Similar studies for GEO DataSets (Select 200094700) - GEO DataSets

Select item 2000947001.

The Increased Toxicity of UV-Degraded Nitroguanidine and IMX-101 Exposures in Zebrafish Larvae: Evidence Implicating Oxidative Stress

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL23036
130 Samples

Download data: TXT

Series

Accession:: GSE94700

ID:: 200094700

Select item 2000946212.

The Increased Toxicity of UV-Degraded Nitroguanidine and IMX-101 Exposures in Zebrafish Larvae: Evidence Implicating Oxidative Stress [6]

(Submitter supplied) Abstract — Insensitive munitions (IMs) improve soldier safety by decreasing sympathetic detonation during training and use in theatre. The environmental effects of IM constituents such as nitroguanidine (NQ) and IM mixture formulations such as IMX-101 remain largely unknown. In the present study, we investigated the acute (96h) toxicity of NQ and IMX-101 to zebrafish larvae, both in the parent IMs and in IMs irradiated with environmentally-relevant levels of ultraviolet (UV) energy. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL23036
28 Samples

Download data: TXT

Series

Accession:: GSE94621

ID:: 200094621

Select item 2000946203.

The Increased Toxicity of UV-Degraded Nitroguanidine and IMX-101 Exposures in Zebrafish Larvae: Evidence Implicating Oxidative Stress [5]

(Submitter supplied) Abstract — Insensitive munitions (IMs) improve soldier safety by decreasing sympathetic detonation during training and use in theatre. The environmental effects of IM constituents such as nitroguanidine (NQ) and IM mixture formulations such as IMX-101 remain largely unknown. In the present study, we investigated the acute (96h) toxicity of NQ and IMX-101 to zebrafish larvae, both in the parent IMs and in IMs irradiated with environmentally-relevant levels of ultraviolet (UV) energy. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL23036
16 Samples

Download data: TXT

Series

Accession:: GSE94620

ID:: 200094620

Select item 2000946184.

The Increased Toxicity of UV-Degraded Nitroguanidine and IMX-101 Exposures in Zebrafish Larvae: Evidence Implicating Oxidative Stress [4]

(Submitter supplied) Abstract — Insensitive munitions (IMs) improve soldier safety by decreasing sympathetic detonation during training and use in theatre. The environmental effects of IM constituents such as nitroguanidine (NQ) and IM mixture formulations such as IMX-101 remain largely unknown. In the present study, we investigated the acute (96h) toxicity of NQ and IMX-101 to zebrafish larvae, both in the parent IMs and in IMs irradiated with environmentally-relevant levels of ultraviolet (UV) energy. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL23036
16 Samples

Download data: TXT

Series

Accession:: GSE94618

ID:: 200094618

Select item 2000946165.

The Increased Toxicity of UV-Degraded Nitroguanidine and IMX-101 Exposures in Zebrafish Larvae: Evidence Implicating Oxidative Stress [3]

(Submitter supplied) Abstract — Insensitive munitions (IMs) improve soldier safety by decreasing sympathetic detonation during training and use in theatre. The environmental effects of IM constituents such as nitroguanidine (NQ) and IM mixture formulations such as IMX-101 remain largely unknown. In the present study, we investigated the acute (96h) toxicity of NQ and IMX-101 to zebrafish larvae, both in the parent IMs and in IMs irradiated with environmentally-relevant levels of ultraviolet (UV) energy. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL23036
32 Samples

Download data: TXT

Series

Accession:: GSE94616

ID:: 200094616

Select item 2000946156.

The Increased Toxicity of UV-Degraded Nitroguanidine and IMX-101 Exposures in Zebrafish Larvae: Evidence Implicating Oxidative Stress [2]

(Submitter supplied) Abstract — Insensitive munitions (IMs) improve soldier safety by decreasing sympathetic detonation during training and use in theatre. The environmental effects of IM constituents such as nitroguanidine (NQ) and IM mixture formulations such as IMX-101 remain largely unknown. In the present study, we investigated the acute (96h) toxicity of NQ and IMX-101 to zebrafish larvae, both in the parent IMs and in IMs irradiated with environmentally-relevant levels of ultraviolet (UV) energy. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL23036
20 Samples

Download data: TXT

Series

Accession:: GSE94615

ID:: 200094615

Select item 2000946147.

