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Il17rc interleukin 17 receptor C [ Rattus norvegicus (Norway rat) ]

Gene ID: 297520, updated on 27-Nov-2024

Summary

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Official Symbol
Il17rcprovided by RGD
Official Full Name
interleukin 17 receptor Cprovided by RGD
Primary source
RGD:1306392
See related
EnsemblRapid:ENSRNOG00000027376 AllianceGenome:RGD:1306392
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable coreceptor activity; interleukin-17 receptor activity; and signaling receptor binding activity. Predicted to be involved in several processes, including granulocyte chemotaxis; interleukin-17A-mediated signaling pathway; and positive regulation of interleukin-6 production. Predicted to act upstream of or within positive regulation of cytokine production involved in inflammatory response. Predicted to be located in cell surface and plasma membrane. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis. Orthologous to human IL17RC (interleukin 17 receptor C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 46.0), Kidney (RPKM 45.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Il17rc in Genome Data Viewer
Location:
4q42
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (148174573..148187071)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (146618321..146631444)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (145426647..145439845)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene jagunal homolog 1 Neighboring gene interleukin 17 receptor E Neighboring gene cysteine-rich with EGF-like domains 1 Neighboring gene proline-rich transmembrane protein 3 Neighboring gene ER membrane protein complex subunit 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F. Kuestner RE, et al. J Immunol, 2007 Oct 15. PMID 17911633, Free PMC Article
  2. Cutting edge: interleukin 17 signals through a heteromeric receptor complex. Toy D, et al. J Immunol, 2006 Jul 1. PMID 16785495
  3. Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis. Farouk S, et al. PLoS One, 2018. PMID 30346985, Free PMC Article
  4. IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail. Ho AW, et al. J Immunol, 2010 Jul 15. PMID 20554964, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables coreceptor activity ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-17 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-17 receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in defense response to fungus ISO
Inferred from Sequence Orthology
more info
  
involved_in granulocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-17A-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interleukin-17 receptor C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170565.2 → NP_001164036.1  interleukin-17 receptor C precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IBS3, D3ZIM0
    Conserved Domains (2) summary
    pfam08357
    Location:497 → 647
    SEFIR; SEFIR domain
    pfam15037
    Location:71 → 456
    IL17_R_N; Interleukin-17 receptor extracellular region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    148174573..148187071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285888.1 → XP_063141958.1  interleukin-17 receptor C isoform X13

  2. XM_017592578.3 → XP_017448067.1  interleukin-17 receptor C isoform X2

    UniProtKB/TrEMBL
    A6IBS3

  3. XM_017592577.3 → XP_017448066.1  interleukin-17 receptor C isoform X1

    UniProtKB/TrEMBL
    A6IBS3
    Related
    ENSRNOP00000037747.6, ENSRNOT00000037788.8

  4. XM_017592579.3 → XP_017448068.1  interleukin-17 receptor C isoform X3

    UniProtKB/TrEMBL
    A0A8I6A339, A6IBS3
    Related
    ENSRNOP00000085036.1, ENSRNOT00000095512.2

  5. XM_039107409.2 → XP_038963337.1  interleukin-17 receptor C isoform X5

    Conserved Domains (2) summary
    pfam08357
    Location:369 → 519
    SEFIR; SEFIR domain
    pfam15037
    Location:112 → 328
    IL17_R_N; Interleukin-17 receptor extracellular region

  6. XM_039107411.2 → XP_038963339.1  interleukin-17 receptor C isoform X9

    Conserved Domains (2) summary
    pfam08357
    Location:354 → 504
    SEFIR; SEFIR domain
    pfam15037
    Location:43 → 313
    IL17_R_N; Interleukin-17 receptor extracellular region

  7. XM_063285883.1 → XP_063141953.1  interleukin-17 receptor C isoform X10

  8. XM_039107408.2 → XP_038963336.1  interleukin-17 receptor C isoform X4

    Conserved Domains (2) summary
    pfam08357
    Location:379 → 529
    SEFIR; SEFIR domain
    pfam15037
    Location:7 → 338
    IL17_R_N; Interleukin-17 receptor extracellular region

  9. XM_063285881.1 → XP_063141951.1  interleukin-17 receptor C isoform X6

  10. XM_039107410.2 → XP_038963338.1  interleukin-17 receptor C isoform X7

    Conserved Domains (2) summary
    pfam08357
    Location:364 → 514
    SEFIR; SEFIR domain
    pfam15037
    Location:7 → 323
    IL17_R_N; Interleukin-17 receptor extracellular region

  11. XM_063285882.1 → XP_063141952.1  interleukin-17 receptor C isoform X8

  12. XM_063285886.1 → XP_063141956.1  interleukin-17 receptor C isoform X11

  13. XM_063285884.1 → XP_063141954.1  interleukin-17 receptor C isoform X11

  14. XM_063285885.1 → XP_063141955.1  interleukin-17 receptor C isoform X11

  15. XM_039107415.2 → XP_038963343.1  interleukin-17 receptor C isoform X11

    Conserved Domains (2) summary
    pfam08357
    Location:210 → 360
    SEFIR; SEFIR domain
    pfam15037
    Location:1 → 169
    IL17_R_N; Interleukin-17 receptor extracellular region

  16. XM_063285887.1 → XP_063141957.1  interleukin-17 receptor C isoform X12

  17. XM_039107419.2 → XP_038963347.1  interleukin-17 receptor C isoform X14

    Conserved Domains (2) summary
    pfam08357
    Location:173 → 323
    SEFIR; SEFIR domain
    pfam15037
    Location:31 → 132
    IL17_R_N; Interleukin-17 receptor extracellular region

RNA

  1. XR_005503200.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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