GSE5462[Accession] - GEO DataSets - NCBI

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Select item 2000054621.

Letrozole (Femara) early response to treatment

(Submitter supplied) In the present investigation, we have exploited the opportunity provided by neoadjuvant treatment of a group of postmenopausal women with large operable or locally advanced breast cancer (in which therapy is given with the primary tumour remaining within the breast) to take sequential biopsies of the same cancers before and after 10-14 days treatment with letrozole. RNA extracted from the biopsies has been subjected to Affymetrix microarray analysis and the data from paired biopsies interrogated to discover genes whose expression is most influenced by oestrogen deprivation. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3116
Platform:: GPL96
116 Samples

Download data: CEL

Series

Accession:: GSE5462

ID:: 200005462

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 31162.

Full record GDS3116

Letrozole effect on breast cancer tumors

Analysis of breast cancer tumors following treatment with letrozole for 14 days. The aromatase inhibitor letrozole is an anti-estrogen drug used to treat postmenopausal women with breast cancer. Results provide insight into the molecular mechanism of action of letrozole in breast cancer.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 58 individual sets

Platform:: GPL96
Series:: GSE5462
116 Samples

Download data: CEL

DataSet

Accession:: GDS3116

ID:: 3116

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000000963.

[HG-U133A] Affymetrix Human Genome U133A Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 June 24, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The U133 set includes 2 arrays with a total of 44928 entries and was indexed 29-Jan-2002. more...

Organism:: Homo sapiens

364 DataSets
1125 Series
11 Related Platforms
42430 Samples

Platform

Accession:: GPL96

ID:: 100000096

Select item 3001252384.

9B;female;breast tumor;Letrozole, 2.5mg/day,oral, 10-14 days; responder

Organism:: Homo sapiens

Source name:: 9B;female;breast tumor;Letrozole, 2.5mg/day,oral, 10-14 days

Platform:: GPL96
Series:: GSE5462 GSE20181
Dataset:: GDS3116

Download data: CEL

Sample

Accession:: GSM125238

ID:: 300125238

Select item 3001252375.

9A;pretreatment;female;breast tumor; responder

Organism:: Homo sapiens

Source name:: 9A;pretreatment;female;breast tumor

Platform:: GPL96
Series:: GSE5462 GSE20181
Dataset:: GDS3116

Download data: CEL

Sample

Accession:: GSM125237

ID:: 300125237

Select item 3001252366.

8B;female;breast tumor;Letrozole, 2.5mg/day,oral, 10-14 days; nonresponder

Organism:: Homo sapiens

Source name:: 8B;female;breast tumor;Letrozole, 2.5mg/day,oral, 10-14 days

Platform:: GPL96
Series:: GSE5462 GSE20181
Dataset:: GDS3116

Download data: CEL

Sample

Accession:: GSM125236

ID:: 300125236

Select item 3001252357.

8A;pretreatment;female;breast tumor; nonresponder

Organism:: Homo sapiens

Source name:: 8A;pretreatment;female;breast tumor

Platform:: GPL96
Series:: GSE5462 GSE20181
Dataset:: GDS3116

Download data: CEL

Sample

Accession:: GSM125235

ID:: 300125235

Select item 3001252348.

7B;female;breast tumor;Letrozole, 2.5mg/day,oral, 10-14 days; responder

Organism:: Homo sapiens

Source name:: 7B;female;breast tumor;Letrozole, 2.5mg/day,oral, 10-14 days

Platform:: GPL96
Series:: GSE5462 GSE20181
Dataset:: GDS3116

Download data: CEL

Sample

Accession:: GSM125234

ID:: 300125234

Select item 3001252339.

7A;pretreatment;female;breast tumor; responder

Organism:: Homo sapiens

Source name:: 7A;pretreatment;female;breast tumor

Platform:: GPL96
Series:: GSE5462 GSE20181
Dataset:: GDS3116

Download data: CEL

Sample

Accession:: GSM125233

ID:: 300125233

Select item 30012523210.

