GEO DataSets

(Submitter supplied) Catheter-associated urinary tract infections (CAUTIs) account for over 30% of acute nosocomial infections in the U.S. and generate $340 million in healthcare costs annually. A major causative agent of CAUTIs is Proteus mirabilis, an understudied Gram-negative pathogen noted for its ability to form urinary stones via the activity of urease. Urease mutants cannot induce stones and are attenuated in a murine UTI model, indicating this enzyme is essential to P. more...

Organism:

Proteus mirabilis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL33818

18 Samples

Download data: XLSX

(Submitter supplied) Proteus mirabilis is a leading cause of catheter-associated urinary tract infections (UTIs) and urolithiasis. The transcriptional regulator MrpJ inversely modulates two critical aspects of P. mirabilis UTI progression: fimbria-mediated attachment to the urinary tract, and flagella-mediated motility. Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) was used for the first time in a CAUTI pathogen to probe for in vivo direct targets of MrpJ. more...

Organism:

Proteus mirabilis

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL23167

8 Samples

Download data: GFF

(Submitter supplied) The enteric bacterium Proteus mirabilis is a common cause of complicated urinary tract infections. In the study, microrarrays were used to analyze P. mirabilis gene expression in vivo from experimentally infected mice. Urine was collected at 1, 3, and 7d postinfection, and RNA was isolated from bacteria in the urine for transcriptional analysis. Across 9 microarrays, 471 genes were upregulated and 82 were downregulated in vivo compared to in vitro broth culture. more...

Organism:

Proteus mirabilis; Proteus mirabilis HI4320

Type:

Expression profiling by array

Platform:

GPL9078

9 Samples

Download data: MEV