GEO DataSets

(Submitter supplied) Here we conducted a temporal analysis of the transcriptomic and microRNA changes in the ventral CA3 of rats that develop (HS group) or not-develop (HNS group) seizures after hyperthermic insult on the eleventh postnatal day. The selected time intervals corresponded to acute, latent, and chronic phases of the disease.

Organism:

Rattus norvegicus

Type:

Non-coding RNA profiling by array

Platforms:

GPL14746 GPL22696

121 Samples

Download data: TXT

(Submitter supplied) This study aimed to identify the genomic differences - through differential gene expression, miRNAs, and WGCNA transcriptional modules among animals with or without seizure after insult and non-insulted controls.

Organism:

Rattus norvegicus

Type:

Non-coding RNA profiling by array

Platform:

GPL14746

16 Samples

Download data: TXT

(Submitter supplied) This study aimed to identify the genomic differences - through differential gene expression, miRNAs, and WGCNA transcriptional modules among animals with or without seizure after insult and non-insulted controls.

Organism:

Rattus norvegicus

Type:

Non-coding RNA profiling by array

Platform:

GPL14746

15 Samples

Download data: TXT

(Submitter supplied) This study aimed to identify the genomic differences - through differential gene expression, miRNAs, and WGCNA transcriptional modules among animals with or without seizure after insult and non-insulted controls.

Organism:

Rattus norvegicus

Type:

Non-coding RNA profiling by array

Platform:

GPL14746

15 Samples

Download data: TXT

(Submitter supplied) This study aimed to identify the genomic differences - through differential gene expression, miRNAs, and WGCNA transcriptional modules among animals with or without seizure after insult and non-insulted controls.

Organism:

Rattus norvegicus

Type:

Non-coding RNA profiling by array

Platform:

GPL14746

17 Samples

Download data: TXT

(Submitter supplied) This study aimed to identify the genomic differences - through differential gene expression, miRNAs, and WGCNA transcriptional modules among animals with or without seizure after insult and non-insulted controls.

Organism:

Rattus norvegicus

Type:

Non-coding RNA profiling by array

Platform:

GPL22696

20 Samples

Download data: TXT

(Submitter supplied) This study aimed to identify the genomic differences - through differential gene expression, miRNAs, and WGCNA transcriptional modules among animals with or without seizure after insult and non-insulted controls.

Organism:

Rattus norvegicus

Type:

Non-coding RNA profiling by array

Platform:

GPL22696

20 Samples

Download data: TXT

(Submitter supplied) This study aimed to identify the genomic differences - through differential gene expression, miRNAs, and WGCNA transcriptional modules among animals with or without seizure after insult and non-insulted controls.

Organism:

Rattus norvegicus

Type:

Non-coding RNA profiling by array

Platform:

GPL22696

18 Samples

Download data: TXT

(Submitter supplied) We analyzed the transcriptomic profile of CA3 explants surgically obtained from patients with refractory MTLE (mesial temporal lobe epilepsy) and HS (hippocampal sclerosis) in order to investigate if the initial precipitating injury (IPI) influences the molecular mechanisms underlying this condition. CA3 transcriptomic profile was found to be significantly different in cases with prolonged febrile seizures as the IPI (identified here as FS) when compared to correspondent data from cases without febrile seizure history (NFS).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

18 Samples

Download data: TXT

(Submitter supplied) Febrile seizures are the most prevalent type of seizures among children up to 5 years of age (2-4% of Western-European children). Complex febrile seizures are associated with an increased risk to develop temporal lobe epilepsy. To investigate short- and long-term effects of experimental febrile seizures (eFS), we induced eFS in highly febrile convulsion-susceptible C57BL/6J mice at post-natal day 10 by exposure to hyperthermia (HT) and compared them to normotherm-exposed (NT) mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL14726

49 Samples

Download data: TXT

(Submitter supplied) We carried out Next Generation Sequencing (NGS) to reveal miRNA expression profiles of 16 patients with mTLE+HS and 8 post mortem controls (with median coverage of 10.8 million of unprocessed reads per sample). The sequencing platform identified 1962 miRNA species, out of which 422 miRNAs were present with the coverage of more than 500 reads altogether in all samples. We discovered 9 miRNAs potentially related to mTLE+HS that have not yet been associated with epilepsy.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL18573

24 Samples

Download data: TXT

(Submitter supplied) Increased miR-135a levels are observed in human patients with temporal lobe Epilepsy (TLE) and in experimental animal models. Upon targeting the increased miR-135a levels in vivo using antagomirs in kainic acid induced status epilepticus mouse model of TLE, we observed a strong reduction of spontaneous recurrent seizures. To understand this further and to find target mRNAs that potentially mediate the seizure suppressive function of miR-135a, we performed immunoprecipitation using biotin tagged miRNA mimics, followed by RNAsequencing (RNAseq). more...

Organism:

Mus musculus

Type:

Other

Platform:

GPL19057

12 Samples

Download data: TXT