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Conserved domains on  [gi|15238462|ref|NP_201345|]
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CYCLIN D4;1 [Arabidopsis thaliana]

Protein Classification

cyclin-D( domain architecture ID 15334368)

cyclin-D such the G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 78-175 4.44e-57

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410246  Cd Length: 99  Bit Score: 179.05  E-value: 4.44e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  78 RRDALNWIWKACEVHQFGPLCFCLAMNYLDRFLSVHDLPSGKGWILQLLAVACLSLAAKIEETEVPMLIDLQVGDPQFVF 157
Cdd:cd20543   2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKPWMLQLLAVACLSLAAKMEETDVPLLVDLQVEEPKYVF 81

                        90
                ....*....|....*...
gi 15238462 158 EAKSVQRMELLVLNKLKW 175
Cdd:cd20543  82 EAKTIQRMELLVLSTLEW 99
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 180-270 1.29e-23

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410247  Cd Length: 90  Bit Score: 92.37  E-value: 1.29e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462 180 ITPCSYIRYFLRKMSKCDqePSNTLISRSLQVIASTTKGIDFLEFRPSEVAAAVALSVSGELQRVH-FDNSSFSPLFSLL 258
Cdd:cd20544   1 VTPFSFLDYFISKIGLSD--SREELLSRATELLLSTTKDIRFLEYRPSVIAAAAILCALDELPPDDaDDASSRLSLLLSP 78

                        90
                ....*....|..
gi 15238462 259 QKERVKKIGEMI 270
Cdd:cd20544  79 NKEKVKKCYELM 90
 
Name Accession Description Interval E-value
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 78-175 4.44e-57

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 179.05  E-value: 4.44e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  78 RRDALNWIWKACEVHQFGPLCFCLAMNYLDRFLSVHDLPSGKGWILQLLAVACLSLAAKIEETEVPMLIDLQVGDPQFVF 157
Cdd:cd20543   2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKPWMLQLLAVACLSLAAKMEETDVPLLVDLQVEEPKYVF 81

                        90
                ....*....|....*...
gi 15238462 158 EAKSVQRMELLVLNKLKW 175
Cdd:cd20543  82 EAKTIQRMELLVLSTLEW 99
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 45-178 1.67e-36

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 127.25  E-value: 1.67e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462    45 EIIMEMVEKEKQHLPSDDYIKRLRSGDLDLnvgRRDALNWIWKACEVHQFGPLCFCLAMNYLDRFLSVHDLPSGKgwiLQ 124
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPKM---RAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNK---LQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 15238462   125 LLAVACLSLAAKIEETEVPMLIDLQVGDPQfVFEAKSVQRMELLVLNKLKWRLR 178
Cdd:pfam00134  75 LVGVTCLFIAAKYEEIYPPTVEDLVYITDN-AYTREEILRMERLILETLNFDLS 127
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 180-270 1.29e-23

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410247  Cd Length: 90  Bit Score: 92.37  E-value: 1.29e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462 180 ITPCSYIRYFLRKMSKCDqePSNTLISRSLQVIASTTKGIDFLEFRPSEVAAAVALSVSGELQRVH-FDNSSFSPLFSLL 258
Cdd:cd20544   1 VTPFSFLDYFISKIGLSD--SREELLSRATELLLSTTKDIRFLEYRPSVIAAAAILCALDELPPDDaDDASSRLSLLLSP 78

                        90
                ....*....|..
gi 15238462 259 QKERVKKIGEMI 270
Cdd:cd20544  79 NKEKVKKCYELM 90
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 83-171 2.14e-14

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 67.23  E-value: 2.14e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462     83 NWIWKACEVHQFGPLCFCLAMNYLDRFLSVHDLPSgkgWILQLLAVACLSLAAKIEETEvPMLIDLQVGDpqFVFEAKSV 162
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLK---YSPSLIAAAALYLASKTEETP-PWTKELVHYT--GYFTEEEI 74


                   ....*....
gi 15238462    163 QRMELLVLN 171
Cdd:smart00385  75 LRMERLLLE 83
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
2-249 3.39e-13

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 69.42  E-value: 3.39e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462   2 AEENLELSLLCTESNVDDEGMIVdetpieiSIPQmgfsqsESEEIIMEMVEKEKQHLPSDDYIKRLRsgdlDLNVGRRDA 81
Cdd:COG5024 153 QAESKRESQSWQDLDATDQEDPL-------MVPE------YASDIFEYLLKLELIDLPNPNYLIKQS----LYEWSMRSI 215

