SESN2 sestrin 2 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: SESN2provided by VGNC
Official Full Name: sestrin 2provided by VGNC
Primary source: VGNC:VGNC:34489
See related: BGD:BT16842; Ensembl:ENSBTAG00000002363
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	2	NC_037329.1 (125114002..125131744, complement)

Chromosome 2 - NC_037329.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SESN2 negatively regulates the mTORC1 pathway and subsequent CSN2 synthesis through the SH3BP4 in response to amino acids depletion.
Title: Sestrin2 Negatively Regulates Casein Synthesis through the SH3BP4-mTORC1 Pathway in Response to AA Depletion or Supplementation in Cow Mammary Epithelial Cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables L-leucine binding	IEA Inferred from Electronic Annotation more info	PubMed
enables oxidoreductase activity, acting on peroxide as acceptor	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to L-leucine	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to leucine starvation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of TORC1 signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of macroautophagy	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of response to reactive oxygen species	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: sestrin-2

NP_001019678.1

EC 1.11.1.15

XP_005203155.1

EC 1.11.1.15

XP_010800833.1

EC 1.11.1.15

XP_010800835.1

EC 1.11.1.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.