GSM2155555[Accession] - GEO DataSets

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Items: 4

Select item 2000815371.

TUT-DIS3L2 is a mammalian surveillance pathway for aberrant structured non-coding RNAs.

(Submitter supplied) Uridylation of various cellular RNA species at the 3' end has been generally linked to RNA degradation. In mammals, uridylated pre-let-7 miRNAs and mRNAs are targeted by the 3' to 5' exoribonuclease DIS3L2. Mutations in DIS3L2 have been associated with Perlman syndrome and with Wilms tumor susceptibility. Using in vivo cross-linking and immunoprecipitation (CLIP) method, we discovered the DIS3L2-dependent cytoplasmic uridylome of human cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL11154
9 Samples

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Accession:: GSE81537

ID:: 200081537

PubMed Full text in PMC Similar studies

Select item 2000815362.

Uridylation-mediated RNA quality control pathway in mammalian cytoplasm [CLIP-Seq]

(Submitter supplied) Uridylation of various cellular RNA species at the 3’ end has been generally linked to RNA degradation. Uridylated pre-miRNAs in mammals and uridylated mRNAs in fission yeast are targeted by the 3′ to 5′ exoribonuclease DIS3L2. In humans, DIS3L2 mutations have been associated with Perlman syndrome development and Wilms tumor susceptibility. In this work, we employ crosslinking in vivo and immunoprecipitation (CLIP) method to assess the RNA binding capacity of human DIS3L2 on a genome-wide scale. more...