69B;female;breast tumor;Letrozole, 2.5mg/day,oral, 10-14 days; responder

Organism:: Homo sapiens

Source name:: 69B;female;breast tumor;Letrozole, 2.5mg/day,oral, 10-14 days

Platform:: GPL96
Series:: GSE5462 GSE20181
Dataset:: GDS3116

Download data: CEL

Sample

Accession:: GSM125232

ID:: 300125232

Select item 30012523111.

69A;pretreatment;female;breast tumor; responder

Organism:: Homo sapiens

Source name:: 69A;pretreatment;female;breast tumor

Platform:: GPL96
Series:: GSE5462 GSE20181
Dataset:: GDS3116

Download data: CEL

Sample

Accession:: GSM125231

ID:: 300125231

Select item 30012523012.

68B;female;breast tumor;Letrozole, 2.5mg/day,oral, 10-14 days; nonresponder

Organism:: Homo sapiens

Source name:: 68B;female;breast tumor;Letrozole, 2.5mg/day,oral, 10-14 days

Platform:: GPL96
Series:: GSE5462 GSE20181
Dataset:: GDS3116

Download data: CEL

Sample

Accession:: GSM125230

ID:: 300125230

Select item 30012522913.

68A;pretreatment;female;breast tumor; nonresponder

Organism:: Homo sapiens

Source name:: 68A;pretreatment;female;breast tumor

Platform:: GPL96
Series:: GSE5462 GSE20181
Dataset:: GDS3116

Download data: CEL

Sample

Accession:: GSM125229

ID:: 300125229

Select item 30012522814.

65B;female;breast tumor;Letrozole, 2.5mg/day,oral, 10-14 days; nonresponder

Organism:: Homo sapiens

Source name:: 65B;female;breast tumor;Letrozole, 2.5mg/day,oral, 10-14 days

Platform:: GPL96
Series:: GSE5462 GSE20181
Dataset:: GDS3116

Download data: CEL

Sample

Accession:: GSM125228

ID:: 300125228

Select item 30012522715.

65A;pretreatment;female;breast tumor; nonresponder

Organism:: Homo sapiens

Source name:: 65A;pretreatment;female;breast tumor

Platform:: GPL96
Series:: GSE5462 GSE20181
Dataset:: GDS3116

Download data: CEL

Sample

Accession:: GSM125227

ID:: 300125227

Select item 30012522616.

64B;female;breast tumor;Letrozole, 2.5mg/day,oral, 10-14 days; responder

Organism:: Homo sapiens

Source name:: 64B;female;breast tumor;Letrozole, 2.5mg/day,oral, 10-14 days

Platform:: GPL96
Series:: GSE5462 GSE20181
Dataset:: GDS3116

Download data: CEL

Sample

Accession:: GSM125226

ID:: 300125226

Select item 30012522517.

64A;pretreatment;female;breast tumor; responder

Organism:: Homo sapiens

Source name:: 64A;pretreatment;female;breast tumor

Platform:: GPL96
Series:: GSE5462 GSE20181
Dataset:: GDS3116

Download data: CEL

Sample

Accession:: GSM125225

ID:: 300125225

Select item 30012522418.

63B;female;breast tumor;Letrozole, 2.5mg/day,oral, 10-14 days; responder

Organism:: Homo sapiens

Source name:: 63B;female;breast tumor;Letrozole, 2.5mg/day,oral, 10-14 days

Platform:: GPL96
Series:: GSE5462 GSE20181
Dataset:: GDS3116

Download data: CEL

Sample

Accession:: GSM125224

ID:: 300125224

Select item 30012522319.

63A;pretreatment;female;breast tumor; responder

Organism:: Homo sapiens

Source name:: 63A;pretreatment;female;breast tumor

Platform:: GPL96
Series:: GSE5462 GSE20181
Dataset:: GDS3116

Download data: CEL

Sample

Accession:: GSM125223

ID:: 300125223

Select item 30012522220.

60B;female;breast tumor;Letrozole, 2.5mg/day,oral, 10-14 days; responder

Organism:: Homo sapiens

Source name:: 60B;female;breast tumor;Letrozole, 2.5mg/day,oral, 10-14 days

Platform:: GPL96
Series:: GSE5462 GSE20181
Dataset:: GDS3116

Download data: CEL

Sample

Accession:: GSM125222

ID:: 300125222

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