
Cdd:cd10533 130 --ADVR---EDDSYLFDLDN--------KDGEVYCIDARYYGNISRFINHLC-DPNIIPVRVFMLHQDLRFPRIAFFSSR 195

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 42572245 396 DVKAMDELTWDYMIDFND-KShpvKAFRCCCGSESCR 431
Cdd:cd10533 196 DIRTGEELGFDYGDRFWDiKS---KYFTCQCGSEKCK 229
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 169-407 1.52e-38

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 139.85  E-value: 1.52e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 169 CCanCKGNCLSADFPCTCARETSGEYAYTKEGLLKEKfldtclkmkkepdsfpkvycKDCplerdhdkgtygkcdghlir 248
Cdd:cd10545  24 CD--CKNRCTDGASDCACVKKNGGEIPYNFNGRLIRA--------------------KPA-------------------- 61

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 249 kfIKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQEgKGWGLRTLQDLPKGTFICEYIGEILTNTELydrNVRSSSErhT 328
Cdd:cd10545  62 --IYECGPLCKCPPSCYNRVTQKGLRYRLEVFKTAE-RGWGVRSWDSIPAGSFICEYVGELLDTSEA---DTRSGND--D 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 329 YPVTLD-------ADWGSEKDLKDEEA------------LCLDATICGNVARFINHRCEdANMIDIPIEIETPDRHYYHI 389
Cdd:cd10545 134 YLFDIDnrqtnrgWDGGQRLDVGMSDGerssaedeesseFTIDAGSFGNVARFINHSCS-PNLFVQCVLYDHNDLRLPRV 212

                       250
                ....*....|....*...
gi 42572245 390 AFFTLRDVKAMDELTWDY 407
Cdd:cd10545 213 MLFAADNIPPLQELTYDY 230
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 251-431 6.50e-38

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 138.59  E-value: 6.50e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 251 IKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQEgKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHTYP 330
Cdd:cd10544  66 VFECNSMCKCSESCQNRVVQNGLQFKLQVFKTPK-KGWGLRTLEFIPKGRFVCEYAGEVIGFEEARRRTKSQTKGDMNYI 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 331 VTLDADWGSEKDLKDeealCLDATICGNVARFINHRCEdANMIDIPIEIETPdrhYYHIAFFTLRDVKAMDELTWDYMID 410
Cdd:cd10544 145 IVLREHLSSGKVLET----FVDPTYIGNIGRFLNHSCE-PNLFMVPVRVDSM---VPKLALFAARDIVAGEELSFDYSGE 216

                       170       180       190
                ....*....|....*....|....*....|
gi 42572245 411 FNDKSHPVKAFR---------CCCGSESCR 431
Cdd:cd10544 217 FSNSVESVTLARqdesksrkpCLCGAENCR 246
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 251-433 6.82e-38

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 139.20  E-value: 6.82e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 251 IKECWRKCGCD-MQCGNRVVQRGIRCQLQVyFTQEGKGWGLRTLQDLPKGTFICEYIGEILTNT---ELYDRNVRSSSER 326
Cdd:cd10523  83 LYECNVSCKCNrMLCQNRVVQHGLQVRLQV-FKTEKKGWGVRCLDDIDKGTFVCIYAGRVLSRArspTEPLPPKLELPSE 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 327 HTYPVTLDADWGSEKDLKDEEALCLDATICGNVARFINHRCEdANMIDIPIEIETPDRHYYHIAFFTLRDVKAMDELTWD 406
Cdd:cd10523 162 NEVEVVTSWLILSKKRKLRENVCFLDASKEGNVGRFLNHSCC-PNLFVQNVFVDTHDKNFPWVAFFTNRVVKAGTELTWD 240

                       170       180
                ....*....|....*....|....*..
gi 42572245 407 YMIDFNdkSHPVKAFRCCCGSESCRDR 433
Cdd:cd10523 241 YSYDAG--TSPEQEIPCLCGVNKCQKK 265
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 248-432 3.19e-34

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 129.36  E-value: 3.19e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 248 RKFIKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERH 327
Cdd:cd19473  78 RLPIYECHEGCACSDDCPNRVVERGRKVPLQIFRTSDGRGWGVRSTVDIKRGQFVDCYVGEIITPEEAQRRRDAATIAQR 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 328 --TYPVTLD--ADWGSEKDLKDEEALCLDATICGNVARFINHRCeDANMIDIPIEIETPDRHYYHIAFFTLRDVKAMDEL 403
Cdd:cd19473 158 kdVYLFALDkfSDPDSLDPRLRGDPYEIDGEFMSGPTRFINHSC-DPNLRIFARVGDHADKHIHDLAFFAIKDIPRGTEL 236

