GEO DataSets

(Submitter supplied) Gene expression measurements were carried out in human primary astrocytes treated with either 0.1% DMSO (Control) or 300nM Topotecan for 24h and 48h, to assess the effect of topoisomerase I inhibition on the transcription of long genes.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

12 Samples

Download data: TXT

(Submitter supplied) With gene expression profiling it was aimed to identify the differentially expressed genes associated with the regulation of the cytoskeleton to investigate the stretch-induced cell alignment mechanism. A whole genome microarray based analysis of the stretch-induced gene expression changes was done. Gene expression was measured at the beginning of the alignment process showing first reoriented cells after 5 h stretching and at the end after 24 h, where nearly all cells are aligned. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13607

40 Samples

Download data: TXT

(Submitter supplied) Comparison of the Streptococcus pneumoniae D39 wild-type in CDM Plus 0mM CO and CDM plus 0,5 mM Co

Organism:

Streptococcus pneumoniae D39

Type:

Expression profiling by array

Platform:

GPL11484

2 Samples

Download data: TXT

(Submitter supplied) We utilized whole-genome microarrays (Illumina Mouse WG-6) to measure changes in mRNA abundance levels induced by steroid hormones in primary neurons and astrocytes. To stimulate gene expression we treated neuronal and astroglial cultures with glucocorticoid receptor agonist (dexamethasone), mineralocorticoid (aldosterone), progesterone (progesterone), androgen (5α-dihydrotestosterone) and estrogen 2 (β-estradiol). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL17543

48 Samples

Download data: TXT

(Submitter supplied) Brain inflammation, a common feature in neurodegenerative diseases, is a complex series of events, which can be detrimental and even lead to neuronal death. Nonetheless, several studies suggest that inflammatory signals are also positively influencing neural cell proliferation, survival, migration and differentiation. Recently, correlative studies suggested that astrocytes are able to dedifferentiate upon injury, and may thereby re-acquire neural stem cells (NSC) potential. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

6 Samples

Download data: CEL

(Submitter supplied) This submission comprises RNA-Seq profiling of in vivo differentiated pancreatic beta cells types and primary islet-derived pancreatic beta cell sources. The study reports that re-aggregation of immature beta-like cells (d20Beta) and removal of progenitor cells leads to further maturation in vitro resulting in beta-cells (eBCBeta) that are closer to human primary islet-derived beta-cells(IsletBeta). more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL20301 GPL16791

8 Samples

Download data: TXT

(Submitter supplied) The maize spikelet contains two florets, each of which contains three anthers. Morphologically, the anthers in the upper and lower florets proceed through the same developmental program. To test for global differences in gene expression between these anthers and to identify genes that are coordinately regulated during development, RNA isolated from upper and lower floret anthers at six developmental stages was used to hybridize cDNA microarrays. more...

Organism:

Zea mays

Type:

Expression profiling by array

Datasets:

GDS2474 GDS2475 GDS2477

Platform:

GPL3021

144 Samples

Download data: PDF

Analysis of upper and lower floret anthers at six developmental stages; morphologically, the anthers proceed through the same developmental program. Each array was scanned at multiple intensities. Results reveal enhanced discovery of differentially expressed genes over the single-scan approach.

Organism:

Zea mays

Type:

Expression profiling by array, log ratio, 6 development stage, 12 other sets

Platform:

GPL3021

Series:

GSE3017

24 Samples

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Analysis of upper and lower floret anthers at six developmental stages; morphologically, the anthers proceed through the same developmental program. Each array was scanned at multiple intensities. Results reveal enhanced discovery of differentially expressed genes over the single-scan approach.

Organism:

Zea mays

Type:

Expression profiling by array, log ratio, 6 development stage, 12 other sets

Platform:

GPL3021

Series:

GSE3017

24 Samples

Download data

Analysis of upper and lower floret anthers at six developmental stages; morphologically, the anthers proceed through the same developmental program. Each array was scanned at multiple intensities. Results reveal enhanced discovery of differentially expressed genes over the single-scan approach.