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  82 LN-WIwkaCEVH-QFG--PLCFCLAMNYLDRFLSVHDLPSGKgwiLQLLAVACLSLAAKIEETEVPMLIDLQVGDPQfVF 157
Cdd:COG5024 216 LVdWL---VEVHgKFGllPETLFLAINIIDRFLSSRVVSLEK---YQLVGISALFIASKYEEVNCPSIKDLVYATDG-AF 288

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462 158 EAKSVQRMELLVLNKLKWRLRAITPCSyiryFLRKMSKCDQEP--SNTLISRSLQVIASTTKgidFLEFRPSEVAAAVAL 235
Cdd:COG5024 289 TRDDIIRAERYMLEVLDFNISWPSPMS----FLRRISKASDYDifSRTPAKFSSEISPVDYK---FIQISPSWCAAAAMY 361

                       250
                ....*....|....
gi 15238462 236 SVSGELQRVHFDNS 249
Cdd:COG5024 362 LSRKILSQNQWDRT 375
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 181-272 2.52e-08

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 51.47  E-value: 2.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462   181 TPCSyiryFLRKMSKCDQEPSN-TLISRSLQVIASTTKGIDFLEFRPSEVAAAVALSVSGELQRVHFDNSsfSPLFSLLQ 259
Cdd:pfam02984   2 TPLS----FLRRFSKAADYLHDlELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPEWTET--LEHYTGYS 75

                          90
                  ....*....|...
gi 15238462   260 KERVKKIGEMIES 272
Cdd:pfam02984  76 EEDLKPCVKLLLE 88
 
Name Accession Description Interval E-value
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 78-175 4.44e-57

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 179.05  E-value: 4.44e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  78 RRDALNWIWKACEVHQFGPLCFCLAMNYLDRFLSVHDLPSGKGWILQLLAVACLSLAAKIEETEVPMLIDLQVGDPQFVF 157
Cdd:cd20543   2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKPWMLQLLAVACLSLAAKMEETDVPLLVDLQVEEPKYVF 81

                        90
                ....*....|....*...
gi 15238462 158 EAKSVQRMELLVLNKLKW 175
Cdd:cd20543  82 EAKTIQRMELLVLSTLEW 99
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 45-178 1.67e-36

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 127.25  E-value: 1.67e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462    45 EIIMEMVEKEKQHLPSDDYIKRLRSGDLDLnvgRRDALNWIWKACEVHQFGPLCFCLAMNYLDRFLSVHDLPSGKgwiLQ 124
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPKM---RAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNK---LQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 15238462   125 LLAVACLSLAAKIEETEVPMLIDLQVGDPQfVFEAKSVQRMELLVLNKLKWRLR 178
Cdd:pfam00134  75 LVGVTCLFIAAKYEEIYPPTVEDLVYITDN-AYTREEILRMERLILETLNFDLS 127
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 180-270 1.29e-23

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410247  Cd Length: 90  Bit Score: 92.37  E-value: 1.29e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462 180 ITPCSYIRYFLRKMSKCDqePSNTLISRSLQVIASTTKGIDFLEFRPSEVAAAVALSVSGELQRVH-FDNSSFSPLFSLL 258
Cdd:cd20544   1 VTPFSFLDYFISKIGLSD--SREELLSRATELLLSTTKDIRFLEYRPSVIAAAAILCALDELPPDDaDDASSRLSLLLSP 78

                        90
                ....*....|..
gi 15238462 259 QKERVKKIGEMI 270
Cdd:cd20544  79 NKEKVKKCYELM 90
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 50-175 4.64e-18

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 79.27  E-value: 4.64e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  50 MVEKEKQHLPSDDYIKRLRSGDLDLNvgRRDALNWIWKACEVHQFGPLCFCLAMNYLDRFLSVHDLPSGKgwiLQLLAVA 129
Cdd:cd20515  30 LLSLEERYLPSASYFKCVQTEIQPFM--RKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPIRKSQ---LQLLGAV 104

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 15238462 130 CLSLAAKIEETeVPMLIDLQVGDPQFVFEAKSVQRMELLVLNKLKW 175
Cdd:cd20515 105 CLFLASKLKET-IPLTAEKLCIYTDNSITLQELLDWELLVLTKLKW 149
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 43-175 3.04e-16

