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Pdpr pyruvate dehydrogenase phosphatase regulatory subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 307852, updated on 4-Jan-2025

Summary

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Official Symbol
Pdprprovided by RGD
Official Full Name
pyruvate dehydrogenase phosphatase regulatory subunitprovided by RGD
Primary source
RGD:1308307
See related
EnsemblRapid:ENSRNOG00000022593 AllianceGenome:RGD:1308307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308307
Summary
Predicted to be active in mitochondrial matrix. Orthologous to human PDPR (pyruvate dehydrogenase phosphatase regulatory subunit). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 261.8), Muscle (RPKM 240.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pdpr in Genome Data Viewer
Location:
19q12
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (55974611..56019045)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (39065226..39109695)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (43107852..43149243, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 18, member A Neighboring gene essential MCU regulator, mitochondrial-like Neighboring gene ribosomal protein S20 like 6 Neighboring gene golgi glycoprotein 1 Neighboring gene ring finger and WD repeat domain 3 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation. Huang B, et al. J Biol Chem, 1998 Jul 10. PMID 9651365
  2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial
NP_001100900.1
XP_008770736.1
XP_017456788.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107430.2 → NP_001100900.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

    See identical proteins and their annotated locations for NP_001100900.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A6IZ83, D3ZXA6
    Conserved Domains (5) summary
    COG0404
    Location:452 → 867
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    pfam01266
    Location:44 → 384
    DAO; FAD dependent oxidoreductase
    pfam01571
    Location:462 → 735
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:747 → 851
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:405 → 459
    FAO_M; FAD dependent oxidoreductase central domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    55974611..56019045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772514.4 → XP_008770736.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X1

    Related
    ENSRNOP00000083707.2, ENSRNOT00000107538.2
    Conserved Domains (5) summary
    COG0404
    Location:452 → 867
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    pfam01266
    Location:44 → 384
    DAO; FAD dependent oxidoreductase
    pfam01571
    Location:462 → 735
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:747 → 851
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:405 → 459
    FAO_M; FAD dependent oxidoreductase central domain

  2. XM_017601299.3 → XP_017456788.1  pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X2

    Conserved Domains (3) summary
    COG0404
    Location:276 → 691
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    pfam01266
    Location:1 → 208
    DAO; FAD dependent oxidoreductase
    pfam16350
    Location:229 → 283
    FAO_M; FAD dependent oxidoreductase central domain
Nucleotide Protein Strain
Heading Accession and Version

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