GEO DataSets

Analysis of laser-microdissected stromal cells from prostate intraepithelial neoplasias and invasive prostate tumors. Results provide insight into the response of stromal cells to tumor invasion.

Organism:

Mus musculus

Type:

Expression profiling by array, log2 ratio, 2 disease state sets

Platform:

GPL4371

Series:

GSE5945

10 Samples

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(Submitter supplied) Primary and metastatic tumor growth induce host tissue responses that are believed to support tumor progression. Understanding the molecular changes within the tumor microenvironment during tumor progression may therefore be relevant not only for discovering potential therapeutic targets but also for identifying putative molecular signatures that may improve tumor classification and predict clinical outcome. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2443

Platform:

GPL4371

10 Samples

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(Submitter supplied) To identify molecular changes that occur during prostate tumor progression, we have characterized a series of prostate cancer cell lines isolated at different stages of tumorigenesis from C3(1)/Tag transgenic mice.

Organism:

Mus musculus; Homo sapiens

Type:

Expression profiling by array

Platform:

GPL20562

19 Samples

Download data: GPR

(Submitter supplied) Genome-wide copy number changes were monitored using array comparative genomic hybridization (aCGH) of laser-capture microdissected prostate cancer samples spanning stages of prostate cancer progression including precursor lesions, clinically localized disease and metastatic disease. A total of 62 specific cell populations from 38 patients were profiled. Keywords: Disease state analysis using array-based comparatavie genomic hybridization

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL2013

64 Samples

Download data: GPR

(Submitter supplied) Primary tumor growth induces host tissue responses that are believed to support and promote tumor progression. Identification of the molecular characteristics of the tumor microenvironment and elucidation of its crosstalk with tumor cells may therefore be crucial for improving our understanding of the processes implicated in cancer progression, identifying potential therapeutic targets, and uncovering stromal gene expression signatures that may predict clinical outcome. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4114

Platform:

GPL570

24 Samples

Download data: CEL

Analysis of stroma associated with prostate and breast invasive tumors. Stromal reaction (tumor-associated tissue remodeling) occurs in various cancers. Results provide insight into whether this stromal response is largely a generic phenomenon or whether it reflects tumor-specific properties.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 2 tissue sets

Platform:

GPL570

Series:

GSE26910

24 Samples

Download data: CEL

(Submitter supplied) The molecular basis of breast cancer invasion and metastasis is not well understood. Our objective was to analyze transcriptome differences between stromal and epithelial cells in normal breast tissue and invasive breast cancer to define the role stroma plays in invasion. Total RNA was isolated from epithelial and stromal cells that were laser captured from normal breast tissue (n=5) and invasive breast cancer (n=28). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3324

Platform:

GPL571

66 Samples

Download data: CEL

Analysis of epithelium and stroma cells in normal and invasive breast cancer tissues. Information on the role that stroma tissues have on the growth and progression of cancer is limited.Results provide insights into the molecular basis of cancer invasion and metastasis.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 cell type, 2 tissue sets

Platform:

GPL571

Series:

GSE10797

66 Samples

Download data: CEL

(Submitter supplied) Identifying the gene expression alterations that occur in both the tumor and stroma is essential to understanding tumor biology. We have developed a dual-species microarray analysis method that allows the dissection of both tumor and stromal gene expression profiles from xenograft models, based on limited interspecies cross-hybridization on Illumina gene expression beadchips. This methodology allows for simultaneous genome-wide analysis of gene expression profiles of both tumor cells and the associated stromal tissue. more...

Organism:

Mus musculus; Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL10558 GPL6887

18 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Methylation profiling by array

Platforms:

GPL10558 GPL13534

29 Samples

Download data: IDAT

(Submitter supplied) Cancer invasion and metastasis is the most morbid aspect of cancer and is governed by different cellular mechanisms than those driving the deregulated growth of tumors. We addressed here the question of whether a common DNA methylation signature of invasion exists in cancer cells from different origins that differentiates invasive from noninvasive cells. We identified a common DNA methylation signature consisting of hyper- and hypomethylation and determined the overlap of differences in DNA methylation with differences in mRNA expression using expression array analyses. more...

