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Series GSE20181 Query DataSets for GSE20181
Status Public on Jul 28, 2010
Title Letrozole (Femara) early and late responses to treatment
Organism Homo sapiens
Experiment type Expression profiling by array
Summary In the present investigation, we have exploited the opportunity provided by neoadjuvant treatment of a group of postmenopausal women with large operable or locally advanced breast cancer (in which therapy is given with the primary tumour remaining within the breast) to take sequential biopsies of the same cancers before and after 10-14 days or 90 days treatment with letrozole. RNA extracted from the biopsies has been subjected to Affymetrix microarray analysis and the data from paired biopsies interrogated to discover genes whose expression is most influenced by oestrogen deprivation.

Keywords: Timecourse between subjects
 
Overall design Biopsies were taken from the same subjects at three timepoints: pretreatment, after 10-14 days Letrozol (2.5 mg/day, oral), and after 90 days Letrozol (2.5 mg/day, oral).
 
Contributor(s) Miller WR, Larionov A, Renshaw L, Anderson TJ, White S, Hampton G, Walker JR, Ho S, Krause A, Evans DB, Dixon JM
Citation(s) 20697427, 20646288
Submission date Feb 03, 2010
Last update date Aug 10, 2018
Contact name John R Walker
E-mail(s) [email protected]
Phone 858-812-1636
Organization name Genomics Institute of the Novartis Research Foundation
Lab Genetics Core
Street address 10675 John Jay Hopkins
City San Diego
State/province CA
ZIP/Postal code 92121
Country USA
 
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (176)
GSM125123 10A;pretreatment;female;breast tumor; responder
GSM125124 10B;female;breast tumor;Letrozole, 2.5mg/day,oral, 10-14 days; responder
GSM125125 11A;pretreatment;female;breast tumor; nonresponder
Relations
BioProject PRJNA125655

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE20181_RAW.tar 628.7 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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