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Series GSE1085 Query DataSets for GSE1085
Status Public on Apr 17, 2004
Title Profiling of aggressive vs benign pancreatic infiltrates in the BDC2.5 Tg model of Type I diabetes
Organism Mus musculus
Experiment type Expression profiling by array
Summary This study was performed to understand what controls the aggressivity of the pancreatic infiltrate during type-I diabetes development. We used the BDC2.5 transgenic mouse model. Samples were obtained at the age of onset of insultis. Depending on their genetic background, mice transgenic for the BDC2.5 T cell receptor present very different forms of insulitis. The NOD genetic background leads to a benign insulitis whereas the C57Bl/6-H2g7/g7 leads to an aggressive insulitis. We first studied how antigen-specific T cells are affected by these differences by obtaining the transcriptional profiles of BDC2.5 T cells from pancreas and pancreatic lymph nodes. We also compared the gene expression profiles of the entire leukocyte population present in the pancreatic lesion.
Keywords: other
 
 
Contributor(s) Poirot L, Benoist C, Mathis D
Citation(s) 15141080
Submission date Mar 01, 2004
Last update date Feb 18, 2018
Contact name CBDM Lab
E-mail(s) [email protected]
Phone 617-432-7747
Organization name Harvard Medical School
Department Microbiology and Immunobiology
Lab CBDM
Street address 77 Avenue Louis Pasteur
City Boston
State/province MA
ZIP/Postal code 02215
Country USA
 
Platforms (1)
GPL81 [MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array
Samples (24)
GSM17036 Total pancreatic infiltrate- BDC2.5 B6g7-rep1
GSM17037 Total pancreatic infiltrate- BDC2.5 B6g7-rep2
GSM17038 Total pancreatic infiltrate- BDC2.5 B6g7-rep3
Relations
BioProject PRJNA87189

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