Similar studies for GEO DataSets (Select 200070791) - GEO DataSets

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Items: 16

Select item 2000707911.

PAK1 is a Therapeutic Target in Acute Myeloid Leukemia and Myelodysplastic Syndrome

(Submitter supplied) Poor clinical outcome of Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) has been attributed to failure of current chemotherapeutic regimens to target leukemic stem cells. We recently identified p21-activated kinase (PAK1) as a downstream effector molecule of H2.0-like homeobox (HLX), a gene functionally relevant for AML pathogenesis. In this study, we find that inhibition of PAK1 activity by small molecule inhibitors or by RNA interference leads to profound leukemia-inhibitory effects both in vitro and in vivo. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
8 Samples

Download data: CEL, CHP

Series

Accession:: GSE70791

ID:: 200070791

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000420542.

Diverse phospho-signaling networks mediate RTK dependent growth and survival in childhood ALL [copy number]

(Submitter supplied) Deregulated RTK activity has been implicated as a causal leukemogenic factor in the context of molecular aberrations that perturb differentiation in the hematopoietic lineage such as in childhood ALL. A deeper understanding of RTK signaling processes on a system-wide scale will be key in defining critical components of signaling networks. To link RTK activity with in vivo output in primary ALL we took a functional approach, which combined SH2 domain binding, mass spectrometry, and transcriptome analyses. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by SNP array

Platform:: GPL6801
12 Samples

Download data: CEL, TXT

Series

Accession:: GSE42054

ID:: 200042054

PubMed Full text in PMC Similar studies

Select item 2000420403.

Diverse phospho-signaling networks mediate RTK dependent growth and survival in childhood ALL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome variation profiling by SNP array

Platforms:: GPL6801 GPL570
115 Samples

Download data: CEL, CHP

Series

Accession:: GSE42040

ID:: 200042040

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000420384.

Transcriptome profiling of T-lymphoblastic leukemia of childhood [gene expression]

(Submitter supplied) The purpose of this study was the principal investigation and frequency of RTK expression in primary T-ALLs. Primary initial T-ALLs were assessed regarding their transcriptome-wide expression profiles and screend for prominent RTK expression.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
79 Samples

Download data: CEL

Series

Accession:: GSE42038

ID:: 200042038

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000420015.

Diverse phospho-signaling networks mediate RTK dependent growth and survival in childhood ALL [gene expression]

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
24 Samples

Download data: CEL, CHP

Series

Accession:: GSE42001

ID:: 200042001

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000350106.

Expression data from human hematopoietic stem and progenitor compartments from patients with acute myeloid leukemia with monosomy 7 and healthy controls

(Submitter supplied) We applied a novel approach of parallel transcriptional analysis of multiple, highly fractionated stem and progenitor populations in a genetically defined subset of AML (AML with monosomy 7). We isolated phenotypic long-term HSC (LT-HSC), short-term HSC (ST-HSC), and committed granulocyte-monocyte progenitors (GMP) from individual patients with AML, and measured gene expression profiles of each population, and in comparison to their phenotypic counterparts from age-matched healthy controls.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
31 Samples

Download data: CEL

Series

Accession:: GSE35010

ID:: 200035010

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000350087.

Expression data from human hematopoietic stem and progenitor compartments from patients with acute myeloid leukemia with normal karyotype and healthy controls

(Submitter supplied) We applied a novel approach of parallel transcriptional analysis of multiple, highly fractionated stem and progenitor populations from patients with acute myeloid leukemia (AML) and a normal karyotype. We isolated phenotypic long-term HSC (LT-HSC), short-term HSC (ST-HSC), and committed granulocyte-monocyte progenitors (GMP) from individual patients, and measured gene expression profiles of each population, and in comparison to their phenotypic counterparts from age-matched healthy controls.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
28 Samples

Download data: CEL

Series

Accession:: GSE35008

ID:: 200035008

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001148698.

