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Items: 3

1.

A Hybrid Mechanism of Action for BCL6 in B Cells Defined by Formation of Functionally Distinct Complexes at Enhancers and Promoters

(Submitter supplied) BCL6 is crucial for B-cell activation and lymphomagenesis. We used integrative genomics to explore BCL6 mechanism in normal and malignant B-cells. Surprisingly, BCL6 assembled distinct complexes at enhancers vs. promoters. At enhancers BCL6 preferentially recruited SMRT, which mediated H3K27 deacetylation through HDAC3, antagonized p300 activity and repressed transcription, but without decommissioning enhancers. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL15433 GPL10999 GPL11154
46 Samples
Download data: BED, BW, TXT, WIG
Series
Accession:
GSE29282
ID:
200029282

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

2.

Illumina HiSeq 1000 (Homo sapiens)

Organism:
Homo sapiens
176 Series
2073 Samples
Download data
Platform
Accession:
GPL15433
ID:
100015433

3.

OCI-LY1_48hrs_mRNAseq_3x_siBCL6_R2

Organism:
Homo sapiens
Source name:
Human DLBCL cel line
Platform:
GPL15433
Series:
GSE29282
Download data: BW
Sample
Accession:
GSM1000985
ID:
301000985

SRA Run Selector

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db=gds|term=GSM1000985[Accession]|query=1|qty=2|blobid=MCID_674d829630e6852f8a9ee916|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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