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 73.89  E-value: 3.04e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  43 SEEIIMEMVEKEKQHLPSDDYIkrLRSGDLDLNVgRRDALNWIWKACEVHQFGPLCFCLAMNYLDRFLSV-HDLPSGKgw 121
Cdd:cd20519   5 SEEVWDLMLKKEELYKRDRDFL--NRHPSLQPRM-RAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTqTNVPKTQ-- 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15238462 122 iLQLLAVACLSLAAKIEETEVPMLIDLQ-VGDPqfVFEAKSVQRMELLVLNKLKW 175
Cdd:cd20519  80 -LQLIGITCLFIAAKLEEIYPPKLSEFAyVTDG--ACTEDEILTMELIILKALNW 131
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 43-175 4.21e-16

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 73.86  E-value: 4.21e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  43 SEEIIMEMVEKEKQHLPSDDYIKRLRSGDLDLNvgRRDALNWIWKACEVHQFGPLCFCLAMNYLDRFLSVHdlPSGKGWi 122
Cdd:cd20573  22 NDRVLQTMLKAEETCLPSVSYFKCVQKEILPSM--RKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVE--PTKKSR- 96

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 15238462 123 LQLLAVACLSLAAKIEETeVPMLIDLQVGDPQFVFEAKSVQRMELLVLNKLKW 175
Cdd:cd20573  97 LQLLGATCMFLASKMKET-IPLTAEKLCIYTDNSIRPEELLQMELLVLNKLKW 148
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 43-174 1.14e-15

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 72.28  E-value: 1.14e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  43 SEEIIMEMVEKEKQHLPSDDYIKRLRsgdlDLNVGRRDAL-NWIWKACEVHQFGPLCFCLAMNYLDRFLSVHDLPSGKgw 121
Cdd:cd20504   3 ADDIYEYLRESELKHRPKPDYMRKQP----DINPSMRSILvDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSK-- 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15238462 122 iLQLLAVACLSLAAKIEETEVPmlidlQVGDpqFVF------EAKSVQRMELLVLNKLK 174
Cdd:cd20504  77 -LQLVGTACMFIAAKYEEIYPP-----EVEE--FVYitddtyTKKQVLRMEHLVLKVLS 127
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 83-171 2.14e-14

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 67.23  E-value: 2.14e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462     83 NWIWKACEVHQFGPLCFCLAMNYLDRFLSVHDLPSgkgWILQLLAVACLSLAAKIEETEvPMLIDLQVGDpqFVFEAKSV 162
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLK---YSPSLIAAAALYLASKTEETP-PWTKELVHYT--GYFTEEEI 74


                   ....*....
gi 15238462    163 QRMELLVLN 171
Cdd:smart00385  75 LRMERLLLE 83
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 78-175 1.09e-13

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 66.09  E-value: 1.09e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  78 RRDALNWIWKACEVHQFGPLCFCLAMNYLDRFLSVHDLPSGKgwiLQLLAVACLSLAAKIEETE--VPMLIDLQVGDPQF 155
Cdd:cd20528   7 RRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQ---LHLVALTCLLLAAKFEELDdnIPKISDLNRYLCNS 83

                        90       100
                ....*....|....*....|
gi 15238462 156 VFEAKSVQRMELLVLNKLKW 175
Cdd:cd20528  84 VYSKQEYLQMELLILEFFQW 103
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
2-249 3.39e-13

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 69.42  E-value: 3.39e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462   2 AEENLELSLLCTESNVDDEGMIVdetpieiSIPQmgfsqsESEEIIMEMVEKEKQHLPSDDYIKRLRsgdlDLNVGRRDA 81
Cdd:COG5024 153 QAESKRESQSWQDLDATDQEDPL-------MVPE------YASDIFEYLLKLELIDLPNPNYLIKQS----LYEWSMRSI 215

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  82 LN-WIwkaCEVH-QFG--PLCFCLAMNYLDRFLSVHDLPSGKgwiLQLLAVACLSLAAKIEETEVPMLIDLQVGDPQfVF 157
Cdd:COG5024 216 LVdWL---VEVHgKFGllPETLFLAINIIDRFLSSRVVSLEK---YQLVGISALFIASKYEEVNCPSIKDLVYATDG-AF 288

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462 158 EAKSVQRMELLVLNKLKWRLRAITPCSyiryFLRKMSKCDQEP--SNTLISRSLQVIASTTKgidFLEFRPSEVAAAVAL 235
Cdd:COG5024 289 TRDDIIRAERYMLEVLDFNISWPSPMS----FLRRISKASDYDifSRTPAKFSSEISPVDYK---FIQISPSWCAAAAMY 361

