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Ccdc62 coiled-coil domain containing 62 [ Rattus norvegicus (Norway rat) ]

Gene ID: 689909, updated on 27-Nov-2024

Summary

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Official Symbol
Ccdc62provided by RGD
Official Full Name
coiled-coil domain containing 62provided by RGD
Primary source
RGD:1586391
See related
EnsemblRapid:ENSRNOG00000038002 AllianceGenome:RGD:1586391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable nuclear estrogen receptor binding activity and nuclear receptor coactivator activity. Predicted to be involved in cellular response to estradiol stimulus; positive regulation of transcription by RNA polymerase II; and spermatid development. Predicted to act upstream of or within blastocyst hatching. Predicted to be located in acrosomal vesicle and nucleus. Human ortholog(s) of this gene implicated in spermatogenic failure 67. Orthologous to human CCDC62 (coiled-coil domain containing 62). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 66.1), Adrenal (RPKM 41.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ccdc62 in Genome Data Viewer
Location:
12q15
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (38284089..38320828, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (32623170..32659912, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (38057532..38093916, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene keratin-associated protein 4-6-like Neighboring gene VPS37B subunit of ESCRT-I Neighboring gene huntingtin interacting protein 1 related Neighboring gene density regulated reinitiation and release factor Neighboring gene hydroxycarboxylic acid receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells. Chen M, et al. Carcinogenesis, 2009 May. PMID 19126643
  2. ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells. Chen M, et al. Prostate, 2008 Sep 1. PMID 18563714
  3. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst hatching ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to estradiol stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatid development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134766.1 → NP_001128238.1  coiled-coil domain-containing protein 62

    See identical proteins and their annotated locations for NP_001128238.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    F1LSQ7
    Related
    ENSRNOP00000054626.2, ENSRNOT00000057814.6
    Conserved Domains (1) summary
    pfam04711
    Location:125 → 163
    ApoA-II; Apolipoprotein A-II (ApoA-II)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    38284089..38320828 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089784.2 → XP_038945712.1  coiled-coil domain-containing protein 62 isoform X10

    Conserved Domains (1) summary
    COG1196
    Location:57 → 332
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_017598459.3 → XP_017453948.1  coiled-coil domain-containing protein 62 isoform X3

  3. XM_039089783.2 → XP_038945711.1  coiled-coil domain-containing protein 62 isoform X10

    Conserved Domains (1) summary
    COG1196
    Location:57 → 332
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  4. XM_039089776.2 → XP_038945704.1  coiled-coil domain-containing protein 62 isoform X4

    Conserved Domains (1) summary
    COG1196
    Location:57 → 353
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  5. XM_006249357.5 → XP_006249419.1  coiled-coil domain-containing protein 62 isoform X4

    Conserved Domains (1) summary
    COG1196
    Location:57 → 353
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  6. XM_006249356.5 → XP_006249418.1  coiled-coil domain-containing protein 62 isoform X2

    Conserved Domains (1) summary
    pfam04711
    Location:125 → 191
    ApoA-II; Apolipoprotein A-II (ApoA-II)

  7. XM_006249355.5 → XP_006249417.1  coiled-coil domain-containing protein 62 isoform X1

    See identical proteins and their annotated locations for XP_006249417.1

    UniProtKB/TrEMBL
    F1LSQ7
    Conserved Domains (1) summary
    pfam04711
    Location:125 → 163
    ApoA-II; Apolipoprotein A-II (ApoA-II)

  8. XM_063271681.1 → XP_063127751.1  coiled-coil domain-containing protein 62 isoform X5

  9. XM_039089777.2 → XP_038945705.1  coiled-coil domain-containing protein 62 isoform X6

    UniProtKB/TrEMBL
    Q4FZT7
    Conserved Domains (1) summary
    COG1196
    Location:2 → 222
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  10. XM_008769265.3 → XP_008767487.1  coiled-coil domain-containing protein 62 isoform X6

    UniProtKB/TrEMBL
    Q4FZT7
    Conserved Domains (1) summary
    COG1196
    Location:2 → 222
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  11. XM_039089779.2 → XP_038945707.1  coiled-coil domain-containing protein 62 isoform X7

    UniProtKB/TrEMBL
    Q4FZT7
    Conserved Domains (1) summary
    COG1196
    Location:42 → 150
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  12. XM_039089781.2 → XP_038945709.1  coiled-coil domain-containing protein 62 isoform X8

    UniProtKB/TrEMBL
    Q4FZT7
    Conserved Domains (1) summary
    COG1196
    Location:8 → 116
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  13. XM_039089778.2 → XP_038945706.1  coiled-coil domain-containing protein 62 isoform X6

    UniProtKB/TrEMBL
    Q4FZT7
    Conserved Domains (1) summary
    COG1196
    Location:2 → 222
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  14. XM_039089782.2 → XP_038945710.1  coiled-coil domain-containing protein 62 isoform X9

    Conserved Domains (1) summary
    COG1196
    Location:57 → 353
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein Strain
Heading Accession and Version

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