The Increased Toxicity of UV-Degraded Nitroguanidine and IMX-101 Exposures in Zebrafish Larvae: Evidence Implicating Oxidative Stress [1]

(Submitter supplied) Abstract — Insensitive munitions (IMs) improve soldier safety by decreasing sympathetic detonation during training and use in theatre. The environmental effects of IM constituents such as nitroguanidine (NQ) and IM mixture formulations such as IMX-101 remain largely unknown. In the present study, we investigated the acute (96h) toxicity of NQ and IMX-101 to zebrafish larvae, both in the parent IMs and in IMs irradiated with environmentally-relevant levels of ultraviolet (UV) energy. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL23036
18 Samples

Download data: TXT

Series

Accession:: GSE94614

ID:: 200094614

Select item 2001018908.

Transcriptomics Provides Mechanistic Indicators of Mixture Toxicology for IMX-101 and IMX-104 Formulations in Fathead Minnows (Pimephales promelas)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Pimephales promelas

Type:: Expression profiling by array

Platform:: GPL17098
60 Samples

Download data: TXT

Series

Accession:: GSE101890

ID:: 200101890

Select item 2001018899.

Transcriptomics Provides Mechanistic Indicators of Mixture Toxicology for IMX-101 and IMX-104 Formulations in Fathead Minnows (Pimephales promelas) [IMX-104]

(Submitter supplied) Abstract — Within the US military, new insensitive munitions (IMs) are rapidly replacing conventional munitions improving safety from unintended detonation. Toxicity data for IM chemicals are expanding rapidly, however IM constituents are typically deployed in mixture formulations, and very little is known about their mixture toxicology. In the present study we sought to characterize the mixture effects and toxicology of the two predominant IM formulations IMX-101 and IMX-104 in acute (48 h) larval fathead minnow (Pimephales promelas) exposures. more...

Organism:: Pimephales promelas

Type:: Expression profiling by array

Platform:: GPL17098
12 Samples

Download data: TXT

Series

Accession:: GSE101889

ID:: 200101889

Select item 20010188810.

Transcriptomics Provides Mechanistic Indicators of Mixture Toxicology for IMX-101 and IMX-104 Formulations in Fathead Minnows (Pimephales promelas) [IMX-101]

(Submitter supplied) Abstract — Within the US military, new insensitive munitions (IMs) are rapidly replacing conventional munitions improving safety from unintended detonation. Toxicity data for IM chemicals are expanding rapidly, however IM constituents are typically deployed in mixture formulations, and very little is known about their mixture toxicology. In the present study we sought to characterize the mixture effects and toxicology of the two predominant IM formulations IMX-101 and IMX-104 in acute (48 h) larval fathead minnow (Pimephales promelas) exposures. more...

Organism:: Pimephales promelas

Type:: Expression profiling by array

Platform:: GPL17098
12 Samples

Download data: TXT

Series

Accession:: GSE101888

ID:: 200101888

Select item 20010188711.

Transcriptomics Provides Mechanistic Indicators of Mixture Toxicology for IMX-101 and IMX-104 Formulations in Fathead Minnows (Pimephales promelas) [NQ]

(Submitter supplied) Abstract — Within the US military, new insensitive munitions (IMs) are rapidly replacing conventional munitions improving safety from unintended detonation. Toxicity data for IM chemicals are expanding rapidly, however IM constituents are typically deployed in mixture formulations, and very little is known about their mixture toxicology. In the present study we sought to characterize the mixture effects and toxicology of the two predominant IM formulations IMX-101 and IMX-104 in acute (48 h) larval fathead minnow (Pimephales promelas) exposures. more...

