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    FLU Tetratricopeptide repeat (TPR)-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820628, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FLU
    Official Full Name
    Tetratricopeptide repeat (TPR)-like superfamily protein
    Primary source
    TAIR:AT3G14110
    Locus tag
    AT3G14110
    See related
    Araport:AT3G14110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    FLUORESCENT IN BLUE LIGHT
    Summary
    Encodes a novel coiled-coil, TPR domain containing protein that is localized to the chloroplast membrane and is involved in chlorophyll biosynthesis. Mutants accumulate protochlorophyllide, an intermediate in the chlorophyll biosynthesis pathway, in dark and release singlet oxygen in plastids in a controlled and non-invasive manner upon a dark/light shift.
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    Genomic context

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    See FLU in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (4676118..4677689, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene exocyst subunit exo70 family protein D3 Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene ncRNA Neighboring gene nuclear pore complex protein Neighboring gene Aldolase-type TIM barrel family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo functional analysis of the structural domains of FLUORESCENT (FLU). Hou Z, et al. Plant J, 2021 Jul. PMID 33901334
    2. A genetic approach towards elucidating the biological activity of different reactive oxygen species in Arabidopsis thaliana. Laloi C, et al. J Exp Bot, 2006. PMID 16720605
    3. FLU: a negative regulator of chlorophyll biosynthesis in Arabidopsis thaliana. Meskauskiene R, et al. Proc Natl Acad Sci U S A, 2001 Oct 23. PMID 11606728, Free PMC Article
    4. The Non-canonical Tetratricopeptide Repeat (TPR) Domain of Fluorescent (FLU) Mediates Complex Formation with Glutamyl-tRNA Reductase. Zhang M, et al. J Biol Chem, 2015 Jul 10. PMID 26037924, Free PMC Article
    5. Enzymatic, but not non-enzymatic, 1O2-mediated peroxidation of polyunsaturated fatty acids forms part of the EXECUTER1-dependent stress response program in the flu mutant of Arabidopsis thaliana. Przybyla D, et al. Plant J, 2008 Apr. PMID 18182022

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In vivo functional analysis of the structural domains of FLUORESCENT (FLU).
      Title: In vivo functional analysis of the structural domains of FLUORESCENT (FLU).
    2. a ternary complex composed of the C-terminal tetratricopepetide-repeat domain of FLU, GBP, and GluTR, is reported
      Title: The Arabidopsis glutamyl-tRNA reductase (GluTR) forms a ternary complex with FLU and GluTR-binding protein.
    3. characterize the FLU-GluTR interaction by solving the crystal structures of the uncomplexed TPR domain of FLU (FLU(TPR)) at 1.45-A resolution and the complex of the dimeric domain of GluTR bound to FLU(TPR) at 2.4-A resolution
      Title: The Non-canonical Tetratricopeptide Repeat (TPR) Domain of Fluorescent (FLU) Mediates Complex Formation with Glutamyl-tRNA Reductase.
    4. FLU links chlorophyll synthesis and the target of feedback control
      Title: FLU, a negative feedback regulator of tetrapyrrole biosynthesis, is physically linked to the final steps of the Mg(++)-branch of this pathway.
    5. The impact of the EXECUTER1 utation and the prevalence of enzymatic or non-enzymatic lipid peroxidation on the modes of singlet oxygen activity in flu mutant A. thaliana is reported.
      Title: Enzymatic, but not non-enzymatic, 1O2-mediated peroxidation of polyunsaturated fatty acids forms part of the EXECUTER1-dependent stress response program in the flu mutant of Arabidopsis thaliana.
    6. Immediately after a dark/light shift of the flu mutant, singlet oxygen is generated within the plastids, activating several stress responses triggered by the Executer1 protein.
      Title: A genetic approach towards elucidating the biological activity of different reactive oxygen species in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001202959.1
    NM_112267.4
    NM_202581.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chlorophyll biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chlorophyll biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within oxylipin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to singlet oxygen IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast thylakoid HDA PubMed 
    located_in chloroplast thylakoid membrane HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tetratricopeptide repeat (TPR)-like superfamily protein
    NP_001189888.1
    • FLUORESCENT IN BLUE LIGHT (FLU); FUNCTIONS IN: binding; INVOLVED IN: chlorophyll biosynthetic process, oxylipin biosynthetic process, response to singlet oxygen; LOCATED IN: chloroplast thylakoid membrane, chloroplast envelope; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026).
    NP_566478.1
    • FLUORESCENT IN BLUE LIGHT (FLU); FUNCTIONS IN: binding; INVOLVED IN: chlorophyll biosynthetic process, oxylipin biosynthetic process, response to singlet oxygen; LOCATED IN: chloroplast thylakoid membrane, chloroplast, membrane, chloroplast envelope; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026); Has 863 Blast hits to 502 proteins in 124 species: Archae - 8; Bacteria - 276; Metazoa - 453; Fungi - 0; Plants - 82; Viruses - 0; Other Eukaryotes - 44 (source: NCBI BLink).
    NP_974310.1
    • FLUORESCENT IN BLUE LIGHT (FLU); FUNCTIONS IN: binding; INVOLVED IN: chlorophyll biosynthetic process, oxylipin biosynthetic process, response to singlet oxygen; LOCATED IN: chloroplast thylakoid membrane, chloroplast, chloroplast envelope, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      4676118..4677689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112267.4 → NP_566478.1  Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566478.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DI70, Q940U6, Q9LJH7
      UniProtKB/TrEMBL
      A0A178VAG9, A0A5S9XC72
      Conserved Domains (2) summary
      sd00006
      Location:242 → 272
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:244 → 314
      TPR_12; Tetratricopeptide repeat

    2. NM_202581.2 → NP_974310.1  Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974310.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JFR2
      Conserved Domains (3) summary
      sd00006
      Location:158 → 188
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:160 → 227
      TPR_11; TPR repeat
      pfam13424
      Location:126 → 191
      TPR_12; Tetratricopeptide repeat

    3. NM_001202959.1 → NP_001189888.1  Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189888.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JFR1
      Conserved Domains (3) summary
      sd00006
      Location:243 → 273
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:245 → 312
      TPR_11; TPR repeat
      pfam13424
      Location:211 → 276
      TPR_12; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q940U6.1

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