GEO DataSets

Analysis of NOD-derived, splenic natural killer (NK) cells cultured with or without cytokines interleukin (IL)-12 + IL-18 in the absence of TGF-β, or with both cytokines in the presence of TGF-β. Results provide insight into the impact of TGF-β on NK cells independent of general activation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 protocol, 2 time sets

Platform:

GPL6246

Series:

GSE39197

9 Samples

Download data: CEL

(Submitter supplied) Following Treg ablation in the BDC/NOD.Foxp3-DTR strain, NK cells produce IFNg and accumulate to higher percentage and number. We explored the signature pathways responsible for this phenomenon using microarray prolifing and comparison to other activation signatures.

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS4946 GDS4948

Platform:

GPL6246

41 Samples

Download data: CEL

Analysis of natural killer (NK) cells isolated from the pancreas or spleen of BDC2.5/NOD.Foxp3DTR animals up to 24 hours after diphtheria toxin (DT) injection to ablate regulatory T (Treg) cells. Results provide insight into molecular mechanisms underlying Treg/NK cross-talk in controlling diabetes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 3 time, 2 tissue sets

Platform:

GPL6246

Series:

GSE39197

32 Samples

Download data: CEL

(Submitter supplied) Comparison of gene expression between T regulatory and T effector cells isolated from the pancreatic lesion of 3-4 wk old BDC2.5 tg NOD mice Keywords: cell type comparison

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS684

Platform:

GPL81

30 Samples

Download data: CEL

Comparison of T regulatory (CD4+CD25+CD69-) and T effector (CD4+CD25lo/-CD69+/-) cells isolated from the pancreatic lesion of 3-4 week old BDC2.5 transgenic NOD mice before type 1 diabetes onset.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 cell type sets

Platform:

GPL81

Series:

GSE1419

8 Samples

Download data: CEL

(Submitter supplied) This study was performed to understand what controls the aggressivity of the pancreatic infiltrate during type-I diabetes development. We used the BDC2.5 transgenic mouse model. Samples were obtained at the age of onset of insultis. Depending on their genetic background, mice transgenic for the BDC2.5 T cell receptor present very different forms of insulitis. The NOD genetic background leads to a benign insulitis whereas the C57Bl/6-H2g7/g7 leads to an aggressive insulitis. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS828

Platform:

GPL81

24 Samples

Download data

Analysis of CD4+ automimmune T and CD45+ hematopoeitic cells from non-obese diabetic (NOD) and C57BL/6-H-2 g7 transgenics with the BDC2.5 T cell receptor (TCR) from a diabetogenic T cell. BDC2.5 TCR in NOD and in C57BL/6-H-2 g7 results in innocuous and destructive insulitis respectively.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 cell type, 2 genotype/variation, 2 strain, 3 tissue sets

Platform:

GPL81

Series:

GSE1085

24 Samples

Download data

(Submitter supplied) Analysis of gene expression levels in ex-vivo and p79-stimulated splenic CD4+ T cells.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL14828

12 Samples

Download data: TXT

(Submitter supplied) Natural killer (NK) cells are innate lymphocytes with the capacity to elicit adaptive features, including clonal expansion and immunological memory. Because signal transducer and activator of transcription 5 (STAT5) is essential for NK cell development, the role of this transcription factor and its upstream cytokines IL-2 and IL-15 during infection have not been carefully investigated. In this study, we investigate how STAT5 regulates transcription during viral infection. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

12 Samples

Download data: TXT