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 42572245 404 TWDYM-------IDFNDKSHPVKAFRCCCGSESCRD 432
Cdd:cd19473 237 TFDYVdgvtgldDDAGDEEKEKEMTKCLCGSPKCRG 272
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 251-431 2.00e-33

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 126.92  E-value: 2.00e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 251 IKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQEgKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHTYP 330
Cdd:cd20073  69 IYECNENCDCGINCPNRVVQRGRKLPLEIFKTKH-KGWGLRCPRFIKAGTFIGVYLGEVITQSEAEIRGKKYDNVGVTYL 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 331 VTLDAdwgseKDLKDEEALCLDATICGNVARFINHRCeDANMIDIPIEIETPDRHYYHIAFFTLRDVKAMDELTWDYMID 410
Cdd:cd20073 148 FDLDL-----FEDQVDEYYTVDAQYCGDVTRFINHSC-DPNLAIYSVLRDKSDSKIYDLAFFAIKDIPALEELTFDYSGR 221

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 42572245 411 FNDksHPV--------------KAFRCC-CGSESCR 431
Cdd:cd20073 222 NNF--DQLgfignrsnskyinlKNKRPCyCGSANCR 255
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 251-433 4.00e-33

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 125.35  E-value: 4.00e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 251 IKECWRKCGCDMQ-CGNRVVQRGIRCQLQVYFTQEgKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSErhty 329
Cdd:cd10541  67 VYECNKLCKCDPNmCQNRLVQHGLQVRLQLFKTQN-KGWGIRCLDDIAKGTFVCIYAGKILTDDFADKEGLEMGDE---- 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 330 pvtldadWGSEKDLKDEEALCLDATICGNVARFINHRCEdANMIDIPIEIETPDRHYYHIAFFTLRDVKAMDELTWDYmi 409
Cdd:cd10541 142 -------YFANLDHIEESCYIIDAKLEGNLGRYLNHSCS-PNLFVQNVFVDTHDLRFPWVAFFASKRIKAGTELTWDY-- 211

                       170       180
                ....*....|....*....|....
gi 42572245 410 DFNDKSHPVKAFRCCCGSESCRDR 433
Cdd:cd10541 212 NYEVGSVEGKELLCCCGSNECRGR 235
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 251-431 1.50e-30

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 118.45  E-value: 1.50e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 251 IKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHTYP 330
Cdd:cd10532  60 IYECNSRCKCGPDCPNRVVQKGTQYSLCIFRTSNGRGWGVKTLQKIKKNSFVMEYVGEVITSEEAERRGQFYDSKGITYL 139

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 331 VTLDAdwgsekdlkDEEALCLDATICGNVARFINHRCeDANMIDIPIEIETPDRHYYHIAFFTLRDVKAMDELTWDYM-- 408
Cdd:cd10532 140 FDLDY---------ESDEFTVDAARYGNVSHFVNHSC-DPNLQVFNVFIDNLDTRLPRIALFSTRTIKAGEELTFDYQmk 209

                       170       180       190
                ....*....|....*....|....*....|.
gi 42572245 409 ------IDFNDKSHPVKAFR--CCCGSESCR 431
Cdd:cd10532 210 gsgdlsSDSIDNSPAKKRVRtvCKCGAVTCR 240
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 251-431 1.00e-29

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 116.53  E-value: 1.00e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 251 IKECWRKCGCDMQCGNRVVQRGIRCQLQVYFTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHTYP 330
Cdd:cd10525  62 IYECNSRCRCGPDCPNRVVQKGIQYDLCIFRTDNGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYL 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 331 VTLDAdwgsekdlkDEEALCLDATICGNVARFINHRCeDANMIDIPIEIETPDRHYYHIAFFTLRDVKAMDELTWDY--M 408
Cdd:cd10525 142 FDLDY---------VEDVYTVDAAYYGNISHFVNHSC-DPNLQVYNVFIDNLDERLPRIALFATRTIRAGEELTFDYnmQ 211

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 42572245 409 IDFND---------------KSHPVKAFR--CCCGSESCR 431
Cdd:cd10525 212 VDPVDaestkmdsnfglaglPGSPKKRVRieCKCGVRSCR 251
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 281-431 2.54e-29

