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Conserved domains on  [gi|1958769025|ref|XP_038963336|]
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interleukin-17 receptor C isoform X4 [Rattus norvegicus]

Protein Classification

SEFIR domain-containing protein; toll-interleukin-resistance domain-containing protein( domain architecture ID 10633270)

SEFIR domain-containing protein may function as signaling components of Toll/IL-1R-similar pathways and the SEFIR domain mediates physical protein-protein interactions between pathway components| toll-interleukin-resistance (TIR) domain-containing protein may act as a disease resistance protein in plant

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IL17_R_N pfam15037
Interleukin-17 receptor extracellular region; This domain is found at the N-terminus ...
 7-338 3.13e-177

Interleukin-17 receptor extracellular region; This domain is found at the N-terminus (extracellular region) of interleukin-17 receptor C and Interleukin-17 receptor E. This is the presumed ligand-binding domain. Human putative interleukin-17 receptor E-like consists only of this domain.


:

Pssm-ID: 464460  Cd Length: 388  Bit Score: 505.17  E-value: 3.13e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769025   7 PKKLESLIQNsrGLGTGSAVFDCFEAGLGAEVRIWSYTKPRYQKELNVTQQLPDCRGLEVQDSIQSCWALPWLNVSTDGD 86
Cdd:pfam15037  72 VEVPAALVRP--GQSVGSVVFDCFEAALGAEVRIWSYTQPRYQKELNHTQQLPDCRAIEVEVSVRSCWALPWLNLSAPGD 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769025  87 NVLLILDVSKEQKFGfLLYWDQAQGPLKSLLYKNLTGPQNITLNHTDLVPCLCIQLWSQEPDSVRTSFCPFKKDPRAHRN 166
Cdd:pfam15037 150 NVQLVLDVSEEQRFG-LLYWWQVQGPPKPRWQKNLTGPQTITLNHTDLVPCLCIQAWPLEEDTVRTKKCPFQEDPRAHSN 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769025 167 LWHMARLRVQSSGSWLLDTPCSLRTEVALCWQAPDQSPCQPLVPPMPQKNVTMNRPFEFPLVKEHPNLCVQVSSWEKVEL 246
Cdd:pfam15037 229 LWKSARLTLLSQHSWMVDAPCPLKAEAALCWRAPGGTLCQPLPPPLPRENVTVNGWYVLPLLDLHPNLCVQVSSGEKSQL 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769025 247 QECLWADSLGPFKDDMLLVEMKTDLNDTSVCALEPSGCTPLPSVASTvtappppltwqRAARLGEQLLLDFRTHQCMQLW 326
Cdd:pfam15037 309 QECPWADSLGPLQDDMLLLETSGPQHNTSSCALEHSGCTPLPSVAQT-----------RAARLGEQLLQDLQSGQCVQLW 377

                         330
                  ....*....|..
gi 1958769025 327 nDDDLGSLWACP 338
Cdd:pfam15037 378 -RDDVGFLWACP 388
SEFIR pfam08357
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
 379-529 1.28e-44

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


:

Pssm-ID: 254756  Cd Length: 150  Bit Score: 154.86  E-value: 1.28e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769025 379 RPALLLHSADGAYYERLVGALASALSQM-PLRVAVDLWSRRELTAHGALAWFHQQrrrtLQEDGVVILLFSPAAVAQCQQ 457
Cdd:pfam08357   1 RKVFIVYSSDSALHTEVVLKFAEFLQDYcGCEVALDLWELNEIAEIGPVAWLERQ----IQEADKVIIVCSKGAKAFCDK 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958769025 458 WLQLQTVEPG---PHDALAAWLSCVLPDFLQGQATGRYVGVYFdGLLHPDTVPALFRVAPLFSLPSQLPAFLDAL 529
Cdd:pfam08357  77 KADKRKGGVGtesQHDLFIPALSLILRDFKQSAALRKYLVVYF-GYADKKDVPTILRVLPKYSLMDQLPQLLAEL 150
 
Name Accession Description Interval E-value
IL17_R_N pfam15037
Interleukin-17 receptor extracellular region; This domain is found at the N-terminus ...
 7-338 3.13e-177

Interleukin-17 receptor extracellular region; This domain is found at the N-terminus (extracellular region) of interleukin-17 receptor C and Interleukin-17 receptor E. This is the presumed ligand-binding domain. Human putative interleukin-17 receptor E-like consists only of this domain.


Pssm-ID: 464460  Cd Length: 388  Bit Score: 505.17  E-value: 3.13e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769025   7 PKKLESLIQNsrGLGTGSAVFDCFEAGLGAEVRIWSYTKPRYQKELNVTQQLPDCRGLEVQDSIQSCWALPWLNVSTDGD 86
Cdd:pfam15037  72 VEVPAALVRP--GQSVGSVVFDCFEAALGAEVRIWSYTQPRYQKELNHTQQLPDCRAIEVEVSVRSCWALPWLNLSAPGD 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769025  87 NVLLILDVSKEQKFGfLLYWDQAQGPLKSLLYKNLTGPQNITLNHTDLVPCLCIQLWSQEPDSVRTSFCPFKKDPRAHRN 166
Cdd:pfam15037 150 NVQLVLDVSEEQRFG-LLYWWQVQGPPKPRWQKNLTGPQTITLNHTDLVPCLCIQAWPLEEDTVRTKKCPFQEDPRAHSN 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769025 167 LWHMARLRVQSSGSWLLDTPCSLRTEVALCWQAPDQSPCQPLVPPMPQKNVTMNRPFEFPLVKEHPNLCVQVSSWEKVEL 246
Cdd:pfam15037 229 LWKSARLTLLSQHSWMVDAPCPLKAEAALCWRAPGGTLCQPLPPPLPRENVTVNGWYVLPLLDLHPNLCVQVSSGEKSQL 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769025 247 QECLWADSLGPFKDDMLLVEMKTDLNDTSVCALEPSGCTPLPSVASTvtappppltwqRAARLGEQLLLDFRTHQCMQLW 326
Cdd:pfam15037 309 QECPWADSLGPLQDDMLLLETSGPQHNTSSCALEHSGCTPLPSVAQT-----------RAARLGEQLLQDLQSGQCVQLW 377