Organism:

Zea mays

Type:

Expression profiling by array, log ratio, 6 development stage, 12 other sets

Platform:

GPL3021

Series:

GSE3017

24 Samples

Download data

(Submitter supplied) The role of G-protein-coupled receptors (GPCRs) in the macrophage polarization remains not well understood. In this study, we illuminate the role of Gpr137b, a GPCR expressed strongly in macrophages, in macrophage polarization. We used RAW264 as a mouse macrophage-like cell line and generated Gpr137b-knockout (KO) cell clones using the CRISPR/Cas9 genome editing system. The Gpr137b-KO and wildtype cells were the treated with interleukin-4 (IL-4) to induce M2 polarization, and their gene expression was analyzed using microarrays.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL23038

8 Samples

Download data: CEL

(Submitter supplied) Soybean is a rich source of protein and oil and a primary feedstock for biodiesel production. Previous research on soybean indicated that protein, oil and yield are controlled quantitatively in soybean seeds. However, genetic mechanisms controlling seed composition and yield in soybean remain unknown. We used Affymetrix Soybean GeneChips® to identify genes that are differentially expressed between developing seeds of the Minsoy and Archer soybean varieties, which differ in seed weight, yield, protein content and oil content. more...

Organism:

Glycine max

Type:

Expression profiling by array

Platform:

GPL4592

54 Samples

Download data: CEL

(Submitter supplied) Noncoding RNAs play important roles in various biological processes and diseases, including cancer. Expression profile of circular RNAs (circRNA) is largely unknown in lung adenocarcinoma. This study is designed to explore mRNA, long noncoding RNA (lncRNA), and circRNA in lung adenocarcinoma.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17303

6 Samples

Download data: TXT

(Submitter supplied) Extremely variable clinic and genetic features characterize Mitochondrial Encephalomyopathy Disorders (MED). Pathogenic mitochondrial DNA (mtDNA) defects can be divided into large-scale rearrangements and single point mutations. Clinical manifestations become evident when a threshold percentage of the total mtDNA is mutated. In some MED, the "mutant load" in an affected tissue is directly related to the severity of the phenotype. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1065

Platform:

GPL96

15 Samples

Download data: CEL

Analysis of muscle from 12 patients with various forms of mitochondrial encephalomyopathies associated with mitochondrial DNA mutations: 8 patients with a A3243G mutation, and 4 patients with a 4977 base pair deletion. Results identify possible expression signature for mitochondrial disorders.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 disease state, 3 genotype/variation sets

Platform:

GPL96

Series:

GSE1462

15 Samples

Download data: CEL

(Submitter supplied) The molecular basis of complex neuropsychiatric disorders most likely involves many genes. In recent years, specific genetic variations influencing risk for schizophrenia and other neuropsychiatric disorders have been reported. We have used custom DNA microarrays and qPCR to investigate the expression of putative schizophrenia susceptibility genes and related genes of interest in the normal human brain. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6893

72 Samples

Download data: TXT

(Submitter supplied) Transcriptome analysis of Wigglesworthia glossinidia endosymbiont derived from uninfected and infected samples at 3 time points (3, 10 and 20 days). Expression profiling by array - Wigglesworthia glossinidia endosymbiont of Glossina morsitans morsitans

Organism:

Wigglesworthia glossinidia endosymbiont of Glossina morsitans

Type:

Expression profiling by array

Platform:

GPL18427

24 Samples

Download data: TXT

(Submitter supplied) Transcriptome analysis of Sodalis glossinidius derived from Trypanosoma brucei gambiense infection self cleared and infected Glossina palpalis gambiensis. At 3 time points (3, 10 and 20 days) after infectived blood meal, flies were analysed by PCR to isolate the infected and infection self cleared flies. Then, infected and infection self cleared flies midgut were dissected for RNA extraction.

Organism:

Sodalis glossinidius

Type:

Expression profiling by array

Platform:

GPL17347

24 Samples

Download data: TXT

(Submitter supplied) Transcriptome analysis of Sodalis glossinidius derived from uninfected (controls) and Trypanosoma brucei gambiense infection self cleared Glossina palpalis gambiensis. 10 days after infectived blood meal, flies anal drop were analysed by PCR to isolate the infected self cleared flies. Then, uninfected (controls) and infection self cleared 10 days-flies midgut were dissected for RNA extraction.

Organism:

Sodalis glossinidius

Type:

Expression profiling by array

Platform:

GPL17347

8 Samples

Download data: TXT

(Submitter supplied) Adenosine binds to 4 G protein-coupled receptors located on the cardiomyocyte (A1-R, A2a-R, A2b-R and A3-R) and modulates cardiac function during both ischemia and load-induced stress. While the role of adenosine receptor-subtypes has been well defined in the setting of ischemia-reperfusion, far less is known regarding their roles in protecting the heart during other forms of cardiac stress. We characterized the gene expression profiles of heart from A2a-R over-expressing mice subjected to transverse aortic constriction to study the potential of A2a-R activation to protect from pressure-induced heart failure.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

6 Samples

Download data: CEL