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 112.00  E-value: 2.54e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 281 FTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRS-SSERHTYPVTLDadwgsekdlkdeEALCLDATICGNV 359
Cdd:cd19174   5 FRTEDKGWGVRTKEPIKAGQFIIEYVGEVVSEQEFRRRMIEQyHNHSHHYCLNLD------------SGMVIDGYRMGNE 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 360 ARFINHRCEdanmidipieietPDRH--------YYHIAFFTLRDVKAMDELTWDYMID-FNDKSHPVkafrCCCGSESC 430
Cdd:cd19174  73 ARFVNHSCD-------------PNCEmqkwsvngVYRIGLFALKDIPAGEELTYDYNFHsFNVEKQQP----CKCGSPNC 135


                .
gi 42572245 431 R 431
Cdd:cd19174 136 R 136
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 277-414 2.32e-28

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 108.58  E-value: 2.32e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245    277 LQVYFTqEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHTYPVTLDADWGsekdlkdeeaLCLDATIC 356
Cdd:smart00317   3 LEVFKS-PGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAKAFYLFDIDSD----------LCIDARRK 71

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 42572245    357 GNVARFINHRCEdANMIDIPIEIETPDrhyyHIAFFTLRDVKAMDELTWDYMIDFNDK 414
Cdd:smart00317  72 GNLARFINHSCE-PNCELLFVEVNGDD----RIVIFALRDIKPGEELTIDYGSDYANE 124
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 281-431 2.14e-27

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 106.51  E-value: 2.14e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 281 FTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSE--RHTYPVTLDadwgsekdlKDEealCLDATICGN 358
Cdd:cd19172   7 FRTEKKGWGLRAAEDLPKGTFVIEYVGEVLDEKEFKRRMKEYAREgnRHYYFMALK---------SDE---IIDATKKGN 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42572245 359 VARFINHRCEdanmidiPiEIETPD---RHYYHIAFFTLRDVKAMDELTWDYMIDfndkSHPVKAFRCCCGSESCR 431
Cdd:cd19172  75 LSRFINHSCE-------P-NCETQKwtvNGELRVGFFAKRDIPAGEELTFDYQFE----RYGKEAQKCYCGSPNCR 138
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 280-431 1.24e-25

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 101.56  E-value: 1.24e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 280 YFTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDR--NVRSSSERHTYPVTLDADwgsekdlkdeeaLCLDATICG 357
Cdd:cd10531   4 LFRTEKKGWGVKAKEDIQKGEFIIEYVGEVIDKKEFKERldEYEELGKSNFYILSLSDD------------VVIDATRKG 71

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42572245 358 NVARFINHRCEdANMIdipIEIETPDRHyYHIAFFTLRDVKAMDELTWDYmidfNDKSHPVKAFRCCCGSESCR 431
Cdd:cd10531  72 NLSRFINHSCE-PNCE---TQKWIVNGE-YRIGIFALRDIPAGEELTFDY----NFVNYNEAKQVCLCGAQNCR 136
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 287-407 5.00e-23

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 93.74  E-value: 5.00e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245   287 GWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHtypvtLDADWGSE-KDLKDEEALCLDATI--CGNVARFI 363
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLLITKEEADKRELLYYDKL-----ELRLWGPYlFTLDEDSEYCIDARAlyYGNWARFI 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 42572245   364 NHRCeDANMIDIPIEIETpdrhYYHIAFFTLRDVKAMDELTWDY 407
Cdd:pfam00856  76 NHSC-DPNCEVRVVYVNG----GPRIVIFALRDIKPGEELTIDY 114
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 287-431 2.18e-22

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 93.05  E-value: 2.18e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 287 GWGLRTLQDLPKGTFICEYIGEILTN--TELYDRNVRSSSERHTYPVTLDADWgsekdlkdeealCLDATICGNVARFIN 364
Cdd:cd10518  25 GWGLFAKRPIAAGEMVIEYVGEVIRPivADKREKRYDEEGGGGTYMFRIDEDL------------VIDATKKGNIARFIN 92

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42572245 365 HRCeDANMIDIPIEIETPDrhyyHIAFFTLRDVKAMDELTWDYMIDFNDKshpvKAFRCCCGSESCR 431
Cdd:cd10518  93 HSC-DPNCYAKIITVDGEK----HIVIFAKRDIAPGEELTYDYKFPIEDE----EKIPCLCGAPNCR 150
WIYLD pfam10440
Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha ...
 25-82 8.95e-21

Ubiquitin-binding WIYLD domain; This presumed domain has been predicted to contain three alpha helices. The domain was named the WIYLD domain based on the pattern of most conserved residues. It binds ubiquitin. In the Arabidopsis thaliana histone-lysine N-methyltransferase SUVR4, binding of ubiquitin to this domain stimulates enzymatic activity and converts its activity from a strict dimethylase to a di/trimethylase.