                         330
                  ....*....|..
gi 1958769025 327 nDDDLGSLWACP 338
Cdd:pfam15037 378 -RDDVGFLWACP 388
SEFIR pfam08357
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
 379-529 1.28e-44

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


Pssm-ID: 254756  Cd Length: 150  Bit Score: 154.86  E-value: 1.28e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769025 379 RPALLLHSADGAYYERLVGALASALSQM-PLRVAVDLWSRRELTAHGALAWFHQQrrrtLQEDGVVILLFSPAAVAQCQQ 457
Cdd:pfam08357   1 RKVFIVYSSDSALHTEVVLKFAEFLQDYcGCEVALDLWELNEIAEIGPVAWLERQ----IQEADKVIIVCSKGAKAFCDK 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958769025 458 WLQLQTVEPG---PHDALAAWLSCVLPDFLQGQATGRYVGVYFdGLLHPDTVPALFRVAPLFSLPSQLPAFLDAL 529
Cdd:pfam08357  77 KADKRKGGVGtesQHDLFIPALSLILRDFKQSAALRKYLVVYF-GYADKKDVPTILRVLPKYSLMDQLPQLLAEL 150
 
Name Accession Description Interval E-value
IL17_R_N pfam15037
Interleukin-17 receptor extracellular region; This domain is found at the N-terminus ...
 7-338 3.13e-177

Interleukin-17 receptor extracellular region; This domain is found at the N-terminus (extracellular region) of interleukin-17 receptor C and Interleukin-17 receptor E. This is the presumed ligand-binding domain. Human putative interleukin-17 receptor E-like consists only of this domain.


Pssm-ID: 464460  Cd Length: 388  Bit Score: 505.17  E-value: 3.13e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769025   7 PKKLESLIQNsrGLGTGSAVFDCFEAGLGAEVRIWSYTKPRYQKELNVTQQLPDCRGLEVQDSIQSCWALPWLNVSTDGD 86
Cdd:pfam15037  72 VEVPAALVRP--GQSVGSVVFDCFEAALGAEVRIWSYTQPRYQKELNHTQQLPDCRAIEVEVSVRSCWALPWLNLSAPGD 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769025  87 NVLLILDVSKEQKFGfLLYWDQAQGPLKSLLYKNLTGPQNITLNHTDLVPCLCIQLWSQEPDSVRTSFCPFKKDPRAHRN 166
Cdd:pfam15037 150 NVQLVLDVSEEQRFG-LLYWWQVQGPPKPRWQKNLTGPQTITLNHTDLVPCLCIQAWPLEEDTVRTKKCPFQEDPRAHSN 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769025 167 LWHMARLRVQSSGSWLLDTPCSLRTEVALCWQAPDQSPCQPLVPPMPQKNVTMNRPFEFPLVKEHPNLCVQVSSWEKVEL 246
Cdd:pfam15037 229 LWKSARLTLLSQHSWMVDAPCPLKAEAALCWRAPGGTLCQPLPPPLPRENVTVNGWYVLPLLDLHPNLCVQVSSGEKSQL 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769025 247 QECLWADSLGPFKDDMLLVEMKTDLNDTSVCALEPSGCTPLPSVASTvtappppltwqRAARLGEQLLLDFRTHQCMQLW 326
Cdd:pfam15037 309 QECPWADSLGPLQDDMLLLETSGPQHNTSSCALEHSGCTPLPSVAQT-----------RAARLGEQLLQDLQSGQCVQLW 377

                         330
                  ....*....|..
gi 1958769025 327 nDDDLGSLWACP 338
Cdd:pfam15037 378 -RDDVGFLWACP 388
SEFIR pfam08357
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
 379-529 1.28e-44

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


Pssm-ID: 254756  Cd Length: 150  Bit Score: 154.86  E-value: 1.28e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958769025 379 RPALLLHSADGAYYERLVGALASALSQM-PLRVAVDLWSRRELTAHGALAWFHQQrrrtLQEDGVVILLFSPAAVAQCQQ 457
Cdd:pfam08357   1 RKVFIVYSSDSALHTEVVLKFAEFLQDYcGCEVALDLWELNEIAEIGPVAWLERQ----IQEADKVIIVCSKGAKAFCDK 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958769025 458 WLQLQTVEPG---PHDALAAWLSCVLPDFLQGQATGRYVGVYFdGLLHPDTVPALFRVAPLFSLPSQLPAFLDAL 529
Cdd:pfam08357  77 KADKRKGGVGtesQHDLFIPALSLILRDFKQSAALRKYLVVYF-GYADKKDVPTILRVLPKYSLMDQLPQLLAEL 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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