Similar studies for GEO DataSets (Select 200030805) - GEO DataSets

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Items: 18

Select item 2000308051.

Expression data from low expressing T58A Mutant Myc Induced Tumors

(Submitter supplied) We used microarrays to futher characterize the effects of T58A mutation in Myc on mammary tumorigenesis.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8321
17 Samples

Download data: CEL

Series

Accession:: GSE30805

ID:: 200030805

Select item 2000224062.

Heterogeneity in MYC-Induced Mammary Tumors Determines Outcomes Following Loss of Myc Activity

(Submitter supplied) We used microarrays to compare gene expression profiles between mouse mammary tumors initiated by Myc to those that have escaped Myc oncogene dependence.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8321
75 Samples

Download data: CEL

Series

Accession:: GSE22406

ID:: 200022406

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001043973.

Expression data from MMTV-PyMT Induced Tumors

(Submitter supplied) Loss of E2F transcription factos alters metastatic capacity of MMTV-PyMT tumors. We used microarrays to futher characterize the effects of E2F loss on mammary tumorigenesis in MMTV-PyMT mice.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8321
80 Samples

Download data: CEL

Series

Accession:: GSE104397

ID:: 200104397

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000425334.

Her2/Neu tumorigenesis and metastasis is regulated by E2F transcription factors

(Submitter supplied) HER2 / Neu is amplified and overexpressed in a large proportion of human breast cancers, but the signaling pathways that contribute to tumor development and metastatic progression are not completely understood. Using gene expression data and pathway signatures we predicted a role for activator E2F transcription factors in Neu induced tumors. This was genetically tested by interbreeding Neu transgenics with knockouts of the three activator E2Fs. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8321
60 Samples

Download data: CEL

Series

Accession:: GSE42533

ID:: 200042533

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000159045.

Genetic Heterogeneity in Mouse Mammary Tumors

(Submitter supplied) Human cancers result from a complex series of genetic alterations resulting in heterogeneous disease states. Dissecting this heterogeneity is critical for understanding underlying mechanisms and providing opportunities for therapeutics matching the complexity. Mouse models of cancer have generally been employed to reduce this complexity and focus on the role of single genes. Nevertheless, our analysis of tumors arising in the MMTV-Myc model of mammary carcinogenesis reveals substantial heterogeneity, seen in both histological and expression phenotypes. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8321
126 Samples

Download data: CEL, CHP

Series

Accession:: GSE15904

ID:: 200015904

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000321526.

Mammary Tissue: Wild type mammary glands vs IGF-IR induced mammary tumors vs IGF-IR independent tumors

(Submitter supplied) Molecular profiling was used to classify mammary tumors that develop in MTB-IGFIR transgenic mice. It was determined that the primary mammary tumors (PMT), which develop due to elevated expression of the type I insulin-like growth factor receptor (IGF-IR) in mammary epithelial cells, most closely resemble murine tumors with basal-like or mixed gene expression profiles and with human basal-like breast cancers. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
28 Samples

Download data: TXT

Series

Accession:: GSE32152

ID:: 200032152

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000417487.

Met synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Non-coding RNA profiling by array; Expression profiling by array; Genome variation profiling by genome tiling array

Platforms:: GPL2884 GPL16199 GPL4134
96 Samples

Download data: TXT

Series

Accession:: GSE41748

ID:: 200041748

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000417238.

Met synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer (miRNA expression data).

(Submitter supplied) miRNA profiling of normal and tumorigenic mouse mammary tissue. Mouse genotypes consist of wildtype, MMTV-Met, MMTV-Met;Trp53fl/+;Cre, and Trp53fl/+;Cre.

Organism:: Mus musculus

Type:: Non-coding RNA profiling by array

Platform:: GPL16199
25 Samples

Download data: TXT

Series

Accession:: GSE41723

ID:: 200041723

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000416329.

Met synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer (aCGH data).

(Submitter supplied) Transcriptional profiling of normal and tumorigenic mouse mammary tissue. Mouse genotypes consist of wildtype, MMTV-Met, MMTV-Met;Trp53fl/+;Cre, and Trp53fl/+;Cre.

Organism:: Mus musculus

Type:: Genome variation profiling by genome tiling array

Platform:: GPL2884
30 Samples

Download data: TXT

Series

Accession:: GSE41632

ID:: 200041632

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004160110.

Met synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer (mRNA expression data).