Pssm-ID: 431288  Cd Length: 58  Bit Score: 85.38  E-value: 8.95e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 42572245    25 KDEKVLKALERTRQLDIPDEKTMPVLMKLLEEAGGNWSYIKLDNYTALVDAIYSVEDE 82
Cdd:pfam10440   1 GDRRIDAAIDAMRPLGIPKEKIRPVLKNLLKVYGGNWPLIEEDNYRVLADAIFEKQDE 58
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
284-431 1.01e-20

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 87.71  E-value: 1.01e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 284 EGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSErHTYPVTLDADWGsekdlkdeealcLDATICGNVARFI 363
Cdd:COG2940  14 PIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPHKEPL-HTYLFELDDDGV------------IDGALGGNPARFI 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42572245 364 NHRCeDANMidipiEIETPDRHYYhiaFFTLRDVKAMDELTWDYMIDFNDkshpvKAFRCCCGseSCR 431
Cdd:COG2940  81 NHSC-DPNC-----EADEEDGRIF---IVALRDIAAGEELTYDYGLDYDE-----EEYPCRCP--NCR 132
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 286-431 1.51e-19

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 85.17  E-value: 1.51e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 286 KGWGLRTLQDLPKGTFICEYIGEILTNtELYDRNVR--SSSERHTYPVTLDADWgsekdlkdeealCLDATICGNVARFI 363
Cdd:cd19171  24 QGLGLYAARDIEKHTMVIEYIGEIIRN-EVANRREKiyESQNRGIYMFRIDNDW------------VIDATMTGGPARYI 90

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42572245 364 NHRCeDANMIdipIEIETPDRHyYHIAFFTLRDVKAMDELTWDYMIDFNDKSHPVKafrCCCGSESCR 431
Cdd:cd19171  91 NHSC-NPNCV---AEVVTFDKE-KKIIIISNRRIAKGEELTYDYKFDFEDDQHKIP---CLCGAPNCR 150
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 280-430 2.26e-17

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 78.51  E-value: 2.26e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 280 YFTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHT--YPVTLDADwgsekdlkdeeaLCLDATICG 357
Cdd:cd19173   6 PFKTGDRGWGLRTKRDIKKGDFVIEYVGELIDEEECRRRLKKAHENNITnfYMLTLDKD------------RIIDAGPKG 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 358 NVARFINHRCeDANMidipieiET------PDrhyYHIAFFTLRDVKAMDELTWDYMIDF--NDKShpvkafRCCCGSES 429
Cdd:cd19173  74 NLSRFMNHSC-QPNC-------ETqkwtvnGD---TRVGLFAVRDIPAGEELTFNYNLDClgNEKK------VCRCGAPN 136


                .
gi 42572245 430 C 430
Cdd:cd19173 137 C 137
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 280-431 9.66e-17

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 76.69  E-value: 9.66e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 280 YFTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDR--NVRSSSERHTYPVTLDADwgsekdlkdeeaLCLDATICG 357
Cdd:cd19175   4 LVKTEKCGWGLVADEDINAGEFIIEYVGEVIDDKTCEERlwDMKHKGEKNFYMCEIDKD------------MVIDATFKG 71

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42572245 358 NVARFINHRCE-DANMIDIPIEIETpdrhyyHIAFFTLRDVKAMDELTWDY-MIDFNDKSHpvkafrCCCGSESCR 431
Cdd:cd19175  72 NLSRFINHSCDpNCELQKWQVDGET------RIGVFAIRDIKKGEELTYDYqFVQFGADQD------CHCGSKNCR 135
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 285-407 4.00e-16

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 74.30  E-value: 4.00e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 285 GKGWGLRTLQDLPKGTFICEYIGEILTNTElYDRNvrssSERH---TYPVTLDADwgsekdlkdeeALCLDATICGNVAR 361
Cdd:cd10522  12 HNGLGLFAAETIAKGEFVGEYTGEVLDRWE-EDRD----SVYHydpLYPFDLNGD-----------ILVIDAGKKGNLTR 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 42572245 362 FINHrCEDANmidipIE-IETPDRHYYHIAFFTLRDVKAMDELTWDY 407
Cdd:cd10522  76 FINH-SDQPN-----LElIVRTLKGEQHIGFVAIRDIKPGEELFISY 116
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 284-430 6.68e-16

