GEO DataSets

(Submitter supplied) In this experiment we catalogue temporal variation in transcription occurring during IL1B stimulation under control (non-targeting siRNA control) conditions and partial MAP3K8 siRNA knockdown in the A549 cell line. We measure global gene transcription at 0, 1, 2, 4, 6, 8, and 12 hours using Affymetrix HuGene 1.1 ST array. Nineteen genes demonstrated a distinct temporal response to Il1B stimulation following suppression of MAP3K8.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

48 Samples

Download data: CEL

(Submitter supplied) An Affymetrix Human Gene 1.1 ST array plate (Thermo Fisher Scientific) was hybridized with 2.3 µg of fragmented and labeled single-stranded complementary DNA (cDNA)

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

41 Samples

Download data: CEL

(Submitter supplied) We studies the effect of Akkermansia perfusion on human by taking biopsies before and after perfusion and assess gene expression. Affymetrix HuGene 1.1 ST arrays were used to assess whole biopsy gene expression profiles

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

30 Samples

Download data: CEL, CSV

(Submitter supplied) Overweight is a growing health problem worldwide. The most effective strategy to reduce weight is energy restriction (ER): restriction of food intake without malnutrition. ER has been shown to be beneficial in disease prevention, healthy aging, and inflammation. Recent studies suggest that reducing the protein content of a diet contributes to the beneficial effects by ER. The first objective of our study was to assess the effect of energy restriction on changes in gene expression in adipose tissue. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

44 Samples

Download data: CEL

(Submitter supplied) Amorphous magnesium-substituted calcium phosphate (AMCP) nanoparticles form constitutively in large numbers in the gastrointestinal tract. Collective evidence indicates that they trap luminal macromolecules, such as bacterial and dietary protein antigen, delivering this cargo to mucosal antigen presenting cells. Here using a precise synthetic mimetic of the AMCP nanomineral, we studied whether trapping of macromolecules by AMCP modulates signalling of the macromolecule itself. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

28 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

48 Samples

Download data: CEL

(Submitter supplied) Background: Macrophages represent an important part of the immune system in the intestine and are crucial for maintaining homeostasis. As part of research investigating the effect of dietary fibres on the intestinal immune barrier THP-1 macrophages were used as model system. Methods: THP-1 monocytes were stimulated for 48 hours with 100 ng/ml PMA and 48 hours rested in medium. Subsequently, they were stimulated with 500 ug/ml dietary fibres and the maximal observed LPS contamination to serve as background control. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

24 Samples

Download data: CEL

(Submitter supplied) Background: Human intestinal tissue samples are barely accessible to study potential health benefits of nutritional compounds. Dietary fibres have been descirbed to be beneficial for intestinal health. Therefore, in this study we explored the applicability of an in vitro model, namely human intestinal Caco-2 cells, to study the effect of dietary fibres on intestinal health. Transcriptomics was applied to obtain more insight into their mode of actions in the intestinal cells. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

24 Samples

Download data: CEL

(Submitter supplied) To discover the regulatory role of CTBP1/2 in high grade serous ovarian cancer, The full cDNA was extracted from SKOV3 shRNA control and CtBP1/2 knockdown and then compared the expression profiles of them to discovery the key functions and pathways regulated by CtBP1/2..

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

8 Samples

Download data: CEL

(Submitter supplied) Malignant breast cancer is often associated with skeletal metastasis and co-morbidities such as cancer-induced hypercalcemia. Although circulating calcium has been linked to aggressive and larger breast tumors, the mechanisms underlying the potential oncogenic effects of high calcium remain poorly understood. Here, we assessed the effects of high extracellular calcium on the modulation of gene expression in TNBC cells. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

12 Samples

Download data: CEL

(Submitter supplied) To discover the regulatory role of human milk exosomes oligosaccharides, The full cDNA was extracted from human macrophages and then compared the expression profiles of them to discovery the key features regulated by human milk exosomes extracted oligosaccharides.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

4 Samples

Download data: CEL

(Submitter supplied) Transcriptome analysis of: 1- WM1716 melanoma cell line transfected with scrambled control or with miR-211. 2- WM3682 cell line mono-cultured or co-cultured with adipocytes.

Organism:

Homo sapiens; synthetic construct

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL11532 GPL19117

6 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

360 Samples

Download data: CEL

(Submitter supplied) Lung cancer is the single most frequent cause of cancer death worldwide and is relatively more common in males. For reasons that are currently unknown, lung cancer is also associated with significantly worse outcomes in men than women. Here we replicate clustering of Y-chromosome transcripts identified previously as showing tumor-specific disruption in men with lung cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

123 Samples

Download data: CEL

(Submitter supplied) Lung cancer is the single most frequent cause of cancer death worldwide and is relatively more common in males. For reasons that are currently unknown, lung cancer is also associated with significantly worse outcomes in men than women. Here we examine the pulmonary transcriptome in lung cancer at a systems level through network analysis. We compare gene expression networks in affected and unaffected tissue derived from 126 patients with lung cancer. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

237 Samples

Download data: CEL

(Submitter supplied) Background: Human intestinal tissue samples are barely accessible to study potential health benefits of nutritional compounds. Numbers of animals used in animal trials, however, need to be minimalized. Therefore, in this study we explored the applicability of an in vitro model, namely human intestinal Caco-2 cells, to study the effect of food compounds on (intestinal) health. In vitro digested yellow (YOd) and white onion extracts (WOd) were used as model food compounds and transcriptomics was applied to obtain more insight into their mode of actions in the intestinal cells. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

15 Samples

Download data: CEL

(Submitter supplied) Affimetrix Human Gene 1.1 ST Array profiling of 13 normal human cerebellum samples. Total RNA from 8 fetal brains and 5 adult brains was obtained from the Biochain company.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

13 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL15496 GPL11532

177 Samples

Download data: CEL, TXT

(Submitter supplied) Sex differences in incidence, prognosis, and treatment response have been described for many cancers. In malignant pleural mesothelioma (MPM), a lethal disease associated with asbestos exposure, men outnumber women 4 to 1, but women consistently live longer than men following surgery-based therapy. This study investigated whether tumor expression of genes associated with estrogen signaling could potentially explain observed survival differences. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

131 Samples

Download data: CEL

(Submitter supplied) The increased usage of alternative Ayurvedic treatments as potential health-beneficial therapies emphasizes the importance of studying its efficacy in sound placebo-controlled intervention trials. An example of such a traditional Ayurvedic herbal preparation is Mohana Choorna, a mixture composed of 20 different herbs and used to prevent and treat type 2-diabetes (T2D). We studied the efficacy of “Mohana Choorna” on T2D-related parameters in subjects with impaired glucose tol-erance. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

26 Samples

Download data: CEL