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HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 695571, updated on 17-Aug-2024

Summary

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Official Symbol
HERC4provided by VGNC
Official Full Name
HECT and RLD domain containing E3 ubiquitin protein ligase 4provided by VGNC
Primary source
VGNC:VGNC:106056
See related
Ensembl:ENSMMUG00000010105
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See HERC4 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
31
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 9 NC_041762.1 (69848820..70001871)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 9 NC_027901.1 (64523136..64676084)

Chromosome 9 - NC_041762.1Genomic Context describing neighboring genes Neighboring gene myopalladin Neighboring gene uncharacterized LOC114670131 Neighboring gene POU domain, class 5, transcription factor 1-like Neighboring gene sirtuin 1 Neighboring gene protein DEK pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase HERC4
Names
hect domain and RLD 4
putative E3 ubiquitin-protein ligase HERC4
NP_001244507.1
XP_015002818.1
XP_015002822.1
XP_015002823.1
XP_028709107.1
XP_028709108.1
XP_028709109.1
XP_028709110.1
XP_028709111.1
XP_028709113.1
XP_028709114.1
XP_028709115.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001257578.1 → NP_001244507.1  probable E3 ubiquitin-protein ligase HERC4

    See identical proteins and their annotated locations for NP_001244507.1

    Status: PROVISIONAL

    Source sequence(s)
    JU321364
    UniProtKB/TrEMBL
    F7GN82, G7N2D0, H9ERW1
    Related
    ENSMMUP00000005917.4, ENSMMUT00000006290.4
    Conserved Domains (2) summary
    COG5184
    Location:2 → 344
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:709 → 1055
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041762.1 Reference Mmul_10 Primary Assembly

    Range
    69848820..70001871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028853274.1 → XP_028709107.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

    UniProtKB/TrEMBL
    G7N2D0
    Conserved Domains (3) summary
    COG5184
    Location:2 → 368
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:775 → 1121
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl00821
    Location:669 → 712
    Ribosomal_S3Ae; Ribosomal S3Ae family

  2. XM_015147332.2 → XP_015002818.1  probable E3 ubiquitin-protein ligase HERC4 isoform X3

    UniProtKB/TrEMBL
    G7N2D0
    Conserved Domains (3) summary
    smart00119
    Location:759 → 1078
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:733 → 1079
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:232 → 281
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  3. XM_015147336.2 → XP_015002822.1  probable E3 ubiquitin-protein ligase HERC4 isoform X5

    UniProtKB/TrEMBL
    G7N2D0
    Conserved Domains (3) summary
    smart00119
    Location:751 → 1070
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:725 → 1071
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:232 → 281
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  4. XM_028853276.1 → XP_028709109.1  probable E3 ubiquitin-protein ligase HERC4 isoform X2

    UniProtKB/TrEMBL
    G7N2D0
    Conserved Domains (3) summary
    COG5184
    Location:2 → 344
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:751 → 1097
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl00821
    Location:645 → 688
    Ribosomal_S3Ae; Ribosomal S3Ae family

  5. XM_015147337.2 → XP_015002823.1  probable E3 ubiquitin-protein ligase HERC4 isoform X8

    UniProtKB/TrEMBL
    F6R799, G7N2D0, H9YZ98
    Related
    ENSMMUP00000013211.4, ENSMMUT00000014107.4
    Conserved Domains (3) summary
    smart00119
    Location:727 → 1046
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:701 → 1047
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:208 → 257
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  6. XM_028853280.1 → XP_028709113.1  probable E3 ubiquitin-protein ligase HERC4 isoform X6

    UniProtKB/TrEMBL
    F7FBK1
    Conserved Domains (3) summary
    COG5184
    Location:4 → 293
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:706 → 1052
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl00821
    Location:600 → 643
    Ribosomal_S3Ae; Ribosomal S3Ae family

  7. XM_028853277.1 → XP_028709110.1  probable E3 ubiquitin-protein ligase HERC4 isoform X4

    UniProtKB/TrEMBL
    F7FBK1
    Conserved Domains (3) summary
    COG5184
    Location:35 → 315
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:728 → 1074
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl00821
    Location:622 → 665
    Ribosomal_S3Ae; Ribosomal S3Ae family

  8. XM_028853281.1 → XP_028709114.1  probable E3 ubiquitin-protein ligase HERC4 isoform X7

    UniProtKB/TrEMBL
    F7FBK1
    Conserved Domains (3) summary
    COG5184
    Location:12 → 292
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:705 → 1051
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl00821
    Location:599 → 642
    Ribosomal_S3Ae; Ribosomal S3Ae family

  9. XM_028853282.1 → XP_028709115.1  probable E3 ubiquitin-protein ligase HERC4 isoform X9

    UniProtKB/TrEMBL
    F7FBK1
    Related
    ENSMMUP00000035810.3, ENSMMUT00000042798.3
    Conserved Domains (3) summary
    COG5184
    Location:12 → 268
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:681 → 1027
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl00821
    Location:575 → 618
    Ribosomal_S3Ae; Ribosomal S3Ae family

  10. XM_028853275.1 → XP_028709108.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

    UniProtKB/TrEMBL
    G7N2D0
    Conserved Domains (3) summary
    COG5184
    Location:2 → 368
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:775 → 1121
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl00821
    Location:669 → 712
    Ribosomal_S3Ae; Ribosomal S3Ae family

  11. XM_028853278.1 → XP_028709111.1  probable E3 ubiquitin-protein ligase HERC4 isoform X4

    UniProtKB/TrEMBL
    F7FBK1
    Conserved Domains (3) summary
    COG5184
    Location:35 → 315
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:728 → 1074
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl00821
    Location:622 → 665
    Ribosomal_S3Ae; Ribosomal S3Ae family

RNA

  1. XR_003732768.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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