7NWL


Conserved Protein Domain Family
Integrin_alpha2

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pfam08441: Integrin_alpha2 
Integrin alpha
This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.
Statistics
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PSSM-Id: 462478
Aligned: 31 rows
Threshold Bit Score: 353.164
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7NWL_A        449 RPIVSASASLTIFPAMf--NPEERS--CSL--EGNPVAC-INLSFCLNASGKHV------A-DSIGFTVELQLDWQ-KQK 513 
Q24247        480 RPIISIQTSVQRKELH---NMDPNTpgCLDd-PASNLTC-FTFRACCSIEPYDE------KnKELRLAYSVEAETF-DHL 547  fruit fly
Q03600        496 RPVISIETKHKMEKRMv--DIDKGVn-CPRg----AKTC-FPLDMVIYVDEETKrgaelvDfSSDVFMCNLEAIPF--RA 565  Caenorhabditi...
Q7QEK5        492 RPVAAMVASTLFEPKSkliALDVKN--CALkrTNKTVPC-TVVNSCLKYNGINVp-------PMLDIEISWTLDA---RK 558  Anopheles gam...
P34446        474 KPVVTV--TGQTEPESaliSVEDKN--CDVdgKLGKQAC-KHINTCFKYEGKGD------TpNDLEFDLRFNLD----DH 538  Caenorhabditi...
CAG09957      443 RPVISIRRDVKVSPQEv--DLTVKT--CGDs------IC-VAVDACFTYTANPAs-----YnPKLTVGFSVESDVErRKQ 506 
P13612        464 RPVVIVDASLSH-PESv--NRTKFD--CVEn--GWPSVC-IDLTLCFSYKGKEVp-------GYIVLFYNMSLDVN-RKA 527  human
Q13797        460 RPVITVDVSIFL-PGSi--NITAPQ--CHDg--QQPVNC-LNVTTCFSFHGKHVp-------GEIGLNYVLMADVAkKEK 524  human
XP_001641435  444 RPIVDVVGKIELSTNRiilESNQTNl-CTLq--GNQHKC-LTARVCLKYKHKVP------VsQGVELDFSLALDQD-RRT 512 
CAG08300      487 RPVVHIGSTLQVTPNNi--DRDKIKeqCD---MSLPSCSnFAARACFSYTAHPEs-----FsPKLILDYTFEADIKrKKA 556  spotted green...
7NWL_A        514 GGVRRALFL-----------------ASRQATLTQTLLIQNGAREDCR-EMKIYLRN--EseFRDKLSPIHIALNFSL-- 571 
Q24247        548 KKFSRVFFFdr--------------eNKRTNVLSRVVRVHTNGRTECQ-AVTGYIKA--N--TRDIQTPVRFRLKYSLv- 607  fruit fly
Q03600        566 DTTARGFIE-----------------GSHSHNYSWPCGSNSHVQKRTY-RQLIYL-PvqE--SKDWITPLKFRFTVSIrn 624  Caenorhabditi...
Q7QEK5        559 ARNPRMFFL-----------------DHEGNHTRTQLMRLARGKLECI-EDKVYVAD--N--IRDKITPLEVEMAYGLrq 616  Anopheles gam...
P34446        539 SPEPRAYFLqkdvksdrsikvaqgskTRDHPSSIEQRVRLEKGRQKCF-RHRFFASS--T--MKDKLSPIHWSVNYTYv- 612  Caenorhabditi...
CAG09957      507 GLPSRLAFLnr-------------slSDAEHQLNGTLELRSRKQEACI-RILGTLKE--N--IRDKLRSIPIEVSTEIld 568 
P13612        528 ESPPRFYFS-----------------SNGTSDVITGSIQVSSREANCR-THQAFMRK--D--VRDILTPIQIEAAYHLgp 585  human
Q13797        525 GQMPRVYFVl----------------LGETMGQVTEKLQLTYMEETCR-HYVAHVKR--R--VQDVISPIVFEAAYSLse 583  human
XP_001641435  513 IELRRMFFDpk-------------ntTDKVFTKRGSAVLTKAGDWHCLpEYKIFLRLreE--IGDLLTALTFDLQYDL-- 575 
CAG08300      557 RLPPRVDF---------------------LGVPRGRLELPGQKRKICT-DIELRLLR--D--FKDWLHAIPISVTASL-- 608  spotted green...
