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Conserved domains on  [gi|1046901404|ref|XP_017451424|]
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trophoblast glycoprotein isoform X1 [Rattus norvegicus]

Protein Classification

LRR and LRRCT domain-containing protein( domain architecture ID 12020582)

protein containing domains LRRNT, LRR, and LRRCT

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-290 1.29e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 1.29e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404  79 NRNLLEVPADLP--PYVRNLFLTGNQMTVLPAgAFARqppLADLAVLNLSGNHLKEVGAgAFEHLPGLRRLDLSHNPLTN 156
Cdd:COG4886   122 GNQLTDLPEELAnlTNLKELDLSNNQLTDLPE-PLGN---LTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITD 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 157 LSAftfagsnvSVSTPSPLLELIL--NHIvppedqrqngsfegmvafegmvaAALRSGLA-LRGLHHLELASNHFLYLPR 233
Cdd:COG4886   197 LPE--------PLGNLTNLEELDLsgNQL-----------------------TDLPEPLAnLTNLETLDLSNNQLTDLPE 245

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1046901404 234 dlLDQLPSLKHLDLRNNSLVSLTyaSFRNLTHLESLHLEDNALKVLHNSTLAEWQGL 290
Cdd:COG4886   246 --LGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGL 298
LRRCT smart00082
Leucine rich repeat C-terminal domain;
300-351 7.05e-12

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 60.14  E-value: 7.05e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1046901404  300 NPWVCDCYMADMVSWLKETEVVPDKARLTCAFPEKMRNRgLLDLTSSDLDCD 351
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 62-90 4.41e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.22  E-value: 4.41e-04
                          10        20
                  ....*....|....*....|....*....
gi 1046901404  62 CPAACECSeaARTVKCVNRNLLEVPADLP 90
Cdd:pfam01462   2 CPVPCHCS--ATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-290 1.29e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 1.29e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404  79 NRNLLEVPADLP--PYVRNLFLTGNQMTVLPAgAFARqppLADLAVLNLSGNHLKEVGAgAFEHLPGLRRLDLSHNPLTN 156
Cdd:COG4886   122 GNQLTDLPEELAnlTNLKELDLSNNQLTDLPE-PLGN---LTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITD 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 157 LSAftfagsnvSVSTPSPLLELIL--NHIvppedqrqngsfegmvafegmvaAALRSGLA-LRGLHHLELASNHFLYLPR 233
Cdd:COG4886   197 LPE--------PLGNLTNLEELDLsgNQL-----------------------TDLPEPLAnLTNLETLDLSNNQLTDLPE 245

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1046901404 234 dlLDQLPSLKHLDLRNNSLVSLTyaSFRNLTHLESLHLEDNALKVLHNSTLAEWQGL 290
Cdd:COG4886   246 --LGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGL 298
LRRCT smart00082
Leucine rich repeat C-terminal domain;
300-351 7.05e-12

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 60.14  E-value: 7.05e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1046901404  300 NPWVCDCYMADMVSWLKETEVVPDKARLTCAFPEKMRNRgLLDLTSSDLDCD 351
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
91-154 2.17e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 2.17e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046901404  91 PYVRNLFLTGNQMTVLPAGAFARqppLADLAVLNLSGNHLKEVGAGAFEHLPGLRRLDLSHNPL 154
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKG---LSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
79-269 8.55e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.24  E-value: 8.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404  79 NRNLLEVPADLPPYVRNLFLTGNQMTVLPAgafarqpPLAD-LAVLNLSGNHLKEVGagafEHLP-GLRRLDLSHNPLT- 155
Cdd:PRK15370  208 NNELKSLPENLQGNIKTLYANSNQLTSIPA-------TLPDtIQEMELSINRITELP----ERLPsALQSLDLFHNKISc 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 156 ----------NLSAFTFAGSNVSVSTPSPLLEL--------ILNHIVPPedqrqngSFEGMVAFEGMVaAALRSGLAlRG 217
Cdd:PRK15370  277 lpenlpeelrYLSVYDNSIRTLPAHLPSGITHLnvqsnsltALPETLPP-------GLKTLEAGENAL-TSLPASLP-PE 347

