GEO DataSets

(Submitter supplied) The objective of this study is to assess gene expression changes and identify gene sets associated with chemo-radiotherapy (CRT) in colorectal cancer (CRC) patients. We performed RNA-seq based transcriptome profiling using primary tumor samples obtained from 22 CRC patients. By a number of statistical tests, a total of 575 genes were statistically significant, indicating a gene set profoundly responded to chemo-radiotherapy in CRC. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

22 Samples

Download data: TXT

(Submitter supplied) The identification of surrogate methylation markers that can predict responses to preoperative chemoradiotherapy (CRT) in rectal cancer patients. Genome-wide association studies in clinical populations are theoretically capable of identifying markers that are capable of tumor regression after CRT. We used Infinium® Methylation Assay to detail methylation status of patient’s group showing differential responsiveness to preoperative CRT and profiled SNP biomarkers. more...

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL13534

45 Samples

Download data: TXT

(Submitter supplied) The identification of surrogate single nucleotide polymorphism (SNP) markers that can predict responses to preoperative chemoradiotherapy (CRT) in rectal cancer patients. Genome-wide association studies in clinical populations are theoretically capable of identifying markers that are capable of tumor regression after CRT. We used Affymetrix’s SNP Array 6.0 to detail genetic polymorphism of patient’s group showing differential responsiveness to preoperative CRT and profiled SNP biomarkers.

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array; SNP genotyping by SNP array

Platform:

GPL6801

43 Samples

Download data: CEL, CHP

(Submitter supplied) To determine a preditcive marker of treatment resistance for rectal cancer, we have employed a microarray gene profiling analysis on pretreated rectal biopsies and compared with their response to therapy as defined by the American Joint Commission on Cancer (AJCC) and the American College of Pathologists.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6102

33 Samples

Download data: IDAT

(Submitter supplied) Gene expression analysis identified a CRC related signature of differentially expressed genes discriminating patients Responder and Non Responder to radiochemotherapy Gene expression signatures of CRC samples Responder and Non Responder to radiochemotherapy were analyzed using supervised analyses

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL4133 GPL570

80 Samples

Download data: CEL, TXT

(Submitter supplied) Using Human WG CodeLink microarrays, we established the expression profiling of 26 LARC without metastasis to gain insight into the molecular signatures associated with response to treatment after CRT.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL18134

26 Samples

Download data: TXT

(Submitter supplied) gene expression profiling of locally invasive breast carcinomas treated with preoperative radiotherapy the purose of this study was to establish molecular signature associated with response to radiotherapy using radiotherapy-naïve biopsies of locally advanced breast cancer

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16699

24 Samples

Download data: TXT

(Submitter supplied) Treatment-related morbidities have been linked to the large post-operative treatment volumes required for external beam partial breast irradiation (PBI). Alternative PBI techniques require equipment that is not readily available. To address these issues, we designed a phase I trial utilizing widely available technology to 1) evaluate the safety of a single radiation treatment delivered preoperatively to the small-volume, intact breast tumor and 2) identify imaging and genomic markers of radiation response.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17586

62 Samples

Download data: CEL

(Submitter supplied) Introduction: Breast radiotherapy is currently “one size fits all” regardless of breast cancer subtype (eg. luminal, basal). However, recent clinical data suggests that radiation response may vary significantly among subtypes. Therefore, current practice leads to over- or under-treatment of women whose tumors are more or less radiation responsive. We hypothesized that this clinical variability may be due, in part, to differences in cellular radiation response. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

96 Samples

Download data: CEL

(Submitter supplied) The goal of this work is to find robust predictors of tumor response to preoperative chemoradiotherapy in LARC patients. Preoperative chemoradiotherapy (pCRT) followed by surgery is the standard treatment for locally advanced rectal cancer (LARC). However, tumour response to pCRT is not uniform and there are no effective predictive methods. This study investigated whether specific gene and miRNA expression is associated with response to pCRT. more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL10850 GPL6480

125 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome variation profiling by array

Platforms:

GPL11357 GPL17077

16 Samples

Download data: TXT

(Submitter supplied) Prostate cancer cell lines DU145 and LNCaP were purchased from the American Type Culture Collection. Radioresistant (RR) sublines were generated form these original parental radiosensitive (RS) cell lines. Gene expression profiles of radiosensitive (RS) and radioresistant (RR) prostate cancer cell lines were measured.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17077

12 Samples

Download data: TXT

(Submitter supplied) Prostate cancer cell lines DU145 and LNCaP were purchased from the American Type Culture Collection. Radioresistant (RR) sublines were generated form these original parental radiosensitive (RS) cell lines. aCGH profiles of radiosensitive (RS) and radioresistant (RR) prostate cancer cell lines were measured and compared to normal DNA.

Organism:

Homo sapiens

Type:

Genome variation profiling by array

Platform:

GPL11357

4 Samples

Download data: TXT

(Submitter supplied) Biopsy specimens were collected from rectal cancer before starting preoperative radiotherapy.The expression profiles were determined using Affymetrix Human Genome U95 version 2 arrays.Comparison between the sample groups allow to identify a set of discriminating genes that can be used for characterization of responders and nonresponders to preoperative radiotherapy in rectal cancer. Keywords: repeat

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1887

Platform:

GPL8300

46 Samples

Download data

Analysis of rectal cancer cells from patients prior to preoperative radiotherapy. Response to radiotherapy determined by histopathologic examination of resected specimens. Results identify gene markers for the characterization and prediction of the response to radiotherapy in rectal cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 2 protocol sets

Platform:

GPL8300

Series:

GSE3493

46 Samples

Download data

(Submitter supplied) In this study, we use cancer cell lines to investigate the molecular differences between resistant and responsive colorectal cancer cells. Since the treatment of patients with locally advanced rectal cancers involves chemoradiotherapy (CT/RT), we specifically implemented an in vitro protocol that mimics this clinical setting. We anticipate that this analysis will unveil relevant pathways underlying the resistance of rectal cancers to CT/RT, and enable the identification of novel therapeutic target genes.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

44 Samples

Download data: TXT

(Submitter supplied) We used microarrays to measure the expression levels of genes in irradiated immortalized B cells, lymphoblastoid cells, from members of Centre d'Etude du Polymorphisme Humain (CEPH) Utah pedigrees. Data were collected for cells at baseline and 2 hours and 6 hours after exposure to 10 Gy of ionizing radiation (IR).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

1086 Samples

Download data: CEL, CHP