Similar studies for GEO DataSets (Select 200043137) - GEO DataSets

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Items: 20

Select item 2000431371.

Real-time quantitative PCR analysis of mRNA from lungs of WT and Pglyrp1-/- mice sensitized with HDM

(Submitter supplied) Wild type (WT) and Pglyrp1-/- mice were treated with PBS or sensitized 5 days/week for 3 or 5 weeks with 10 µl per application of 2.5 mg/ml of purified house dust mite allergen. 3 days after the last sensitization the lungs were removed and homogenized, and RNA was isolated from the right lobes using the TRIZOL method. Quantitative reverse transcription real-time PCR (qRT-PCR) was used to quantify the amounts of mRNA in the lungs using custom RT2 Profiler PCR Arrays designed by us and manufactured by Qiagen/SA Biosciences.

Organism:: Mus musculus

Type:: Expression profiling by RT-PCR

Platform:: GPL16426
18 Samples

Download data: TXT

Series

Accession:: GSE43137

ID:: 200043137

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Select item 2000552472.

Expression data from lungs of Vldlr-/- mice and wild type (WT) B6129SF2/J mice that had received intranasal house dust mite (HDM) challenges to induce experimental asthma or saline, as a control.

(Submitter supplied) The very low density lipoprotein receptor (VLDLR) is a multi-ligand receptor that mediates pleiotropic biological processes, such as brain development. In this dataset, we include the expression data obtained from lungs from mice that had been challenged with house dust mite to induce experimental asthma or saline, as a control. These data are used to obtain genes that are differentially expressed in response to VLDLR signaling.

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4999
Platform:: GPL6246
16 Samples

Download data: CEL

Series

Accession:: GSE55247

ID:: 200055247

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Select item 49993.

Very low density lipoprotein receptor knockout effect in house dust mite model of asthma: lung

Analysis of lung from B6129SF2/J animals depleted for very low density lipoprotein receptor (VLDLR) and subjected to intranasal challenge with house dust mite (HDM). VLDLR is a multiligand apolipoprotein E receptor. Results provide insight into the role of VLDLR in HDM-induced airway inflammation.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation, 2 stress sets

Platform:: GPL6246
Series:: GSE55247
16 Samples

Download data: CEL

DataSet

Accession:: GDS4999

ID:: 4999

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000720054.

Expression data in CD4 T cells from lungs of PBS or house dust mite treated mice

(Submitter supplied) CD4 T cells are essential mediators of the asthmatic process. We used the clinically relevant allergen house dust mites to induce signs of allergy in mice and performed gene expression arrays specifically on CD4 T cells infiltrating the lung Reference: IL-21-producing CD4+ T cells promote type 2 immunity to house dust mites

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
6 Samples

Download data: CEL

Series

Accession:: GSE72005

ID:: 200072005

Select item 2001365565.

Bcl6 restrains ST2+ Treg cell development through negative regulation of Blimp1 in the context of allergic inflammation

(Submitter supplied) Bcl6 play a key role in CD4+ T cell development including follicular regulatory T cells. However, the role of Bcl6 in Treg cells in context of allergic inflammation was not fully understood. In this study, we describe the role of Bcl6 in development and function of ST2+Treg cells by analyzing ST2+Treg cell RNA seq.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
4 Samples

Download data: XLSX

Series

Accession:: GSE136556

ID:: 200136556

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Select item 2000808046.

A Pro-Asthmatic IL-4 Receptor Allele Promotes Airway Inflammation by Programming TH17 Cell-Like Regulatory T cells

(Submitter supplied) Mechanisms by which regulatory T (Treg) cells fail to control inflammation in asthma remain poorly understood. We show that a severe asthma-associated polymorphism in the interleukin-4 receptor alpha chain (IL-4Rα-R576) biases induced Treg (iTreg) cells towards a T helper 17 (TH17) cell fate. This skewing reflects the recruitment by IL-4Rα-R576 of the adaptor protein growth factor receptor-bound protein 2 (GRB2), which drives IL-17 expression by an extracellular signal-regulated kinase-, IL-6- and STAT3-dependent mechanism. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21493
7 Samples

Download data: TXT

Series

Accession:: GSE80804

ID:: 200080804

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Select item 2001565277.