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046901404 218 LHHLELASNHFLYLPRDLldqLPSLKHLDLRNNSLVSL----------TYASFRNLTHL-ESL 269
Cdd:PRK15370  348 LQVLDVSKNQITVLPETL---PPTITTLDVSRNALTNLpenlpaalqiMQASRNNLVRLpESL 407
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 119-328 5.80e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.74  E-value: 5.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 119 DLAVLNLSGNHLKEVGAG------AFEHLPGLRRLDLSHNPLTNLSAFTFAgsnvSVSTPSPLLELILNH---------- 182
Cdd:cd00116    52 SLKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSDNALGPDGCGVLE----SLLRSSSLQELKLNNnglgdrglrl 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 183 ------IVPPE----DQRQNG-SFEGMVAfegmVAAALRsglALRGLHHLELASNHFL-----YLPRDLLDQlPSLKHLD 246
Cdd:cd00116   128 lakglkDLPPAleklVLGRNRlEGASCEA----LAKALR---ANRDLKELNLANNGIGdagirALAEGLKAN-CNLEVLD 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 247 LRNNSL----VSLTYASFRNLTHLESLHLEDNALK-----VLHNSTLAEWQGLahVRVFLDNNPWVCDCYMAdmvswlkE 317
Cdd:cd00116   200 LNNNGLtdegASALAETLASLKSLEVLNLGDNNLTdagaaALASALLSPNISL--LTLSLSCNDITDDGAKD-------L 270

                         250
                  ....*....|.
gi 1046901404 318 TEVVPDKARLT 328
Cdd:cd00116   271 AEVLAEKESLL 281
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 271-357 6.99e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.54  E-value: 6.99e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404  271 LEDNALKVLHNSTLAEWQGLAHVRvfLDNNPWVCDCYMADMVSWLKETEV-VPDKARLTCAFPEKMRNRGLLDLTSSDLD 349
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEID--LSGNPFECDCGLARLPRWAEEKGVkVRQPEAALCAGPGALAGQPLLGIPLLDSG 79

                           90
                   ....*....|..
gi 1046901404  350 CD----ATLPQS 357
Cdd:TIGR00864   80 CDeeyvACLKDN 91
LRRNT smart00013
Leucine rich repeat N-terminal domain;
62-95 3.68e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.38  E-value: 3.68e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1046901404   62 CPAACECSeaARTVKCVNRNLLEVPADLPPYVRN 95
Cdd:smart00013   2 CPAPCNCS--GTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 62-90 4.41e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.22  E-value: 4.41e-04
                          10        20
                  ....*....|....*....|....*....
gi 1046901404  62 CPAACECSeaARTVKCVNRNLLEVPADLP 90
Cdd:pfam01462   2 CPVPCHCS--ATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-290 1.29e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 1.29e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404  79 NRNLLEVPADLP--PYVRNLFLTGNQMTVLPAgAFARqppLADLAVLNLSGNHLKEVGAgAFEHLPGLRRLDLSHNPLTN 156
Cdd:COG4886   122 GNQLTDLPEELAnlTNLKELDLSNNQLTDLPE-PLGN---LTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITD 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 157 LSAftfagsnvSVSTPSPLLELIL--NHIvppedqrqngsfegmvafegmvaAALRSGLA-LRGLHHLELASNHFLYLPR 233
Cdd:COG4886   197 LPE--------PLGNLTNLEELDLsgNQL-----------------------TDLPEPLAnLTNLETLDLSNNQLTDLPE 245

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1046901404 234 dlLDQLPSLKHLDLRNNSLVSLTyaSFRNLTHLESLHLEDNALKVLHNSTLAEWQGL 290
Cdd:COG4886   246 --LGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGL 298
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
94-301 8.51e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.74  E-value: 8.51e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404  94 RNLFLTGNQMTVLPAgAFARqppLADLAVLNLSGNHLKEVGAgAFEHLPGLRRLDLSHNPLTNLSAFTFAGSNvsvstps 173
Cdd:COG4886   116 ESLDLSGNQLTDLPE-ELAN---LTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLTN------- 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 174 pLLELIL--NHIvppedqrqngsfegmvafegmvaAALRSGLA-LRGLHHLELASNHFLYLPRDlLDQLPSLKHLDLRNN 250
Cdd:COG4886   184 -LKELDLsnNQI-----------------------TDLPEPLGnLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN 238