(Submitter supplied) Transcriptional profiling of normal and tumorigenic mouse mammary tissue. Mouse genotypes consist of wildtype, MMTV-Met, MMTV-Met;Trp53fl/+;Cre, and Trp53fl/+;Cre.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL4134
41 Samples

Download data: TXT

Series

Accession:: GSE41601

ID:: 200041601

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006248111.

The effect of MFNG knockdown on gene expression profile of xenograft tumor derived from MDA-MB231 cells

(Submitter supplied) Mfng, a modulator of Notch signaling, is highly expressed in human claudin-low breast cancer (CLBC). To determine Mfng’s roles in CLBC pathogenesis,we knocked down Mfng in a CLBC cell line MDA-MB231, and found that Mfng knockdown altered Notch activation, decreased tumor sphere formation in vitro, and reduced tumor growth in xenograft model. To identify the potential downstream targets of Mfng during CLBC tumorigenesis, we compared the gene expression profiles between xenografts tumor derived from of MDA-MB231 cells carrying Mfng shRNA and the control vector. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE62481

ID:: 200062481

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20015733312.

Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells

(Submitter supplied) Claudin-low breast cancer represents an aggressive molecular subtype that is comprised of mostly triple-negative mammary tumor cells that possess stem cell-like and mesenchymal features. Little is known about the cellular origin and oncogenic drivers that promote claudin-low breast cancer. In this study, we show that persistent oncogenic RAS signaling causes highly metastatic triple-negative mammary tumors in mice. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
16 Samples

Download data: BW, CSV

Series

Accession:: GSE157333

ID:: 200157333

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007006013.

caArray_green-00160: Initiating oncogenic event determines gene-expression patterns of human breast cancer models

(Submitter supplied) Comparison of six well characterized mouse models of human breast cancer to determine the fundamental differences in gene expression between the normal mammary gland and mammary tumors and to define genes that are associated specifically with each oncogenic pathway.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array

Platform:: GPL20562
25 Samples

Download data: GPR

Series

Accession:: GSE70060

ID:: 200070060

PubMed Full text in PMC Similar studies

Select item 20024775714.

A Germline Point Mutation in the MYC-FBW7 Phosphodegron Results in a Tumor-Prone Phenotype

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL30172 GPL17021
58 Samples

Download data: BW

Series

Accession:: GSE247757

ID:: 200247757

PubMed Full text in PMC Similar studies

Select item 20024775615.

RNASeq, multiome, and genomic profiling of hematopoietic progenitors and B cells from mice with a point mutation in MYC [Multiome]

(Submitter supplied) We generated mice with a mutation at threonine 58 of MYC in the mouse germline (T58A mutant). These mice ultimately develop AML or B cell lymphomas. We profiled changes in gene expression and genomic occupation of MYC in single cells of sorted, immature bone marrow progenitor cells, mature (spleen derived) and immature (marrow derived) B cells. B cells were stimulated with LPS and IL7, respectively.

Organism:: Mus musculus

Type:: Other

Platform:: GPL30172
8 Samples

Download data: TSV

Series

Accession:: GSE247756

ID:: 200247756

PubMed Full text in PMC Similar studies

Select item 20024761416.

RNASeq, multiome, and genomic profiling of hematopoietic progenitors and B cells from mice with a point mutation in MYC [RNA-seq]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: TXT

Series

Accession:: GSE247614

ID:: 200247614

PubMed Full text in PMC Similar studies

Select item 20024761217.

RNASeq, multiome, and genomic profiling of hematopoietic progenitors and B cells from mice with a point mutation in MYC [CUT&RUN]

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
38 Samples

Download data: BW

Series

Accession:: GSE247612

ID:: 200247612

PubMed Full text in PMC Similar studies

Select item 20012260218.

Gene regulation changes driven by wild type and cancer-associated mutant variants of Myc as B-cells convert to Lymphoma-like cells

(Submitter supplied) cMyc plays a major role in lymphoma development. In addition, missense mutations including T58A and T58I the substitution mutations augment cMyc activity during lymphoma development. In this study, we characterized lymphoma-associated gene expression changes as increasing levels of wild type or mutant cMyc proteins progressively drive conversion of B-cells to lymphoma-like cells. To this end we established a cell system in which primary mouse B-cells were transduced with constructs that over-express the anti-apoptotic proteins, BMI1 and BCLXL and allow variable expression of cMyc (wild type, T58A or T58I) from a doxycycline-regulated promoter. more...