Single-cell transcriptomic analysis of mouse lung CD11b+ dendritic cells post allergic sensitization

(Submitter supplied) Conventional dendritic cells (cDCs) in the lung that drive effector T cell differentiation, and initiate allergic responses upon inhalation of allergens. However, since CD11b+ cDCs are heterogeneous, the specific function of each subpopulation has been elusive. To identify subpopulations of CD11b+ cDCs, we performed single cell RNA-sequencing (scRNAS-Seq) of total lung CD11b+ cDCs following inhalation of house dust extracts, and detected multiple clusters based on their differential transcriptomes. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
2 Samples

Download data: H5, MTX, TSV

Series

Accession:: GSE156527

ID:: 200156527

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Select item 2000545858.

Gene expression of alveolar macrophages before and after allergen challenge

(Submitter supplied) Mild asthmatics who met the criteria of the IRB approved protocol of Sub-segmental Bronchial Provocation with Allergen were recruited. The subjects were challenged with sensitive allergen through bronchoscopy. Bronchoalveolar lavage (BAL) fluids were collected before and at 48 hours after allergen challegen. From the BAL fluids, alveolar macrophages were purifed and their RNA was extracted. Total 138 genes including five house keeping genes were evaluated.

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL18239
2 Samples

Download data: TXT

Series

Accession:: GSE54585

ID:: 200054585

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Select item 2000664319.

Role of IRAKM in IL-33-induced dendritic cell activation

(Submitter supplied) To gain additional insight into the role of IRAKM in dendritic cell activation in response to IL-33 challenge, we profiled transcriptomes of mouse DC2.4 dendritic cell lines with or without IRAKM following IL-33 treatment in vitro.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE66431

ID:: 200066431

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Select item 20016596910.

Differential gene expression analysis in eosinophilic and mixed granulomatous lung inflammation

(Submitter supplied) Alteration in the gene expression level in the lungs are thought to play a crucial role during the development of asthma and airway hyperresponsiveness. House dust mite induced allergic asthma is a Th2-lymphocyte driven inflammation characterized by airway hyperresponsiveness and eosinophilia while c-di-GMP, which is a potent mucosal adjuvant, induces a Th1-Th17 response accompanied by neutrophilia along with a low Th2 response. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL24242
14 Samples

Download data: CEL, CSV

Series

Accession:: GSE165969

ID:: 200165969

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Select item 20020084011.

Androgens Alleviate Allergic Airway Inflammation by Suppressing Cytokine Production of Th2 Cells

(Submitter supplied) This study reveraled that androgen signaling suppresses differentiation and cytokine production of Th2 cells by inducing DUSP-2, explaining, in part, the sex bias of asthma after adolescence.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
8 Samples

Download data: CSV

Series

Accession:: GSE200840

ID:: 200200840

PubMed Similar studies

Select item 20024472212.

Gene expression profiles at the single cell levels of murine airway T helper cells challenged with dog allergens

(Submitter supplied) We established a mouse model of dog allergy by repeatedly administering dog dander and epithelium extracts via the intranasal route. scRNA-Seq analysis of T helper cells in the airways pinpointed a unique gene signature for TH17 cells. Analysis of T-cell receptors depicted a high frequency of clones that were shared between TH17, TH2 and suppressive Treg cells, indicative of a common differentiation trajectory for these subsets.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
1 Sample

Download data: CSV, MTX, TSV

Series

Accession:: GSE244722

ID:: 200244722

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Select item 20022362913.

Anti-asthmatic effect of nafamostat is associated with modulated expression of pro-inflammatory genes, reduced eosinophil infiltration and attenuated airway hyperreactivity

(Submitter supplied) Asthma is typically characterized by an imbalance between the expression of proteases and of inhibitors capable of neutralizing such enzymes. Hence, an attractive option for intervening with asthma could be to interfere with asthma-associated proteases. In this study, we exploited this option by assessing the impact of nafamostat, a serine protease inhibitor with known capacity to neutralize mast cell tryptase, on the manifestations of airway responses in a house dust mite (HDM)-based model of experimental asthma. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL27583
10 Samples

Download data: XLS, XLSX

Series

Accession:: GSE223629

ID:: 200223629

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Select item 20018450514.