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1046901404 251 SLVSLtyASFRNLTHLESLHLEDNALKVLhnSTLAEWQGLAHvrVFLDNNP 301
Cdd:COG4886   239 QLTDL--PELGNLTNLEELDLSNNQLTDL--PPLANLTNLKT--LDLSNNQ 283
LRRCT smart00082
Leucine rich repeat C-terminal domain;
300-351 7.05e-12

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 60.14  E-value: 7.05e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1046901404  300 NPWVCDCYMADMVSWLKETEVVPDKARLTCAFPEKMRNRgLLDLTSSDLDCD 351
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
117-300 1.82e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 1.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 117 LADLAVLNLSGNHLKEVGAgAFEHLPGLRRLDLSHNPLTNLsaftfagsnvsvstPSPLLELilnhivppedqrqngsfe 196
Cdd:COG4886   112 LTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL--------------PEPLGNL------------------ 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 197 gmvafegmvaaalrsglalRGLHHLELASNHFLYLPRDLLdQLPSLKHLDLRNNSLVSLTyASFRNLTHLESLHLEDNAL 276
Cdd:COG4886   159 -------------------TNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQL 217

                         170       180
                  ....*....|....*....|....
gi 1046901404 277 KVLhNSTLAEWQGLAHVRvfLDNN 300
Cdd:COG4886   218 TDL-PEPLANLTNLETLD--LSNN 238
LRR_8 pfam13855
Leucine rich repeat;
91-154 2.17e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 2.17e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046901404  91 PYVRNLFLTGNQMTVLPAGAFARqppLADLAVLNLSGNHLKEVGAGAFEHLPGLRRLDLSHNPL 154
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKG---LSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
216-276 3.96e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 3.96e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046901404 216 RGLHHLELASNHFLYLPRDLLDQLPSLKHLDLRNNSLVSLTYASFRNLTHLESLHLEDNAL 276
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-300 2.52e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.71  E-value: 2.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404  79 NRNLLEVPADLPPYVRNLFLTGNQMTVLPAGAFARQPPLADLAVLNLSGNhlkevgaGAFEHLPGLRRLDLSHNPLTNLs 158
Cdd:COG4886    57 LRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL- 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 159 aftfagsnvsvstPSPLLELilnhivppedqrqngsfegmvafegmvaaalrsglalRGLHHLELASNHFLYLPRDLlDQ 238
Cdd:COG4886   129 -------------PEELANL-------------------------------------TNLKELDLSNNQLTDLPEPL-GN 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046901404 239 LPSLKHLDLRNNSLVSLTyASFRNLTHLESLHLEDNALKVLHNStLAEWQGLahVRVFLDNN 300
Cdd:COG4886   158 LTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPEP-LGNLTNL--EELDLSGN 215
LRR_8 pfam13855
Leucine rich repeat;
120-164 6.56e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 6.56e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1046901404 120 LAVLNLSGNHLKEVGAGAFEHLPGLRRLDLSHNPLTNLSAFTFAG 164
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG 47
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
94-279 2.40e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.63  E-value: 2.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404  94 RNLFLTGNQMTVLPAgAFARqppLADLAVLNLSGNHLKEVGAgAFEHLPGLRRLDLSHNPLTNLSAFTfagsnvsvstps 173
Cdd:COG4886   185 KELDLSNNQITDLPE-PLGN---LTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPELG------------ 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 174 pllelilnhivppedqrqngsfegmvafegmvaaalrsglALRGLHHLELASNHFLYLPrdLLDQLPSLKHLDLRNNSLV 253
Cdd:COG4886   248 ----------------------------------------NLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLT 285

