GEO DataSets

(Submitter supplied) Embryonic mouse brain development involves a sequential differentiation of multipotent progenitor cells into neurons and glia. Using microarrays and large 2-D electrophoresis, we investigated the transcriptome and proteome of mouse brains at embryonic days 9.5, 11.5 and 13.5. During this developmental period, neural progenitor cells shift from proliferation to neuronal differentiation. As expected, we detected numerous expression changes between the time points investigated but interestingly, the rate of alteration was about 10% to 13% of all proteins and mRNAs during every two days of development. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3442

Platform:

GPL1261

16 Samples

Download data: CEL, CHP

Analysis of brains at embryonic days (E) 9.5, 11.5, and 13.5. Mostly undifferentiated neural progenitor cells (NPCs) are present at E9.5, NPCs begin to differentiate into neurons at E11.5, and neurogenesis peaks at E13.5. Results provide insight into the molecular mechanisms underlying neurogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age sets

Platform:

GPL1261

Series:

GSE8091

16 Samples

Download data: CEL, CHP

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) Cellular diversity of the brain is largely attributed to the spatial and temporal heterogeneity of progenitor cells. In mammalian cerebral development, it has been difficult to determine how neural progenitor cells are heterogeneous, due to their dynamic changes in nuclear position and gene expression. To address this issue, we systematically analyzed the cDNA profiles of a large number of single progenitor cells at the mid-embryonic stage. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

70 Samples

Download data: CEL, CHP

(Submitter supplied) Evaluation of the transcriptomic profile of the rabbit embryo along the preimplantation period during in vivo development. Three embryonic stages were used: four cell embryos (H32 post-coïtum); morula (H58 pc) and blastocyst (H90 pc). Keywords: time course rabbit embryo

Organism:

Oryctolagus cuniculus

Type:

Expression profiling by array

Platform:

GPL7019

18 Samples

Download data: TXT

(Submitter supplied) Transcriptomes of mouse embryonic autopods were generated detecting expression of approximately 26179 transcripts in the developing forelimb or hindlimb autopods, representing about 58 % of the probe sets on MOE-430 A/B GeneChip. Three biological replicate array experiments were finished for each condition and MAS5.0 signal were used to do data analysis. Forty-four transcripts with expression differences higher than 2-fold were detected(T test, P<0.05), including Tbx4, Tbx5, Hoxc10 and Pitx1 which were previously shown to be differentially expressed in developing forelimb and hindlimb bud by in situ hybridization and SAGE study (Margulies 2001). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS1342 GDS1343

Platforms:

GPL339 GPL340

12 Samples

Download data: CEL

Analysis of forelimb and hindlimb autopod tissues at embryonic day 12.5. Results provide insight into the molecular mechanisms regulating the formation of forelimbs and hindlimbs.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 tissue sets

Platform:

GPL340

Series:

GSE2560

6 Samples

Download data: CEL

Analysis of forelimb and hindlimb autopod tissues at embryonic day 12.5. Results provide insight into the molecular mechanisms regulating the formation of forelimbs and hindlimbs.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 tissue sets

Platform:

GPL339

Series:

GSE2560

6 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

4556 Samples

Download data

(Submitter supplied) Purpose: Exploring mechanisms defining the unique nature of vascular development and differentiation in the brain . Methods: High-resolution gene expression profiles of embryonic endothelial cells (EC) using translating ribosome affinity purification (TRAP) and single cell RNA-sequencing. RNA-sequenzing of transcription factor infected HUVEC. Results: Comparisons of different organ-, temporal- or Ctnnb1 knock out-specific vascular translatomes revealed extensive molecular changes during the unique development of the brain endothelium. more...

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by high throughput sequencing; Other

Platforms:

GPL11154 GPL13112

175 Samples

Download data: TXT

(Submitter supplied) Enriched forebrain microvessels from P5, P10 and adult mice. Transcript comparisons identified 5873 genes with FC>2 between ages and 93 pathways. The observations were confronted to proteome study using NanoLS-MS/MS and deposited on proteomeXchange platform under # PXD001718. The 2 techniques converge towards extracellular matrix, cell adhesion and junction pathways, indicating early changes in development. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10333

8 Samples

Download data: TXT, XLSX