GEO DataSets

(Submitter supplied) Here we compared the expression of an engineered kidney tissue, created by recombining an in vitro budded Wolffian duct with fresh E13 metanephric mesenchyme, with that of three in vivo rat embryonic kidney timepoints (E13, E18, and week 4) Keywords: time course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

12 Samples

Download data: CEL, CHP

(Submitter supplied) In this study we identify molecules with highly restricted expression patterns during the initial stages of metanephric development, when the ureteric bud has entered the metanephric mesenchyme and initiated branching morphogenesis. Using the Affymetrix Mouse Genome 430 2.0 Array, we compare gene expression patterns in ureteric bud tips, stalks and metanephric mesenchymes from mouse E12.5 embryos. To identify conserved molecular pathways, we also analyze transcriptional profiles in rat E13.5 ureteric buds and metanephric mesenchymes using the Affymetrix Rat Genome U34 Set. more...

Organism:

Mus musculus; Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS1572 GDS1581 GDS1582 GDS1583

4 related Platforms

18 Samples

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Analysis of ureteric bud (UB) tips and stalks and metanephric mesenchyme (MM) from E12.5 kidneys. UB-secreted factors induce conversion of adjacent MM cells into nephrons. Results identify as potential regulators a set of 20 secreted molecules specific to the UB and conserved between species.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 tissue sets

Platform:

GPL1261

Series:

GSE1983

6 Samples

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Analysis of ureteric buds (UBs) and metanephric mesenchyme (MM) from E13.5 kidneys. UB-secreted factors induce conversion of adjacent MM cells into nephrons. Results identify as potential regulators a set of 20 secreted molecules specific to the UB and conserved between species.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 tissue sets

Platform:

GPL87

Series:

GSE1983

4 Samples

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Analysis of ureteric buds (UBs) and metanephric mesenchyme (MM) from E13.5 kidneys. UB-secreted factors induce conversion of adjacent MM cells into nephrons. Results identify as potential regulators a set of 20 secreted molecules specific to the UB and conserved between species.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 tissue sets

Platform:

GPL86

Series:

GSE1983

4 Samples

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Analysis of ureteric buds (UBs) and metanephric mesenchyme (MM) from E13.5 kidneys. UB-secreted factors induce conversion of adjacent MM cells into nephrons. Results identify as potential regulators a set of 20 secreted molecules specific to the UB and conserved between species.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 tissue sets

Platform:

GPL85

Series:

GSE1983

4 Samples

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(Submitter supplied) Genes ontologically classified as proliferative and developmental were down-regulated by HRG, whereas those involved in transport were up-regulated. For example, the mRNA for the GDNF receptors, GFRa1 and ret9 were down-regulated while the mRNA for collecting duct transporters, such as urea transporter2, aquaporin3, sodium-hydrogen exchanger2 were up-regulated in HRG-treated UBs compared with UBs grown in the presence of branch-promoting factors Keywords: Comparing different growth factor treatment

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1518

Platform:

GPL341

9 Samples

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Analysis of isolated ureteric buds (UBs) cultured in the presence of non-branching growth factor heregulin (HRG) or branching growth factor pleiotrophin (PTN). HRG and PTN purified from BSN cell conditioned medium. Results provide insight into how HRG induces non-branching growth.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 agent sets

Platform:

GPL341

Series:

GSE3394

9 Samples

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(Submitter supplied) We report a new method to generate UB organoids that possess epithelial polarity and tubular lumen and repeat branching morphogenesis. We also succeeded in monitoring UB tip cells by utilizing the ability of tip cells to uptake very-low-density lipoprotein, cryopreserving UB progenitor cells and expanding UB tip cells that can reconstitute the organoids and differentiate into collecting duct progenitors. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

1 Sample

Download data: MTX, TSV

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

4 Samples

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(Submitter supplied) Ureteric bud (UB) is the embryonic kidney progenitor tissue that gives rise to the collecting duct and lower urinary tract. UB-like structures generated from human pluripotent stem cells by previously reported methods show limited developmental ability and limited branching. Here we report a new method to generate UB organoids that possess epithelial polarity and tubular lumen and repeat branching morphogenesis. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

2 Samples

Download data: TXT

(Submitter supplied) Ureteric bud (UB) is the embryonic kidney progenitor tissue that gives rise to the collecting duct and lower urinary tract. UB-like structures generated from human pluripotent stem cells by previously reported methods show limited developmental ability and limited branching. Here we report a new method to generate UB organoids that possess epithelial polarity and tubular lumen and repeat branching morphogenesis. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

2 Samples

Download data: TXT

(Submitter supplied) Evaluation of splicing in ureteric epithelium in Esrp1;Esrp2 double knockout mice compared to Esrp1+/+;Esrp2-/- control mice.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

4 Samples

Download data: XLSX

(Submitter supplied) A platform for generating expandable, branching and gene-editable ureteric bud organoid from primary mouse and human ureteric bud progenitor cells and human pluripotent stem cells, and its maturation into collecting duct organoid.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

10 Samples

Download data: CSV

(Submitter supplied) Kidney development depends critically on proper ureteric bud branching giving rise to the entire collecting duct system. The transcription factor HNF1B is required for the early steps of ureteric bud branching. Yet, the molecular and cellular events regulated by HNF1B are poorly understood. We report that specific removal of Hnf1b from the ureteric bud leads to defective cell-cell contacts and apico-basal polarity during the early branching events. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18635

4 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of mouse embryonic kidneys lacking Mdm4 function in the ureteric bud lineage

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL21810

8 Samples

Download data: TXT

(Submitter supplied) Our laboratory's interest is in understanding the molecular principles that underlie the regional organization of the mammalian metanephric kidney. Our goal is to generate a detailed spatial map of the cellular expression of selected regulatory genes during mammalian kidney development. The goal of this study is to identify a population of genes that are enriched in the renal vesicle (RV) and its derivatives using Wnt4 mutants. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

4 Samples

Download data: CEL

(Submitter supplied) The long term objective is to create an encyclopedia of the expression levels of all genes in multiple components of the developing kidney. The central thesis is straightforward. The combination of laser capture microdissection (LCM) plus microarray analysis offers a powerful, efficient and effective method for the creation of a global gene expression atlas of the developing kidney. Microarrays with essentially complete genome coverage can be used to quantitate expression levels of every gene in laser capture microdissected components of the developing kidney. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3865

Platform:

GPL1261

37 Samples

Download data: CEL

Spatial and temporal analysis of laser capture microdissected wild-type, CD1 embryonic kidney sections across 3 developmental time points (E11.5, E12.5, E15.5) representing early stages of nephron formation. Results provide insight into molecular mechanisms underlying the stages of nephrogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 development stage, 9 tissue sets

Platform:

GPL1261

Series:

GSE6290

37 Samples

Download data: CEL

(Submitter supplied) To study cell heterogeneity and state transitions in the developing urinary tract we performed spatial transcriptomics from the trunk of E9.5 Pax2GFP mouse embryos using the 10X Genomics Visium Spatial Gene Expression protocol

Organism:

Mus musculus

Type:

Other; Expression profiling by high throughput sequencing

Platform:

GPL24247

4 Samples

Download data: CSV, H5, JSON, PNG