                         170       180
                  ....*....|....*....|....*.
gi 1046901404 254 SLTYASFRNLTHLESLHLEDNALKVL 279
Cdd:COG4886   286 DLKLKELELLLGLNSLLLLLLLLNLL 311
LRR_8 pfam13855
Leucine rich repeat;
240-301 3.44e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 3.44e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046901404 240 PSLKHLDLRNNSLVSLTYASFRNLTHLESLHLEDNALKVLHNSTLaewQGLAHVRV-FLDNNP 301
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAF---SGLPSLRYlDLSGNR 60
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
79-269 8.55e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.24  E-value: 8.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404  79 NRNLLEVPADLPPYVRNLFLTGNQMTVLPAgafarqpPLAD-LAVLNLSGNHLKEVGagafEHLP-GLRRLDLSHNPLT- 155
Cdd:PRK15370  208 NNELKSLPENLQGNIKTLYANSNQLTSIPA-------TLPDtIQEMELSINRITELP----ERLPsALQSLDLFHNKISc 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 156 ----------NLSAFTFAGSNVSVSTPSPLLEL--------ILNHIVPPedqrqngSFEGMVAFEGMVaAALRSGLAlRG 217
Cdd:PRK15370  277 lpenlpeelrYLSVYDNSIRTLPAHLPSGITHLnvqsnsltALPETLPP-------GLKTLEAGENAL-TSLPASLP-PE 347

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046901404 218 LHHLELASNHFLYLPRDLldqLPSLKHLDLRNNSLVSL----------TYASFRNLTHL-ESL 269
Cdd:PRK15370  348 LQVLDVSKNQITVLPETL---PPTITTLDVSRNALTNLpenlpaalqiMQASRNNLVRLpESL 407
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 119-328 5.80e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.74  E-value: 5.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 119 DLAVLNLSGNHLKEVGAG------AFEHLPGLRRLDLSHNPLTNLSAFTFAgsnvSVSTPSPLLELILNH---------- 182
Cdd:cd00116    52 SLKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSDNALGPDGCGVLE----SLLRSSSLQELKLNNnglgdrglrl 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 183 ------IVPPE----DQRQNG-SFEGMVAfegmVAAALRsglALRGLHHLELASNHFL-----YLPRDLLDQlPSLKHLD 246
Cdd:cd00116   128 lakglkDLPPAleklVLGRNRlEGASCEA----LAKALR---ANRDLKELNLANNGIGdagirALAEGLKAN-CNLEVLD 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 247 LRNNSL----VSLTYASFRNLTHLESLHLEDNALK-----VLHNSTLAEWQGLahVRVFLDNNPWVCDCYMAdmvswlkE 317
Cdd:cd00116   200 LNNNGLtdegASALAETLASLKSLEVLNLGDNNLTdagaaALASALLSPNISL--LTLSLSCNDITDDGAKD-------L 270

                         250
                  ....*....|.
gi 1046901404 318 TEVVPDKARLT 328
Cdd:cd00116   271 AEVLAEKESLL 281
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 271-357 6.99e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.54  E-value: 6.99e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404  271 LEDNALKVLHNSTLAEWQGLAHVRvfLDNNPWVCDCYMADMVSWLKETEV-VPDKARLTCAFPEKMRNRGLLDLTSSDLD 349
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEID--LSGNPFECDCGLARLPRWAEEKGVkVRQPEAALCAGPGALAGQPLLGIPLLDSG 79

                           90
                   ....*....|..
gi 1046901404  350 CD----ATLPQS 357
Cdd:TIGR00864   80 CDeeyvACLKDN 91
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 75-304 1.46e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404  75 VKCVNRNLLEVPA-DLPPYVRNLFLTGNQMTVLPAGAFARQppladLAVLNLSGNHLKEVGAgaFEHLPGLRRLDLSHNP 153
Cdd:cd21340     7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIENLEFLTN-----LTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 154 LTNLSAFTfagsnvsvsTPSPLLELilnHIvppEDQRqngsfegmvafegmvaaaLRSGLALrglhhlelasnhfLYLPR 233
Cdd:cd21340    80 ISVVEGLE---------NLTNLEEL---HI---ENQR------------------LPPGEKL-------------TFDPR 113