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL13534

17 Samples

Download data: IDAT, TXT

(Submitter supplied) Cancer invasion and metastasis is the most morbid aspect of cancer and is governed by different cellular mechanisms than those driving the deregulated growth of tumors. We addressed here the question of whether a common DNA methylation signature of invasion exists in cancer cells from different origins that differentiates invasive from noninvasive cells. We identified a common DNA methylation signature consisting of hyper- and hypomethylation and determined the overlap of differences in DNA methylation with differences in mRNA expression using expression array analyses. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

12 Samples

Download data: IDAT, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL9551 GPL9550

20 Samples

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(Submitter supplied) To characterize the effects of IGF 1 on CCL171 cells, we cultured pre-starved CCL 171 fibroblasts with or without 50ng/ml IGF 1 for 24 h. We then profiled gene expression changes using Human Exonic Evidence Based Oligonucleotide (HEEBO) microarrays. After stimulation, total RNA was extracted and amplified using a modified Eberwine procedure. The amplified RNA was labeled with the fluorescent dye Cy5 and pooled with Cy3 labeled reference RNA, and then the pooled RNA was hybridized onto HEEBO microarrays. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL9550

4 Samples

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(Submitter supplied) To characterize the effects of IGF 1 on MCF 7 breast cancer cells, we cultured pre-starved MCF 7 cells with or without 50ng/ml IGF 1 for 24 h. We then profiled gene expression changes using Human Exonic Evidence Based Oligonucleotide (HEEBO) microarrays. After stimulation, total RNA was extracted and amplified using a modified Eberwine procedure. The amplified RNA was labeled with the fluorescent dye Cy5 and pooled with Cy3 labeled reference RNA, and then the pooled RNA was hybridized onto HEEBO microarrays. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL9550

4 Samples

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(Submitter supplied) To characterize the effects of IGF 1 on primary breast fibroblasts, we cultured pre-starved primary breast fibroblasts (normal and carcinoma associated) from three patients with or without 50ng/ml IGF 1 for 24 h. We then profiled gene expression changes using Human Exonic Evidence Based Oligonucleotide (HEEBO) microarrays. After stimulation, total RNA was extracted and amplified using a modified Eberwine procedure. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL9551

12 Samples

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(Submitter supplied) Purpose: Multiple studies from last decades have shown that the microenvironment of carcinomas plays an important role in the initiation, progression and metastasis of cancer. Our group has previously identified novel cancer stroma gene expression signatures associated with outcome differences in breast cancer by gene expression profiling of two tumors of fibroblasts as surrogates for physiologic stromal expression patterns. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL10999

53 Samples

Download data: TXT, XLSX

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS2545 GDS2546 GDS2547

Platforms:

GPL8300 GPL93 GPL92

504 Samples

Download data: CEL

(Submitter supplied) Prostate cancer is characterized by heterogeneity in the clinical course that often does not to correlate with morphologic features of the tumor. Metastasis reflects the most adverse outcome of prostate cancer, and to date there are no reliable morphologic features or serum biomarkers that can reliably predict which patients are at higher risk of developing metastatic disease. Understanding the differences in the biology of metastatic and organ confined primary tumors is essential for developing new prognostic markers and therapeutic targets. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2891

31 Samples

Download data: TXT

(Submitter supplied) Prostate cancer is characterized by heterogeneity in the clinical course that often does not to correlate with morphologic features of the tumor. Metastasis reflects the most adverse outcome of prostate cancer, and to date there are no reliable morphologic features or serum biomarkers that can reliably predict which patients are at higher risk of developing metastatic disease. Understanding the differences in the biology of metastatic and organ confined primary tumors is essential for developing new prognostic markers and therapeutic targets. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL93 GPL8300 GPL92

181 Samples

Download data: CEL