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Links from GEO DataSets

Items: 14

1.
Full record GDS5363

Osteoarthritis: peripheral blood mononuclear cells

Analysis of peripheral blood mononuclear cells (PBMCs) from osteoarthritis (OA) patients. Patients participated in the Genetics osteoARthritis and Progression (GARP) study. Results provide insight into the feasibility of using gene expression profiling of PBMCs to detect the onset of OA.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state, 2 gender sets
Platform:
GPL6947
Series:
GSE48556
139 Samples
Download data
DataSet
Accession:
GDS5363
ID:
5363
2.

Gene expression profiles from peripheral blood mononuclear cells (PBMCs) of osteoarthritis patients and healthy controls

(Submitter supplied) By performing a comprehensive exploration of peripheral blood by microarray analysis from a subset of the Genetics osteoARthritis and Progression (GARP) study in comparison with sex and age-matched healthy controls we have identified disease specific gene expression networks. Our data hint at the relevance of apoptosis as an etiological factor in osteoarthritis onset, thereby qualifying expression profiling of blood as a useful tool to understand the underlying molecular mechanisms of osteoarthritis.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5363
Platform:
GPL6947
139 Samples
Download data: TXT
Series
Accession:
GSE48556
ID:
200048556
3.

Transcriptomic analyis of the response of porcine PBMC to stimulation with concanavalin A

(Submitter supplied) One of the top priorities of the swine industry worldwide is to decrease the susceptibility of its animals to infectious diseases. There is therefore now an increased focus on the production of more “robust” animals, which have lower susceptibility to a broad range of infectious diseases. One general measure of immune competence is the proliferative response of peripheral blood mononuclear cells (PBMC) to mitogenic stimulation. more...
Organism:
Sus scrofa
Type:
Expression profiling by array
Platform:
GPL14897
24 Samples
Download data: GPR
Series
Accession:
GSE33760
ID:
200033760
4.

Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis

(Submitter supplied) Purpose: The goal of the study was to integrate verified signals from previous genetic association studies with gene expression and pathway analysis for discovery of new candidate genes and signalling networks, relevant for rheumatoid arthritis (RA). Method:RNA-seq based expression analysis of 377 genes from previously verified RA-associated loci was performed in blood cells from 5 newly diagnosed, non-treated RA patients, 7 patients with treated RA and 12 healthy controls. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
24 Samples
Download data: TXT
5.

Transcriptional analysis of normal and pathological synovial fibroblasts

(Submitter supplied) The aim of this study was to compare gene expression between two pathological groups of human synovial fibroblasts (SF) from rheumatoid arthritis (RA) and osteoarthritis (OA) synovial tissues with normal SF from healthy individuals (HSF). We used microarray expression profiling in SF cultured from OA, RA and normal synovial tissues. We found larger numbers of transcripts with differential expression in OASF compared to the other groups than in RASF compared to HSF. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
31 Samples
Download data: TXT
Series
Accession:
GSE29746
ID:
200029746
6.

Gene expression networks in COPD: microRNA and mRNA regulation

(Submitter supplied) 70 miRNAs and 2667 mRNAs were differentially expressed between lung tissue from subjects with COPD and smokers without COPD. miRNA and mRNA expression profiles enriched for biological pathways that may be relevant to the pathogenesis of COPD including the transforming growth factor b, Wnt and focal adhesion pathways. miR-223 and miR-1274a were the most affected miRNAs in subjects with COPD compared with smokers without obstruction. more...
Organism:
Mus musculus; Human gammaherpesvirus 8; Rattus norvegicus; JC polyomavirus; Murid gammaherpesvirus 4; Betapolyomavirus hominis; Human alphaherpesvirus 1; human gammaherpesvirus 4; Betapolyomavirus macacae; Homo sapiens; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL4133 GPL7723
59 Samples
Download data
Series
Accession:
GSE38974
ID:
200038974
7.

Genome wide-DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Methylation profiling by array
Platforms:
GPL11532 GPL8490
64 Samples
Download data: CEL
Series
Accession:
GSE43270
ID:
200043270
8.

Genome wide-DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients (methylation)

(Submitter supplied) The aim of this study is to identify, for the first time, the genome-wide DNA methylation profiles of human articular chondrocytes from OA and healtly cartilage samples. Genome wide DNA methylation profiling of normal and osteoarthritic samples. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in cartilage knee samples. more...
Organism:
Homo sapiens
Type:
Methylation profiling by array
Platform:
GPL8490
41 Samples
Download data: TXT
Series
Accession:
GSE43269
ID:
200043269
9.

Genome wide-DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients (gene expression)

(Submitter supplied) The aim of this study is to identify, for the first time, the genome-wide DNA methylation profiles of human articular chondrocytes from OA and healtly cartilage samples. A subsequent validation of methylation profiles were performed in an idependent cohort of OA samples with Affymetrix Hugene 1.1 st array This represents the gene expression component of the study only
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL11532
23 Samples
Download data: CEL
Series
Accession:
GSE43191
ID:
200043191
10.

Pooled B-Cell C441MC-C442MC

(Submitter supplied) A genome-scale assessment of peripheral blood B-cell molecular homeostasis in patients with rheumatoid arthritis. Keywords: Rheumatoid Arthritis, B-cells
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL3463
2 Samples
Download data
Series
Accession:
GSE4255
ID:
200004255
11.

Expression Changes Relevant for Apoptosis in K562 Cells Co-Treated with Amifostine and Imatinib

(Submitter supplied) We had previously demonstrated an increased proapoptotic effect of Imatinib (STI571) in combination with Amifostine (AMI) in K562 cell line. In this study we used genomic scale gene expression profiling to monitor changes at transcriptional level in K562 cells during the treatment with AMI+STI571. We identified a transcriptional repressor of survival genes, known as BTF, which triggers a pro-apoptotic signal, potentially helpful to overcome the resistance to STI571. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2829
4 Samples
Download data
Series
Accession:
GSE3312
ID:
200003312
12.

Comparative study of gene expression in human colorectal cancer tissues and normal mucosa

(Submitter supplied) The purpose of our study was to better understand the genetic mechanism of oncogenesis for human colorectal cancer and to identify potential new tumour markers of use in clinical practice. Results: Comparing cancerous tissues with normal colonic mucosa we identified 584 known genes (3%) differentially expressed to a significant degree (p<0.001). Many of the transcripts that were more abundant in tumours than in non-neoplastic tissues appear to reflect important events for colon carcinogenesis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2829
24 Samples
Download data
Series
Accession:
GSE3294
ID:
200003294
13.

Expression in blood of schizophrenia patients and healthy controls

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Rattus norvegicus; JC polyomavirus; Human immunodeficiency virus 1; Merkel cell polyomavirus; Human alphaherpesvirus 1; Human alphaherpesvirus 2; Lymphocryptovirus; Cytomegalovirus; Betapolyomavirus macacae; Homo sapiens; Human betaherpesvirus 5; Rhadinovirus; Murid gammaherpesvirus 4; Betapolyomavirus hominis
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL15314 GPL16016
60 Samples
Download data: TXT
Series
Accession:
GSE54914
ID:
200054914
14.

mRNA expression in blood of 18 schizophrenia patients and 12 healthy controls

(Submitter supplied) The study profiles genome-wide mRNA expression in blood from 18 early-onset SZ (EOS) cases and 12 healthy controls. A total of 1070 mRNAs were detected by the microarrays in our samples.
Organism:
Homo sapiens
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platform:
GPL15314
30 Samples
Download data: TXT
Series
Accession:
GSE54913
ID:
200054913
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