7NWL_A        572 -----DPQAPVDSHGLR--PAL-HYq--SKSRIEDKAQIL-LD-CGEDNICVPDLQLEVFGE----QN------------ 623 
Q24247        608 ----ePPLADSALVRLN--PIL-DQ---TQAHVDFEGTFQ-KD-CGDDDLCESNLIIRVEPNitesSGne---------- 665  fruit fly
Q03600        625 ekkpvQPPQGSQLVDLKhyPVL-NK---YGASYEFDVPFN-TL-CGEDHTCQTDLSLKAAFKdiplTS------------ 686  Caenorhabditi...
Q7QEK5        617 ---nvLGRQRRPRAHTE--PVL-DQn--RGTVQRDAINIQ-KN-CGPDNVCVPDLRMEVKSVd----------------- 669  Anopheles gam...
P34446        613 ----eSKTGKLRGDKLE--PAI-DTt--VPLSFQNKINIA-NN-CGKDDLCVPDLKVTAVADre---------------- 665  Caenorhabditi...
CAG09957      569 ---trRSKPKNSLPPLM--PIL-DAs--QPSKDVVMVNFL-KEgCGSDHVCQSNLRMEYKLLykenNQdvyspvptedni 639 
P13612        586 h--viSKRSTEEFPPLQ--PIL-QQk-kEKDIMKKTINFA-RF-CAHEN-CSADLQVSAKIGflkpHEnk---------- 646  human
Q13797        584 ---hvTGEEERELPPLT--PVL-RWkkgQKIAQKNQTVFE-RN-CRSED-CAADLQLQGKLLlssmDEkt---------- 644  human
XP_001641435  576 --------KKNAICEVC--PILnDYddaRQRTVRAEAIFQ-KH-CKDK-VCVPDLSVSGSASfsggFK------------ 630 
CAG08300      609 -----GDSTQWTSERVT--PVL-DLf--QPKYTVSEINITnRG-CGSDNICQSNLSLEYRFCsrqmENsksvfrslsrkd 677  spotted green...
7NWL_A        624 -HVYLg-DK--NALNLTFHAQN-VGE-GgAYEAELRVTA-PPEAEYSGLVrh--pGNFSSlSCDYFAVNqs----rLLVC 690 
Q24247        666 yTLIL--DE--TELEVRINVSN-LAD-S-AYEAQLFIAH-QAGVSYVATK-----KPTNA-TCNSYNTT-------LVAC 724  fruit fly
Q03600        687 -NGYVsnVGekDYLDLTFTVEN-KKE-K-AYQANFYLEYnEEELELPQVQ-------------GSKRMIaetigknIVHL 749  Caenorhabditi...
Q7QEK5        670 -dYLLg-SN--NLLSVEVLITN-RGE-D-AFEAGFYMAV-PNGLDFRRVDrl-geVKDVPvLCTAPSAAtn----kTLKC 736  Anopheles gam...
P34446        666 -kFLLgtQD--NTMLINVTVQN-GGE-D-SYETKLYFDV-PQGFEYGGIEsvggdGSKSApACSPTSDEpdsdgkwTFAC 738  Caenorhabditi...