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046901404 234 DLLDQLPSLKHLDLRNNSLVSLTyaSFRNLTHLESLHLEDNALKVLHN--STLAEWQGLAHVRvfLDNNPwVC 304
Cdd:cd21340   114 SLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELD--LTGNP-VC 181
LRRNT smart00013
Leucine rich repeat N-terminal domain;
62-95 3.68e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.38  E-value: 3.68e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1046901404   62 CPAACECSeaARTVKCVNRNLLEVPADLPPYVRN 95
Cdd:smart00013   2 CPAPCNCS--GTAVDCSGRGLTEVPLDLPPDTTL 33
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-288 2.78e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.00  E-value: 2.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404  96 LFLTGNQMTVLPAgAFARqppLADLAVLNLSGNHLKEVGAgaFEHLPGLRRLDLSHNPLTNLSAFTFAGSNVSVS-TPSP 174
Cdd:COG4886   210 LDLSGNQLTDLPE-PLAN---LTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDlSNNQ 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 175 LLELILNHIVPPEDQRQNGSFEGMVAFEGMVAAALRSGLALRGLHHLELASNHFLYLPRDLLDqLPSLKHLDLRNNSLVS 254
Cdd:COG4886   284 LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL-LALLTLLLLLNLLSLL 362

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1046901404 255 LTYASFRNLTHLESLHLEDNALKVLHNSTLAEWQ 288
Cdd:COG4886   363 LTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTT 396
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 240-274 4.18e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 4.18e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1046901404 240 PSLKHLDLRNNSLVSLtyASFRNLTHLESLHLEDN 274
Cdd:pfam12799   1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGN 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 62-90 4.41e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.22  E-value: 4.41e-04
                          10        20
                  ....*....|....*....|....*....
gi 1046901404  62 CPAACECSeaARTVKCVNRNLLEVPADLP 90
Cdd:pfam01462   2 CPVPCHCS--ATVVNCSDRGLTAVPRDLP 28
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 120-276 4.93e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 4.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 120 LAVLNLSGNHLKEVGAGAFEHLPGLRRLDLSHNPLT-----------------NLSAFTFAGSNVSVSTPSpLLELIL-N 181
Cdd:PLN00113   71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgpipddifttssslrylNLSNNNFTGSIPRGSIPN-LETLDLsN 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 182 HIVPPEDQRQNGSFE-------GMVAFEGMVAAALRSglaLRGLHHLELASNHFL-YLPRDL------------------ 235
Cdd:PLN00113  150 NMLSGEIPNDIGSFSslkvldlGGNVLVGKIPNSLTN---LTSLEFLTLASNQLVgQIPRELgqmkslkwiylgynnlsg 226

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1046901404 236 -----LDQLPSLKHLDLRNNSLVSLTYASFRNLTHLESLHLEDNAL 276
Cdd:PLN00113  227 eipyeIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKL 272
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
79-286 1.05e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 41.30  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404  79 NRNLLEVPAdLPPYVRNLFLTGNQMTVLPagafARQPPLADLAVLNLSGNHLKEVGAGAFEHL-------------PGLR 145
Cdd:PRK15387  231 DNNLTSLPA-LPPELRTLEVSGNQLTSLP----VLPPGLLELSIFSNPLTHLPALPSGLCKLWifgnqltslpvlpPGLQ 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 146 RLDLSHNPLTNLSA--------FTFAGSNVSVST-PSPLLELILNHIVPPEDQRQNGSFEGMVAFEGMVAA--ALRSgla 214
Cdd:PRK15387  306 ELSVSDNQLASLPAlpselcklWAYNNQLTSLPTlPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSlpALPS--- 382

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 215 lrGLHHLELASNHFLYLPrdlldQLPS-LKHLDLRNNSLVS--------LTYASFRN-LTHL-ESL-HLEDNALKVLHNS 282
Cdd:PRK15387  383 --GLKELIVSGNRLTSLP-----VLPSeLKELMVSGNRLTSlpmlpsglLSLSVYRNqLTRLpESLiHLSSETTVNLEGN 455