                       250
                ....*....|....
gi 15238462 236 SVSGELQRVHFDNS 249
Cdd:COG5024 362 LSRKILSQNQWDRT 375
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 44-175 6.88e-13

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 65.01  E-value: 6.88e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  44 EEIIMEMVEKEKQHLPSDDYIKRLRSgdlDLN-VGRRDALNWIWKACEVHQFGPLCFCLAMNYLDRFLSVhdLPSGKGWi 122
Cdd:cd20574  24 DRVLQNLLTIEERYLPQCSYFKCVQK---DIQpFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAV--VPTRKCH- 97

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 15238462 123 LQLLAVACLSLAAKIEETeVPMLIDLQVGDPQFVFEAKSVQRMELLVLNKLKW 175
Cdd:cd20574  98 LQLLGAVCMFLASKLKET-IPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKW 149
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 45-174 1.85e-12

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 63.32  E-value: 1.85e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  45 EIIMEMVEKEKQHLPSDDYIKRLRsgdlDLNVGRRDAL-NWIwkaCEVHQ-FG--PLCFCLAMNYLDRFLSVHDLPSGKg 120
Cdd:cd20507   7 DIYKYLRQLEKKYAIDPDYLSGQP----EITERMRAILvDWL---VEVHLkFKllPETLYLTVNIIDRYLSKKQVPRKK- 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462 121 wiLQLLAVACLSLAAKIEETEVPmlidlQVGDpqFV------FEAKSVQRMELLVLNKLK 174
Cdd:cd20507  79 --LQLVGVTALLIASKYEEIYPP-----EIKD--FVyitdnaYTREEILQMERDILKTLD 129
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 78-177 1.43e-10

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 57.32  E-value: 1.43e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  78 RRDALNWIWKACEVHQFGPLCFCLAMNYLDRFLSVhdlPSGKGWILQLLAVACLSLAAKI-EETEV-PMLIDLqVGDPQF 155
Cdd:cd20526   2 RDEAVRWLAELNSQFKFYPETFALAVSILDRFLAS---VKARPKYLRCIAISCLFLAAKTnEEDEViPSTKDL-VRVSKC 77

                        90       100
                ....*....|....*....|..
gi 15238462 156 VFEAKSVQRMELLVLNKLKWRL 177
Cdd:cd20526  78 GCSVAEVLRMERIILDKLHWDL 99
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 84-175 1.56e-10

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 58.46  E-value: 1.56e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  84 WIWKACEVHQFGPLCFCLAMNYLDRFLSVhdLPSGKGWiLQLLAVACLSLAAKIEETeVPMLIDLQVGDPQFVFEAKSVQ 163
Cdd:cd20575  62 WMLEVCEEQKCEEEVFPLAMNYVDRYLSC--VPTRKAQ-LQLLGAVCMLLASKLRET-TPLTIEKLCIYTDNSISPRQLL 137

                        90
                ....*....|..
gi 15238462 164 RMELLVLNKLKW 175
Cdd:cd20575 138 DWEILVLGKLKW 149
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 34-176 2.05e-10

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 57.80  E-value: 2.05e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  34 PQMgfSQSESEEIIMEMVEKEKQHLPSDDYIKRLRSgdlDLNVGRRDAL-NWIWKACEVHQFGPLCFCLAMNYLDRFLSV 112
Cdd:cd20562   2 PQM--CSLYATDIYLNLRVAELKRRPLPDYMEKIQR---DITPSMRGILvDWLVEVAEEYKLVPDTLYLTVSYIDRFLSG 76

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15238462 113 HDLPSGKgwiLQLLAVACLSLAAKIEETEVPmlidlQVGDPQFV----FEAKSVQRMELLVLNKLKWR 176
Cdd:cd20562  77 NYVNRQR---LQLLGVSCMLIASKYEEICAP-----QVEEFCYItdntYTKQEVLEMEIDVLNALQFE 136
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 54-175 1.06e-09

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 56.20  E-value: 1.06e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  54 EKQHLPSDDYIKRLRsgdlDLNVGRRDAL-NWIwkaCEVH-QFG--PLCFCLAMNYLDRFLSVHDLPSGKgwiLQLLAVA 129
Cdd:cd20567  33 EPESCVPPYYMSQQP----DINEKMRAILiDWL---IEVHlKFElmPETLYLTVNLIDRFLSVKQVPRKE---LQLVGVT 102