CAG09957      640 pVFHLtyQR--KDLAVQVTVSNeKGD-D-AYEAKLLTTF-PTALSYSGVRfs-ppPAEKQiICTAGQNGs------QADC 707 
P13612        647 tYLAVg-SM--KTLMLNVSLFN-AGD-D-AYETTLHVKL-PVGLYFIKILe----LEEKQiNCEVTDNSgv----vQLDC 711  human
Q13797        645 lYLALg-AV--KNISLNISISN-LGD-D-AYDANVSFNV-SRELFFINMWq----KEEMGiSCELLESD-------FLKC 706  human
XP_001641435  631 -DLRIgiS---QQMLVTITVEN-KAEdF-AYPGKVLVTY-PSFLGYVGVA------AKQDvQCKRLITSdd---feQAVC 694 
CAG08300      678 gVAVItpTE--EDIALEMTVTNrGGD-D-AHQTRSIISL-PDTLHYSSVVt---tASEPKvDCTANDKGt------LIDC 743  spotted green...
7NWL_A        691 DLGNPMKA--GASLWGGLRFTVPHLRDTKKTIQFDFQILSKNLNNS---QSDVvsFRLSVEAQAQVTLNGVSKPEAVL-- 763 
Q24247        725 SLGNPMLR--DTTTFVTIRFQPKGLEPSEKIMLFHIFANTTSKLVGperPERD--LRVNVVRRAKLNFRGWAIPEQSFys 800  fruit fly
Q03600        750 PLGNPMNGasKHQFTIQFKLTRGRTEGIGKALKFMAHVNSTSQETEeelKDNKweAEVQIIKKAELEIYGISDPDRVF-- 827  Caenorhabditi...
Q7QEK5        737 DIGNPLSS--GKVVHFKVILAPSFSAGMGSSYDFYLETNSTNAELDgnrQDNVmrKTIGILVQTDLAMSGVSLPDQFH-- 812  Anopheles gam...
P34446        739 DLGNPLPA--NKVVSSVVRVTASSDKPPLAPISINAHVNSSNDEEAhtvADNKvtFTIPVDFKNQLSLNGRSNPEQVD-- 814  Caenorhabditi...
CAG09957      708 ELGNPFKR--DSQVTFYIILSTKKMPLDTTEVDLDLQLQTTSVQH----NISPvkAKAKILIEFPLSVSGEARPNLVSf- 780 
P13612        712 SIGYIYVDh-LSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMdnlKHSRvtVAIPLKYEVKLTVHGFVNPTSFV-- 788  human
Q13797        707 SVGFPFMRs-KSKYEFSVIFDTSHLSGEEEVLSFIVTAQSGNTERSeslHDNTlvLMVPLMHEVDTSITGIMSPTSFVy- 784  human
XP_001641435  695 LVGMPFQG--KTKKTFDMLFATAGVKGNISMFKVDLEATSPGADANp--SDNKvsLQLAVKFEADLSISGASLPDELV-- 768 
CAG08300      744 ELGNPIEK--DAEVTFYVMLTTSGISLSTKAVNISLQLQTTSTQV-----LKPveASAKVFFELKLQLYGVARPSQVSf- 815  spotted green...
7NWL_A        764 ------------FPVSDWHPRDqpqKEEDLGPAVHHVYELINQGPS--SISQGVLELSCPQAL-EGQ-------QLLYVT 821 
Q24247        801 gssvansvantaATDIEGHGPM---GMDDVGSQVHHMFTIFNEGPS--TAPKVQMVIHWPYSLySDPqsgrpvqYLLYLE 875  fruit fly
Q03600        828 -------------FGGKARAESeleLEEDIGTMVRHNYTIINHGPW--TVRNVEAHISWPYQLrSRFgr---gkNALYLL 889  Caenorhabditi...
Q7QEK5        813 ------------YNHSEYKSLAeakTERDIGPQVVHIYEIRNEGPS--TIDEAEFFVLWPYETvDGV-------PLMYLL 871  Anopheles gam...
P34446        815 -------------FSMTNKTRVdafDDNEIGPVVSHLYQISNRGPS--EVDSATLDIFWPSFStEGG-------HLLYII 872  Caenorhabditi...