Long non-coding RNA HOXB-AS3 promotes myeloid cell proliferation and its higher expression is an adverse prognostic marker in myeloid malignancies [MDS_normal]

(Submitter supplied) The mononucleated cells were collected from the bone marrow samples of MDS patients and healthy controls. We compared the expressions between MDS patients and the healthy controls.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17586
320 Samples

Download data: CEL

Series

Accession:: GSE114869

ID:: 200114869

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001148689.

Long non-coding RNA HOXB-AS3 promotes myeloid cell proliferation and its higher expression is an adverse prognostic marker in myeloid malignancies [AML_normal]

(Submitter supplied) The mononucleated cells were collected from the bone marrow samples of AML patients and healthy controls. We compared the expressions between AML patients and the healthy controls.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17586
214 Samples

Download data: CEL

Series

Accession:: GSE114868

ID:: 200114868

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20011482310.

HOXB-AS3 expressions promote cell proliferation

(Submitter supplied) We knock down HOXB-AS3 with shRNA in OCI/AML3 cell line to investigate the downstream pathways of HOXB-AS3 in the cell proliferation.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17586
4 Samples

Download data: CEL

Series

Accession:: GSE114823

ID:: 200114823

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013111311.

NKL homeobox gene activity in normal and malignant myeloid cells

(Submitter supplied) Recently, we have reported a hematopoietic NKL-code which describes normal expression patterns of NKL homeobox genes in early hematopoiesis and lymphopoiesis including T-cell, B-cell and NK-cell development. This code allows the identification of deregulated NKL homeobox genes in lymphoid malignancies. Here, we report normal activities of NKL homeobox genes in myelopoiesis, thus, extending the NKL-code for the hematopoietic system. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
4 Samples

Download data: CEL

Series

Accession:: GSE131113

ID:: 200131113

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003002912.

Gene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML

(Submitter supplied) Mononuclear cells from AML patients (n=46) were sorted into CD34+ and CD34- subfractions and genome-wide expression analysis was performed using Illumina BeadChip Arrays (HT12 v3). Of 2 AML samples only the CD34+ fraction could be analyzed. AML CD34+ and CD34- gene expression was compared to a large group of normal CD34+ bone marrow cells (n=31).

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
121 Samples

Download data: TXT

Series

Accession:: GSE30029

ID:: 200030029

Select item 20006892513.

RNAi profiling of primary human AML cells identifies ROCK1 as a therapeutic target and nominates Fasudil as an anti-leukemic drug.

(Submitter supplied) Acute myeloid leukemia (AML) is characterized by a marked genetic heterogeneity, which complicates the development of novel therapeutics. The delineation of pathways essential within the patient-individual mutational background might overcome this limitation and facilitate personalized treatment. We report the results of a large-scale lentiviral loss-offunction RNA-interference-(RNAi)-screen in primary leukemic cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome variation profiling by high throughput sequencing; Other

Platform:: GPL11154
10 Samples

Download data: TXT, VCF

Series

Accession:: GSE68925

ID:: 200068925

Select item 20002794714.

Identification of differentially regulated genes in hematopoietic stem cells and URE leukemia cell line

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
12 Samples

Download data: CEL

Series

Accession:: GSE27947

ID:: 200027947

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002793915.

Identification of differentially regulated genes upon shRNA-mediated knock-down of HLX in the URE leukemia cell line

(Submitter supplied) To study the role of Hlx in hematopoietic differentiation and tumorigenesis, URE cells were infected with short-hairpin-containing pSIH1-H1-copGFP lentiviral vector (System Biosciences, Mountain View, CA) containing either nucleotide sequences targeting luciferase (shControl) or HLX (shHLX). After 24hrs incubation in Iscove’s modified Dulbecco’s medium (IMDM) containing FBS, mIL-3, mIL-6 and mSCF with lentiviral supernatants in the presence of 8ug/ml polybrene, cells were cultured in fresh medium for several days. more...