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 74.64  E-value: 6.68e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 284 EGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRnVRSSSER---HTYPVTLDADwgsekdlkdeeaLCLDATICGNVA 360
Cdd:cd19211  10 EGKGWGLIAKRDIKKGEFVNEYVGELIDEEECMAR-IKHAHENditHFYMLTIDKD------------RIIDAGPKGNYS 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42572245 361 RFINHRCE-DANMIDIPIEIETpdrhyyHIAFFTLRDVKAMDELTWDYMIDF--NDKShpvkafRCCCGSESC 430
Cdd:cd19211  77 RFMNHSCQpNCETQKWTVNGDT------RVGLFAVCDIPAGTELTFNYNLDClgNEKT------VCRCGAPNC 137
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 120-267 8.27e-15

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 70.14  E-value: 8.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245   120 ITKGSESVKIPLVDDVGSEAVP-KFTYIPHNIVYQSAYLHvslarisDEDCCaNCkGNCLSAdfPCTCARETSGE--YAY 196
Cdd:pfam05033   1 ISKGKENVPIPVVNEVDDEPPPpDFTYITSYIYPKEFLLI-------IPQGC-DC-GDCSSE--KCSCAQLNGGEfrFPY 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 42572245   197 TKEGLLKEKfldtclkmkkepdsfpkvyckdcplerdhdkgtygkcdghlIRKFIKECWRKCGCDMQCGNR 267
Cdd:pfam05033  70 DKDGLLVPE-----------------------------------------SKPPIYECNPLCGCPPSCPNR 99
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 287-431 1.53e-14

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 70.83  E-value: 1.53e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 287 GWGLRTLQDLPKGTFICEYIGEILTNT--ELYDRNVRSSSERHTYPVTLDADwgsekdlkdeeaLCLDATICGNVARFIN 364
Cdd:cd19169  24 DWGLFALEPIAADEMVIEYVGQVIRQSvaDEREKRYEAIGIGSSYLFRVDDD------------TIIDATKCGNLARFIN 91

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42572245 365 HRCeDANMIDIPIEIETPDRhyyhIAFFTLRDVKAMDELTWDYMIDFNDKSHPvkafrCCCGSESCR 431
Cdd:cd19169  92 HSC-NPNCYAKIITVESQKK----IVIYSKRPIAVNEEITYDYKFPIEDEKIP-----CLCGAPQCR 148
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 287-407 5.00e-14

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 68.42  E-value: 5.00e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 287 GWGLRTLQDLPKGTFICEYIGEILTNTE------LYDRNVRSsserhtYPVTLDADWgsekdlkdeealCLDATICGNVA 360
Cdd:cd10519  12 GWGLFLKEPIKKDEFIGEYTGELISQDEadrrgkIYDKYNSS------YLFNLNDQF------------VVDATRKGNKI 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 42572245 361 RFINHRCeDAN-----MIdipieietpDRHYYHIAFFTLRDVKAMDELTWDY 407
Cdd:cd10519  74 RFANHSS-NPNcyakvMM---------VNGDHRIGIFAKRDIEAGEELFFDY 115
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 281-430 7.71e-14

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 68.42  E-value: 7.71e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 281 FTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRnVRSSSER---HTYPVTLDADwgsekdlkdeeaLCLDATICG 357
Cdd:cd19210   7 FRTLGRGWGLRCKTDIKKGEFVNEYVGELIDEEECRAR-IRYAQEHditNFYMLTLDKD------------RIIDAGPKG 73

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42572245 358 NVARFINHRCEdANMIDIPIEIETPDRhyyhIAFFTLRDVKAMDELTWDYMIDFNDKSHPVkafrCCCGSESC 430
Cdd:cd19210  74 NYARFMNHCCQ-PNCETQKWTVNGDTR----VGLFALCDIKAGTELTFNYNLECLGNGKTV----CKCGAPNC 137
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 267-407 1.09e-13

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 67.99  E-value: 1.09e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 267 RVVQRGIRCQLQVYFTqEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNvrssserhtypvtldadwgsEKDLKDE 346
Cdd:cd10528   9 ELILSGKEEGLKVIEI-DGKGRGVIATRPFEKGDFVVEYHGDLITITEAKKRE--------------------ALYAKDP 67

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42572245 347 EA-------------LCLDAT-ICGNVARFINHRCEDANMIDIPIEIETPDrhyyHIAFFTLRDVKAMDELTWDY 407
Cdd:cd10528  68 STgcymyyfqykgktYCVDATkESGRLGRLINHSKKKPNLKTKLLVIDGVP----HLILVAKRDIKPGEELLYDY 138
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 281-407 1.49e-13

