6030468B19Rik RIKEN cDNA 6030468B19 gene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: 6030468B19Rikprovided by MGI
Official Full Name: RIKEN cDNA 6030468B19 geneprovided by MGI
Primary source: MGI:MGI:1924977
See related: Ensembl:ENSMUSG00000025573 AllianceGenome:MGI:1924977
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il-40
Summary: Predicted to enable transmembrane signaling receptor activity. Involved in mature B cell differentiation involved in immune response and positive regulation of immunoglobulin production in mucosal tissue. Predicted to be located in extracellular space. Predicted to be active in external side of plasma membrane. Orthologous to human C17orf99 (chromosome 17 open reading frame 99). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver E14.5 (RPKM 83.6), liver E14 (RPKM 60.2) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 82.96 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (117688460..117698134)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (117797634..117807308)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these observations indicate that C17orf99 encodes a novel B cell-associated cytokine, which we have called IL-40, that plays an important role in humoral immune responses and may also play a role in B cell development.
Title: Identification of IL-40, a Novel B Cell-Associated Cytokine.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in mature B cell differentiation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of immunoglobulin production in mucosal tissue	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein IL-40

Names: interleukin-40; uncharacterized protein C17orf99 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029964.1 → NP_084240.1 protein IL-40 precursor

See identical proteins and their annotated locations for NP_084240.1

Status: VALIDATED

Source sequence(s)

AK020081, AL645856, BB843270

Consensus CDS

CCDS48992.1

UniProtKB/Swiss-Prot

B1ATC1, Q9CX63

Related

ENSMUSP00000101938.2, ENSMUST00000106331.2

Conserved Domains (2) summary

smart00410
Location:139 → 202

IG_like; Immunoglobulin like

pfam13927
Location:136 → 195

Ig_3; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

117688460..117698134

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534500.4 → XP_006534563.1 protein IL-40 isoform X3

Conserved Domains (1) summary

pfam17736
Location:25 → 116

Ig_C17orf99; C17orf99 Ig domain
XM_006534498.4 → XP_006534561.1 protein IL-40 isoform X1

Conserved Domains (1) summary

pfam17736
Location:23 → 117

Ig_C17orf99; C17orf99 Ig domain
XM_006534499.5 → XP_006534562.1 protein IL-40 isoform X2

Conserved Domains (1) summary

pfam17736
Location:23 → 117

Ig_C17orf99; C17orf99 Ig domain