                  ....
gi 1046901404 283 TLAE 286
Cdd:PRK15387  456 PLSE 459
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 120-160 1.74e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 1.74e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1046901404 120 LAVLNLSGNHLKEVGAgaFEHLPGLRRLDLSHN-PLTNLSAF 160
Cdd:pfam12799   3 LEVLDLSNNQITDIPP--LAKLPNLETLDLSGNnKITDLSDL 42
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 215-281 2.06e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 2.06e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1046901404 215 LRGLHHLELASNHFLYLprDLLDQLPSLKHLDLRNNSLVSLTyaSFRNLTHLESLHLEDNALKVLHN 281
Cdd:cd21340     1 LKRITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN 63
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 93-243 2.82e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.77  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404  93 VRNLFLTGNQMTvlPAGAFARQPPLA---DLAVLNLSGNHLKEVGAGA-FEHL---PGLRRLDLSHNPLTNLSAFTFAGS 165
Cdd:COG5238   294 LTSLDLSVNRIG--DEGAIALAEGLQgnkTLHTLNLAYNGIGAQGAIAlAKALqenTTLHSLDLSDNQIGDEGAIALAKY 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 166 NVSVSTpspLLELILnhivppedqRQNG-SFEGmvafegmvAAALRSGLALRGLHHLELASNHFLYLPRDLL-DQLPSLK 243
Cdd:COG5238   372 LEGNTT---LRELNL---------GKNNiGKQG--------AEALIDALQTNRLHTLILDGNLIGAEAQQRLeQLLERIK 431
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
47-160 2.95e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.15  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404  47 AFLASGSAQPPPAE---------RCPAACECSEAARTVK----CVNRN----------LLEVPADLPPYVRNLFLTGNQM 103
Cdd:PRK15387  155 SFLPATTAPQTPAEydavwsawrRAAPAEESRGRAAVVQkmraCLNNGnavlnvgesgLTTLPDCLPAHITTLVIPDNNL 234

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1046901404 104 TVLPAgafarQPPlaDLAVLNLSGNHLKEVGAGAfehlPGLRRLDLSHNPLTNLSAF 160
Cdd:PRK15387  235 TSLPA-----LPP--ELRTLEVSGNQLTSLPVLP----PGLLELSIFSNPLTHLPAL 280
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 82-287 3.48e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 3.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404  82 LLEVPADLPPYVRNLFLTGNQMTVLPAGAFARQ-PPLADLAVLNLSGNHLKEVG----AGAFEHLPGLRRLDLSHNPLTN 156
Cdd:cd00116   128 LAKGLKDLPPALEKLVLGRNRLEGASCEALAKAlRANRDLKELNLANNGIGDAGiralAEGLKANCNLEVLDLNNNGLTD 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 157 LSAFTFAGSnvsVSTPSPLLELILNHivppedqrQNGSFEGMVAFegmvAAALRSGLalRGLHHLELASNHFLYLP-RDL 235
Cdd:cd00116   208 EGASALAET---LASLKSLEVLNLGD--------NNLTDAGAAAL----ASALLSPN--ISLLTLSLSCNDITDDGaKDL 270

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1046901404 236 ---LDQLPSLKHLDLRNNSLVSltyasfrnlthlESLHLEDNALKVLHNSTLAEW 287
Cdd:cd00116   271 aevLAEKESLLELDLRGNKFGE------------EGAQLLAESLLEPGNELESLW 313
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 123-252 9.07e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 38.23  E-value: 9.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046901404 123 LNLSGNHLKEVGAGAF-EHLPG---LRRLDLSHNPLTNLSAFTFAGsnvSVSTPSPLLELILNHivppedqrqNG-SFEG 197
Cdd:COG5238   269 LYLSGNQIGAEGAIALaKALQGnttLTSLDLSVNRIGDEGAIALAE---GLQGNKTLHTLNLAY---------NGiGAQG 336

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1046901404 198 MVAfegmVAAALRSGlalRGLHHLELASNHFLYLPRDLLDQL----PSLKHLDLRNNSL 252
Cdd:COG5238   337 AIA----LAKALQEN---TTLHSLDLSDNQIGDEGAIALAKYlegnTTLRELNLGKNNI 388
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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