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 67.21  E-value: 1.49e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 281 FTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHTYPVTLDADWGsekdlkdeealcLDATICGNVA 360
Cdd:cd19168   7 KSQLECGLGLFAAEDIKEGEFVIEYTGELISHDEGVRREHRRGDVSYLYLFEEQEGIW------------VDAAIYGNLS 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 42572245 361 RFINHRCEDANMIDIPIEIeTPDRHYYHIAFFTLRDVKAMDELTWDY 407
Cdd:cd19168  75 RYINHATDKVKTGNCMPKI-MYVNHEWRIKFTAIKDIKIGEELFFNY 120
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 278-430 1.67e-13

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 67.64  E-value: 1.67e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 278 QVYFTqEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRnVRSSSERHT---YPVTLDADwgsekdlkdeeaLCLDAT 354
Cdd:cd19212   5 EIIKT-ERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLR-IKRAHENSVtnfYMLTVTKD------------RIIDAG 70

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42572245 355 ICGNVARFINHRCeDANMIDIPIEIETPDRhyyhIAFFTLRDVKAMDELTWDYMIDF--NDKShpvkafRCCCGSESC 430
Cdd:cd19212  71 PKGNYSRFMNHSC-NPNCETQKWTVNGDVR----VGLFALCDIPAGMELTFNYNLDClgNGRT------ECHCGADNC 137
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 288-431 3.21e-13

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 67.06  E-value: 3.21e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 288 WGLRTLQDLPKGTFICEYIGEILTNT--ELYDRNVRSSSERHTYPVTLDADwgsekdlkdeeaLCLDATICGNVARFINH 365
Cdd:cd20072  25 WGLYAMENISAKDMVIEYVGEVIRQQvaDEREKRYLRQGIGSSYLFRIDDD------------TVVDATKKGNIARFINH 92

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42572245 366 RCeDANMIDIPIEIETPDRhyyhIAFFTLRDVKAMDELTWDYMIDFNDKSHPvkafrCCCGSESCR 431
Cdd:cd20072  93 CC-DPNCTAKIIKVEGEKR----IVIYAKRDIAAGEELTYDYKFPREEDKIP-----CLCGAPNCR 148
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 287-431 4.59e-12

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 63.56  E-value: 4.59e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 287 GWGLRTLQDLPKGTFICEYIGEILTNTeLYDRNVRSSSERHT--YPVTLDADwgsekdlkdeeaLCLDATICGNVARFIN 364
Cdd:cd19170  25 GRGLFCKRNIDAGEMVIEYAGEVIRSV-LTDKREKYYESKGIgcYMFRIDDD------------EVVDATMHGNAARFIN 91

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42572245 365 HRCEdANMIDIPIEIETPDrhyyHIAFFTLRDVKAMDELTWDYMIDFNDKSHPvkafrCCCGSESCR 431
Cdd:cd19170  92 HSCE-PNCYSRVVNIDGKK----HIVIFALRRILRGEELTYDYKFPIEDVKIP-----CTCGSKKCR 148
SET_KMT2C cd19208
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...
 279-431 6.81e-12

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.


Pssm-ID: 380985 [Multi-domain]  Cd Length: 154  Bit Score: 63.49  E-value: 6.81e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 279 VYFTQEG-KGWGLRTLQDLPKGTFICEYIGEILTNtELYDRNVR--SSSERHTYPVTLDADWgsekdlkdeealCLDATI 355
Cdd:cd19208  17 VYLARSRiQGLGLYAARDIEKHTMVIEYIGTIIRN-EVANRKEKlyESQNRGVYMFRIDNDH------------VIDATL 83

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42572245 356 CGNVARFINHRCEdANMIDIPIEIETPDRhyyhIAFFTLRDVKAMDELTWDYMIDFNDKSHPVKafrCCCGSESCR 431
Cdd:cd19208  84 TGGPARYINHSCA-PNCVAEVVTFEKGHK----IIISSSRRIQKGEELCYDYKFDFEDDQHKIP---CHCGAVNCR 151
SET_KMT2D cd19209
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...
 286-431 6.81e-11

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380986 [Multi-domain]  Cd Length: 155  Bit Score: 60.48  E-value: 6.81e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 286 KGWGLRTLQDLPKGTFICEYIGEILTNtELYDR--NVRSSSERHTYPVTLDADWgsekdlkdeealCLDATICGNVARFI 363
Cdd:cd19209  26 QGLGLYAAKDLEKHTMVIEYIGTIIRN-EVANRreKIYEEQNRGIYMFRINNEH------------VIDATLTGGPARYI 92

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42572245 364 NHRCEdANMIDIPIEIETPDRhyyhIAFFTLRDVKAMDELTWDYMIDFNDKSHPVKafrCCCGSESCR 431
Cdd:cd19209  93 NHSCA-PNCVAEVVTFDKEDK----IIIISSRRIPKGEELTYDYQFDFEDDQHKIP---CHCGAWNCR 152
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 288-431 1.51e-10

