Similar studies for GEO DataSets (Select 200172352) - GEO DataSets

(Submitter supplied) Differential expression of prostatic fibroblasts were determined using RNA-sequencing of FACS sorted fibroblasts from normal human prostate transition and peripheral.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
9 Samples

Download data: TXT

Series

Accession:: GSE172347

ID:: 200172347

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001723166.

Single-cell RNA-sequencing of adult human prostates from organ donors v2

(Submitter supplied) Single-cell RNA-sequencing was conducted on heterogeneous human prostates FACS sorted for viability from organ donors (with no known prostatic diseases) on the 10x Genomics platform.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
6 Samples

Download data: H5

Series

Accession:: GSE172316

ID:: 200172316

PubMed Full text in PMC Similar studies

Select item 2001723017.

Single-cell RNA-sequencing of adult human prostates from BPH patients (glandular and stromal phenothpes)

(Submitter supplied) Single-cell RNA-sequencing was conducted on heterogeneous human prostates from BPH patients on the 10x Genomics platform.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL18573
13 Samples

Download data: H5

Series

Accession:: GSE172301

ID:: 200172301

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2002415568.

Single-cell RNA sequencing of human prostate basal epithelial cells reveals zone-specific cellular populations and gene expression signatures

(Submitter supplied) Prostatic basal cells have been implicated in differentiation and proliferation during prostate development and regeneration; however, the contribution of zonal variation and the critical role of basal cells in prostatic disease etiology is not well understood. Using single-cell RNA sequencing of primary prostate epithelial cultures, we elucidated organ-specific, zone-specific, and cluster-specific gene expression differences in basal cells isolated from human prostate and seminal vesicle (SV).

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
8 Samples

Download data: CSV, MTX, TSV

Series

Accession:: GSE241556

ID:: 200241556

PubMed Similar studies

Select item 2001459299.

Single-cell RNA-sequencing of adult mouse lower urinary tracts

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
6 Samples

Download data: H5

Series

Accession:: GSE145929

ID:: 200145929

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Select item 20014592810.

Single-cell RNA-sequencing of adult human prostates and urethra (normal and diseased)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
9 Samples

Download data: H5

Series

Accession:: GSE145928

ID:: 200145928

PubMed Full text in PMC Similar studies

Select item 20014586511.

Single-cell RNA-sequencing of adult mouse urethra

(Submitter supplied) Single-cell RNA-sequencing was conducted on heterogeneous mouse urethra on the 10x Genomics platform.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
2 Samples

Download data: H5

Series

Accession:: GSE145865

ID:: 200145865

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014586112.

Single-cell RNA-sequencing of adult mouse prostates

(Submitter supplied) Single-cell RNA-sequencing was conducted on heterogeneous mouse prostates on the 10x Genomics platform.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
4 Samples

Download data: H5

Series

Accession:: GSE145861

ID:: 200145861

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014584313.

Single-cell RNA-sequencing of adult human prostates from organ donors

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
6 Samples

Download data: H5

Series

Accession:: GSE145843

ID:: 200145843

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014583814.

Single-cell RNA-sequencing of adult human prostates from BPH patients

(Submitter supplied) Single-cell RNA-sequencing was conducted on heterogeneous human prostates FACS sorted for viability from BPH patients on the 10x Genomics platform.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
3 Samples

Download data: H5

Series

Accession:: GSE145838

ID:: 200145838

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016574115.

Single cell atlas of epithelial and stromal cell heterogeneity by lobe and strain in the mouse prostate

(Submitter supplied) Evaluating the complex interplay of cell types in the tissue microenvironment is critical to understanding the origin and progression of diseases in the prostate and potential opportunities for intervention. Mouse models are an essential tool to investigate the molecular and cell-type-specific contributions of prostate disease at an organismal level. While there are well-documented differences in the extent, timing, and nature of disease development in various genetically engineered and exposure-based mouse models in different mouse strains and prostate lobes within each mouse strain, the underlying molecular phenotypic differences in cell types across mouse strains and prostate lobes are incompletely understood.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
20 Samples

Download data: MTX, TSV

Series

Accession:: GSE165741

ID:: 200165741

PubMed Similar studies SRA Run Selector

Select item 20011563116.

Gene expression profiling of prostate basal cells at proximal and distal ducts

(Submitter supplied) We have noticed that the proliferative potential of epithelial cells in the mouse proximal prostatic ducts is less than those at the distal prostatic ducts. To determine whether specific signaling is differentially activated in distal and proximal prostate basal cells, we isolated respective basal cells in the two regions and performed an RNA-seq analysis.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL9185
6 Samples

Download data: TXT

Series

Accession:: GSE115631

ID:: 200115631

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011546717.

Gene expression profiling of mouse prostate stromal cells with beta-catenin S37A mutation

(Submitter supplied) To identify such inhibitory signaling mediated by the stromal cells with active Wnt activity, we performed an RNA-seq analysis comparing the gene expression profiles of primarily cultured adult mouse prostate stromal cells that express S37A β-Catenin and the control cells that only express GFP. We identified 783 genes that were differentially expressed by at least 1.2 fold (Fig. 4A). Genes associated with the Wnt receptor signaling pathway were enriched in the S37A β-catenin group, corroborating the higher Wnt activity in this group.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL9185
6 Samples

Download data: TAB

Series

Accession:: GSE115467

ID:: 200115467

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007231818.

FACS-isolated Lin-CD24-CD49f-Sca-1+stromal cells from adult mouse proximal and distal prostatic ducts

(Submitter supplied) We have noticed that the proliferative potential of epithelial cells in the mouse proximal prostatic ducts is less than those at the distal prostatic ducts. We were curious whether the tissue microenvironment in the two anatomic regions play a role in the distinct epithelial proliferative indices. So we isolated respective stromal cells in the two regions and performed an RNA-seq analysis.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL9185
4 Samples

Download data: TAB

Series

Accession:: GSE72318

ID:: 200072318

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20019093819.

Ablating Lgr5-expressing prostatic stromal cells activates the ERK-mediated mechanosensory signaling and disrupts prostate tissue homeostasis

(Submitter supplied) The heterogeneity of the prostate stromal cells is widely appreciated but the functional implication remains incompletely understood. Using genetic lineage tracing and light-sheet imaging, we show that some fibroblast cells near the junction of the mouse proximal prostatic ducts and prostatic urethra highly express Lgr5. Genetic ablation of these anatomically restricted stromal cells, but not nonselective ablation of prostatic stromal cells, rapidly induces prostate epithelial turnover and dedifferentiation that are reversed following spontaneous restoration of the Lgr5+ stromal cells. more...