Organism:: Pimephales promelas

Type:: Expression profiling by array

Platform:: GPL17098
12 Samples

Download data: TXT

Series

Accession:: GSE101887

ID:: 200101887

Select item 20010188612.

Transcriptomics Provides Mechanistic Indicators of Mixture Toxicology for IMX-101 and IMX-104 Formulations in Fathead Minnows (Pimephales promelas) [NTO]

(Submitter supplied) Abstract — Within the US military, new insensitive munitions (IMs) are rapidly replacing conventional munitions improving safety from unintended detonation. Toxicity data for IM chemicals are expanding rapidly, however IM constituents are typically deployed in mixture formulations, and very little is known about their mixture toxicology. In the present study we sought to characterize the mixture effects and toxicology of the two predominant IM formulations IMX-101 and IMX-104 in acute (48 h) larval fathead minnow (Pimephales promelas) exposures. more...

Organism:: Pimephales promelas

Type:: Expression profiling by array

Platform:: GPL17098
12 Samples

Download data: TXT

Series

Accession:: GSE101886

ID:: 200101886

Select item 20010187013.

Transcriptomics Provides Mechanistic Indicators of Mixture Toxicology for IMX-101 and IMX-104 Formulations in Fathead Minnows (Pimephales promelas) [DNAN]

(Submitter supplied) Abstract — Within the US military, new insensitive munitions (IMs) are rapidly replacing conventional munitions improving safety from unintended detonation. Toxicity data for IM chemicals are expanding rapidly, however IM constituents are typically deployed in mixture formulations, and very little is known about their mixture toxicology. In the present study we sought to characterize the mixture effects and toxicology of the two predominant IM formulations IMX-101 and IMX-104 in acute (48 h) larval fathead minnow (Pimephales promelas) exposures. more...

Organism:: Pimephales promelas

Type:: Expression profiling by array

Platform:: GPL17098
12 Samples

Download data: TXT

Series

Accession:: GSE101870

ID:: 200101870

Select item 20012787814.

Molecular Evaluation of Impacted Reproductive Physiology in Fathead Minnow Testes Provides Mechanistic Insights into Insensitive Munitions Toxicology (IMX-101)

(Submitter supplied) Abstract — Previous toxicological investigations of the insensitive munition (IM), 3-nitro-1,2,4-triazol-5-one (NTO), demonstrated histopathological and physiological impacts in mammalian testes. The implications of these findings for fish was unknown, therefore we investigated the effects of chronic (21 day) exposures to NTO and an NTO-containing IM formulation called IMX-101 (composed of 2,4-dinitroanisole (DNAN), nitroguanidine (NQ), and NTO) in adult male fathead minnows to assess if impacts on testes were conserved. more...

Organism:: Pimephales promelas

Type:: Expression profiling by array

Platform:: GPL17098
10 Samples

Download data: TXT

Series

Accession:: GSE127878

ID:: 200127878

Select item 20012787715.

Molecular Evaluation of Impacted Reproductive Physiology in Fathead Minnow Testes Provides Mechanistic Insights into Insensitive Munitions Toxicology (NTO)

(Submitter supplied) Abstract — Previous toxicological investigations of the insensitive munition (IM), 3-nitro-1,2,4-triazol-5-one (NTO), demonstrated histopathological and physiological impacts in mammalian testes. The implications of these findings for fish was unknown, therefore we investigated the effects of chronic (21 day) exposures to NTO and an NTO-containing IM formulation called IMX-101 (composed of 2,4-dinitroanisole (DNAN), nitroguanidine (NQ), and NTO) in adult male fathead minnows to assess if impacts on testes were conserved. more...

Organism:: Pimephales promelas

Type:: Expression profiling by array

Platform:: GPL17098
20 Samples

Download data: TXT

Series

Accession:: GSE127877

ID:: 200127877

Select item 20013678216.

