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    Tpbg trophoblast glycoprotein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83684, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tpbgprovided by RGD
    Official Full Name
    trophoblast glycoproteinprovided by RGD
    Primary source
    RGD:621453
    See related
    EnsemblRapid:ENSRNOG00000010694 AllianceGenome:RGD:621453
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    5T4; WAIF1
    Summary
    Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within several processes, including dendrite arborization; olfactory learning; and positive regulation of intracellular signal transduction. Predicted to be located in axon terminus; dendrite; and endoplasmic reticulum. Predicted to be active in plasma membrane. Orthologous to human TPBG (trophoblast glycoprotein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 45.8), Lung (RPKM 45.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Tpbg in Genome Data Viewer
    Location:
    8q31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (95673993..95677364)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (86793953..86797324)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (93491761..93495132)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094219 Neighboring gene ribosomal protein L7 like 3 Neighboring gene uncharacterized LOC134480084 Neighboring gene ubiquitin protein ligase E3D Neighboring gene stathmin-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Clone Names

    • MGC93332

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    trophoblast glycoprotein
    Names
    5T4 oncofetal trophoblast glycoprotein
    5T4 oncotrophoblast glycoprotein
    wnt-activated inhibitory factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431631.1NP_001418560.1  trophoblast glycoprotein precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q5PQV5, Q9QYD9
      UniProtKB/TrEMBL
      A6I1T6
    2. NM_031807.3NP_113995.2  trophoblast glycoprotein precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q5PQV5, Q9QYD9
      UniProtKB/TrEMBL
      A6I1T6
      Conserved Domains (4) summary
      smart00013
      Location:6295
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:300351
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:7395
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:91154
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      95673993..95677364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243499.5XP_006243561.1  trophoblast glycoprotein isoform X1

      Related
      ENSRNOP00000099969.1, ENSRNOT00000153056.1
      Conserved Domains (4) summary
      smart00013
      Location:6295
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:300351
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:7395
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:91154
      LRR_8; Leucine rich repeat
    2. XM_017595935.3XP_017451424.1  trophoblast glycoprotein isoform X1

      UniProtKB/Swiss-Prot
      Q5PQV5, Q9QYD9
      UniProtKB/TrEMBL
      A6I1T6
      Related
      ENSRNOP00000100654.1, ENSRNOT00000139740.1
      Conserved Domains (4) summary
      smart00013
      Location:6295
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:300351
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:7395
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:91154
      LRR_8; Leucine rich repeat
    3. XM_008766457.4XP_008764679.1  trophoblast glycoprotein isoform X1

      See identical proteins and their annotated locations for XP_008764679.1

      UniProtKB/Swiss-Prot
      Q5PQV5, Q9QYD9
      UniProtKB/TrEMBL
      A6I1T6
      Related
      ENSRNOP00000101915.1, ENSRNOT00000130631.1
      Conserved Domains (4) summary
      smart00013
      Location:6295
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:300351
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:7395
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:91154
      LRR_8; Leucine rich repeat