GEO DataSets

Analysis of LV from males subjected to left coronary artery ligation to induce large, moderate, or small myocardial infarctions (MI). Only animals with large MIs develop LV remodeling and heart failure (HF). Results provide insight into the molecular basis of the progression of LV remodeling and HF.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 3 disease state, 4 protocol sets

Platform:

GPL6247

Series:

GSE47495

23 Samples

Download data: CEL

(Submitter supplied) Myocardial infarction (MI) often results in left ventricular (LV) remodeling followed by heart failure (HF). It is of great clinical importance to understand the molecular mechanisms that trigger transition from compensated LV injury to HF and to identify relevant diagnostic biomarkers. In this study, we performed transcriptional profiling of LVs in rats with a wide range of experimentally induced infarct sizes and of peripheral blood mononuclear cells (PBMCs) in animals that developed HF. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS4907 GDS4908

Platform:

GPL6247

34 Samples

Download data: CEL

Analysis of PBMCs from males subjected to left coronary artery ligation to induce large myocardial infarctions (MI). Only animals with large MIs develop LV remodeling and heart failure (HF). Results provide insight into the molecular basis of the progression of LV remodeling and HF.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 3 disease state, 2 protocol sets

Platform:

GPL6247

Series:

GSE47495

11 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL11202 GPL6885

37 Samples

Download data: TXT

(Submitter supplied) Wild type, female, C57BL/6 mice were subjected to sham (n=6) surgery, or TAC + MI to cause progressive LV remodeling (n=12). At 2wks post-TAC, one group of mice underwent de-banding (HF-DB, n=6), whereas in a second group of mice the band remained intact (HF; n = 6). LV remodeling was evaluated by 2D echocardiography at 14 days post-TAC+MI , and 4 wks post-debanding. At 6 wks the hearts were excised and analyzed for changes in gene expression using transcriptional profiling. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

18 Samples

Download data: TXT

(Submitter supplied) Wild type, female, C57BL/6 mice were subjected to sham (n=6) surgery, or TAC + MI to cause progressive LV remodeling (n=13). At 2wks post-TAC, one group of mice underwent de-banding (HF-DB, n=6), whereas in a second group of mice the band remained intact (HF_shDB; n = 7). LV remodeling was evaluated by 2D echocardiography at 14 days post-TAC+MI , and 2 wks post-debanding. At 4 wks the hearts were excised and analyzed for changes in gene expression using transcriptional profiling.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11202

19 Samples

Download data: TXT

(Submitter supplied) The molecular mechanism underlying cardiac remodeling following myocardial infarction have been incompletely understood. Until now, most studies have been performed in rodents. We studied cardiac remodeling in the physiologically more relevant animal model, the swine. Microarray analysis was performed on animals that underwent either sham surgery or permanent ligation of the left coronary artery (MI). more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Dataset:

GDS4307

Platform:

GPL3533

16 Samples

Download data: CEL

Analysis of remote, non-ischemic, regions of the left ventricle from animals that underwent permanent ligation of the left coronary artery to induce myocardial infarction (MI). Results provide insight into the molecular mechanisms underlying cardiac remodeling following MI.

Organism:

Sus scrofa

Type:

Expression profiling by array, transformed count, 2 disease state sets

Platform:

GPL3533

Series:

GSE27962

16 Samples

Download data: CEL