GEO DataSets

(Submitter supplied) An 8 hours timecourse was performed with human DCs infected either with A/California/7/2009 and A/Brevig Mission/1/1918 (pandemic) or A/New Caledonia/20/99 and A/Texas/36/91 seosonal.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

120 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

240 Samples

Download data

(Submitter supplied) An 8 hours timecourse was performed with human DCs infected either with A/California/7/2009 and A/Brevig Mission/1/1918 (pandemic) or A/New Caledonia/20/99 and A/Texas/36/91 seosonal.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

120 Samples

Download data: TXT

(Submitter supplied) Pandemic influenza H1N1 (pdmH1N1) virus causes mild disease in humans but occasionally leads to severe complications and even death, especially in those who are pregnant or have underlying disease. Cytokine responses induced by pdmH1N1 viruses in vitro are comparable to other seasonal influenza viruses, suggesting the cytokine dysregulation as seen in H5N1 infection is not a feature of the pdmH1N1 virus. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4239

Platform:

GPL6244

9 Samples

Download data: CEL, CHP

Analysis of type I-like alveolar epithelial cells infected with pandemic influenza H1N1 (pdmH1N1) or seasonal H1N1. Type I alveolar epithelial cells are a key target cell in pdmH1N1 pneumonia. Results provide insight into molecular mechanisms underlying host responses induced by H1N1 infections.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 individual, 3 infection sets

Platform:

GPL6244

Series:

GSE24533

9 Samples

Download data: CEL, CHP

(Submitter supplied) We used microarrays to compare the gene expression profiles of different H1N1 isolates (seasonal and pandemic) in lung epithelial cells in vitro.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4855

Platform:

GPL570

12 Samples

Download data: CEL

Analysis of well-differentiated primary lung bronchial epithelial cells 36 hs after infection with various H1N1 influenza isolates: seasonal H1N1 BN/59, pandemic H1N1 KY/136 and KY/180. Results provide insight into the molecular basis of host responses to different H1N1 Influenza isolates.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 infection sets

Platform:

GPL570

Series:

GSE48466

12 Samples

Download data: CEL

(Submitter supplied) Plasmacytoid dendritic cells (pDCs) are key components of the innate immune response that are capable of synthesizing and rapidly releasing vast amounts of type I interferons (IFNs), particularly IFN-alpha. Here we investigated whether pDCs, often regarded as a mere source of IFN, discriminate between various functionally discrete stimuli and to what extent this reflects differences in pDC responses other than IFN-alpha release. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL7088

95 Samples

Download data: TXT

(Submitter supplied) Critical disease caused by the new 2009 pandemic influenza virus (nvH1N1) is a challenge for physicians and scientist. As evidenced in SARS and H5N1, the development of an effective immune response plays a key role to overcome viral diseases. We studied host`s gene expression signatures, cytokine and antibody responses along the first week of hospitalization in 19 critically ill patients with primary nvH1N1 pneumonia and two degrees of respiratory involvement. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6102

40 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array; Expression profiling by array

Platforms:

GPL6947 GPL15271

133 Samples

Download data

(Submitter supplied) MicroRNAs (miRNAs) repress the expression levels of genes by binding to mRNA transcripts, acting as master regulators of cellular processes. Differential expression of miRNAs has been linked to viral-associated diseases involving members of the hepacivirus, herpesvirus, and retrovirus families. In contrast, limited biological and molecular information has been reported on the potential role of cellular miRNAs in the lifecycle of influenza A viruses (infA). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

40 Samples

Download data: TXT

(Submitter supplied) MicroRNAs (miRNAs) repress the expression levels of genes by binding to mRNA transcripts, acting as master regulators of cellular processes. Differential expression of miRNAs has been linked to viral-associated diseases involving members of the hepacivirus, herpesvirus, and retrovirus families. In contrast, limited biological and molecular information has been reported on the potential role of cellular miRNAs in the lifecycle of influenza A viruses (infA). more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL15271

48 Samples

Download data: TXT

(Submitter supplied) MicroRNAs (miRNAs) repress the expression levels of genes by binding to mRNA transcripts, acting as master regulators of cellular processes. Differential expression of miRNAs has been linked to viral-associated diseases involving members of the hepacivirus, herpesvirus, and retrovirus families. In contrast, limited biological and molecular information has been reported on the potential role of cellular miRNAs in the lifecycle of influenza A viruses (infA). more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL15271

45 Samples

Download data: TXT

(Submitter supplied) The transcriptional responses of human hosts towards influenza viral pathogens are important for understanding virus-mediated immunopathology. Despite great advances gained through studies using model organisms, the complete temporal host transcriptional responses in a natural human system are poorly understood. In a human challenge study using live influenza (H3N2/Wisconsin) viruses, we conducted a clinically uninformed (unsupervised) factor analysis on gene expression profiles and established an ab initio molecular signature that strongly correlates to symptomatic clinical disease. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL9188

268 Samples

Download data: CEL

(Submitter supplied) In order to understand the immunopathogenesis of severe influenza H1N1/09, we compared the whole blood RNA transcriptome of children hospitalised with H1N1/09 infection with that of children hospitalised with RSV or bacterial infection Blood was collected into PAX gene tubes (PreAnalytiX). Total RNA integrity was assessed using an Agilent 2100 Bioanalyzer (Agilent, Palo Alto, CA). Labeled cRNA was hybridized to Illumina Human HT-12 v3 Beadchips.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

92 Samples

Download data: TXT

(Submitter supplied) Transcriptional profile in influenza infected patients with different clinical outcomes were investigated.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

402 Samples

Download data: TXT

(Submitter supplied) While genetic variants are known to be associated with overall gene abundance in stimulated immune cells, less is known about their effects on alternative isoform usage. Analyzing RNA-seq profiles of monocyte-derived dendritic cells from 243 individuals, we uncovered thousands of unannotated isoforms synthesized in response to influenza infection and type 1 interferon stimulation. We identified more than a thousand quantitative trait loci (QTLs) associated with alternate isoform usage (isoQTLs), many of which are independent of expression QTLs for the same gene. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

576 Samples

Download data: BED, TXT

(Submitter supplied) Humans show remarkable variation in susceptibility to infectious diseases as well as chronic inflammatory and autoimmune disorders. This heterogeneity arises partially from variation in the immune response, which is responsible for preventing and controlling infection. To better understand the major factors driving antiviral immune response differences, we used single-cell RNA-sequencing to measure the effects of genetic ancestry and cis-regulatory variation on the transcriptional response to influenza infection in various immune cell types in 90 European and African American individuals. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24676

292 Samples

Download data: MTX, TSV, TXT

(Submitter supplied) Transcriptional profiles are increasingly used to investigate the severity, subtype and pathogenesis of disease. We now describe whole blood RNA signatures and local and systemic immune mediator levels in a large cohort of adults hospitalised with influenza from which extensive clinical and investigational data was obtained. Signatures reflecting interferon-related antiviral pathways were common up to day 4 of symptoms in cases not requiring mechanical ventilatory support; in those needing mechanical ventilation, an inflammatory, activated neutrophil and cell stress/death (‘bacterial’) pattern was seen, even early after disease onset. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

359 Samples

Download data: TXT

(Submitter supplied) Longitudinal Gene expression profiling of whole blood from critically ill influenza and bacterial pneumonia patients. In addition before vs 7 days post influenza vaccination volunteer samples are assayed.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3919

Platform:

GPL6947

81 Samples

Download data: TXT