GEO DataSets

Analysis of rectal cancer cells from patients prior to preoperative radiotherapy. Response to radiotherapy determined by histopathologic examination of resected specimens. Results identify gene markers for the characterization and prediction of the response to radiotherapy in rectal cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 2 protocol sets

Platform:

GPL8300

Series:

GSE3493

46 Samples

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(Submitter supplied) Biopsy specimens were collected from rectal cancer before starting preoperative radiotherapy.The expression profiles were determined using Affymetrix Human Genome U95 version 2 arrays.Comparison between the sample groups allow to identify a set of discriminating genes that can be used for characterization of responders and nonresponders to preoperative radiotherapy in rectal cancer. Keywords: repeat

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1887

Platform:

GPL8300

46 Samples

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(Submitter supplied) Samples were taken from colorectal cancers in surgically resected specimens in 89 colorectal cancer patients. The expression profiles were determined using Affymetrix Human Genome U133 Plus 2.0 arrays. Comparison between the sample groups allow to identify a set of discriminating genes that can be used for molecular markers for predicting lymph node metastases. Keywords: disease state analysis

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

89 Samples

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(Submitter supplied) The objective of this study is to assess gene expression changes and identify gene sets associated with chemo-radiotherapy (CRT) in colorectal cancer (CRC) patients. We performed RNA-seq based transcriptome profiling using primary tumor samples obtained from 22 CRC patients. By a number of statistical tests, a total of 575 genes were statistically significant, indicating a gene set profoundly responded to chemo-radiotherapy in CRC. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

22 Samples

Download data: TXT

(Submitter supplied) Gene expression analysis identified a CRC related signature of differentially expressed genes discriminating patients Responder and Non Responder to radiochemotherapy Gene expression signatures of CRC samples Responder and Non Responder to radiochemotherapy were analyzed using supervised analyses

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL4133 GPL570

80 Samples

Download data: CEL, TXT

(Submitter supplied) A promising treatment for patients with advanced colorectal cancer is preoperative radiochemotherapy. The early side effects of this treatment have been considered to be acceptable. The aim of this study was to identify the effects of preoperative radiochemotherapy (PRT) on gene expression in tumour and normal colon rectal tissue form the same patients, before and after PRT. For that purpose, tissue samples from ten patients with operable rectal adenocarcinomas were collected for use in whole genome–microarray based gene expression analysis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3756

Platform:

GPL2986

42 Samples

Download data: TXT

Analysis of normal and tumor tissue specimens from Norwegian patients with resectable adenocarcinoma of the rectum, before and after preoperative radio-chemotherapy (RCT). Results provide insight into the molecular mechanisms underlying tumor response to neoadjuvant RCT.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol, 2 tissue sets

Platform:

GPL2986

Series:

GSE15781

42 Samples

Download data: TXT

(Submitter supplied) Using Human WG CodeLink microarrays, we established the expression profiling of 26 LARC without metastasis to gain insight into the molecular signatures associated with response to treatment after CRT.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL18134

26 Samples

Download data: TXT