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Links from GEO DataSets

Items: 20

1.

FOXP1 inhibits cell growth and attenuates tumorigenicity of neuroblastoma

(Submitter supplied) Single-color gene expression profiles from 3 neuroblastoma cell lines were generated using 44K oligonucleotide microarrays. To gain insights into the molecular processes occurring upon FOXP1 re-expression, we performed series of time-resolved gene expression measurements in FOXP1 and GFP transgenic neuroblastoma cell lines.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16876
24 Samples
Download data: TXT
Series
Accession:
GSE62419
ID:
200062419
2.

GRHL1 acts as a tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3

(Submitter supplied) Neuroblastoma is an embryonic solid tumor of neural crest origin and accounts for 11% of all cancer-related deaths in children. Novel therapeutic strategies are therefore urgently required. MYCN oncogene amplification, which occurs in 20% of neuroblastomas, is a hallmark of high risk. Here we aimed to exploit molecular mechanisms that can be pharmacologically addressed with epigenetically modifying drugs, such as histone deacetylase (HDAC) inhibitors. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5263
Platform:
GPL10558
12 Samples
Download data: TXT
Series
Accession:
GSE47407
ID:
200047407
3.
Full record GDS5263

Enforced Grainyhead-like 1 expression effect on BE(2)-C neuroblastoma cell line: time course

Analysis of BE(2)-C cells up to 72 hrs after transient transfection with construct pTRex-GRHL1. The three mammalian GRHL genes (GRHL1, -2, and -3) represent a highly conserved family of β-scaffold transcription factors. Results provide insight into the role of GRHL1 in neuroblastoma biology.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 protocol, 3 time sets
Platform:
GPL10558
Series:
GSE47407
12 Samples
Download data
DataSet
Accession:
GDS5263
ID:
5263
4.

Identification of candidate neuroblastoma genes by combining genomic and expression microarrays

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome variation profiling by SNP array; SNP genotyping by SNP array
Platforms:
GPL570 GPL2004
53 Samples
Download data: CEL
Series
Accession:
GSE13141
ID:
200013141
5.

Identification of candidate neuroblastoma genes by combining genomic and expression microarrays: SNP data

(Submitter supplied) Gene expression analysis was performed on 30 Neuroblastomas to identify genes whose transcription is significantly altered by recurrent chromosomal alterations. Genomic copy number losses and gains had been delineated in the tumours using FISH and SNP arrays. We have identified genes significantly altered by 7 recurrent alterations: 1p, 3p, 4p, 10q and 11q loss, 2p and 17q gain, and genes co-amplified and over-expressed as a result of MYCN amplification. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array; SNP genotyping by SNP array
Platform:
GPL2004
23 Samples
Download data: CEL
Series
Accession:
GSE13137
ID:
200013137
6.

Identification of candidate neuroblastoma genes by combining genomic and expression microarrays: expression data

(Submitter supplied) Gene expression analysis was performed on 30 Neuroblastomas to identify genes whose transcription is significantly altered by recurrent chromosomal alterations. Genomic copy number losses and gains had been delineated in the tumours using FISH and SNP arrays. We have identified genes significantly altered by 7 recurrent alterations: 1p, 3p, 4p, 10q and 11q loss, 2p and 17q gain, and genes co-amplified and over-expressed as a result of MYCN amplification. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
30 Samples
Download data: CEL
Series
Accession:
GSE13136
ID:
200013136
7.

Transcription factor activating protein 2 beta (TFAP2B) mediates noradrenergic neuronal differentiation in neuroblastoma

(Submitter supplied) Single-color gene expression profiles from IMR-32 neuroblastoma cell lines were generated using 44K oligonucleotide microarrays. To gain insights into the molecular processes occurring upon TFAP2B re-expression, we performed gene expression measurements in TFAP2B and GFP expressing transgenic IMR-32 neuroblastoma cell lines at d2 and d7 of transgene induction.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16876
4 Samples
Download data: TXT
Series
Accession:
GSE74350
ID:
200074350
8.

Array-based gene expression, CGH and tissue data define a 12q24 gain in neuroblastic tumors with prognostic implication

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome variation profiling by genome tiling array
Platforms:
GPL570 GPL9202
5 Samples
Download data: CEL, TXT
Series
Accession:
GSE18144
ID:
200018144
9.

aCGH of neuroblastic tumors

(Submitter supplied) Title: Array-based gene expression, CGH and tissue data define a 12q24 gain in neuroblastic tumors with prognostic implication. Background: Neuroblastoma has successfully served as a model system for the identification of neuroectoderm-derived oncogenes. However, in spite of various efforts, only a few clinically useful prognostic markers have been found. Here, we present a framework, which integrates DNA, RNA and tissue data to identify and prioritize genetic events that represent clinically relevant new therapeutic targets and prognostic biomarkers for neuroblastoma. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL9202
2 Samples
Download data: TXT
Series
Accession:
GSE18143
ID:
200018143
10.

