GEO DataSets

(Submitter supplied) AGEMAP is an initiative of the National Institute on Aging (NIA) designed to study the aging process on mice with Caloric Restriction (CR) versus Ad Libitum (AL) diet. The aim of the AGEMAP project is to provide a valuable source of information about genetic influences involved in aging of the major organ systems. A total of 67 mice (C57BL/6) were sacrificed. Both male and female mice were divided in 7 categories based on the diet and the age. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL4358 GPL2552

28 Samples

Download data: TIFF, TXT

(Submitter supplied) This study describes a temporal profile of gene expression from normal human fetal testes and ovaries. Gonads from 34 fetuses between 9 weeks and 20 weeks of gestation were obtained from the Department of Pathology and the Birth Defects Research Laboratory at the University of Washington. Relative transcript levels were determined using the Affymetrix Human Genome U133A Plus 2.0 arrays. Sex determination occurs in the human gonad at approximately 6 weeks gestation with development of the testis driven by expression of SRY. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

34 Samples

Download data: CEL

(Submitter supplied) Fetal life is a crucial period for sexual reproduction when bipotential gonads differentiate into either a testis or an ovary. Gaining insights into the complex molecular events underlying this process is central to a better understanding of disorders of sexual development. The present work therefore intends to improve the knowledge on molecular pathways at play during gonad development in humans using RNA-Sequencing.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

48 Samples

Download data: BED, GTF, TXT, XLSX

(Submitter supplied) Sustained caloric restriction (CR) extends lifespan in animal models but the mechanism and primary tissue target(s) have not been identified. Gene expression changes with aging and CR were examined in both heart and subcutaneous white adipose tissue (WAT) of F344 male rats using Affymetrix® RAE 230 arrays and validated by qRT-PCR on 18 genes. In heart, age- associated changes but not CR-associated changes in old. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3102

Platform:

GPL1355

39 Samples

Download data: CEL

Analysis of hearts and white adipose tissues of 28 month old male animals fed a calorie restricted diet since 4 months of age. Sustained caloric restriction (CR) extends lifespan in animal models. Results provide insight into the molecular basis of CR-induced lifespan extension.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 age, 2 growth protocol, 2 tissue sets

Platform:

GPL1355

Series:

GSE6718

39 Samples

Download data: CEL

(Submitter supplied) We performed a factorial experiment examining the effects of calorie restriction (CR) and exercise (EX) in mice. CR mice received 70% of calories but 100% of all other nutrients compared to AL mice. Food consumption, weight gain, and physical activity levels were recorded for 6 weeks. Diet and exercise treatments, both alone and in combination, had significant effects on body composition and levels of physical activity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

37 Samples

Download data: CEL

(Submitter supplied) African clawed frog Xenopus sp. is used extensively for developmental biology and toxicology research. Amid concerns of environmental pollutants disrupting endocrine systems and causing altered reproductive development in wildlife, eco-toxicology research has led to a focus on linking molecular initiating events to population-level effects. As such, efforts to better understand reproductive development at the molecular level in these model species are warranted. more...

Organism:

Xenopus tropicalis

Type:

Expression profiling by array

Platform:

GPL10263

38 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2719

Platform:

GPL1261

20 Samples

Download data: CEL, EXP

(Submitter supplied) Time course of gene expression in the murine embryonic ovary from the time of the indifferent gonad (11.5dpc) to birth (18.5dpc) Keywords: Time course

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

10 Samples

Download data: CEL, EXP

(Submitter supplied) Time course of gene expression in the murine embryonic testis from the time of the indifferent gonad (11.5dpc) to birth (18.5dpc) Keywords: Time Course

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

10 Samples

Download data: CEL, EXP

(Submitter supplied) Time course of gene expression in the murine embryonic ovary from the time of the indifferent gonad (11.5dpc) to birth (18.5dpc) Keywords: time-course

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS663 GDS665 GDS666

Platforms:

GPL82 GPL83 GPL81

30 Samples

Download data: CEL

(Submitter supplied) Time course of gene expression in the murine embryonic testis from the time of the indifferent gonad (11.5dpc) to birth (18.5dpc) Keywords: time-course

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS660 GDS661 GDS662

Platforms:

GPL83 GPL82 GPL81

30 Samples

Download data: CEL

Analysis of male and female gonads at 11.5 to 18.5 days postcoitum (dpc). Results provide insight into the molecular mechanisms underlying the functional and structural changes in the developing male and female embryonic gonads.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 gender, 5 time sets

Platform:

GPL1261

Series:

GSE6916

20 Samples

Download data: CEL, EXP

Time course of gene expression in BL/6-129 embryonic ovary from the time of the indifferent gonad (11.5 days post coitum) to birth (18.5 days post coitum).

Organism:

Mus musculus

Type:

Expression profiling by array, count, 5 development stage sets

Platform:

GPL83

Series:

GSE1359

10 Samples

Download data: CEL

Time course of gene expression in BL/6-129 embryonic ovary from the time of the indifferent gonad (11.5 days post coitum) to birth (18.5 days post coitum).

Organism:

Mus musculus

Type:

Expression profiling by array, count, 5 development stage sets

Platform:

GPL82

Series:

GSE1359

10 Samples

Download data: CEL

Time course of gene expression in BL/6-129 embryonic ovary from the time of the indifferent gonad (11.5 days post coitum) to birth (18.5 days post coitum).

Organism:

Mus musculus

Type:

Expression profiling by array, count, 5 development stage sets

Platform:

GPL81

Series:

GSE1359

10 Samples

Download data: CEL

Time course of gene expression in BL/6-129 embryonic testis from the time of the indifferent gonad (11.5 days post coitum) to birth (18.5 days post coitum).

Organism:

Mus musculus

Type:

Expression profiling by array, count, 5 development stage sets

Platform:

GPL83

Series:

GSE1358

10 Samples

Download data: CEL

Time course of gene expression in BL/6-129 embryonic testis from the time of the indifferent gonad (11.5 days post coitum) to birth (18.5 days post coitum).

Organism:

Mus musculus

Type:

Expression profiling by array, count, 5 development stage sets

Platform:

GPL82

Series:

GSE1358

10 Samples

Download data: CEL

Time course of gene expression in BL/6-129 embryonic testis from the time of the indifferent gonad (11.5 days post coitum) to birth (18.5 days post coitum).

Organism:

Mus musculus

Type:

Expression profiling by array, count, 5 development stage sets

Platform:

GPL81

Series:

GSE1358

10 Samples

Download data: CEL

(Submitter supplied) Diminishment of colonic health is associated with various age-related pathologies. Calorie restriction (CR) is an efficient strategy to increase healthy lifespan, although underlying mechanisms are not fully elucidated. Here we report the effects of lifelong CR on markers of colonic health in aging mice. We show that 30% energy reduction, as compared to a control (C) and moderate-fat (MF) diet, is associated with attenuated immune-related gene expression and lower levels of bile acids in the colon. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11533

42 Samples

Download data: CEL