GEO DataSets

(Submitter supplied) In this study, we describe the development and use of an ad hoc protein microarray to study the immune response induced by the OMV component of 4CMenB vaccine in infant sera before and after vaccination

Organism:

Homo sapiens; Neisseria meningitidis

Type:

Protein profiling by protein array

Platform:

GPL33085

6 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; Neisseria meningitidis; Homo sapiens

Type:

Protein profiling by protein array

Platforms:

GPL33085 GPL33086

10 Samples

Download data: TXT

(Submitter supplied) In this study, we describe the development and use of an ad hoc protein microarray to study the immune response induced by the OMV component of 4CMenB vaccine in mouse sera before and after immunization.

Organism:

Neisseria meningitidis; Mus musculus

Type:

Protein profiling by protein array

Platform:

GPL33086

4 Samples

Download data: TXT

(Submitter supplied) Pathogenic bacteria encounter a variety of stressful host environments during infection. Their responses to meet these challenges protect them from deadly damages and aid in adaption to harmful environments. Bacterial products critical for this protection are therefore interesting as suitable targets for new antimicrobials. To shed light on the complex array of molecular pathways involved in bacterial stress responses we challenged 32 diverse human pathogenic bacteria to 11 infection related stress conditions and catalogued their transcriptomes. more...

Organism:

Neisseria meningitidis; Staphylococcus epidermidis; Streptococcus pyogenes; Listeria monocytogenes; Salmonella enterica; Achromobacter xylosoxidans; Borreliella burgdorferi; Pseudomonas aeruginosa; Legionella pneumophila; Klebsiella pneumoniae; Yersinia pseudotuberculosis; Vibrio cholerae; Streptococcus suis; Streptococcus agalactiae; Streptococcus pneumoniae; Mycobacterium tuberculosis; Burkholderia pseudomallei; Helicobacter pylori; Enterococcus faecalis; Campylobacter jejuni; Francisella tularensis; Acinetobacter baumannii; Neisseria gonorrhoeae; Escherichia coli; Shigella flexneri; Aggregatibacter actinomycetemcomitans; Haemophilus influenzae; Staphylococcus aureus subsp. aureus MRSA252; Staphylococcus aureus subsp. aureus MSSA476

Type:

Expression profiling by high throughput sequencing

30 related Platforms

1122 Samples

Download data: TXT

(Submitter supplied) In this study, we describe the development and use of an ad hoc protein microarray to study the immune response induced by the three major 4CMenB antigenic components (fHbp, NHBA and NadA) in individual sera from vaccinated infants, adolescents and adults.

Organism:

Neisseria meningitidis; Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL28712

219 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Neisseria meningitidis 8013

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24628

10 Samples

Download data: WIG

(Submitter supplied) In this study the RNA targetome of the RNA-binding protein ProQ was determined in Neisseria meninigitidis serogroup C strain 8013 by RNA-seq.

Organism:

Neisseria meningitidis 8013

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24628

6 Samples

Download data: WIG

(Submitter supplied) In this study binding sites for the RNA-binding protein ProQ was determined in Neisseria meninigitidis serogroup C strain 8013

Organism:

Neisseria meningitidis 8013

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24628

4 Samples

Download data: WIG

(Submitter supplied) This study investigates host transcriptome changes of infected human iPS-derived brain endothelial cells in response to prolonged Nm infection (24h)

Organism:

Neisseria meningitidis MC58; Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL26178 GPL18573

2 Samples

Download data: WIG

(Submitter supplied) We investigated an improved method that combines competitive PCR and microarray techniques. This approach allowed us to quantify specific bacterial groups mounted on DNA chips with accuracy close to that of real-time PCR, despite a measurement at the end point of PCR, and also to estimate the bacterial DNA content in sample DNA.

Organism:

Neisseria meningitidis; Porphyromonas gingivalis; Fusobacterium nucleatum; Clostridium beijerinckii; Lactobacillus gasseri; Tannerella forsythia; Treponema denticola; Cereibacter sphaeroides; Streptococcus gordonii; Streptococcus agalactiae; Enterococcus faecalis; Bifidobacterium adolescentis; Homo sapiens; Prevotella intermedia; Prevotella nigrescens; Campylobacter rectus; Helicobacter pylori; Pseudomonas aeruginosa; Aggregatibacter actinomycetemcomitans; Phocaeicola vulgatus; Capnocytophaga gingivalis; Deinococcus radiodurans; Streptococcus mutans; Streptococcus intermedius; Cutibacterium acnes; Bacteria; Acinetobacter baumannii; Escherichia coli; Staphylococcus aureus; Staphylococcus epidermidis; Bacillus cereus; Schaalia odontolytica; Fusobacterium nucleatum subsp. nucleatum

Type:

Other

Platform:

GPL25612

178 Samples

Download data: CSV

(Submitter supplied) The aim of the study was to determine the epitope targeted by 5H2 human Fab directed against NHBA and the crossreactivity aginst a panel of nine different NHBA long and short peptide variants (p2, p3, p5, p10, p17, p20, p21, p24, p29). 5H2 were diluted at 1:2000 and incubated on a non-commercial Protein Microarray platform printed with NHBAp2 specific recombinant protein fragments and full length NHBA of different variants.