Vacuolar protein sorting 33B deficiency effect on conventional dendritic cell type 1 subpopulation

(Submitter supplied) Analysis of FACS-sorted conventional dendritic cell type 1 (cDC1) subpopulation in mediastinal lymph nodes (mLNs) from mice with vacuolar protein sorting 33B (Vps33B) specific deletion in DCs in response to house dust mite (HDM). Our results provide insight into the role of Vps33B in regulating the function of cDC1s upon HDM stimulation.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: CSV

Series

Accession:: GSE184505

ID:: 200184505

PubMed Similar studies SRA Run Selector

Select item 20007961515.

MYD88-dependent dendritic and epithelial cell crosstalk in the lung orchestrates immune responses to inhaled allergens

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Other

Platforms:: GPL19964 GPL19057 GPL20775
92 Samples

Download data: BED, CEL, CHP, RCC

Series

Accession:: GSE79615

ID:: 200079615

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Select item 20007961416.

Nanostring of sorted lung conventional dendritic cells (cDCs) from cell-specific MyD88 KO at 6h after in vivo sensitization with OVA/standard flagellin

(Submitter supplied) Allergic asthma is a chronic disease of the airways characterized by eosinophilic and neutrophilic inflammation. MYD88, the adaptor molecule for TLR and IL-1 family member signaling, is required for allergic sensitization through the airway in animal models of allergic asthma. We generated conditionally mutant mice separately lacking Myd88 in airway epithelial cells (ECs) or dendritic cells (DCs) to define the contribution of Myd88 expression in each of these cell types. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL19964
14 Samples

Download data: RCC

Series

Accession:: GSE79614

ID:: 200079614

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Select item 20007959417.

Nanostring of whole lung RNA from cell-specific MyD88 KO at 0h, 2h and 6h after in vivo sensitization with OVA/standard flagellin

(Submitter supplied) Allergic asthma is a chronic disease of the airways characterized by eosinophilic and neutrophilic inflammation. MYD88, the adaptor molecule for TLR and IL-1 family member signaling, is required for allergic sensitization through the airway in animal models of allergic asthma. We generated conditionally mutant mice separately lacking Myd88 in airway epithelial cells (ECs) or dendritic cells (DCs) and alveolar macrophages (AMs) to define the contribution of Myd88 expression in each of these cell types. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL19964
35 Samples

Download data: RCC

Series

Accession:: GSE79594

ID:: 200079594

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Select item 20007959218.

Nanostring of sorted lung alveolar macrophages (AM) from cell-specific MyD88 KO at 6h after in vivo sensitization with OVA/standard flagellin

(Submitter supplied) Allergic asthma is a chronic disease of the airways characterized by eosinophilic and neutrophilic inflammation. MYD88, the adaptor molecule for TLR and IL-1 family member signaling, is required for allergic sensitization through the airway in animal models of allergic asthma. We generated conditionally mutant mice separately lacking Myd88 in airway epithelial cells (ECs) or dendritic cells (DCs) and alveolar macrophages (AMs) to define the contribution of Myd88 expression in each of these cell types. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL19964
8 Samples

Download data: RCC

Series

Accession:: GSE79592

ID:: 200079592

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Select item 20007959119.

Nanostring of sorted airway epithelial cells (AECs) from cell-specific MyD88 KO at 2h after in vivo sensitization with OVA/standard flagellin

(Submitter supplied) Allergic asthma is a chronic disease of the airways characterized by eosinophilic and neutrophilic inflammation. MYD88, the adaptor molecule for TLR and IL-1 family member signaling, is required for allergic sensitization through the airway in animal models of allergic asthma. We generated conditionally mutant mice separately lacking Myd88 in airway epithelial cells (ECs) or dendritic cells (DCs) and alveolar macrophages (AMs) to define the contribution of Myd88 expression in each of these cell types. more...