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 15238462 130 CLSLAAKIEETEVPmlidlQVGDpqFVF------EAKSVQRMELLVLNKLKW 175
Cdd:cd20567 103 AMLIASKYEEIWAP-----EVND--FVYisdnayTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 33-175 3.03e-09

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 54.50  E-value: 3.03e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  33 IPQMGFSQSEseEIIMEMVEKEKQHLPSDDYIKRlrSGDLDLNVgRRDALNWIWKACEVHQFGPLCFCLAMNYLDRFLSV 112
Cdd:cd20579   3 LPVLGWANRD--EVWKNMLNKDKTYLRDKNFLQK--HPLLQPKM-RAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMAT 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15238462 113 HDlpSGKGWILQLLAVACLSLAAKIEETEVPMLidlqvgdPQFVF------EAKSVQRMELLVLNKLKW 175
Cdd:cd20579  78 QE--NVVKTRLQLIGISSLFIAAKLEEIYPPKL-------HQFAYvtdgacTEDEILSMELIIMKALKW 137
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 43-175 3.46e-09

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 54.22  E-value: 3.46e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  43 SEEIIMEMVEKEKQHLPSDDYIkrLRSGDLDLNVgRRDALNWIwkaCEVH-QFG--PLCFCLAMNYLDRFLSVHDLPSGK 119
Cdd:cd20568   9 VPEIFEYLRELELKTLPNPNYM--DDQKELRWKM-RGILVDWL---VEVHeKFRllPETLFLAVNIIDRFLSKRVVSLNK 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15238462 120 gwiLQLLAVACLSLAAKIEETEVPMLIDLqVGDPQFVFEAKSVQRMELLVLNKLKW 175
Cdd:cd20568  83 ---LQLVGISALFIASKYEEVNSPSIKNF-AYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 82-173 1.95e-08

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 51.17  E-value: 1.95e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  82 LNWIWKACEVHQFGPLCFCLAMNYLDRFLSVHDLPSGKgwiLQLLAVACLSLAAKIEETEVPMLIDLQ-VGDPQFVFEAk 160
Cdd:cd20536   6 ISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDC---FQLLGVTSLLIACKQEEIYPPEVKDLLaLCCGAYTREQ- 81

                        90
                ....*....|...
gi 15238462 161 sVQRMELLVLNKL 173
Cdd:cd20536  82 -ICNLECIILTKL 93
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 181-272 2.52e-08

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 51.47  E-value: 2.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462   181 TPCSyiryFLRKMSKCDQEPSN-TLISRSLQVIASTTKGIDFLEFRPSEVAAAVALSVSGELQRVHFDNSsfSPLFSLLQ 259
Cdd:pfam02984   2 TPLS----FLRRFSKAADYLHDlELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPEWTET--LEHYTGYS 75

                          90
                  ....*....|...
gi 15238462   260 KERVKKIGEMIES 272
Cdd:pfam02984  76 EEDLKPCVKLLLE 88
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 43-175 2.59e-08

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 51.60  E-value: 2.59e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  43 SEEIIMEMVEKEKQHLPSDDYIKRlrSGDLDlNVGRRDALNWIWKACEVHQFGPLCFCLAMNYLDRFLSVHDLPSGKgwi 122
Cdd:cd20561   5 HEDIHTYLREMEVKCKPKVGYMKK--QPDIT-NSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGK--- 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15238462 123 LQLLAVACLSLAAKIEETEVPmlidlQVGDPQFV----FEAKSVQRMELLVLNKLKW 175
Cdd:cd20561  79 LQLVGTAAMLLASKFEEIYPP-----EVAEFVYItddtYTKKQVLRMEHLVLKVLTF 130
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 101-177 3.43e-08

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 50.40  E-value: 3.43e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462 101 LAMNYLDRFLSVHDLPSGKgwiLQLLAVACLSLAAKIEET---EVPMLIDLQVGdpqfVFEAKSVQRMELLVLNKLKWRL 177
Cdd:cd20542  24 LAVALLDRYLSRQKISLSL---LQLLGITCLFIACKFEERfppEVATLCYLTDD----SYSKKQVLRMERRVLRRLRFDL 96
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 39-175 7.71e-08