Comparative Toxicological Evaluation of the Insensitive Munition (IM) 1-methyl-3-nitroguanidine versus its UV-Degradation Products in Fathead Minnow

(Submitter supplied) Abstract: The Army is replacing traditional munitions with insensitive munitions (IM) resistant to accidental detonation. Although the parent IM compound nitroguanidine (NQ) is generally not acutely toxic at concentrations >1000 mg/L in aquatic exposures, products formed by intensive UV-degradation resulted in of multiple-order of magnitude increase in toxicity. A methylated congener of NQ, 1-methyl-3-nitroguanidine (MeNQ), is also being assessed for potential use in IM explosive formulations and consequently was here investigated for UV-degradation hazard and bioaccumulation potential. more...

Organism:: Pimephales promelas

Type:: Expression profiling by array

Platform:: GPL17098
40 Samples

Download data: TXT

Series

Accession:: GSE136782

ID:: 200136782

Select item 20015492417.

Genomic Investigations of Acute Munitions Exposures on the Health and Skin Microbiome Composition of Leopard Frog (Rana pipiens) Tadpoles

(Submitter supplied) Abstract: Natural communities of microbes inhabiting amphibian skin, the skin microbiome, are critical to supporting amphibian health and disease resistance. To enable the pro-active health assessment and management of amphibians on Army installations and beyond, we investigated the effects of acute (96h) munitions exposures to Rana pipiens (leopard frog) tadpoles and the associated skin microbiome, integrated with RNAseq-based transcriptomic responses in the tadpole host. more...

Organism:: Lithobates pipiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28905
72 Samples

Download data: FASTA, TXT

Series

Accession:: GSE154924

ID:: 200154924

PubMed Similar studies SRA Run Selector

Select item 20016495718.

Mechanistic Evaluation of Reduced Reproduction in Daphnia pulex Exposed to the Insensitive Munition, 1-methyl-3-nitro-1-nitroguanidine (MeNQ)

(Submitter supplied) The US Department of Defense (DOD) is developing insensitive munitions (IMs) that are resistant to unintended detonation to protect warfighters. To enable evaluation of the material life-cycle for the IM, 1-methyl-3-nitro-1-nitroguanidine (MeNQ), ecotoxicological impacts assessment was required. A previous investigation of MeNQ exposures in Daphnia pulex revealed concentration-responsive decreases in reproduction relative to controls (0 mg/L) across a 174, 346, 709, 1385, and 2286 mg/L exposure range. more...

Organism:: Daphnia pulex

Type:: Expression profiling by array

Platform:: GPL29611
24 Samples

Download data: TXT

Series

Accession:: GSE164957

ID:: 200164957

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010105819.

Concentration dependent transcriptome responses of zebrafish embryos after exposure to cadmium, cobalt and copper.

(Submitter supplied) Environmental metals are known to cause harmful effects to fish of which many molecular mechanisms still require elucidation. Particularly concentration dependence of gene expression effects is unclear. Focusing on this matter, zebrafish embryo toxicity tests were used in combination with transcriptomics. Embryos were exposed to three concentrations of copper (CuSO4), cadmium (CdCl2) and cobalt (CoSO4) from just after fertilization until the end of the 48 hpf pre- and 96 hpf post-hatch stage. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL14688
84 Samples

Download data: TXT

Series

Accession:: GSE101058

ID:: 200101058

Select item 20007291820.

Mitochondrial dysfunction, disruption of F-actin polymerization, and transcriptomic alterations in zebrafish larvae exposed to trichloroethylene

(Submitter supplied) Trichloroethylene (TCE) is primarily used as an industrial degreasing agent and has been in use since the 1940s. TCE is released into the soil, surface, and groundwater. From an environmental and regulatory standpoint more than half of Superfund hazardous waste sites on the National Priority List are contaminated with TCE. Occupational exposure to TCE occurs primarily via inhalation, while environmental TCE exposure also occurs through ingestion of contaminated drinking water. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL20834
8 Samples

Download data: TXT, XLSX

Series

Accession:: GSE72918

ID:: 200072918

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