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Conserved domains on  [gi|1958769048|ref|XP_038963347|]
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interleukin-17 receptor C isoform X14 [Rattus norvegicus]

Protein Classification

IL17_R_N and SEFIR domain-containing protein( domain architecture ID 10386761)

IL17_R_N and SEFIR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SEFIR pfam08357
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
 173-323 7.12e-46

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


:

Pssm-ID: 254756  Cd Length: 150  Bit Score: 153.71  E-value: 7.12e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769048 173 RPALLLHSADGAYYERLVGALASALSQM-PLRVAVDLWSRRELTAHGALAWFHQQrrrtLQEDGVVILLFSPAAVAQCQQ 251
Cdd:pfam08357   1 RKVFIVYSSDSALHTEVVLKFAEFLQDYcGCEVALDLWELNEIAEIGPVAWLERQ----IQEADKVIIVCSKGAKAFCDK 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958769048 252 WLQLQTVEPG---PHDALAAWLSCVLPDFLQGQATGRYVGVYFdGLLHPDTVPALFRVAPLFSLPSQLPAFLDAL 323
Cdd:pfam08357  77 KADKRKGGVGtesQHDLFIPALSLILRDFKQSAALRKYLVVYF-GYADKKDVPTILRVLPKYSLMDQLPQLLAEL 150
IL17_R_N super family cl20911
Interleukin-17 receptor extracellular region; This domain is found at the N-terminus ...
 31-132 4.36e-39

Interleukin-17 receptor extracellular region; This domain is found at the N-terminus (extracellular region) of interleukin-17 receptor C and Interleukin-17 receptor E. This is the presumed ligand-binding domain. Human putative interleukin-17 receptor E-like consists only of this domain.


The actual alignment was detected with superfamily member pfam15037:

Pssm-ID: 464460  Cd Length: 388  Bit Score: 142.69  E-value: 4.36e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769048  31 QVSSWEKVELQECLWADSLGPFKDDMLLVEMKTDLNDTSVCALEPSGCTPLPSVASTvtappppltwqRAARLGEQLLLD 110
Cdd:pfam15037 299 QVSSGEKSQLQECPWADSLGPLQDDMLLLETSGPQHNTSSCALEHSGCTPLPSVAQT-----------RAARLGEQLLQD 367

                          90       100
                  ....*....|....*....|..
gi 1958769048 111 FRTHQCMQLWnDDDLGSLWACP 132
Cdd:pfam15037 368 LQSGQCVQLW-RDDVGFLWACP 388
 
Name Accession Description Interval E-value
SEFIR pfam08357
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
 173-323 7.12e-46

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


Pssm-ID: 254756  Cd Length: 150  Bit Score: 153.71  E-value: 7.12e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769048 173 RPALLLHSADGAYYERLVGALASALSQM-PLRVAVDLWSRRELTAHGALAWFHQQrrrtLQEDGVVILLFSPAAVAQCQQ 251
Cdd:pfam08357   1 RKVFIVYSSDSALHTEVVLKFAEFLQDYcGCEVALDLWELNEIAEIGPVAWLERQ----IQEADKVIIVCSKGAKAFCDK 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958769048 252 WLQLQTVEPG---PHDALAAWLSCVLPDFLQGQATGRYVGVYFdGLLHPDTVPALFRVAPLFSLPSQLPAFLDAL 323
Cdd:pfam08357  77 KADKRKGGVGtesQHDLFIPALSLILRDFKQSAALRKYLVVYF-GYADKKDVPTILRVLPKYSLMDQLPQLLAEL 150
IL17_R_N pfam15037
Interleukin-17 receptor extracellular region; This domain is found at the N-terminus ...
 31-132 4.36e-39

Interleukin-17 receptor extracellular region; This domain is found at the N-terminus (extracellular region) of interleukin-17 receptor C and Interleukin-17 receptor E. This is the presumed ligand-binding domain. Human putative interleukin-17 receptor E-like consists only of this domain.


Pssm-ID: 464460  Cd Length: 388  Bit Score: 142.69  E-value: 4.36e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769048  31 QVSSWEKVELQECLWADSLGPFKDDMLLVEMKTDLNDTSVCALEPSGCTPLPSVASTvtappppltwqRAARLGEQLLLD 110
Cdd:pfam15037 299 QVSSGEKSQLQECPWADSLGPLQDDMLLLETSGPQHNTSSCALEHSGCTPLPSVAQT-----------RAARLGEQLLQD 367

                          90       100
                  ....*....|....*....|..
gi 1958769048 111 FRTHQCMQLWnDDDLGSLWACP 132
Cdd:pfam15037 368 LQSGQCVQLW-RDDVGFLWACP 388
 
Name Accession Description Interval E-value
SEFIR pfam08357
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
 173-323 7.12e-46

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


Pssm-ID: 254756  Cd Length: 150  Bit Score: 153.71  E-value: 7.12e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769048 173 RPALLLHSADGAYYERLVGALASALSQM-PLRVAVDLWSRRELTAHGALAWFHQQrrrtLQEDGVVILLFSPAAVAQCQQ 251
Cdd:pfam08357   1 RKVFIVYSSDSALHTEVVLKFAEFLQDYcGCEVALDLWELNEIAEIGPVAWLERQ----IQEADKVIIVCSKGAKAFCDK 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958769048 252 WLQLQTVEPG---PHDALAAWLSCVLPDFLQGQATGRYVGVYFdGLLHPDTVPALFRVAPLFSLPSQLPAFLDAL 323
Cdd:pfam08357  77 KADKRKGGVGtesQHDLFIPALSLILRDFKQSAALRKYLVVYF-GYADKKDVPTILRVLPKYSLMDQLPQLLAEL 150
IL17_R_N pfam15037
Interleukin-17 receptor extracellular region; This domain is found at the N-terminus ...
 31-132 4.36e-39

Interleukin-17 receptor extracellular region; This domain is found at the N-terminus (extracellular region) of interleukin-17 receptor C and Interleukin-17 receptor E. This is the presumed ligand-binding domain. Human putative interleukin-17 receptor E-like consists only of this domain.


Pssm-ID: 464460  Cd Length: 388  Bit Score: 142.69  E-value: 4.36e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769048  31 QVSSWEKVELQECLWADSLGPFKDDMLLVEMKTDLNDTSVCALEPSGCTPLPSVASTvtappppltwqRAARLGEQLLLD 110
Cdd:pfam15037 299 QVSSGEKSQLQECPWADSLGPLQDDMLLLETSGPQHNTSSCALEHSGCTPLPSVAQT-----------RAARLGEQLLQD 367

                          90       100
                  ....*....|....*....|..
gi 1958769048 111 FRTHQCMQLWnDDDLGSLWACP 132
Cdd:pfam15037 368 LQSGQCVQLW-RDDVGFLWACP 388
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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