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 50.62  E-value: 7.71e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  39 SQSESEEIIMEMVEKEKQHLPSddyiKRLRSGDLDLNVGRRDAL-NWIWKACEVHQFGPLCFCLAMNYLDRF-LSVHDLP 116
Cdd:cd20580   7 SWGNSKDVWLNMLKKESKYVHD----KHFLQLHPALQPKMRSILlDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKNIN 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462 117 SGKgwiLQLLAVACLSLAAKIEETEVPMLIDLQ-VGDPQFVFEakSVQRMELLVLNKLKW 175
Cdd:cd20580  83 KSM---LQLIGITSLFIASKLEEIYPPKLHEFAyVTDGACSED--DILDMELIILKALKW 137
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 43-173 9.20e-08

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 51.00  E-value: 9.20e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  43 SEEIIMEMVEKEKQHLPSDDYIKRlrsgDLDLNVGRRDAL-NWIWKACEVHQFGPLCFCLAMNYLDRFLSVHDLPSGKgw 121
Cdd:cd20560  37 AEDIHQYLREAELKHRPKPGYMRK----QPDITTGMRTILvDWLVEVGEEYKLQTETLYLAVNYLDRFLSCMSVLRGK-- 110

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 15238462 122 iLQLLAVACLSLAAKIEETEVPMlIDLQVGDPQFVFEAKSVQRMELLVLNKL 173
Cdd:cd20560 111 -LQLVGTAAILLASKYEEIYPPE-VDEFVYITDDTYTKKQLLRMEHLLLKVL 160
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 80-144 1.13e-07

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 48.56  E-value: 1.13e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15238462  80 DALNWIWKACEVHQFGPLCFCLAMNYLDRFLSVHDLpsgKGWILQLLAVACLSLAAKIEETEVPM 144
Cdd:cd00043   1 KAVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLL---LGRSPELIAAACLYLACKLEELPRTL 62
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 99-176 4.12e-06

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 44.43  E-value: 4.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  99 FCLAMNYLDRFLSVHDLPSGKgwiLQLLAVACLSLAAKI--EETEVPMLIDLqVGDPQFVFEAKSVQRMELLVLNKLKWR 176
Cdd:cd20583  23 FSLAVNLLDRFLAKMKVQPKH---LGCVGLSCFYLAVKAieEERNVPLATDL-IRISQYRFTVSDMMRMEKIILEKLCWK 98
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 94-173 5.72e-06

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 44.27  E-value: 5.72e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  94 FGPLCFCLAMNYLDRFLSVHDLpsgKGWILQLLAVACLSLAAKI--EETEVPMLIDLqVGDPQFVFEAKSVQRMELLVLN 171
Cdd:cd20523  17 FSPETFALAVNLLDRFLSKVKV---KPKHLACITVSCFHIAIKSveEDQNIPSAEDL-IRISQCGCTAADLMRMEGIILE 92


                ..
gi 15238462 172 KL 173
Cdd:cd20523  93 KL 94
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 82-142 1.47e-05

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 43.07  E-value: 1.47e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15238462  82 LNWIWKACEVHQFGPLCFCLAMNYLDRFLSVHDLPSGKgwiLQLLAVACLSLAAKIEETEV 142
Cdd:cd20521   8 VDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSK---LQLLGIACMVIATRFLGKDI 65
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 99-176 1.03e-03

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 37.75  E-value: 1.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238462  99 FCLAMNYLDRFLSVHDLpsgKGWILQLLAVACLSLAAKIEETE--VPMLIDLQ--VGDPQfvfEAKSVQRMELLVLNKLK 174
Cdd:cd20559  20 FFLSVNLIDRYCSKRIV---LKKHYQLVGCTCLWIASKFWESKarVPLLSELSkmCCNSY---GEELFIQMEMHILNTLN 93


                ..
gi 15238462 175 WR 176
Cdd:cd20559  94 WD 95
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 99-173 1.32e-03

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 37.52  E-value: 1.32e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15238462  99 FCLAMNYLDRFLSVHDLpsgKGWILQLLAVACLSLAAKI--EETEVPMLIDLqVGDPQFVFEAKSVQRMELLVLNKL 173
Cdd:cd20584  23 FVLAVNILDRFLALMKV---KPKHLSCIGICCFHLAARVveEECNIPSSHDL-IRISQCKCTVSDLKRMEKIISEKL 95
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 106-175 2.03e-03

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 37.55  E-value: 2.03e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15238462 106 LDRFLSVHDLPSGkgwILQLLAVACLSLAAKIEETEVPmlidlQVGDPQFV----FEAKSVQRMELLVLNKLKW 175
Cdd:cd20565  64 IDRFLQNNPVPKK---MLQLVGVTAMFIASKYEEMYPP-----EIGDFAFVtdntYTKHQIRQMEMKILRALDF 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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