CAG09957      781 ------------GGLVRGESAMk--TEEEVGSLVRFTFRINNLWKS--PAK-ASLHIHWPKTNkDGK-------WLLYLV 836 
P13612        789 ----------------YGSNDEn-ePETCMVEKMNLTFHVINTGNS--MAPNVSVEIMVPNSFsPQTd------KLFNIL 843  human
Q13797        785 ------------GESVDAANFIqldDLECHFQPINITLQVYNTGPS--TLPGSSVSISFPNRLsSGGa------EMFHVQ 844  human
XP_001641435  769 -------------FSSKGKTSEevrTERDIGPLVQQTIMVRNNGPG--AVDGSEVTVSLPWKKsEEDl-----sYLLYLL 828 
CAG08300      816 ------------GRSLEGKSTIn--SVEEIGALVQYEFRITNLGRSlkYFTNASLNIFWPKENsLGK-------WLLYLT 874  spotted green...
7NWL_A        822 RVT--------G---LN-CT---TNHPINPKGL----------------------------ELDPEGSL-------HHQQ 851 
Q24247        876 QVPt------vEvsqGE-CHv--AKEYVNPLNLasgsrenpaylsapaqmrmfpsqsrhsfNKSLIHSQrsyysssHRDD 946  fruit fly
Q03600        890 DVPtitteftdGtseVRkCFikqQYEYVNPAEIk---------------------------LNTKYSTQetaphrvEHRM 942  Caenorhabditi...
Q7QEK5        872 NQPe-------ThgnIE-CL---PTEYANPLNL------------------------------AIDSALarksfldKVGV 910  Anopheles gam...
P34446        873 TEPvv-----nPpnkGR-CRv-kQLQNVNPLNLr--------------------------iTNEHVPTEppvaktpNEYS 919  Caenorhabditi...
CAG09957      837 GISs------sGpqeVL-CS---PLSEVNPLKL----------------------------TQESDVSRpkreigeRKPV 878 
P13612        844 DVQtt---------tGE-CH---FENYQRVCAL----------------------------EQQKSAMQtlkgivrFLSK 882  human
Q13797        845 EMVv-------GqekGN-CS---FQKNPTPCII------------------------------PQEQENifhtifaFFTK 883  human
XP_001641435  829 SVQ--------VhgsAAtCD-----VKTNPLNI----------------------------KMSNNTDKpavlestSRVG 867 
CAG08300      875 QTSn------tGvqsVP-CS---PVKEINPLKN----------------------------V-KGLSRKkreaeleALTS 915  spotted green...
7NWL_A        852 KREAPSRS--SASSG------------------------------PQILKCPEA----ECFRLRC 880 
Q24247        947 HSDDTQSNrnRVRRSflervtrlerlmyd---pessnaangkkqdIVELDCNKGa--tNCVRIEC 1006 fruit fly
Q03600        943 KREIDEDEeeQSDDLgaveenipwfstanfwnlfaikggdgrpreVKHLSCQDNt--aNCFTVIC 1005 Caenorhabditis elegans
Q7QEK5        911 SSASYSSSmgRTAKFn-----------------------------SAAGSGTVGaegaSYSSNVR 946  Anopheles gambiae str. PEST
P34446        920 REEDDESYedETTT--------------------------------------------QSQSTRH 940  Caenorhabditis elegans
CAG09957      879 AKASLLPSknKL------------------------------------LSCGRGs---RCVVLEC 904 
P13612        883 TDKRLLYCikADP---------------------------------------------HCLNFLC 902  human
Q13797        884 SGRKVLDCekPGI---------------------------------------------SCLTAHC 903  human
XP_001641435  868 ANKRTRKEvkKGDQ----------------------------------LSCDNV----KCLLFTC 894 
CAG08300      916 GDFSFLPTkrKYKT----------------------------------LTCADGl---RCVEICC 943  spotted green pufferfish
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