Array-based gene expression in neuroblastic tumors

(Submitter supplied) Title: Array-based gene expression, CGH and tissue data define a 12q24 gain in neuroblastic tumors with prognostic implication. Background: Neuroblastoma has successfully served as a model system for the identification of neuroectoderm-derived oncogenes. However, in spite of various efforts, only a few clinically useful prognostic markers have been found. Here, we present a framework, which integrates DNA, RNA and tissue data to identify and prioritize genetic events that represent clinically relevant new therapeutic targets and prognostic biomarkers for neuroblastoma. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
3 Samples
Download data: CEL
Series
Accession:
GSE18139
ID:
200018139
11.

Epigenetic mechanisms regulate FOXP1 expression in CD4+ T cells

(Submitter supplied) Genome-scaled profiling of naive and memory CD4+ T cells in activated and resting state. Differential methylation can be observed between resting naïve and memory cells at cg related to FOXP1 gene.
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL13534
12 Samples
Download data: IDAT
Series
Accession:
GSE71825
ID:
200071825
12.

Array-based comparative genomic hybridization analysis of primary neuroblastoma

(Submitter supplied) We conducted microarray-based comparative genomic hybridization (array-CGH) with a DNA chip carrying 2,464 BAC clones to examine genomic aberrations of 236 neuroblastomas (112 sporadic and 124 mass screening-detected). In paralell, gene-expression profiling was also performed by using in-house cDNA microarrays. Keywords: Comparative genomic hybridization
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL4242
236 Samples
Download data
Series
Accession:
GSE5784
ID:
200005784
13.

High-resolution, genome-wide analysis of human metastatic neuroblastoma samples by array-Comparative Genomic Hybridization (aCGH)

(Submitter supplied) Less than 30% of children with high-risk (HR) metastatic neuroblastoma (NB) show a long survival (Pearson 2000). In order to identify novel molecular prognostic markers useful to better predict patients’ relapse risk estimation, we performed genome- and/or transcriptome-wide analyses of 129 stage 4 HR-NBs. This is the largest study for this NB subtype. Children older than 1 year of age at diagnosis were categorized as “short-survivors” (dead of disease within 5 years from diagnosis) and “long-survivors” (alive with an overall survival time > 5 years). more...
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platforms:
GPL2873 GPL5477
35 Samples
Download data: TXT
Series
Accession:
GSE35953
ID:
200035953
14.

Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma [tumor_genex_44k]

(Submitter supplied) Single-color gene expression profiles from 649 neuroblastoma tumors were generated using 44K oligonucleotide microarrays. We aimed at determining the association of class I HOX gene expression patterns with prognostic markers in neuroblastoma.We investigated the functional consequences of HOXC9 re-expression on neuroblastoma growth and programmed cell death. One-color gene expression analysis.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16876
649 Samples
Download data: TXT
Series
Accession:
GSE45547
ID:
200045547
15.

Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma [cell line_genex_44k]

(Submitter supplied) Single-color gene expression profiles from 2 neuroblastoma cell lines were generated using 44K oligonucleotide microarrays. To gain insights into the molecular processes occurring upon HOXC9 re-expression, we analyzed gene expression profiles of IMR-32 and SK-N-AS cells after Hox-C9 induction using microarrays. We used gene ontology (GO) annotations to find classes of genes that are significantly over-represented in gene sets that were either up- or downregulated after HOXC9 re-expression. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16876
24 Samples
Download data: TXT
Series
Accession:
GSE45545
ID:
200045545
16.

Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome variation profiling by array; Expression profiling by array
6 related Platforms
881 Samples
Download data: TXT
Series
Accession:
GSE45480
ID:
200045480
17.

Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma [aCGH_105k]

(Submitter supplied) Oligonucleotide aCGH profiles from 209 neuroblastoma tumor samples were generated using 44K, 105K or 1M microarrays. The 209th sample is represented by Sample GSM634116.
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platform:
GPL4093
123 Samples
Download data: TXT
Series
Accession:
GSE45478
ID:
200045478
18.

Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma [aCGH_1M]

(Submitter supplied) Oligonucleotide aCGH profiles from 209 neuroblastoma tumor samples were generated using 44K, 105K or 1M microarrays. The 209th sample is represented by Sample GSM634116.
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platform:
GPL8736
9 Samples
Download data: TXT
Series
Accession:
GSE45477
ID:
200045477
19.

Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma [aCGH_44k]

(Submitter supplied) Oligonucleotide aCGH profiles from 209 neuroblastoma tumor samples were generated using 44K, 105K or 1M microarrays. The 209th sample is represented by Sample GSM634116.
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platforms:
GPL8355 GPL2873 GPL16865
76 Samples
Download data: TXT
Series
Accession:
GSE45476
ID:
200045476
20.

ChIP-seq-based analysis of differential K27me3 coverage in neuroblastoma cell lines treated with epigenetic drugs

(Submitter supplied) The impact of drugs inhibiting DNA methylation (5-aza-2'-deoxycytodine, DAC) and EZH2 (EPZ-6438) on H3K27me3 coverage was analyzed in two neuroblastoma cell lines. Parallel analyses investigated associated changes in RNA expression and DNA methylation.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
12 Samples
Download data: BW
Series
Accession:
GSE80445
ID:
200080445
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