Organism:

Homo sapiens; Neisseria meningitidis

Type:

Protein profiling by protein array

Platform:

GPL24853

1 Sample

Download data: TXT

(Submitter supplied) Neisseria meningitidis, a commensal β-proteobacterium of the human nasopharynx, constitutes a worldwide leading cause of sepsis and epidemic meningitis. The molecular basis for their "accidental" pathogenicity is still not fully understood. Here, we show that knock-out strains lacking the Cas9 protein are impaired in the adhesion to human nasopharyngeal cells which constitutes a central step in the pathogenesis of invasive meningococcal disease. more...

Organism:

Neisseria meningitidis 8013

Type:

Expression profiling by high throughput sequencing; Other

Platform:

GPL24628

8 Samples

Download data: WIG

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Neisseria meningitidis; Homo sapiens; Neisseria meningitidis serogroup B

Type:

Protein profiling by protein array

4 related Platforms

57 Samples

Download data: TXT

(Submitter supplied) The aim of the study was to determine the epitope targeted by four different HumAbs and the cross-reactivity to linear peptide epitopes of 10 different Neisserial Heparin Binding Antigen (NHBA) variants. the HumAbs were diluted at 1:60 and incubated on a custom PepStar Peptide Microarray platform printed with 561 different peptides.

Organism:

Homo sapiens; Neisseria meningitidis serogroup B

Type:

Protein profiling by protein array

Platform:

GPL21866

4 Samples

Download data: TXT

(Submitter supplied) The aim of the study was to determine the epitope targeted by four different HumAbs and the cross-reactivity to linear peptide epitopes of 5 different Neisserial adesin A (NadA) variants. the HumAbs were diluted at 1:200 and incubated on a custom PepStar Peptide Microarray platform printed with 348 different peptides.

Organism:

Neisseria meningitidis serogroup B; Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL23476

11 Samples

Download data: TXT

(Submitter supplied) The aim of the study was to determine the epitope targeted by 5 different HumAbs and the cross-reactivity to linear peptide epitopes of 12 different factor H binding protein (fHbp) variants. The HumAbs were diluted at 1:200 and incubated on a custom PepStar Peptide Microarray platform printed with 363 different peptides.

Organism:

Neisseria meningitidis serogroup B; Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL23475

5 Samples

Download data: TXT

(Submitter supplied) The aim of the study was to determine the epitope targeted by a panel of Human Fabs. Fabs were diluted at 1:50 and incubated on a non-commercial Protein Microarray platform printed with fHbp, NHBA and NadA specific recombinant protein fragments and full length fHbp, NHBA and NadA of different variants.

Organism:

Homo sapiens; Neisseria meningitidis

Type:

Protein profiling by protein array

Platform:

GPL23474

37 Samples

Download data: TXT

(Submitter supplied) Neisseria meningitidis is a human commensal that occasionally causes life-threatening infections such as bacterial meningitis and septicemia. Despite experimental evidence that gene regulation as well as the expression of small non-coding RNAs (sRNAs) affect meningococcal virulence, the organization of its transcriptome, including in particular the biogenesis of sRNAs and their mode of action, is only poorly understood. more...

Organism:

Neisseria meningitidis 8013

Type:

Expression profiling by high throughput sequencing; Other

Platforms:

GPL22295 GPL22296

8 Samples

Download data: WIG

(Submitter supplied) Neisseria meningitidis is an obligate commensal colonising the human nasopharynx and occasionally invades the bloodstream causing life-threatening meningitis and septicaemia. The gene NMB0419 on the genome of N. meningitidis MC58 encodes a putative Sel1-like repeat (SLR) containing protein, which has been implicated in mediating meningococcal invasion of epithelial cells. We prepared RNA samples from N. more...

Organism:

Neisseria meningitidis MC58

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21879

6 Samples

Download data: TXT

(Submitter supplied) Differences in the transcriptional profile of the menigococcal strains MC58 and α710 were compared upon growth in PPM+ and on exposure to human saliva, whole blood and cerebrospinal fluid

Organism:

Neisseria meningitidis

Type:

Expression profiling by array

Platform:

GPL8787

24 Samples

Download data: GPR