GSM1196243[Accession] - GEO DataSets

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Items: 4

Select item 2000492691.

Progression from low- to high-grade astrocytoma is characterized by transcriptomal heterogeneity and genomic number copy alterations

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome variation profiling by genome tiling array

Platforms:: GPL11202 GPL7202 GPL15076
172 Samples

Download data: TXT

Series

Accession:: GSE49269

ID:: 200049269

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000492662.

Progression from low- to high-grade astrocytoma is characterized by transcriptomal heterogeneity and genomic number copy alterations (part 2)

(Submitter supplied) We used genetically-engineered mice (GEM) to target constitutive RTK effector pathway (KrasG12D and/or Pten deletion) mutations in G1/S checkpoint-defective adult mouse astrocytes. Genetic lineage tracing showed that these mutations potentiated tumor initiation in cortical, diencephalic, brainstem, and olfactory bulb astrocytes, producing low-grade astrocytomas (LGA). LGA lacked copy number abnormalities (CNA), but showed oncogenic driver- and astrocyte location-specific transcriptome profiles, suggesting that both driver mutations and cellular origin contribute to LGA genomic heterogeneity. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11202
43 Samples

Download data: TXT

Series

Accession:: GSE49266

ID:: 200049266

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000112023.

Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)

(Submitter supplied) *** The ID column includes the Agilent Probe Names. A different version of this platform with the Agilent Feature Extraction feature numbers in the ID column is assigned accession number GPL10333. Protocol: see manufacturer's web site at http://www.agilent.com/