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 59.27  E-value: 1.51e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 288 WGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSErhtypvtldaDWGSEKDLKDEEALCLDATICGNVARFINHRC 367
Cdd:cd19204  26 WGLFAMEPIAADEMVIEYVGQNIRQVVADMREKRYVQE----------GIGSSYLFRVDHDTIIDATKCGNLARFINHCC 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42572245 368 EdANMIDIPIEIETPDRhyyhIAFFTLRDVKAMDELTWDYMIDFNDKSHPvkafrCCCGSESCR 431
Cdd:cd19204  96 T-PNCYAKVITIESQKK----IVIYSKQPIGVNEEITYDYKFPIEDNKIP-----CLCGTENCR 149
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 289-407 1.77e-10

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 58.44  E-value: 1.77e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 289 GLRTLQDLPKGTFICEYIGEILTNTELYDRNvrsSSERHTYPVTLdadwgsEKDLKDEEALCLDATICGNVARFINHRCe 368
Cdd:cd10529  18 GLVATEDISPGEPILEYKGEVSLRSEFKEDN---GFFKRPSPFVF------FYDGFEGLPLCVDARKYGNEARFIRRSC- 87

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 42572245 369 danmidipieieTPD---RHYY------HIAFFTLRDVKAMDELT--WDY 407
Cdd:cd10529  88 ------------RPNaelRHVVvsngelRLFIFALKDIRKGTEITipFDY 125
SET_SETD1B cd19205
SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...
 288-431 3.16e-10

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.


Pssm-ID: 380982 [Multi-domain]  Cd Length: 153  Bit Score: 58.53  E-value: 3.16e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 288 WGLRTLQDLPKGTFICEYIGEILtntelydRNVRSSSERHTYPvtlDADWGSEKDLKDEEALCLDATICGNVARFINHRC 367
Cdd:cd19205  26 WGLFAMEPIAADEMVIEYVGQNI-------RQVIADMREKRYE---DEGIGSSYMFRVDHDTIIDATKCGNFARFINHSC 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42572245 368 eDANMIDIPIEIETPDRhyyhIAFFTLRDVKAMDELTWDYMIDFNDKSHPvkafrCCCGSESCR 431
Cdd:cd19205  96 -NPNCYAKVITVESQKK----IVIYSKQHINVNEEITYDYKFPIEDVKIP-----CLCGSENCR 149
PreSET smart00468
N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal ...
 117-205 3.24e-09

N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal to some SET domains. Function is unknown. Unpublished.


Pssm-ID: 128744 [Multi-domain]  Cd Length: 98  Bit Score: 53.96  E-value: 3.24e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245    117 IADITKGSESVKIPLVDDV-GSEAVPKFTYIPHNIVYQSAylhVSLARISDEDCCaNCKGNClSADFPCTCARETSGEYA 195
Cdd:smart00468   1 CLDISNGKENVPVPLVNEVdEDPPPPDFEYISEYIYGQGV---PIDRSPSPLVGC-SCSGDC-SSSNKCECARKNGGEFA 75

                           90
                   ....*....|
gi 42572245    196 YTKEGLLKEK 205
Cdd:smart00468  76 YELNGGLRLK 85
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 285-407 6.01e-09

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 52.25  E-value: 6.01e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 285 GKGWGLRTLQDLPKGTFICeyigeiltntelydrnvrssserhtypvtldadwgsekdlkdeealcldaticgnVARFIN 364
Cdd:cd08161   9 GAGFGLFATRDIPKGEVIG-------------------------------------------------------LARFIN 33

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 42572245 365 HRCeDANMIDIPIEIETPdrhyYHIAFFTLRDVKAMDELTWDY 407
Cdd:cd08161  34 HSC-EPNCEFEEVYVGGK----PRVFIVALRDIKAGEELTVDY 71
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 289-421 7.28e-09

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 55.10  E-value: 7.28e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 289 GLRTLQDLPKGTFICEYIGEILTNTE-LYDRNVRSSSERHTYP-VTLDADWgsekdlkdeeALCLDATICGNVARFINHR 366
Cdd:cd19183  15 GLFADRPIPAGDPIQELLGEIGLQSEyIADPENQYQILGAPKPhVFFHPQS----------PLYIDTRRSGSVARFIRRS 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 42572245 367 CEdANMIDIPIEIETPDRhyYHIAFFTLRDVKAMDELT--WDYmidfnDKSHPVKAF 421
Cdd:cd19183  85 CR-PNAELVTVASDSGSV--LKFVLYASRDISPGEEITigWDW-----DNPHPFRRF 133
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 287-431 7.41e-09

