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| Status |
Public on Dec 14, 2017 |
| Title |
Load-Dependent Changes in Left Ventricular Gene Expression in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure (2 weeks heart failure, 2 weeks reversal) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Wild type, female, C57BL/6 mice were subjected to sham (n=6) surgery, or TAC + MI to cause progressive LV remodeling (n=13). At 2wks post-TAC, one group of mice underwent de-banding (HF-DB, n=6), whereas in a second group of mice the band remained intact (HF_shDB; n = 7). LV remodeling was evaluated by 2D echocardiography at 14 days post-TAC+MI , and 2 wks post-debanding. At 4 wks the hearts were excised and analyzed for changes in gene expression using transcriptional profiling.
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| Overall design |
Gene expression in mouse cardiac left ventricular samples was measured after 4 wk of sustained transverse aortic constriction + small apical myocardial infarction (TAC+MI) (HF_shDB group), after 2 wk of TAC+MI with 2 wk of de-banding (HF_DB), and in time-matched animals subjected to sham surgeries both for TAC+MI initiation and for de-banding. 6 individual mice were used per group, except for HF_shDB which used 7 mice.
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| Contributor(s) |
Matkovich SJ, Mann DL |
| Citation(s) |
29716898 |
| |
| Submission date |
Dec 01, 2017 |
| Last update date |
Dec 13, 2019 |
| Contact name |
Scot J Matkovich |
| E-mail(s) |
[email protected]
|
| Organization name |
Eli Lilly and Company
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| Street address |
Lilly Corporate Center
|
| City |
Indianapolis |
| State/province |
IN |
| ZIP/Postal code |
46285 |
| Country |
USA |
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| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (19)
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| This SubSeries is part of SuperSeries: |
| GSE107569 |
Load-Dependent Changes in Left Ventricular Gene Expression in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure |
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| Relations |
| BioProject |
PRJNA420795 |
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