U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    CYCD4;1 CYCLIN D4;1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836667, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CYCD4;1
    Official Full Name
    CYCLIN D4;1
    Primary source
    TAIR:AT5G65420
    Locus tag
    AT5G65420
    See related
    Araport:AT5G65420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CYCLIN D4;1; MNA5.15; MNA5_15
    Summary
    Encodes a D-type cyclin CYCD4;1 that physically interacts with CDC2A and is expressed during vascular tissue development, embryogenesis, and formation of lateral root primordia. Its expression is upregulated early during germination.Involved in stomatal cell lineage proliferation in the hypocotyl.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CYCD4;1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (26141470..26144020, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene homeobox protein 25 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene miscRNA Neighboring gene general regulatory factor 8

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The D-type cyclin CYCD4;1 modulates lateral root density in Arabidopsis by affecting the basal meristem region. Nieuwland J, et al. Proc Natl Acad Sci U S A, 2009 Dec 29. PMID 20018777, Free PMC Article
    2. A new D-type cyclin of Arabidopsis thaliana expressed during lateral root primordia formation. De Veylder L, et al. Planta, 1999 Jun. PMID 10420643
    3. The Arabidopsis D-type cyclin CYCD4 controls cell division in the stomatal lineage of the hypocotyl epidermis. Kono A, et al. Plant Cell, 2007 Apr. PMID 17449809, Free PMC Article
    4. Arabidopsis D-type cyclin CYCD4;1 is a novel cyclin partner of B2-type cyclin-dependent kinase. Kono A, et al. Plant Physiol, 2003 Jul. PMID 12857813, Free PMC Article
    5. Functional analysis of cyclin-dependent kinase inhibitors of Arabidopsis. De Veylder L, et al. Plant Cell, 2001 Jul. PMID 11449057, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CYCD4;1 links meristem pericycle cell behavior to lateral root density consistent with a basal meristem prepatterning model and
      Title: The D-type cyclin CYCD4;1 modulates lateral root density in Arabidopsis by affecting the basal meristem region.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_001203690.2
    NM_001203691.1
    NM_001345680.1
    NM_125940.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to sucrose IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal lineage progression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    CYCLIN D4;1
    NP_001190619.1
    • CYCLIN D4;1 (CYCD4;1); FUNCTIONS IN: cyclin-dependent protein kinase regulator activity; INVOLVED IN: G1 phase of mitotic cell cycle, regulation of cell cycle, response to sucrose stimulus, stomatal lineage progression; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cyclin D (InterPro:IPR015451), Cyclin-like (InterPro:IPR011028), Cyclin-related (InterPro:IPR013763), Cyclin, N-terminal (InterPro:IPR006671), Cyclin (InterPro:IPR006670); BEST Arabidopsis thaliana protein match is: cyclin d4;2 (TAIR:AT5G10440.1).
    NP_001190620.1
    • CYCLIN D4;1 (CYCD4;1); FUNCTIONS IN: cyclin-dependent protein kinase regulator activity; INVOLVED IN: G1 phase of mitotic cell cycle, regulation of cell cycle, response to sucrose stimulus, stomatal lineage progression; LOCATED IN: nucleus; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cyclin, C-terminal (InterPro:IPR004367), Cyclin D (InterPro:IPR015451), Cyclin-like (InterPro:IPR011028), Cyclin-related (InterPro:IPR013763), Cyclin, N-terminal (InterPro:IPR006671), Cyclin (InterPro:IPR006670); BEST Arabidopsis thaliana protein match is: cyclin d4;2 (TAIR:AT5G10440.1).
    NP_201345.1
    • CYCLIN D4;1 (CYCD4;1); FUNCTIONS IN: cyclin-dependent protein kinase regulator activity; INVOLVED IN: G1 phase of mitotic cell cycle, regulation of cell cycle, response to sucrose stimulus, stomatal lineage progression; LOCATED IN: nucleus; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cyclin, C-terminal (InterPro:IPR004367), Cyclin D (InterPro:IPR015451), Cyclin-like (InterPro:IPR011028), Cyclin, N-terminal (InterPro:IPR006671), Cyclin (InterPro:IPR006670); BEST Arabidopsis thaliana protein match is: cyclin d4;2 (TAIR:AT5G10440.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      26141470..26144020 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125940.3 → NP_201345.1  CYCLIN D4;1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201345.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LGA1, Q9FKP7, Q9XFR7
      UniProtKB/TrEMBL
      A0A178UJX6
      Conserved Domains (2) summary
      pfam00134
      Location:45 → 178
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:181 → 272
      Cyclin_C; Cyclin, C-terminal domain

    2. NM_001345680.1 → NP_001331197.1  CYCLIN D4;1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BD64, A0A5S9YHS2

    3. NM_001203691.1 → NP_001190620.1  CYCLIN D4;1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190620.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UJX6, F4KHY3
      Conserved Domains (2) summary
      pfam00134
      Location:45 → 188
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:191 → 282
      Cyclin_C; Cyclin, C-terminal domain

    4. NM_001203690.2 → NP_001190619.1  CYCLIN D4;1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190619.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9YHS2, F4KHY4
      Conserved Domains (1) summary
      pfam00134
      Location:45 → 178
      Cyclin_N; Cyclin, N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LGA1.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.