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 54.64  E-value: 7.41e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 287 GWGLRTLQDLPKGTFICEYIGEILtntelydRNVRSSSERHTYpvtlDADWGSEKDLKDEEALCLDATICGNVARFINHR 366
Cdd:cd19206  25 GRGLFCKRNIDAGEMVIEYSGNVI-------RSILTDKREKYY----DSKGIGCYMFRIDDSEVVDATMHGNAARFINHS 93

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42572245 367 CEdANMIDIPIEIETPDrhyyHIAFFTLRDVKAMDELTWDYMIDFNDKSHPVKafrCCCGSESCR 431
Cdd:cd19206  94 CE-PNCYSRVINIDGQK----HIVIFAMRKIYRGEELTYDYKFPIEDASNKLP---CNCGAKKCR 150
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 351-431 3.46e-08

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 52.72  E-value: 3.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 351 LDATICGNVARFINHRCEdANMIDIPIEIETPDrhyyHIAFFTLRDVKAMDELTWDYMIDFNDKSHPVKafrCCCGSESC 430
Cdd:cd19207  78 VDATMHGNAARFINHSCE-PNCYSRVIHVEGQK----HIVIFALRKIYRGEELTYDYKFPIEDASNKLP---CNCGAKRC 149


                .
gi 42572245 431 R 431
Cdd:cd19207 150 R 150
SET_EZH1 cd19217
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...
 270-407 5.60e-04

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380994  Cd Length: 136  Bit Score: 40.05  E-value: 5.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 270 QRGIRCQLqVYFTQEGKGWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHTYPVTLDADWgsekdlkdeeal 349
Cdd:cd19217   1 QRGLKKHL-LLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDF------------ 67

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 42572245 350 CLDATICGNVARFINHRCeDANMIDIPIEIETPDRhyyhIAFFTLRDVKAMDELTWDY 407
Cdd:cd19217  68 VVDATRKGNKIRFANHSV-NPNCYAKVVMVNGDHR----IGIFAKRAIQQGEELFFDY 120
SET_EZH2 cd19218
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...
 287-407 1.37e-03

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380995  Cd Length: 120  Bit Score: 38.74  E-value: 1.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 287 GWGLRTLQDLPKGTFICEYIGEILTNTELYDRNVRSSSERHTYPVTLDADWgsekdlkdeealCLDATICGNVARFINH- 365
Cdd:cd19218  15 GWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDF------------VVDATRKGNKIRFANHs 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 42572245 366 ---RCEDANMidipieIETPDrhyYHIAFFTLRDVKAMDELTWDY 407
Cdd:cd19218  83 vnpNCYAKVM------MVNGD---HRIGIFAKRAIQTGEELFFDY 118
SET_SETD5 cd19181
SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and ...
 290-430 3.30e-03

SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. SETD5 loss-of-function mutations are a likely cause of a familial syndromic intellectual disability with variable phenotypic expression.


Pssm-ID: 380958  Cd Length: 150  Bit Score: 38.07  E-value: 3.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 290 LRTLQDLPKGTFICEYIGEILTNTELydrNVRSSSERHTYPVTLDADWGSEKDLkdeealCLDATICGNVARFINHRCed 369
Cdd:cd19181  21 LRAARDLALDTLIIEYRGKVMLRQQF---EVNGHFFKRPYPFVLFYSKFNGVEM------CVDARTFGNDARFIRRSC-- 89

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 42572245 370 anmidipieieTPD---RH-----YYHIAFFTLRDVKAMDELTWDYMIDFNDKSHPVKafrCCC--GSESC 430
Cdd:cd19181  90 -----------TPNaevRHmiadgMIHLCIYAVAAIAKDAEVTIAFDYEYSNCNYKVD---CAChkGNRNC 146
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 278-425 8.00e-03

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 36.20  E-value: 8.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572245 278 QVYFTQEGKGWGLRTLQDLPKGTFICeyigeiltntelydrnvrssSERHTYPVTLDAdwGSEKDLKDEEALCLDATICg 357
Cdd:cd20071   1 EVRESEGSKGRGLVATRDIEPGELIL--------------------VEKPLVSVPSNS--FSLTDGLNEIGVGLFPLAS- 57

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42572245 358 nvarFINHRCeDANmidipIEIETPDRHyyHIAFFTLRDVKAMDELTWDYMIDFNDKSHPVKA------FRCCC 425
Cdd:cd20071  58 ----LLNHSC-DPN-----AVVVFDGNG--TLRVRALRDIKAGEELTISYIDPLLPRTERRREllekygFTCSC 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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